Protein Information

General Information of the Protein

Protein ID	PT01827
Protein Name	Adenosine receptor A3
Secondarily Protein Name	TGPCR1
Gene Name	ADORA3
Sequence	MKANNTTTSALWLQITYITMEAAIGLCAVVGNMLVIWVVKLNRTLRTTTFYFIVSLALADIAVGVLVIPLAIAVSLEVQMHFYACLFMSCVLLVFTHASIMSLLAIAVDRYLRVKLTVRYRTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKVTLELSQNSSTLSCHFRSVVGLDYMVFFSFITWILIPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFNVKIPEIAMCLGILLSHANSMMNPIVYACKIKKFKETYFVILRACRLCQTSDSLDSNLEQTTE Show/Hide
Organism	Rattus norvegicus, Rat
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Nucleotide-like receptor (family A GPCR) > Adenosine receptor
Function	Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (PubMed:1323836). May play a role during reproduction (PubMed:1647979). Show/Hide
Uniprot ID	Primary ID: P28647 Secondarily ID: Q63792 Show/Hide
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0017043 Compound Info	(2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl]amino}-9H-purin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C18H18ClIN6O4	2
1	Ki = 0.33 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.9 nM Bioactivity Info	TI LI LO TS
CP0383160 Compound Info	(2S,3S,4R)-5-[6-[(2-chloro-3-iodophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C18H18ClIN6O4	1
1	Ki = 0.33 nM Bioactivity Info	TI LI LO TS
CP0310622 Compound Info	(1S,2R,3S,4R,5S)-4-(6-(3-bromobenzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C20H20BrClN6O3	1
1	Ki = 0.76 nM Bioactivity Info	TI LI LO TS
CP0118650 Compound Info	(2S,3S,4R,5R)-5-(2-chloro-6-(3-iodobenzylamino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyltetrahydrothiophene-2-carboxamide Show/Hide	C18H18ClIN6O3S	1
1	Ki = 0.82 nM Bioactivity Info	TI LI LO TS
CP0161398 Compound Info	(1S,2R,3S,4R,5S)-4-(6-(2,5-dimethoxybenzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C22H25ClN6O5	1
1	Ki = 0.87 nM Bioactivity Info	TI LI LO TS
CP0169052 Compound Info	(1S,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C20H20Cl2N6O3	1
1	Ki = 1 nM Bioactivity Info	TI LI LO TS
CP0018686 Compound Info	(2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylamino)-purin-9-yl]-tetrahydro-furan-2-carboxylic acid methylamide Show/Hide	C18H19IN6O4	1
1	Ki = 1.1 nM Bioactivity Info	TI LI LO TS
CP0315311 Compound Info	(1S,2R,3S,4R,5S)-4-(6-(3-iodobenzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C20H20ClIN6O3	1
1	Ki = 1.1 nM Bioactivity Info	TI LI LO TS
CP0395496 Compound Info	5-[6-(4-Amino-3-iodo-benzylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid methylamide Show/Hide	C18H20IN7O4	2
1	Ki = 1.27 nM Bioactivity Info	TI LI LO TS
2	Ki = 1.3 nM Bioactivity Info	TI LI LO TS
CP0208376 Compound Info	4-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-1-hydroxymethyl-bicyclo[3.1.0]hexane-2,3-diol Show/Hide	C19H19ClIN5O3	1
1	Ki = 1.3 nM Bioactivity Info	TI LI LO TS
CP0102094 Compound Info	(2R,3R,4S,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol Show/Hide	C17H17ClIN5O4	3
1	Ki = 1.41 nM Bioactivity Info	TI LI LO TS
2	Ki = 1.6 nM Bioactivity Info	TI LI LO TS
3	Ki = 2.7 nM Bioactivity Info	TI LI LO TS
CP0202457 Compound Info	(1S,2R,3S,4R,5S)-4-(6-(3-(3-hydroxyprop-1-ynyl)benzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C23H23ClN6O4	1
1	Ki = 1.6 nM Bioactivity Info	TI LI LO TS
CP0849058 Compound Info	1N-methyl-4-[2-chloro-6-(3-fluorobenzylamino)-9H-9-purinyl]-2,3-dihydroxy-(1S,2R,3S,4R,5S)-bicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C20H20ClFN6O3	1
1	Ki = 1.6 nM Bioactivity Info	TI LI LO TS
CP0118648 Compound Info	(2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyl-tetrahydrothiophene-2-carboxamide Show/Hide	C18H19IN6O3S	1
1	Ki = 1.86 nM Bioactivity Info	TI LI LO TS
CP0477153 Compound Info	(2S,3S,4R,5R)-5-[6-[(3-bromophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C18H19BrN6O4	1
1	Ki = 1.9 nM Bioactivity Info	TI LI LO TS
CP0197411 Compound Info	(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]-2-methylsulfanylpurin-9-yl]-N-methyloxolane-2-carboxamide Show/Hide	C19H21IN6O4S	1
1	Ki = 2.3 nM Bioactivity Info	TI LI LO TS
CP0566426 Compound Info	(2R,3R,4S,5R)-2-[2-chloro-6-[(3-iodophenyl)methylamino]purin-9-yl]-5-(2-ethyltetrazol-5-yl)oxolane-3,4-diol Show/Hide	C19H19ClIN9O3	1
1	Ki = 2.53 nM Bioactivity Info	TI LI LO TS
CP0389279 Compound Info	(2R,3R,4S,5R)-2-[6-[(3-chlorophenyl)methylamino]purin-9-yl]-5-(2-ethyltetrazol-5-yl)oxolane-3,4-diol Show/Hide	C19H20ClN9O3	1
1	Ki = 2.69 nM Bioactivity Info	TI LI LO TS
CP0544892 Compound Info	(2S,3S,4R)-5-[6-[(3-bromophenyl)methylamino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C19H21BrN6O4	1
1	Ki = 2.8 nM Bioactivity Info	TI LI LO TS
CP0401322 Compound Info	(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]-2-(methylamino)purin-9-yl]-N-methyloxolane-2-carboxamide Show/Hide	C19H22IN7O4	1
1	Ki = 3.12 nM Bioactivity Info	TI LI LO TS
CP0460291 Compound Info	4-Amino-5-[2-chloro-6-(3-iodo-benzylamino)-purin-9-yl]-tetrahydro-furan-2-carboxylic acid methylamide Show/Hide	C18H19ClIN7O2	1
1	Ki = 3.4 nM Bioactivity Info	TI LI LO TS
CP0156790 Compound Info	(1S,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-2-iodo-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C20H20ClIN6O3	1
1	Ki = 3.9 nM Bioactivity Info	TI LI LO TS
CP0408567 Compound Info	(2R,3R,4S,5R)-2-[6-[(3-bromophenyl)methylamino]purin-9-yl]-5-(2-ethyltetrazol-5-yl)oxolane-3,4-diol Show/Hide	C19H20BrN9O3	1
1	Ki = 4.11 nM Bioactivity Info	TI LI LO TS
CP0468075 Compound Info	(2S,3S,4R,5R)-5-[6-[(3-chlorophenyl)carbamoylamino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C19H20ClN7O5	1
1	Ki = 4.4 nM Bioactivity Info	TI LI LO TS
CP0378926 Compound Info	(1S,2R,3S,4R,5S)-4-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C18H23ClN6O3	1
1	Ki = 5.8 nM Bioactivity Info	TI LI LO TS
CP0389281 Compound Info	(2R,3S,4R,5R)-2-(2-ethyltetrazol-5-yl)-5-[6-[(3-iodophenyl)methylamino]purin-9-yl]oxolane-3,4-diol Show/Hide	C19H20IN9O3	1
1	Ki = 6.1 nM Bioactivity Info	TI LI LO TS
CP0514766 Compound Info	(2R,3R,4S)-2-(6-(3-Bromobenzylamino)-9H-purin-9-yl)-tetrahydrothiophene-3,4-diol Show/Hide	C16H16BrN5O2S	1
1	Ki = 6.3 nM Bioactivity Info	TI LI LO TS
CP0522229 Compound Info	(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[(4-methoxyphenyl)carbamoylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C20H23N7O6	1
1	Ki = 6.6 nM Bioactivity Info	TI LI LO TS
CP0406535 Compound Info	(2S,3S,4R,5R)-5-[6-[(2-chlorophenyl)carbamoylamino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C19H20ClN7O5	1
1	Ki = 7.4 nM Bioactivity Info	TI LI LO TS
CP0401241 Compound Info	(1'S, 2'R, 3'S, 4'S, 5'S)-4'-[6-(3-Chlorobenzylamino)-2-(4-(delta-aminobutylaminocarbonyl)-1-butynyl)-9-yl]-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic acid N-methylamide Show/Hide	C29H35ClN8O4	1
1	Ki = 8.68 nM Bioactivity Info	TI LI LO TS
CP0408454 Compound Info	(2R,3S,4R,5R)-2-(2-ethyltetrazol-5-yl)-5-[6-[(3-fluorophenyl)methylamino]purin-9-yl]oxolane-3,4-diol Show/Hide	C19H20FN9O3	1
1	Ki = 9.26 nM Bioactivity Info	TI LI LO TS
CP0037176 Compound Info	(2R,3R,4S,5R)-2-(6-(3-iodobenzylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol Show/Hide	C17H18IN5O4	1
1	Ki = 9.5 nM Bioactivity Info	TI LI LO TS
CP0847899 Compound Info	(1S,2R,3S,4R,5S)-4-(6-(bicyclo[2.2.1]heptan-7-ylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C20H25ClN6O3	1
1	Ki = 9.6 nM Bioactivity Info	TI LI LO TS
CP0397193 Compound Info	(1'S,2'R,3'S,4'S,5'S)-4'-[6-(3-Chlorobenzylamino)-2-(N-cyanine(beta-aminoethylaminocarbonyl)-1-butynyl)-9-yl]-2',3'-dihydroxybicyclo[3.1.0]hexane-1'-carboxylic Acid N-Methylamide Show/Hide	C60H69ClN10O8S	1
1	Ki = 9.62 nM Bioactivity Info	TI LI LO TS
CP0269239 Compound Info	(2S,3S,4R,5R)-3,4-Dihydroxy-5-{6-[3-(4-sulfamoyl-phenyl)-ureido]-purin-9-yl}-tetrahydro-furan-2-carboxylic acid ethylamide Show/Hide	C19H22N8O7S	1
1	Ki = 9.73 nM Bioactivity Info	TI LI LO TS
CP0374714 Compound Info	(2S,3S,4R,5R)-3,4-dihydroxy-N-methyl-5-[6-[(3-methylphenyl)methylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C19H22N6O4	1
1	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0169051 Compound Info	(1S,2R,3S,4R,5S)-4-(2-chloro-6-(2,2-diphenylethylamino)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C27H27ClN6O3	1
1	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0396249 Compound Info	(2R,3S,4R,5R)-2-(2-ethyltetrazol-5-yl)-5-[6-(thiophen-2-ylmethylamino)purin-9-yl]oxolane-3,4-diol Show/Hide	C17H19N9O3S	1
1	Ki = 10.1 nM Bioactivity Info	TI LI LO TS
CP0847898 Compound Info	(1S,2R,3S,4R,5S)-4-(6-(cyclopentylamino)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C18H24N6O3	1
1	Ki = 10.2 nM Bioactivity Info	TI LI LO TS
CP0375913 Compound Info	1N-methyl-4-[6-(2-benzyloxy-5-chlorobenzylamino)-2-chloro-9H-9-purinyl]-2,3-dihydroxy-(1S,2R,3S,4R,5S)-bicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C27H26Cl2N6O4	1
1	Ki = 11 nM Bioactivity Info	TI LI LO TS
CP0538814 Compound Info	(2S,3S,4R)-5-[6-[(4-bromophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C18H19BrN6O4	1
1	Ki = 12 nM Bioactivity Info	TI LI LO TS
CP0879086 Compound Info	SID90341364 Show/Hide	C18H21N7O4	1
1	Ki = 14 nM Bioactivity Info	TI LI LO TS
CP0183628 Compound Info	(2S,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid (2-amino-ethyl)-amide Show/Hide	C12H17N7O4	1
1	Ki = 14.7 nM Bioactivity Info	TI LI LO TS
CP0277824 Compound Info	(3R,4S,5R)-2-[6-[2-(4-amino-3-iodophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C18H21IN6O4	1
1	Ki = 15.5 nM Bioactivity Info	TI LI LO TS
CP0367826 Compound Info	(2S,3S,4R,5R)-5-(6-Benzylamino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid methylamide Show/Hide	C18H20N6O4	1
1	Ki = 16 nM Bioactivity Info	TI LI LO TS
CP0442548 Compound Info	1-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-6-yl)-3-((R)-1-phenylethyl)urea Show/Hide	C21H25N7O5	1
1	Ki = 16.3 nM Bioactivity Info	TI LI LO TS
CP0458777 Compound Info	(2S,3S,4R)-5-[6-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C18H19ClN6O4	1
1	Ki = 17 nM Bioactivity Info	TI LI LO TS
CP0459671 Compound Info	(2R,3R,4S)-2-(6-(3-Chlorobenzylamino)-9H-purin-9-yl)-tetrahydrothiophene-3,4-diol Show/Hide	C16H16ClN5O2S	1
1	Ki = 17 nM Bioactivity Info	TI LI LO TS
CP0425949 Compound Info	1-(2-chloro-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-6-yl)-3-(4-methoxyphenyl)urea Show/Hide	C20H22ClN7O6	1
1	Ki = 17.1 nM Bioactivity Info	TI LI LO TS
CP0374656 Compound Info	(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[[(1R)-1-phenylethyl]amino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C20H24N6O4	1
1	Ki = 18 nM Bioactivity Info	TI LI LO TS
CP0554929 Compound Info	(2S,3S,4R)-3,4-dihydroxy-N-methyl-5-[6-[(3-nitrophenyl)methylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C18H19N7O6	1
1	Ki = 19 nM Bioactivity Info	TI LI LO TS
CP0466862 Compound Info	(2S,3S,4R,5R)-N-ethyl-5-[6-[(4-fluorophenyl)carbamoylamino]purin-9-yl]-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C19H20FN7O5	1
1	Ki = 19 nM Bioactivity Info	TI LI LO TS
CP0376938 Compound Info	(1R,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-9H-purin-9-yl)bicyclo[3.1.0]hexane-2,3-diol Show/Hide	C18H18ClN5O2	1
1	Ki = 20.3 nM Bioactivity Info	TI LI LO TS
CP0442550 Compound Info	1-(4-acetylphenyl)-3-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-6-yl)urea Show/Hide	C21H23N7O6	1
1	Ki = 20.9 nM Bioactivity Info	TI LI LO TS
CP0398200 Compound Info	(2R,3R,4S,5R)-2-[6-(4-chloro-2-fluoroanilino)purin-9-yl]-5-(2-ethyltetrazol-5-yl)oxolane-3,4-diol Show/Hide	C18H17ClFN9O3	1
1	Ki = 21.4 nM Bioactivity Info	TI LI LO TS
CP0404600 Compound Info	(2R,3R,4S,5R)-2-[6-[(4-chloro-2-fluorophenyl)methylamino]purin-9-yl]-5-(2-ethyltetrazol-5-yl)oxolane-3,4-diol Show/Hide	C19H19ClFN9O3	1
1	Ki = 22.6 nM Bioactivity Info	TI LI LO TS
CP0206269 Compound Info	2-(l-hexyn-l-yl)-adenosine-5'-N-methyluronamide (16c) Show/Hide	C18H24N6O4	1
1	Ki = 25.6 nM Bioactivity Info	TI LI LO TS
CP0389422 Compound Info	(2S,3S,4R)-5-[6-[(3-aminophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C18H21N7O4	1
1	Ki = 28 nM Bioactivity Info	TI LI LO TS
CP0438100 Compound Info	(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[(2-methoxyphenyl)carbamoylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C20H23N7O6	1
1	Ki = 30 nM Bioactivity Info	TI LI LO TS
CP0460081 Compound Info	(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[(3-iodophenyl)carbamoylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C19H20IN7O5	1
1	Ki = 30 nM Bioactivity Info	TI LI LO TS
CP0497919 Compound Info	(2S,3S,4R)-3,4-dihydroxy-N-methyl-5-[6-[[3-(trifluoromethyl)phenyl]methylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C19H19F3N6O4	1
1	Ki = 31 nM Bioactivity Info	TI LI LO TS
CP0534523 Compound Info	(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[(2-iodophenyl)carbamoylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C19H20IN7O5	1
1	Ki = 32 nM Bioactivity Info	TI LI LO TS
CP0507246 Compound Info	(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[(4-methylphenyl)carbamoylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C20H23N7O5	1
1	Ki = 32.3 nM Bioactivity Info	TI LI LO TS
CP0408565 Compound Info	(2R,3S,4R,5R)-2-(2-ethyltetrazol-5-yl)-5-[6-(furan-2-ylmethylamino)purin-9-yl]oxolane-3,4-diol Show/Hide	C17H19N9O4	1
1	Ki = 33.1 nM Bioactivity Info	TI LI LO TS
CP0573096 Compound Info	(2S,3S,4R,5R)-N-ethyl-5-[6-[(2-fluorophenyl)carbamoylamino]purin-9-yl]-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C19H20FN7O5	1
1	Ki = 34 nM Bioactivity Info	TI LI LO TS
CP0145353 Compound Info	(2R,3R,4S,5R)-2-(6-(3-chlorobenzylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol Show/Hide	C17H18ClN5O4	1
1	Ki = 35 nM Bioactivity Info	TI LI LO TS
CP0276773 Compound Info	(2R,3R,4S,5R)-2-(6-(2-methyl-benzylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol Show/Hide	C18H21N5O4	2
1	Ki = 38 nM Bioactivity Info	TI LI LO TS
2	Ki = 360 nM Bioactivity Info	TI LI LO TS
CP0371756 Compound Info	1-benzyl-3-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-6-yl)urea Show/Hide	C20H23N7O5	1
1	Ki = 38.3 nM Bioactivity Info	TI LI LO TS
CP0511687 Compound Info	(2S,3S,4R,5R)-N-ethyl-5-[6-[(3-fluorophenyl)carbamoylamino]purin-9-yl]-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C19H20FN7O5	1
1	Ki = 39 nM Bioactivity Info	TI LI LO TS
CP0524555 Compound Info	(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-(phenylcarbamoylamino)purin-9-yl]oxolane-2-carboxamide Show/Hide	C19H21N7O5	1
1	Ki = 39 nM Bioactivity Info	TI LI LO TS
CP0530214 Compound Info	(2S,3S,4R)-5-[6-[(3-acetamidophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C20H23N7O5	1
1	Ki = 41.4 nM Bioactivity Info	TI LI LO TS
CP0466122 Compound Info	(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[(3-methoxyphenyl)carbamoylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C20H23N7O6	1
1	Ki = 42 nM Bioactivity Info	TI LI LO TS
CP0109444 Compound Info	(2R,3R,4S)-2-(6-(3-Iodobenzylamino)-9H-purin-9-yl)-tetrahydrothiophene-3,4-diol Show/Hide	C16H16IN5O2S	1
1	Ki = 48 nM Bioactivity Info	TI LI LO TS
CP0265869 Compound Info	(2R,3R,4S,5S)-3,4-dihydroxy-2-[6-(3-iodo-benzylamino)-purin-9-yl]-1-oxa-7-aza-spiro[4.4]nonan-6-one Show/Hide	C19H19IN6O4	1
1	Ki = 49 nM Bioactivity Info	TI LI LO TS
CP0316067 Compound Info	(2S,3S,4R,5R)-5-[6-amino-2-[2-[4-[3-(2-aminoethylamino)-3-oxopropyl]phenyl]ethylamino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C25H35N9O5	1
1	Ki = 50 nM Bioactivity Info	TI LI LO TS
CP0539049 Compound Info	(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[[2-(trifluoromethyl)phenyl]carbamoylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C20H20F3N7O5	1
1	Ki = 54 nM Bioactivity Info	TI LI LO TS
CP0475540 Compound Info	(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[[4-(pyridin-2-ylsulfonylamino)phenyl]carbamoylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C24H25N9O7S	1
1	Ki = 54.1 nM Bioactivity Info	TI LI LO TS
CP0511969 Compound Info	(2S,3S,4R,5R)-3,4-Dihydroxy-5-(6-{3-[4-(pyridin-2-ylsulfamoyl)-phenyl]-ureido}-purin-9-yl)-tetrahydro-furan-2-carboxylic acid ethylamide Show/Hide	C24H25N9O7S	1
1	Ki = 54.1 nM Bioactivity Info	TI LI LO TS
CP0853787 Compound Info	3,4-Dihydroxy-5-(6-{3-[4-(pyridin-2-ylsulfamoyl)-phenyl]-ureido}-purin-9-yl)-tetrahydro-furan-2-carboxylic acid ethylamide Show/Hide	C24H25N9O7S	1
1	Ki = 54.1 nM Bioactivity Info	TI LI LO TS
CP0530989 Compound Info	(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(4-methoxyphenyl)carbamoylamino]purin-9-yl]-N-methyloxolane-2-carboxamide Show/Hide	C19H21N7O6	1
1	Ki = 56 nM Bioactivity Info	TI LI LO TS
CP0217091 Compound Info	(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C11H14N6O4	1
1	Ki = 63 nM Bioactivity Info	TI LI LO TS
CP0396248 Compound Info	(2R,3R,4S,5R)-2-[6-(cyclopropylmethylamino)purin-9-yl]-5-(2-ethyltetrazol-5-yl)oxolane-3,4-diol Show/Hide	C16H21N9O3	1
1	Ki = 65.2 nM Bioactivity Info	TI LI LO TS
CP0396254 Compound Info	(2R,3R,4S,5R)-2-[6-(cyclopropylamino)purin-9-yl]-5-(2-ethyltetrazol-5-yl)oxolane-3,4-diol Show/Hide	C15H19N9O3	1
1	Ki = 66 nM Bioactivity Info	TI LI LO TS
CP0418190 Compound Info	6-[6-[(3-chlorophenyl)methylamino]-9-[(1S,2R,3S,4R,5S)-3,4-dihydroxy-5-(methylcarbamoyl)-2-bicyclo[3.1.0]hexanyl]purin-2-yl]hex-5-ynoic acid Show/Hide	C26H27ClN6O5	1
1	Ki = 66.5 nM Bioactivity Info	TI LI LO TS
CP0522563 Compound Info	7-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-methoxy-1,3-dimethylpurine-2,6-dione Show/Hide	C13H18N4O7	1
1	Ki = 74 nM Bioactivity Info	TI LI LO TS
CP0438803 Compound Info	(2S,3S,4R)-N-ethyl-3,4-dihydroxy-5-[6-[[3-(trifluoromethyl)phenyl]carbamoylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C20H20F3N7O5	1
1	Ki = 77 nM Bioactivity Info	TI LI LO TS
CP0469510 Compound Info	1-(2-chloro-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-6-yl)-3-(3-chlorophenyl)urea Show/Hide	C19H19Cl2N7O5	1
1	Ki = 77.6 nM Bioactivity Info	TI LI LO TS
CP0430366 Compound Info	1-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-2-(5-phenylpent-1-ynyl)-9H-purin-6-yl)-3-(4-methoxyphenyl)urea Show/Hide	C31H33N7O6	1
1	Ki = 89.5 nM Bioactivity Info	TI LI LO TS
CP0049200 Compound Info	(2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C15H21N5O4	3
1	Ki = 97 nM Bioactivity Info	TI LI LO TS
2	Ki = 240 nM Bioactivity Info	TI LI LO TS
3	Ki = 274 nM Bioactivity Info	TI LI LO TS
CP0484752 Compound Info	(2R,3R,4S)-2-(6-(3-Fluorobenzylamino)-9H-purin-9-yl)tetrahydrothiophene-3,4-diol Show/Hide	C16H16FN5O2S	1
1	Ki = 98 nM Bioactivity Info	TI LI LO TS
CP0001102 Compound Info	(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C10H13N5O4	1
1	Ki = 100 nM Bioactivity Info	TI LI LO TS
CP0503188 Compound Info	(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[(4-iodophenyl)carbamoylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C19H20IN7O5	1
1	Ki = 101 nM Bioactivity Info	TI LI LO TS
CP0348781 Compound Info	(2R,3R,4S,5R)-2-(6-(bicyclo[2.2.1]heptan-7-ylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol Show/Hide	C17H23N5O4	1
1	Ki = 103 nM Bioactivity Info	TI LI LO TS
CP0869956 Compound Info	3,4-Dihydroxy-5-{6-[3-(4-propoxy-phenyl)-ureido]-purin-9-yl}-tetrahydro-furan-2-carboxylic acid ethylamide Show/Hide	C22H27N7O6	1
1	Ki = 107 nM Bioactivity Info	TI LI LO TS
CP0483615 Compound Info	1-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-6-yl)-3-(4-propoxyphenyl)urea Show/Hide	C22H27N7O6	1
1	Ki = 107 nM Bioactivity Info	TI LI LO TS
CP0039348 Compound Info	(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C12H16N6O4	1
1	Ki = 113 nM Bioactivity Info	TI LI LO TS
CP0210711 Compound Info	6-Ethyl-5-ethylsulfanylcarbonyl-2-phenyl-4-propyl-nicotinic acid propyl ester Show/Hide	C23H29NO3S	2
1	Ki = 113 nM Bioactivity Info	TI LI LO TS
2	Ki = 234 nM Bioactivity Info	TI LI LO TS
CP0475641 Compound Info	(2S,3S,4R,5R)-5-[6-[(4-chlorophenyl)carbamoylamino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C19H20ClN7O5	1
1	Ki = 114 nM Bioactivity Info	TI LI LO TS
CP0466110 Compound Info	(2S,3S,4R,5R)-5-[6-[(3-chlorophenyl)carbamoylamino]purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C18H18ClN7O5	1
1	Ki = 115 nM Bioactivity Info	TI LI LO TS
CP0514062 Compound Info	(2R,3R,4S,5R)-2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C18H22N6O4	1
1	Ki = 116 nM Bioactivity Info	TI LI LO TS
CP0047889 Compound Info	(2R,3R,4S,5R)-2-(6-(benzylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol Show/Hide	C17H19N5O4	1
1	Ki = 120 nM Bioactivity Info	TI LI LO TS
CP0463373 Compound Info	1-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-6-yl)-3-phenethylurea Show/Hide	C21H25N7O5	1
1	Ki = 149 nM Bioactivity Info	TI LI LO TS
CP0506398 Compound Info	(2S,3S,4R)-N-ethyl-3,4-dihydroxy-5-[6-[[4-(trifluoromethyl)phenyl]carbamoylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C20H20F3N7O5	1
1	Ki = 150 nM Bioactivity Info	TI LI LO TS
CP0449703 Compound Info	1-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-2-(2-phenylethynyl)-9H-purin-6-yl)-3-(4-methoxyphenyl)urea Show/Hide	C28H27N7O6	1
1	Ki = 154 nM Bioactivity Info	TI LI LO TS
CP0430132 Compound Info	(2S,3S,4R)-N-ethyl-3,4-dihydroxy-5-[6-[[4-[(5-methyl-1,2-oxazol-3-yl)sulfonylamino]phenyl]carbamoylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C23H25N9O8S	1
1	Ki = 155 nM Bioactivity Info	TI LI LO TS
CP0527936 Compound Info	(2S,3S,4R,5R)-3,4-Dihydroxy-5-(6-{3-[4-(5-methyl-isoxazol-3-ylsulfamoyl)-phenyl]-ureido}-purin-9-yl)-tetrahydro-furan-2-carboxylic acid ethylamide Show/Hide	C23H25N9O8S	1
1	Ki = 155 nM Bioactivity Info	TI LI LO TS
CP0494986 Compound Info	1-[9-[(2R,3R,4S,5S)-5-[ethylamino(hydroxy)methyl]-3,4-dihydroxyoxolan-2-yl]purin-6-yl]-3-[4-[(5-methyl-1,2-oxazol-3-yl)sulfamoyl]phenyl]urea Show/Hide	C23H27N9O8S	1
1	Ki = 155 nM Bioactivity Info	TI LI LO TS
CP0445180 Compound Info	6-Ethyl-5-(3-fluoro-propylsulfanylcarbonyl)-2-phenyl-4-propyl-nicotinic acid propyl ester Show/Hide	C24H30FNO3S	1
1	Ki = 156 nM Bioactivity Info	TI LI LO TS
CP0162587 Compound Info	(1S,2R,3S,4R,5S)-4-(2-Chloro-6-methylamino-purin-9-yl)-2,3-dihydroxy-bicyclo[3.1.0]hexane-1-carboxylic acid methylamide Show/Hide	C14H17ClN6O3	1
1	Ki = 160 nM Bioactivity Info	TI LI LO TS
CP0431263 Compound Info	(2S,3S,4R,5R)-5-(6-(2-(2,4-dichlorophenyl)acetamido)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide Show/Hide	C20H20Cl2N6O5	1
1	Ki = 167 nM Bioactivity Info	TI LI LO TS
CP0382954 Compound Info	(2S,3S,4R,5R)-5-(6-{bis[(4-nitrophenyl)carbamoyl]amino}-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C26H24N10O10	1
1	Ki = 168 nM Bioactivity Info	TI LI LO TS
CP0383232 Compound Info	(2R,3R,4S,5R)-2-[2-amino-6-[(3-iodophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C17H19IN6O4	1
1	Ki = 181 nM Bioactivity Info	TI LI LO TS
CP0047864 Compound Info	4,6-Diethyl-5-ethylsulfanylcarbonyl-2-phenyl-nicotinic acid propyl ester Show/Hide	C22H27NO3S	1
1	Ki = 183 nM Bioactivity Info	TI LI LO TS
CP0438137 Compound Info	1-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-2-(hex-1-ynyl)-9H-purin-6-yl)-3-(4-methoxyphenyl)urea Show/Hide	C26H31N7O6	1
1	Ki = 211 nM Bioactivity Info	TI LI LO TS
CP0381985 Compound Info	(2R,3R,4S,5R)-2-(6-amino-2-chloropurin-9-yl)-5-(2-ethyltetrazol-5-yl)oxolane-3,4-diol Show/Hide	C12H14ClN9O3	1
1	Ki = 212 nM Bioactivity Info	TI LI LO TS
CP0397901 Compound Info	(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(2-ethyltetrazol-5-yl)oxolane-3,4-diol Show/Hide	C12H15N9O3	1
1	Ki = 228 nM Bioactivity Info	TI LI LO TS
CP0879186 Compound Info	5-(1,3-Dibutyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid methylamide Show/Hide	C19H29N5O6	1
1	Ki = 229 nM Bioactivity Info	TI LI LO TS
CP0077413 Compound Info	(2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol Show/Hide	C15H20ClN5O4	1
1	Ki = 237 nM Bioactivity Info	TI LI LO TS
CP0441654 Compound Info	1-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-2-iodo-9H-purin-6-yl)-3-(4-methoxyphenyl)urea Show/Hide	C20H22IN7O6	1
1	Ki = 251 nM Bioactivity Info	TI LI LO TS
CP0438117 Compound Info	(2S,3S,4R,5R)-5-[6-[(3-bromophenyl)carbamoylamino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C19H20BrN7O5	1
1	Ki = 275 nM Bioactivity Info	TI LI LO TS
CP0362924 Compound Info	(2R,3R,4S,5R)-2-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C17H23N5O4	1
1	Ki = 282 nM Bioactivity Info	TI LI LO TS
CP0395074 Compound Info	(2R,3S,4R,5R)-2-Hydroxymethyl-5-{6-[(pyridin-3-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-3,4-diol Show/Hide	C16H18N6O4	1
1	Ki = 290 nM Bioactivity Info	TI LI LO TS
CP0442710 Compound Info	2-(4-cyclopentylmethyl-1,2,3-triazol-1-yl)-N6-methyl-9-(beta-Dribofuranosyl)adenine Show/Hide	C19H26N8O4	1
1	Ki = 312 nM Bioactivity Info	TI LI LO TS
CP0439446 Compound Info	1-(3-chlorophenyl)-3-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-2-iodo-9H-purin-6-yl)urea Show/Hide	C19H19ClIN7O5	1
1	Ki = 315 nM Bioactivity Info	TI LI LO TS
CP0470526 Compound Info	1-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-6-yl)-3-((S)-1-phenylethyl)urea Show/Hide	C21H25N7O5	1
1	Ki = 319 nM Bioactivity Info	TI LI LO TS
CP0064086 Compound Info	(2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-2-chloro-9H-purin-9-yl)-3,4-dihydroxy-N,N-dimethyl-tetrahydrothiophene-2-carboxamide Show/Hide	C19H20ClIN6O3S	1
1	Ki = 321 nM Bioactivity Info	TI LI LO TS
CP0371752 Compound Info	1-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-2-(3-hydroxy-3-phenylprop-1-ynyl)-9H-purin-6-yl)-3-(4-methoxyphenyl)urea Show/Hide	C29H29N7O7	1
1	Ki = 324 nM Bioactivity Info	TI LI LO TS
CP0402210 Compound Info	(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-(octylcarbamoylamino)purin-9-yl]oxolane-2-carboxamide Show/Hide	C21H33N7O5	1
1	Ki = 326 nM Bioactivity Info	TI LI LO TS
CP0378104 Compound Info	(2R,3S,4R,5R)-2-Hydroxymethyl-5-[6-(2-phenyl-cyclopropylamino)-purin-9-yl]-tetrahydro-furan-3,4-diol Show/Hide	C19H21N5O4	1
1	Ki = 400 nM Bioactivity Info	TI LI LO TS
CP0438552 Compound Info	(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[[4-(pyrimidin-2-ylsulfonylamino)phenyl]carbamoylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C23H24N10O7S	1
1	Ki = 405 nM Bioactivity Info	TI LI LO TS
CP0419451 Compound Info	(2S,3S,4R,5R)-3,4-Dihydroxy-5-(6-{3-[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-ureido}-purin-9-yl)-tetrahydro-furan-2-carboxylic acid ethylamide Show/Hide	C23H24N10O7S	1
1	Ki = 405 nM Bioactivity Info	TI LI LO TS
CP0509752 Compound Info	(2R,3R,4S)-N-ethyl-3,4-dihydroxy-5-[6-[[4-(pyrimidin-2-ylsulfamoyl)phenyl]carbamoylamino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C23H24N10O7S	1
1	Ki = 405 nM Bioactivity Info	TI LI LO TS
CP0184463 Compound Info	4,6-Diethyl-5-ethylsulfanylcarbonyl-2-phenyl-nicotinic acid ethyl ester Show/Hide	C21H25NO3S	1
1	Ki = 410 nM Bioactivity Info	TI LI LO TS
CP0425341 Compound Info	1-(3,4-dimethoxyphenethyl)-3-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-6-yl)urea Show/Hide	C23H29N7O7	1
1	Ki = 411 nM Bioactivity Info	TI LI LO TS
CP0397897 Compound Info	(2R,3S,4R,5R)-2-(2-ethyltetrazol-5-yl)-5-[6-(methylamino)purin-9-yl]oxolane-3,4-diol Show/Hide	C13H17N9O3	1
1	Ki = 484 nM Bioactivity Info	TI LI LO TS
CP0438463 Compound Info	(2S,3S,4R)-N-ethyl-3,4-dihydroxy-5-[6-[[(1S)-1-phenylethyl]amino]purin-9-yl]oxolane-2-carboxamide Show/Hide	C20H24N6O4	1
1	Ki = 494 nM Bioactivity Info	TI LI LO TS
CP0918853 Compound Info	3-Ethyl-10-oxo-1-propyl-10H-9-oxa-4-aza-phenanthrene-2-carbothioic acid S-(2,2,2-trifluoro-ethyl) ester Show/Hide	C23H26F3NO3S	1
1	Ki = 495 nM Bioactivity Info	TI LI LO TS
CP0409365 Compound Info	6-Ethyl-5-ethylsulfanylcarbonyl-2-phenyl-4-propyl-nicotinic acid 3-fluoro-propyl ester Show/Hide	C23H28FNO3S	1
1	Ki = 512 nM Bioactivity Info	TI LI LO TS
CP0438182 Compound Info	1-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-6-yl)-3-(5-methylisoxazol-3-yl)urea Show/Hide	C17H20N8O6	1
1	Ki = 532 nM Bioactivity Info	TI LI LO TS
CP0146806 Compound Info	(2R,3R,4S,5R)-2-[6-(2,2-Diphenyl-ethylamino)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol Show/Hide	C24H25N5O4	1
1	Ki = 540 nM Bioactivity Info	TI LI LO TS
CP0509731 Compound Info	1-(3-chlorophenyl)-3-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-2-(hex-1-ynyl)-9H-purin-6-yl)urea Show/Hide	C25H28ClN7O5	1
1	Ki = 581 nM Bioactivity Info	TI LI LO TS
CP0041258 Compound Info	(CGS21680) 3-(4-{2-[6-Amino-9-(5-ethylcarbamoylmethyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-ylamino]-ethyl}-phenyl)-propionic acid Show/Hide	C23H29N7O6	1
1	Ki = 584 nM Bioactivity Info	TI LI LO TS
CP0500293 Compound Info	4,6-Diethyl-5-ethylsulfanylcarbonyl-2-phenyl-nicotinic acid 2-fluoro-ethyl ester Show/Hide	C21H24FNO3S	1
1	Ki = 600 nM Bioactivity Info	TI LI LO TS
CP0397896 Compound Info	(2R,3R,4S,5R)-2-[2-chloro-6-(methylamino)purin-9-yl]-5-(2-ethyltetrazol-5-yl)oxolane-3,4-diol Show/Hide	C13H16ClN9O3	1
1	Ki = 600 nM Bioactivity Info	TI LI LO TS
CP0448608 Compound Info	(2S,3S,4R)-5-(1,3-dibutyl-2,6-dioxopurin-7-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C20H31N5O6	1
1	Ki = 602 nM Bioactivity Info	TI LI LO TS
CP0502308 Compound Info	(2S,3S,4R,5R)-5-[6-(benzylamino)purin-9-yl]-3,4-dihydroxy-N,2-dimethyloxolane-2-carboxamide Show/Hide	C19H22N6O4	1
1	Ki = 604 nM Bioactivity Info	TI LI LO TS
CP0442546 Compound Info	1-(3-chlorophenyl)-3-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-2-(2-phenylethynyl)-9H-purin-6-yl)urea Show/Hide	C27H24ClN7O5	1
1	Ki = 611 nM Bioactivity Info	TI LI LO TS
CP0435685 Compound Info	1-(3-chlorophenyl)-3-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-2-(3-hydroxy-3-phenylprop-1-ynyl)-9H-purin-6-yl)urea Show/Hide	C28H26ClN7O6	1
1	Ki = 696 nM Bioactivity Info	TI LI LO TS
CP0391823 Compound Info	(2S,3S,4R,5R)-5-(7-aminoimidazo[4,5-b]pyridin-3-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C13H17N5O4	1
1	Ki = 703 nM Bioactivity Info	TI LI LO TS
CP0449706 Compound Info	1-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-6-yl)-3-(furan-2-ylmethyl)urea Show/Hide	C18H21N7O6	1
1	Ki = 713 nM Bioactivity Info	TI LI LO TS
CP0465076 Compound Info	(2S,3S,4R,5R)-5-[6-(furan-2-ylmethylamino)purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C16H18N6O5	1
1	Ki = 720 nM Bioactivity Info	TI LI LO TS
CP0128793 Compound Info	(2R,3R,4S,5R)-2-(6-(furan-2-ylmethylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol Show/Hide	C15H17N5O5	1
1	Ki = 742 nM Bioactivity Info	TI LI LO TS
CP0481220 Compound Info	(2S,3S,4R,5R)-5-(6-(2-chlorobenzamido)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide Show/Hide	C19H19ClN6O5	1
1	Ki = 754 nM Bioactivity Info	TI LI LO TS
CP0438158 Compound Info	(2S,3S,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide Show/Hide	C19H20N6O5	1
1	Ki = 824 nM Bioactivity Info	TI LI LO TS
CP0419454 Compound Info	(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-(6-(4-methoxybenzamido)-9H-purin-9-yl)-tetrahydrofuran-2-carboxamide Show/Hide	C20H22N6O6	1
1	Ki = 837 nM Bioactivity Info	TI LI LO TS
CP0453737 Compound Info	6-Ethyl-5-ethylsulfanylcarbonyl-4-(3-fluoro-propyl)-2-phenyl-nicotinic acid propyl ester Show/Hide	C23H28FNO3S	1
1	Ki = 900 nM Bioactivity Info	TI LI LO TS
CP0494985 Compound Info	(2S,3S,4R,5R)-5-{6-[(Biphenyl-4-carbonyl)-amino]-purin-9-yl}-3,4-dihydroxy-tetrahydro-furan-2-carboxylicacid ethylamide Show/Hide	C25H24N6O5	1
1	Ki = 979 nM Bioactivity Info	TI LI LO TS
CP0457195 Compound Info	(2R,3R,4S,5R)-2-(6-amino-2-chloropurin-9-yl)-5-(hydroxymethyl)thiolane-3,4-diol Show/Hide	C10H12ClN5O3S	1
1	Ki = 1090 nM Bioactivity Info	TI LI LO TS
CP0655043 Compound Info	2-Methyl-6-phenyl-4-phenylethynyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-benzyl ester 3-propyl ester Show/Hide	C32H29NO4	1
1	Ki = 1120 nM Bioactivity Info	TI LI LO TS
CP0367137 Compound Info	CAS_163889 Show/Hide	C23H22IN5O5	1
1	Ki = 1170 nM Bioactivity Info	TI LI LO TS
CP0438447 Compound Info	3-[[[9-[(3R,4S,5S)-3,4-dihydroxy-5-(methylcarbamoyl)oxolan-2-yl]purin-6-yl]amino]methyl]benzenesulfonic acid Show/Hide	C18H20N6O7S	1
1	Ki = 1310 nM Bioactivity Info	TI LI LO TS
CP0801963 Compound Info	2-Methyl-6-phenyl-4-phenylethynyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-phenethyl ester Show/Hide	C32H29NO4	1
1	Ki = 1320 nM Bioactivity Info	TI LI LO TS
CP0828463 Compound Info	2-Methyl-6-phenyl-4-phenylethynyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(3-phenyl-propyl) ester Show/Hide	C33H31NO4	1
1	Ki = 1380 nM Bioactivity Info	TI LI LO TS
CP0524182 Compound Info	1,3-dibutyl-7-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-sulfanylidenepurin-6-one Show/Hide	C18H28N4O5S	1
1	Ki = 1400 nM Bioactivity Info	TI LI LO TS
CP0713932 Compound Info	2-Methyl-6-phenyl-4-phenylethynyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-benzyl ester 3-ethyl ester Show/Hide	C31H27NO4	1
1	Ki = 1420 nM Bioactivity Info	TI LI LO TS
CP0377017 Compound Info	(2R,3R,4S,5R)-2-[6-(2,3-dihydro-1,4-benzodioxin-3-ylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C18H19N5O6	1
1	Ki = 1480 nM Bioactivity Info	TI LI LO TS
CP0702248 Compound Info	2-Methyl-6-phenyl-4-phenylethynyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(3-methyl-benzyl) ester Show/Hide	C32H29NO4	1
1	Ki = 1520 nM Bioactivity Info	TI LI LO TS
CP0039632 Compound Info	(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-cyclopropyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C13H16N6O4	1
1	Ki = 1600 nM Bioactivity Info	TI LI LO TS
CP0776655 Compound Info	2-Methyl-6-phenyl-4-phenylethynyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(4-methyl-benzyl) ester Show/Hide	C32H29NO4	1
1	Ki = 1690 nM Bioactivity Info	TI LI LO TS
CP0461141 Compound Info	3-O-benzyl 5-O-ethyl 2-cyclobutyl-6-methyl-4-(2-phenylethynyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C29H29NO4	1
1	Ki = 1750 nM Bioactivity Info	TI LI LO TS
CP0442712 Compound Info	(2R,3R,4S,5R)-2-[2-(4-benzyltriazol-1-yl)-6-(methylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C20H22N8O4	1
1	Ki = 1790 nM Bioactivity Info	TI LI LO TS
CP0155498 Compound Info	2-CI Adenosine Show/Hide	C10H12ClN5O4	1
1	Ki = 1890 nM Bioactivity Info	TI LI LO TS
CP0433188 Compound Info	2-Cyclobutyl-6-methyl-4-phenylethynyl-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-ethyl ester Show/Hide	C29H27NO4	1
1	Ki = 1900 nM Bioactivity Info	TI LI LO TS
CP0527748 Compound Info	(2S,3S,4R,5R)-5-[6-(tert-butylcarbamoylamino)purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C17H25N7O5	1
1	Ki = 1930 nM Bioactivity Info	TI LI LO TS
CP0286643 Compound Info	(2R,3R,4S,5R)-2-(7-amino-5-chloroimidazo[4,5-b]pyridin-3-yl)-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C11H13ClN4O4	1
1	Ki = 2480 nM Bioactivity Info	TI LI LO TS
CP0443785 Compound Info	8-Ethyl-1-oxo-6-phenyl-3,4-dihydro-1H-thiopyrano[3,4-c]pyridine-5-carboxylic acid propyl ester Show/Hide	C20H21NO3S	1
1	Ki = 2580 nM Bioactivity Info	TI LI LO TS
CP0524187 Compound Info	(2S,3S,4R)-5-(2,6-dioxo-1,3-dipentylpurin-7-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C21H33N5O6	1
1	Ki = 2630 nM Bioactivity Info	TI LI LO TS
CP0081728 Compound Info	5''-Deoxyadenosine Show/Hide	C10H13N5O3	1
1	Ki = 2830 nM Bioactivity Info	TI LI LO TS
CP0833492 Compound Info	2-Methyl-6-phenyl-4-phenylethynyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(4-trifluoromethyl-benzyl) ester Show/Hide	C32H26F3NO4	1
1	Ki = 3000 nM Bioactivity Info	TI LI LO TS
CP0431032 Compound Info	[(2R,3S,4R)-5-(1,3-dibutyl-2,6-dioxopurin-7-yl)-3,4-dihydroxyoxolan-2-yl] acetate Show/Hide	C19H28N4O7	1
1	Ki = 3230 nM Bioactivity Info	TI LI LO TS
CP0730689 Compound Info	3-ethyl 5-(4-nitrobenzyl)2-methyl-6-phenyl-4-(phenylethynyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C31H26N2O6	1
1	Ki = 3850 nM Bioactivity Info	TI LI LO TS
CP0825703 Compound Info	2-Methyl-6-phenyl-4-phenylethynyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(3-iodo-benzyl) ester Show/Hide	C31H26INO4	1
1	Ki = 4020 nM Bioactivity Info	TI LI LO TS
CP0829636 Compound Info	2-Methyl-6-phenyl-4-((E)-styryl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester Show/Hide	C26H27NO4	1
1	Ki = 4160 nM Bioactivity Info	TI LI LO TS
CP0855037 Compound Info	2-Ethyl-3-ethylsulfanylcarbonyl-1-methyl-6-phenyl-5-propoxycarbonyl-4-propyl-pyridinium iodide Show/Hide	C24H32INO3S	1
1	Ki = 4260 nM Bioactivity Info	TI LI LO TS
CP0373274 Compound Info	4-[[[9-[(3R,4S,5S)-3,4-dihydroxy-5-(methylcarbamoyl)oxolan-2-yl]purin-6-yl]amino]methyl]benzenesulfonic acid Show/Hide	C18H20N6O7S	1
1	Ki = 4500 nM Bioactivity Info	TI LI LO TS
CP0506348 Compound Info	7-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-dipentylpurine-2,6-dione Show/Hide	C20H32N4O6	1
1	Ki = 4810 nM Bioactivity Info	TI LI LO TS
CP0654834 Compound Info	2-Methyl-6-phenyl-4-phenylethynyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(3-nitro-benzyl) ester Show/Hide	C31H26N2O6	1
1	Ki = 5070 nM Bioactivity Info	TI LI LO TS
CP0778929 Compound Info	2-Methyl-6-phenyl-4-phenylethynyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-(3,5-dinitro-benzyl) ester 3-ethyl ester Show/Hide	C31H25N3O8	1
1	Ki = 5070 nM Bioactivity Info	TI LI LO TS
CP0058033 Compound Info	1,3-dipropyl-8-cyclopentylxanthine Show/Hide	C16H24N4O2	1
1	Ki = 5290 nM Bioactivity Info	TI LI LO TS
CP0438136 Compound Info	1-(9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-6-yl)-3-(1,3,4-thiadiazol-2-yl)urea Show/Hide	C15H17N9O5S	1
1	Ki = 5550 nM Bioactivity Info	TI LI LO TS
CP0440088 Compound Info	(2S,3S,4R,5R)-5-(6-{bis[(5-chloropyridin-2-yl)carbamoyl]amino}-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C24H22Cl2N10O6	1
1	Ki = 5700 nM Bioactivity Info	TI LI LO TS
CP0376446 Compound Info	1,3-dibutyl-7-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purine-2,6-dione Show/Hide	C18H28N4O6	1
1	Ki = 6030 nM Bioactivity Info	TI LI LO TS
CP0648338 Compound Info	2,6-Dimethyl-5-nitro-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid methyl ester Show/Hide	C16H15F3N2O4	1
1	Ki = 6200 nM Bioactivity Info	TI LI LO TS
CP0264079 Compound Info	(2R,3S,4R,5R)-2-Hydroxymethyl-5-(6-methylamino-purin-9-yl)-tetrahydro-furan-3,4-diol Show/Hide	C11H15N5O4	1
1	Ki = 6400 nM Bioactivity Info	TI LI LO TS
CP0441222 Compound Info	2-[4-(6-oxo-1,3-dipropyl-2-sulfanylidene-7H-purin-8-yl)phenoxy]acetic acid Show/Hide	C19H22N4O4S	1
1	Ki = 6770 nM Bioactivity Info	TI LI LO TS
CP0514434 Compound Info	4-(1,3-Dimethyl-6-oxo-2-thioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-butyric acid Show/Hide	C11H14N4O3S	1
1	Ki = 9360 nM Bioactivity Info	TI LI LO TS
CP0409147 Compound Info	2-(4-dimethylaminomethyl-1,2,3-triazol-1-yl)-N6-methyl-9-(beta-D-ribofuranosyl)adenine Show/Hide	C16H23N9O4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0442711 Compound Info	(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(methylamino)-2-(4-pyridin-2-yltriazol-1-yl)purin-9-yl]oxolane-3,4-diol Show/Hide	C18H19N9O4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0461532 Compound Info	(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(methylamino)-2-[4-(4-propoxyphenyl)triazol-1-yl]purin-9-yl]oxolane-3,4-diol Show/Hide	C22H26N8O5	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0374631 Compound Info	(2R,3R,4S,5R)-2-(2-Amino-6-methylamino-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol Show/Hide	C11H16N6O4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0534354 Compound Info	3-Ethoxycarbonylmethylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid ethyl ester Show/Hide	C15H18O5S2	1
1	Ki = 10200 nM Bioactivity Info	TI LI LO TS
CP0496403 Compound Info	(2S,3S,4R)-5-(1,3-dihexyl-2,6-dioxopurin-7-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C23H37N5O6	1
1	Ki = 10300 nM Bioactivity Info	TI LI LO TS
CP0061146 Compound Info	(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C10H12FN5O4	1
1	Ki = 10400 nM Bioactivity Info	TI LI LO TS
CP0159463 Compound Info	5''-O-(Sulfamoyl)Adenosine Show/Hide	C10H14N6O6S	1
1	Ki = 11000 nM Bioactivity Info	TI LI LO TS
CP0055461 Compound Info	CHEBI:7550 Show/Hide	C26H29N3O6	1
1	Ki = 11000 nM Bioactivity Info	TI LI LO TS
CP0271478 Compound Info	5-O-ethyl 3-O-methyl 2,6-dimethyl-4-[(E)-2-phenylethenyl]-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H23NO4	1
1	Ki = 12100 nM Bioactivity Info	TI LI LO TS
CP0421520 Compound Info	1-benzoyl-3-butyl-7-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purine-2,6-dione Show/Hide	C21H24N4O7	1
1	Ki = 12400 nM Bioactivity Info	TI LI LO TS
CP0448551 Compound Info	3-benzyl-1-butyl-7-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purine-2,6-dione Show/Hide	C21H26N4O6	1
1	Ki = 12900 nM Bioactivity Info	TI LI LO TS
CP0745889 Compound Info	2-Methyl-6-phenyl-4-phenylethynyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-[4-(2,2,2-trichloro-ethoxycarbonyl)-benzyl] ester Show/Hide	C34H28Cl3NO6	1
1	Ki = 13000 nM Bioactivity Info	TI LI LO TS
CP0448323 Compound Info	3-Methylsulfanyl-6,7-dihydro-benzo[c]thiophene-1-carboxylic acid hydrazide Show/Hide	C10H12N2OS2	1
1	Ki = 13100 nM Bioactivity Info	TI LI LO TS
CP0040261 Compound Info	BW-A1433 Show/Hide	C20H22N4O4	1
1	Ki = 15000 nM Bioactivity Info	TI LI LO TS
CP0304151 Compound Info	3-Methylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid ethyl ester Show/Hide	C12H14O3S2	1
1	Ki = 15200 nM Bioactivity Info	TI LI LO TS
CP0511516 Compound Info	(2S,3S,4R)-5-(1,3-dibutyl-2,6-dioxopurin-7-yl)-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C18H27N5O6	1
1	Ki = 15300 nM Bioactivity Info	TI LI LO TS
CP0530044 Compound Info	4-Hydroxy-3-methylsulfanyl-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid ethyl ester Show/Hide	C12H16O3S2	1
1	Ki = 15400 nM Bioactivity Info	TI LI LO TS
CP0200365 Compound Info	(2R,3R,4S,5R)-2-(6-hydrazinylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C10H14N6O4	1
1	Ki = 16900 nM Bioactivity Info	TI LI LO TS
CP0449438 Compound Info	2,3-Dihydroxy-4-[6-(3-iodo-benzylamino)-purin-9-yl]-cyclopentanecarboxylic acid methylamide Show/Hide	C19H21IN6O3	1
1	Ki = 19500 nM Bioactivity Info	TI LI LO TS
CP0082264 Compound Info	(1R,2S,3R,5R)-3-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol Show/Hide	C11H15N5O3	1
1	Ki = 20000 nM Bioactivity Info	TI LI LO TS
CP0439033 Compound Info	2-[2-[[2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetyl]amino]ethylcarbamoyloxymethyl-(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic acid Show/Hide	C40H43N7O10	1
1	Ki = 21700 nM Bioactivity Info	TI LI LO TS
CP0397632 Compound Info	2-[4-(1,3-dibutyl-2,6-dioxo-7H-purin-8-yl)phenoxy]acetic acid Show/Hide	C21H26N4O5	1
1	Ki = 27500 nM Bioactivity Info	TI LI LO TS
CP0104008 Compound Info	N-(2-aminoethyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide Show/Hide	C21H28N6O4	1
1	Ki = 29000 nM Bioactivity Info	TI LI LO TS
CP0523889 Compound Info	4-[2-[[2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetyl]amino]ethylamino]-4-oxobutanoic acid Show/Hide	C25H32N6O7	1
1	Ki = 40600 nM Bioactivity Info	TI LI LO TS
CP0511085 Compound Info	3-Benzylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid Show/Hide	C16H14O3S2	1
1	Ki = 42000 nM Bioactivity Info	TI LI LO TS
CP0522561 Compound Info	7-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-dihexylpurine-2,6-dione Show/Hide	C22H36N4O6	1
1	Ki = 43000 nM Bioactivity Info	TI LI LO TS
CP0279912 Compound Info	4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzoic acid Show/Hide	C18H20N4O4	1
1	Ki = 45100 nM Bioactivity Info	TI LI LO TS
CP0525947 Compound Info	(2R,3S,4S,5R)-2-(6-amino-2-chloropurin-9-yl)-5-(hydroxymethyl)thiolane-3,4-diol Show/Hide	C10H12ClN5O3S	1
1	Ki = 49300 nM Bioactivity Info	TI LI LO TS
CP0491703 Compound Info	ethyl 6,6-dimethyl-3-methylsulfonyl-4-oxo-5,7-dihydro-2-benzothiophene-1-carboxylate Show/Hide	C14H18O5S2	1
1	Ki = 51800 nM Bioactivity Info	TI LI LO TS
CP0514427 Compound Info	2-[[2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetyl]amino]acetic acid Show/Hide	C21H25N5O6	1
1	Ki = 58500 nM Bioactivity Info	TI LI LO TS
CP0559785 Compound Info	4-(6-Amino-2-phenethylamino-purin-9-yl)-cyclopentane-1,2,3-triol Show/Hide	C18H22N6O3	1
1	Ki = 59200 nM Bioactivity Info	TI LI LO TS
CP0112229 Compound Info	3-DEAZAADENOSINE Show/Hide	C11H14N4O4	1
1	Ki = 61700 nM Bioactivity Info	TI LI LO TS
CP0534932 Compound Info	3-[4-Amino-2-(4-butyl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-5-hydroxymethyl-cyclopentane-1,2-diol Show/Hide	C22H29N5O3	1
1	Ki = 70400 nM Bioactivity Info	TI LI LO TS
CP0886321 Compound Info	(E)-3-(1,3-Dibutyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-acrylic acid Show/Hide	C16H22N4O4	1
1	Ki = 73700 nM Bioactivity Info	TI LI LO TS
CP0464937 Compound Info	3-Benzyl-1-butyl-3,7-dihydro-purine-2,6-dione Show/Hide	C16H18N4O2	1
1	Ki = 74200 nM Bioactivity Info	TI LI LO TS
CP0057629 Compound Info	2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy)acetic acid Show/Hide	C19H22N4O5	1
1	Ki = 75700 nM Bioactivity Info	TI LI LO TS
CP0423089 Compound Info	7-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-dipropylpurine-2,6-dione Show/Hide	C16H24N4O6	1
1	Ki = 81200 nM Bioactivity Info	TI LI LO TS
CP0893206 Compound Info	SID50112931 Show/Hide	C10H11ClFN5O3	1
1	Ki = 82400 nM Bioactivity Info	TI LI LO TS
CP0392568 Compound Info	7-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-dimethylpurine-2,6-dione Show/Hide	C12H16N4O6	1
1	Ki = 89400 nM Bioactivity Info	TI LI LO TS
CP0039790 Compound Info	4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzenesulfonic acid Show/Hide	C17H20N4O5S	1
1	Ki = 90100 nM Bioactivity Info	TI LI LO TS
CP0540203 Compound Info	4-(1,3-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-butyric acid Show/Hide	C11H14N4O4	1
1	Ki = 93400 nM Bioactivity Info	TI LI LO TS
CP0487356 Compound Info	2-[[2-[2-[[2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetyl]amino]ethylamino]-2-oxoethyl]amino]acetic acid Show/Hide	C25H33N7O7	1
1	Ki = 98000 nM Bioactivity Info	TI LI LO TS
CP0397991 Compound Info	4-[carboxymethyl-[2-[2-[[2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetyl]amino]ethylamino]-2-oxoethyl]amino]-4-oxobutanoic acid Show/Hide	C29H37N7O10	1
1	Ki = 99900 nM Bioactivity Info	TI LI LO TS
CP0039042 Compound Info	N-[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-2-phenylacetamide Show/Hide	C21H14ClN5O2	1
1	Ki > 10 nM Bioactivity Info	TI LI LO TS
CP0398703 Compound Info	1,3-dipropyl-9-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione Show/Hide	C26H36N6O3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0398705 Compound Info	1,3-dibutyl-9-[4-[2-(diethylamino)ethoxy]phenyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione Show/Hide	C28H42N6O3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0398706 Compound Info	1,3-dibutyl-9-[4-(2-piperidin-1-ylethoxy)phenyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione Show/Hide	C29H42N6O3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0398710 Compound Info	1,3-dibutyl-9-[2-[4-[2-(diethylamino)ethoxy]phenyl]ethyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione Show/Hide	C30H46N6O3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0408997 Compound Info	1,3-diethyl-9-[2-(4-hydroxyphenyl)ethyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione Show/Hide	C20H25N5O3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0420550 Compound Info	1,3-dibutyl-9-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione Show/Hide	C28H40N6O3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0450331 Compound Info	9-[2-[4-[2-(diethylamino)ethoxy]phenyl]ethyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione Show/Hide	C24H34N6O3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0473554 Compound Info	1,3-dibutyl-9-[4-[2-(dimethylamino)ethoxy]phenyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione Show/Hide	C26H38N6O3	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000278 , RBL-2H3

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0315311 Compound Info	(1S,2R,3S,4R,5S)-4-(6-(3-iodobenzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C20H20ClIN6O3	2
1	Kd = 0.17 nM
2	Ki = 1.1 nM
CP0395496 Compound Info	5-[6-(4-Amino-3-iodo-benzylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid methylamide Show/Hide	C18H20IN7O4	1
1	Kd = 1 nM
CP0017043 Compound Info	(2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl]amino}-9H-purin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C18H18ClIN6O4	1
1	Ki = 0.33 nM
CP0310622 Compound Info	(1S,2R,3S,4R,5S)-4-(6-(3-bromobenzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C20H20BrClN6O3	1
1	Ki = 0.76 nM
CP0161398 Compound Info	(1S,2R,3S,4R,5S)-4-(6-(2,5-dimethoxybenzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C22H25ClN6O5	1
1	Ki = 0.87 nM
CP0018686 Compound Info	(2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylamino)-purin-9-yl]-tetrahydro-furan-2-carboxylic acid methylamide Show/Hide	C18H19IN6O4	1
1	Ki = 1.1 nM
CP0202457 Compound Info	(1S,2R,3S,4R,5S)-4-(6-(3-(3-hydroxyprop-1-ynyl)benzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C23H23ClN6O4	1
1	Ki = 1.6 nM
CP0118648 Compound Info	(2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyl-tetrahydrothiophene-2-carboxamide Show/Hide	C18H19IN6O3S	1
1	Ki = 1.86 nM
CP0102094 Compound Info	(2R,3R,4S,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol Show/Hide	C17H17ClIN5O4	1
1	Ki = 2.7 nM
CP0208376 Compound Info	4-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-1-hydroxymethyl-bicyclo[3.1.0]hexane-2,3-diol Show/Hide	C19H19ClIN5O3	1
1	Ki = 2.9 nM
CP0156790 Compound Info	(1S,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-2-iodo-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C20H20ClIN6O3	1
1	Ki = 3.9 nM
CP0269239 Compound Info	(2S,3S,4R,5R)-3,4-Dihydroxy-5-{6-[3-(4-sulfamoyl-phenyl)-ureido]-purin-9-yl}-tetrahydro-furan-2-carboxylic acid ethylamide Show/Hide	C19H22N8O7S	1
1	Ki = 9.73 nM
CP0169051 Compound Info	(1S,2R,3S,4R,5S)-4-(2-chloro-6-(2,2-diphenylethylamino)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C27H27ClN6O3	1
1	Ki = 10 nM
CP0367826 Compound Info	(2S,3S,4R,5R)-5-(6-Benzylamino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid methylamide Show/Hide	C18H20N6O4	1
1	Ki = 16 nM
CP0145353 Compound Info	(2R,3R,4S,5R)-2-(6-(3-chlorobenzylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol Show/Hide	C17H18ClN5O4	1
1	Ki = 35 nM
CP0265869 Compound Info	(2R,3R,4S,5S)-3,4-dihydroxy-2-[6-(3-iodo-benzylamino)-purin-9-yl]-1-oxa-7-aza-spiro[4.4]nonan-6-one Show/Hide	C19H19IN6O4	1
1	Ki = 51 nM
CP0217091 Compound Info	(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C11H14N6O4	1
1	Ki = 72 nM
CP0039348 Compound Info	(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C12H16N6O4	1
1	Ki = 113 nM
CP0162587 Compound Info	(1S,2R,3S,4R,5S)-4-(2-Chloro-6-methylamino-purin-9-yl)-2,3-dihydroxy-bicyclo[3.1.0]hexane-1-carboxylic acid methylamide Show/Hide	C14H17ClN6O3	1
1	Ki = 160 nM
CP0362924 Compound Info	(2R,3R,4S,5R)-2-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C17H23N5O4	1
1	Ki = 282 nM
CP0064086 Compound Info	(2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-2-chloro-9H-purin-9-yl)-3,4-dihydroxy-N,N-dimethyl-tetrahydrothiophene-2-carboxamide Show/Hide	C19H20ClIN6O3S	1
1	Ki = 321 nM
CP0210711 Compound Info	6-Ethyl-5-ethylsulfanylcarbonyl-2-phenyl-4-propyl-nicotinic acid propyl ester Show/Hide	C23H29NO3S	1
1	Ki = 357 nM
CP0041258 Compound Info	(CGS21680) 3-(4-{2-[6-Amino-9-(5-ethylcarbamoylmethyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-ylamino]-ethyl}-phenyl)-propionic acid Show/Hide	C23H29N7O6	1
1	Ki = 584 nM
CP0039632 Compound Info	(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-cyclopropyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C13H16N6O4	1
1	Ki = 1600 nM
CP0183628 Compound Info	(2S,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid (2-amino-ethyl)-amide Show/Hide	C12H17N7O4	1
1	Ki = 14700 nM

Similar Protein(s) and Bioactivity Statistics

90% Identity

Protein ID	Protein Name	Protein Organism
PT05025	Adenosine receptor A3	Mus musculus, Mouse	Protein Info

50% Identity

Protein ID	Protein Name	Protein Organism
PT01279	Adenosine receptor A3	Homo sapiens, Human	Protein Info
PT06240	Adenosine receptor A3	Canis lupus familiaris, Dog, Canis familiaris	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han