General Information of the Compound
Compound ID
CP0577003
Compound Name
N-[[5-chloro-2-[(4-oxo-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-1-yl)methyl]phenyl]methyl]acetamide
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Structure
Formula
C16H15ClN4O2S
Molecular Weight
362.842
Canonical SMILES
CC(=O)NCc1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
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InChI
InChI=1S/C16H15ClN4O2S/c1-9(22)19-7-11-6-12(17)3-2-10(11)8-21-13-4-5-18-14(13)15(23)20-16(21)24/h2-6,18H,7-8H2,1H3,(H,19,22)(H,20,23,24)
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InChIKey
CZYBHRFKMUJCPS-UHFFFAOYSA-N
Physicochemical Property
logP
2.72499
Rotatable Bonds
4
Heavy Atom Count
24
Polar Areas
82.68
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
4
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168276915
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02317, Myeloperoxidase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000018 HL-60 Homo sapiens (Human)  1
1
IC50 = 16000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 140.3 nM