Protein Information

General Information of the Protein

Protein ID	PT06240
Protein Name	Adenosine receptor A3
Gene Name	ADORA3
Sequence	MAVNGTALLLANVTYITVEILIGLCAIVGNVLVIWVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVISLGITIQFYNCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYRRVTTQRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEHQRNVTFLSCQFSSVMRMDYMVYFSFFTWILIPLVVMCAIYLDIFYVIRNKLNQNFSSSKETGAFYGREFKTAKSLFLVLFLFAFSWLPLSIINCITYFHGEVPQIILYLGILLSHANSMMNPIVYAYKIKKFKETYLLIFKTYMICQSSDSLDSSTE Show/Hide
Organism	Canis lupus familiaris, Dog, Canis familiaris
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Nucleotide-like receptor (family A GPCR) > Adenosine receptor
Function	Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Show/Hide
Uniprot ID	Q28309
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000006 , HEK293

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0089367 Compound Info	(1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C20H19ClN6O3S	1
1	IC50 = 8500 nM Bioactivity Info	TI LI LO TS
CP0484479 Compound Info	(1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(ethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C21H21ClN6O3S	1
1	Ki = 1.5 nM Bioactivity Info	TI LI LO TS
CP0236158 Compound Info	(1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(propylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C22H23ClN6O3S	1
1	Ki = 5.8 nM Bioactivity Info	TI LI LO TS
CP0108871 Compound Info	(1S,2R,3S,4R,5S)-4-[5-[2-(5-chlorothiophen-2-yl)ethynyl]-7-(ethylamino)imidazo[4,5-b]pyridin-3-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C22H22ClN5O3S	1
1	Ki = 49 nM Bioactivity Info	TI LI LO TS
CP0380403 Compound Info	(1S,2R,3S,4R,5S)-4-[5-[2-(5-chlorothiophen-2-yl)ethynyl]-7-(methylamino)imidazo[4,5-b]pyridin-3-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C21H20ClN5O3S	1
1	Ki = 75 nM Bioactivity Info	TI LI LO TS

Similar Protein(s) and Bioactivity Statistics

50% Identity