General Information of the Protein
Protein ID
PT01577
Protein Name
Androgen receptor
Secondarily
Protein Name
Dihydrotestosterone receptor
Nuclear receptor subfamily 3 group C member 4
Gene Name
AR
Secondarily
Gene Name
Nr3c4
Sequence
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAANIAPPGACLQQRQETSPRRRRRQQHTEDGSPQAHIRGPTGYLALEEEQQPSQQQAASEGHPESSCLPEPGAATAPGKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADIKDILNEAGTMQLLQQQQQQQQHQQQHQQHQQQQEVISEGSSARAREATGAPSSSKDSYLGGNSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPLPECKGLPLDEGPGKSTEETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGALDEAAAYQNRDYYNFPLALSGPPHPPPPTHPHARIKLENPLDYGSAWAAAAAQCRYGDLGSLHGGSVAGPSTGSPPATTSSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLTSQESDYSASEVWYPGGVVNRVPYPSPNCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGENSNAGSPTEDPSQKMTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
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Organism
Mus musculus, Mouse
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
>
Nuclear hormone receptor subfamily 3 group C member 4
Function
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
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Uniprot ID
P19091
Ensembl ID
ENSG00000169083
Subcellular Location
Nucleus
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000361 , C2C12
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0255862
 Compound Info 
BMS-564929
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C14H12ClN3O3
  1
1
EC50 = 0.44 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0645750
 Compound Info 
(7R,7aS)-4-(tetrahydro-7-hydroxy-1,3-dioxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-1-naphthalenecarbonitrile
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C17H13N3O3
  1
1
EC50 = 2.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0087810
 Compound Info 
[(8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] propanoate
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C22H32O3
  1
1
EC50 = 2.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0505476
 Compound Info 
(2S,3R)-1-(3-chloro-4-cyano-2-methyl-phenylsulfamoyl)-3-hydroxy-pyrrolidine-2-carboxylic acid
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C13H14ClN3O5S
  1
1
EC50 = 2.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0462960
 Compound Info 
2-Chloro-4-((3aS,4R)-4-hydroxy-1,1,3-trioxo-tetrahydro-1lambda*6*-thia-2,6a-diaza-pentalen-2-yl)-3-methyl-benzonitrile
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C13H12ClN3O4S
  1
1
EC50 = 11.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0501696
 Compound Info 
2-chloro-4-((3aS,4R)-4-hydroxy-3a-methyl-1,1,3-trioxo-tetrahydro-1lambda6-thia-2,6a-diaza-pentalen-2-yl)-3-methyl-benzonitrile
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C14H14ClN3O4S
  1
1
EC50 = 1251 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0505479
 Compound Info 
2-chloro-4-((3aS,4S)-4-hydroxy-1,1,3-trioxo-tetrahydro-1lambda6-thia-2,6a-diaza-pentalen-2-yl)-3-methyl-benzonitrile
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C13H12ClN3O4S
  1
1
EC50 = 2959 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0434434
 Compound Info 
2-chloro-4-((3aS,5S)-5-hydroxy-1,1,3-trioxo-tetrahydro-1lambda6-thia-2,6a-diaza-pentalen-2-yl)-3-methyl-benzonitrile
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C13H12ClN3O4S
  1
1
EC50 = 3517 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0490931
 Compound Info 
(2S,3R)-1-(3-chloro-4-cyano-2-methyl-phenylsulfamoyl)-3-hydroxy-pyrrolidine-2-carboxylic acid methyl ester
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C14H16ClN3O5S
  1
1
EC50 = 7459 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0536440
 Compound Info 
2-chloro-4-((3aR,4R)-4-hydroxy-1,1-dioxo-tetrahydro-1lambda6-thia-2,6a-diaza-pentalen-2-yl)-3-methyl-benzonitrile
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C13H14ClN3O3S
  1
1
EC50 = 7729 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0530871
 Compound Info 
2-chloro-4-((3aR,4S)-4-hydroxy-3-methyl-1,1-dioxo-tetrahydro-1lambda6-thia-2,6a-diaza-pentalen-2-yl)-3-methyl-benzonitrile
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C14H16ClN3O3S
  1
1
EC50 = 8962 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0539652
 Compound Info 
(2S,3R)-methyl 1-(3-chloro-4-cyano-2-methylphenylsulfonyl)-3-hydroxypyrrolidine-2-carboxylate
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C14H15ClN2O5S
  2
1
EC50 > 3000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 278 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000309 , NCTC clone 929
 Cell Line Info 
Cell Line ID: CL000035 , NIH 3T3
 Cell Line Info 
Cell Line ID: CL000370 , SC-3
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0041416
 Compound Info 
(6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-dione
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C24H34O4
  1
1 EC50 = 6.1 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01486 Androgen receptor Rattus norvegicus, Rat
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT00894 Androgen receptor Homo sapiens, Human
 Protein Info