General Information of the Protein
Protein ID
PT02317
Protein Name
Myeloperoxidase
Gene Name
MPO
Sequence
MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWREAS
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Oxidoreductase
Function
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971).
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Uniprot ID
Primary ID:
P05164

Secondarily ID:
A1L4B8
Q14862
Q4PJH5
Q9UCL7
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Ensembl ID
ENSG00000005381
HGNC ID
HGNC:7218
Subcellular Location
Lysosome
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000018 , HL-60
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0572939
 Compound Info 
Alternative Preparation
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C15H15ClN4OS
  1
1
IC50 = 800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0543572
 Compound Info 
1-[[4-chloro-2-[(2,2-dimethylpropylamino)methyl]phenyl]methyl]-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one
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C19H23ClN4OS
  1
1
IC50 = 1300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0960966
 Compound Info 
(R)-3-(2-(1-aminoethyl)-4-chlorobenzyl)-2-thioxo-2,3-dihydro-1H-purin-6-(7H)-one
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C14H14ClN5OS
  1
1
IC50 = 3100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0960965
 Compound Info 
(R/S)-1-(4-chloro-2-(1-(methylamino)ethyl)benzyl)-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
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C16H17ClN4OS
  1
1
IC50 = 4600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0562623
 Compound Info 
1-[[5-chloro-2-(methylaminomethyl)phenyl]methyl]-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one
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C15H15ClN4OS
  1
1
IC50 = 6100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0569026
 Compound Info 
1-[[2-(azetidin-1-ylmethyl)phenyl]methyl]-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one
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C17H18N4OS
  1
1
IC50 = 6600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0576228
 Compound Info 
1-{4-Chloro-2-[(methylamino)methyl]benzyl}-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
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C15H15ClN4OS
  1
1
IC50 = 6600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0567838
 Compound Info 
1-[[3-chloro-2-(methylaminomethyl)phenyl]methyl]-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one
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C15H15ClN4OS
  1
1
IC50 = 9400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0542998
 Compound Info 
1-[2-(Aminomethyl)-4-chlorobenzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
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C14H13ClN4OS
  1
1
IC50 = 11000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0567865
 Compound Info 
1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
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C17H20N4OS
  1
1
IC50 = 13000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0577003
 Compound Info 
N-[[5-chloro-2-[(4-oxo-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-1-yl)methyl]phenyl]methyl]acetamide
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C16H15ClN4O2S
  1
1
IC50 = 16000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0543576
 Compound Info 
1-{2-[(1S)-1-Aminoethyl]-4-chlorobenzyl}-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
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C15H15ClN4OS
  1
1
IC50 = 20000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0069658
 Compound Info 
2-Thioxanthine, TX4
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C10H12N4O2S
  1
1
IC50 = 29000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0174612
 Compound Info 
2-[6-(5-chloro-2-methoxyphenyl)-4-oxo-2-sulfanylidenepyrimidin-1-yl]acetamide
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C13H12ClN3O3S
  1
1
IC50 = 35500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0577159
 Compound Info 
3-[[2-[(propan-2-ylamino)methyl]phenyl]methyl]-2-sulfanylidene-7H-purin-6-one
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C16H19N5OS
  1
1
IC50 = 80000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0960966
 Compound Info 
(R)-3-(2-(1-aminoethyl)-4-chlorobenzyl)-2-thioxo-2,3-dihydro-1H-purin-6-(7H)-one
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C14H14ClN5OS
  1
1 IC50 = 3.6 nM
CP0069658
 Compound Info 
2-Thioxanthine, TX4
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C10H12N4O2S
  5
1 IC50 = 9 nM
2 IC50 = 12 nM
3 IC50 = 56 nM
4 IC50 = 1000 nM
5 Kd = 63095.73 nM
CP0960965
 Compound Info 
(R/S)-1-(4-chloro-2-(1-(methylamino)ethyl)benzyl)-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
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C16H17ClN4OS
  1
1 IC50 = 12.7 nM
CP0569026
 Compound Info 
1-[[2-(azetidin-1-ylmethyl)phenyl]methyl]-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one
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C17H18N4OS
  1
1 IC50 = 15.1 nM
CP0576228
 Compound Info 
1-{4-Chloro-2-[(methylamino)methyl]benzyl}-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
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C15H15ClN4OS
  1
1 IC50 = 15.9 nM
CP0543576
 Compound Info 
1-{2-[(1S)-1-Aminoethyl]-4-chlorobenzyl}-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
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C15H15ClN4OS
  1
1 IC50 = 26.4 nM
CP0562623
 Compound Info 
1-[[5-chloro-2-(methylaminomethyl)phenyl]methyl]-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one
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C15H15ClN4OS
  1
1 IC50 = 27.1 nM
CP0567865
 Compound Info 
1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
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C17H20N4OS
  1
1 IC50 = 30.9 nM
CP0543572
 Compound Info 
1-[[4-chloro-2-[(2,2-dimethylpropylamino)methyl]phenyl]methyl]-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one
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C19H23ClN4OS
  1
1 IC50 = 35 nM
CP0577159
 Compound Info 
3-[[2-[(propan-2-ylamino)methyl]phenyl]methyl]-2-sulfanylidene-7H-purin-6-one
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C16H19N5OS
  1
1 IC50 = 38.6 nM
CP0567838
 Compound Info 
1-[[3-chloro-2-(methylaminomethyl)phenyl]methyl]-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one
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C15H15ClN4OS
  1
1 IC50 = 39.3 nM
CP0577003
 Compound Info 
N-[[5-chloro-2-[(4-oxo-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-1-yl)methyl]phenyl]methyl]acetamide
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C16H15ClN4O2S
  1
1 IC50 = 140.3 nM
CP0174612
 Compound Info 
2-[6-(5-chloro-2-methoxyphenyl)-4-oxo-2-sulfanylidenepyrimidin-1-yl]acetamide
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C13H12ClN3O3S
  2
1 IC50 = 187 nM
2 IC50 = 1900 nM
CP0572939
 Compound Info 
Alternative Preparation
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C15H15ClN4OS
  1
1 Kd = 501.19 nM
CP0542998
 Compound Info 
1-[2-(Aminomethyl)-4-chlorobenzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
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C14H13ClN4OS
  1
1 Kd = 3981.07 nM
Clinical Information about the Protein
Target 1 ( Myeloperoxidase (MPO) )
Target Type Clinical trial Target
Disease 4 Target-related Diseases  4
1 Infectious disease [ICD-11: 1A00-CA43.1]
2 Parkinson disease [ICD-11: 8A00.0]
3 Heart failure with preserved ejection fraction [ICD-11: BD11.0]
4 Multiple sclerosis [ICD-11: 8A40]
Clinical Trial Drug(s) 3 Clinical Trial Drugs  3
1 E-101
 Drug Info 
Phase 3
Infectious disease
2 AZD-3241
 Drug Info 
Phase 2
Parkinson disease
3 Mitiperstat
 Drug Info 
Phase 2/3
Heart failure with preserved ejection fraction
Discontinued Drug(s) 1 Discontinued Drug  1
1 AZD5904
 Drug Info 
Discontinued in Phase 1
Multiple sclerosis