General Information of the Compound
Compound ID
CP0577159
Compound Name
3-[[2-[(propan-2-ylamino)methyl]phenyl]methyl]-2-sulfanylidene-7H-purin-6-one
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Structure
Formula
C16H19N5OS
Molecular Weight
329.429
Canonical SMILES
CC(C)NCc1ccccc1Cn1c2nc[nH]c2c(=O)[nH]c1=S
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InChI
InChI=1S/C16H19N5OS/c1-10(2)17-7-11-5-3-4-6-12(11)8-21-14-13(18-9-19-14)15(22)20-16(21)23/h3-6,9-10,17H,7-8H2,1-2H3,(H,18,19)(H,20,22,23)
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InChIKey
CUBUGDAWEWYIEQ-UHFFFAOYSA-N
Physicochemical Property
logP
2.32849
Rotatable Bonds
5
Heavy Atom Count
23
Polar Areas
78.5
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168277928
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02317, Myeloperoxidase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000018 HL-60 Homo sapiens (Human)  1
1
IC50 = 80000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 38.6 nM