General Information of the Compound
Compound ID
CP0069658
Compound Name
2-Thioxanthine, TX4
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Synonyms
(R)-3-((Tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one
2-Thioxanthine, TX4
3-(((2R)-Oxolan-2-yl)methyl)-2-sulfanylidene-7H-purin-6-one
3-[[(2R)-oxolan-2-yl]methyl]-2-sulfanylidene-7H-purin-6-one
618913-30-7
62A9CG81VN
6H-Purin-6-one, 1,2,3,7-tetrahydro-3-(((2R)-tetrahydro-2-furanyl)methyl)-2-thioxo-
6H-Purin-6-one, 1,2,3,9-tetrahydro-3-(((2R)-tetrahydro-2-furanyl)methyl)-2-thioxo-
AZD 5904
AZD-5904
AZD5904
BDBM92469
CS-0035112
GTPL7728
HY-111341
SCHEMBL2288062
TX-4
UNII-62A9CG81VN
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Structure
Formula
C10H12N4O2S
Molecular Weight
252.299
Canonical SMILES
O=c1[nH]c(=S)n(C[C@H]2CCCO2)c2nc[nH]c12
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InChI
InChI=1S/C10H12N4O2S/c15-9-7-8(12-5-11-7)14(10(17)13-9)4-6-2-1-3-16-6/h5-6H,1-4H2,(H,11,12)(H,13,15,17)/t6-/m1/s1
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InChIKey
RSPDBEVKURKEII-ZCFIWIBFSA-N
Physicochemical Property
logP
0.96119
Rotatable Bonds
2
Heavy Atom Count
17
Polar Areas
75.7
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
17

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10264211
SID: 15268512
ChEMBL ID
CHEMBL4278946
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02317, Myeloperoxidase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000018 HL-60 Homo sapiens (Human)  1
1
IC50 = 29000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 9 nM
2 IC50 = 12 nM
3 IC50 = 56 nM
4 IC50 = 1000 nM
5 Kd = 63095.73 nM
Clinical Information about the Compound
Drug 1 ( AZD5904 )
Drug Name AZD5904
Company AstraZeneca
Indication
Multiple sclerosis
Discontinued in Phase 1
Chronic obstructive pulmonary disease
Discontinued in Phase 1
Target(s)
Myeloperoxidase (MPO)
Inhibitor