General Information of the Protein
| Protein ID |
PT02130
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| Protein Name |
Ribosyldihydronicotinamide dehydrogenase [quinone]
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| Secondarily Protein Name |
NRH dehydrogenase [quinone] 2
NRH:quinone oxidoreductase 2
Quinone reductase 2
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| Gene Name |
NQO2
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| Secondarily Gene Name |
NMOR2
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| Sequence |
MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Enzyme
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Oxidoreductase
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| Function |
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
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| Uniprot ID |
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| Subcellular Location |
Cytoplasm
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
Cell Line ID: CL000084 , SK-OV-3
Biochemical Assays
Clinical Information about the Protein
Target 1 ( Quinone reductase 2 (NQO2) )
| Target Type | Successful Target | ||||
|---|---|---|---|---|---|
| Disease | 3 Target-related Diseases | 3 | |||
| 1 | Insomnia [ICD-11: 7A00-7A0Z] | ||||
| 2 | Breast cancer [ICD-11: 2C60-2C65] | ||||
| 3 | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | ||||
| Approved Drug(s) | 1 Approved Drug | 1 | |||
| 1 | Melatonin | Approved | |||
| Clinical Trial Drug(s) | 1 Clinical Trial Drug | 1 | |||
| 1 | NSC-645809 | Phase 2 | |||
| Discontinued Drug(s) | 1 Discontinued Drug | 1 | |||
| 1 | CB1954 | Discontinued in Phase 2 | |||