General Information of the Compound
Compound ID
CP0543572
Compound Name
1-[[4-chloro-2-[(2,2-dimethylpropylamino)methyl]phenyl]methyl]-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one
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Structure
Formula
C19H23ClN4OS
Molecular Weight
390.94
Canonical SMILES
CC(C)(C)CNCc1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S
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InChI
InChI=1S/C19H23ClN4OS/c1-19(2,3)11-21-9-13-8-14(20)5-4-12(13)10-24-15-6-7-22-16(15)17(25)23-18(24)26/h4-8,21-22H,9-11H2,1-3H3,(H,23,25,26)
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InChIKey
LXBSZQFHHPQENT-UHFFFAOYSA-N
Physicochemical Property
logP
4.22459
Rotatable Bonds
5
Heavy Atom Count
26
Polar Areas
65.61
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
4
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168286801
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02317, Myeloperoxidase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000018 HL-60 Homo sapiens (Human)  1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 35 nM