Protein Information

General Information of the Protein

Protein ID	PT01448
Protein Name	5-hydroxytryptamine receptor 1A
Secondarily Protein Name	Serotonin receptor 1A
Gene Name	HTR1A
Secondarily Gene Name	5ht1a
Sequence	MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR Show/Hide
Organism	Rattus norvegicus, Rat
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Serotonin receptor
Function	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. Show/Hide
Uniprot ID	P19327
Ensembl ID	ENSG00000178394
Subcellular Location	Cell membrane Cell projection Dendrite

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0487167 Compound Info	3-{4-[4-(2-Cyano-3-fluoro-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid amide Show/Hide	C24H26FN5O	1
1	IC50 = 0.01 nM Bioactivity Info	TI LI LO TS
CP0469266 Compound Info	3-{4-[4-(2,4-Dimethoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid amide Show/Hide	C25H32N4O3	1
1	IC50 = 0.07 nM Bioactivity Info	TI LI LO TS
CP0379270 Compound Info	3-{4-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid amide Show/Hide	C24H30N4O2	1
1	IC50 = 0.09 nM Bioactivity Info	TI LI LO TS
CP0485030 Compound Info	3-{4-[4-(4-Acetylamino-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid amide Show/Hide	C25H31N5O2	1
1	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
CP0485110 Compound Info	3-[4-(4-Phenyl-piperazin-1-yl)-butyl]-1H-indole-5-carboxylic acid amide Show/Hide	C23H28N4O	1
1	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
CP0485978 Compound Info	3-[4-(4-Phenyl-piperidin-1-yl)-butyl]-1H-indole-5-carboxylic acid amide Show/Hide	C24H29N3O	1
1	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
CP0548858 Compound Info	3-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid amide Show/Hide	C24H30N4O2	1
1	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
CP0491992 Compound Info	3-{4-[4-(2-Oxo-2H-chromen-6-yl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C26H26N4O2	1
1	IC50 = 0.1 nM Bioactivity Info	TI LI LO TS
CP0374508 Compound Info	3-{4-[4-(2-Cyano-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid amide Show/Hide	C24H27N5O	1
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0399895 Compound Info	3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid amide Show/Hide	C25H30N4O3	1
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0522473 Compound Info	3-{4-[4-(4-Hydroxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid amide Show/Hide	C23H28N4O2	1
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0485031 Compound Info	3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-piperazin-1-yl]-butyl}-1H-indol-5-ol Show/Hide	C24H29N3O3	1
1	IC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0494625 Compound Info	3-{4-[4-(2-Carbamoyl-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid amide Show/Hide	C24H29N5O2	1
1	IC50 = 0.3 nM Bioactivity Info	TI LI LO TS
CP0024732 Compound Info	5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzofuran-2-carboxylic acid amide Show/Hide	C26H27N5O2	1
1	IC50 = 0.3 nM Bioactivity Info	TI LI LO TS
CP0469267 Compound Info	3-[4-(4-Benzo[1,3]dioxol-5-yl-piperazin-1-yl)-butyl]-1H-indole-5-carboxylic acid amide Show/Hide	C24H28N4O3	1
1	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0486421 Compound Info	3-[4-(4-Benzo[1,3]dioxol-5-yl-3,6-dihydro-2H-pyridin-1-yl)-butyl]-5-methoxy-1H-indole Show/Hide	C25H28N2O3	1
1	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0497076 Compound Info	3-{4-[4-(2,3-Dihydro-benzofuran-5-yl)-piperazin-1-yl]-butyl}-5-methoxy-1H-indole Show/Hide	C25H31N3O2	1
1	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0548902 Compound Info	4-{1-[4-(5-Methoxy-1H-indol-3-yl)-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-phenol Show/Hide	C24H28N2O2	1
1	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0374562 Compound Info	3-{4-[4-(2-Cyano-benzofuran-5-yl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C26H25N5O	1
1	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0845614 Compound Info	3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-piperazin-1-yl]-butyl}-1H-indole-5-carbaldehyde oxime Show/Hide	C25H30N4O3	1
1	IC50 = 0.4 nM Bioactivity Info	TI LI LO TS
CP0159608 Compound Info	3-[4-(4-Chroman-6-yl-piperazin-1-yl)-butyl]-1H-indole-5-carboxylic acid amide Show/Hide	C26H32N4O2	1
1	IC50 = 0.5 nM Bioactivity Info	TI LI LO TS
CP0485029 Compound Info	3-{4-[4-(2,3-Dihydro-benzofuran-5-yl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid amide Show/Hide	C25H30N4O2	1
1	IC50 = 0.5 nM Bioactivity Info	TI LI LO TS
CP0497037 Compound Info	3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-piperazin-1-yl]-butyl}-5-methoxy-1H-indole Show/Hide	C25H31N3O3	1
1	IC50 = 0.5 nM Bioactivity Info	TI LI LO TS
CP0502835 Compound Info	Acetic acid 3-{4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indol-5-yl ester Show/Hide	C25H31N3O3	1
1	IC50 = 0.5 nM Bioactivity Info	TI LI LO TS
CP0497087 Compound Info	5-Methoxy-3-{4-[4-(4-methoxy-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-butyl}-1H-indole Show/Hide	C25H30N2O2	1
1	IC50 = 0.6 nM Bioactivity Info	TI LI LO TS
CP0435561 Compound Info	3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid methyl ester Show/Hide	C26H31N3O4	1
1	IC50 = 0.6 nM Bioactivity Info	TI LI LO TS
CP0499086 Compound Info	3-{4-[4-(3,5-Dichloro-4-methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid amide Show/Hide	C24H28Cl2N4O2	1
1	IC50 = 0.7 nM Bioactivity Info	TI LI LO TS
CP0374492 Compound Info	3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-piperazin-1-yl]-butyl}-1H-indole-5-carbaldehyde Show/Hide	C25H29N3O3	1
1	IC50 = 0.7 nM Bioactivity Info	TI LI LO TS
CP0435565 Compound Info	6-{4-[4-(5-Fluoro-1H-indol-3-yl)-butyl]-piperazin-1-yl}-chromen-2-one Show/Hide	C25H26FN3O2	1
1	IC50 = 0.7 nM Bioactivity Info	TI LI LO TS
CP0536481 Compound Info	3-[4-(4-Benzo[1,3]dioxol-5-yl-piperazin-1-yl)-butyl]-1H-indole-5-carbonitrile Show/Hide	C24H26N4O2	1
1	IC50 = 0.7 nM Bioactivity Info	TI LI LO TS
CP0055058 Compound Info	3-(4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)butyl)-1H-indol-5-ol Show/Hide	C23H26N2O	1
1	IC50 = 0.8 nM Bioactivity Info	TI LI LO TS
CP0442318 Compound Info	3-[4-(4-Phenyl-piperazin-1-yl)-butyl]-1H-indol-5-ol Show/Hide	C22H27N3O	1
1	IC50 = 0.8 nM Bioactivity Info	TI LI LO TS
CP0485704 Compound Info	3-{4-[4-(4-Ethoxy-phenyl)-piperazin-1-yl]-butyl}-5-methoxy-1H-indole Show/Hide	C25H33N3O2	1
1	IC50 = 0.8 nM Bioactivity Info	TI LI LO TS
CP0484120 Compound Info	3-[4-(4-{2-Cyano-3-[2-(2-ethoxy-ethoxy)-ethoxy]-phenyl}-piperazin-1-yl)-butyl]-1H-indole-5-carboxylic acid amide Show/Hide	C30H39N5O4	1
1	IC50 = 0.9 nM Bioactivity Info	TI LI LO TS
CP0501482 Compound Info	3-{4-[4-(4-Carbamoyl-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid amide Show/Hide	C24H29N5O2	1
1	IC50 = 0.9 nM Bioactivity Info	TI LI LO TS
CP0498494 Compound Info	Acetic acid 4-{4-[4-(5-methoxy-1H-indol-3-yl)-butyl]-piperazin-1-yl}-phenyl ester Show/Hide	C25H31N3O3	1
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0502171 Compound Info	3-[4-(4-Phenyl-piperidin-1-yl)-butyl]-1H-indol-5-ol Show/Hide	C23H28N2O	1
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0374515 Compound Info	3-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C24H28N4O	1
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0406581 Compound Info	3-{4-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C24H28N4O	1
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0435562 Compound Info	3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C25H28N4O2	1
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0499956 Compound Info	3-[4-(4-Benzo[1,2,5]thiadiazol-4-yl-piperazin-1-yl)-butyl]-1H-indole-5-carbonitrile Show/Hide	C23H24N6S	1
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0487162 Compound Info	3-{4-[4-(4-Cyano-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C24H25N5	1
1	IC50 = 1.1 nM Bioactivity Info	TI LI LO TS
CP0445506 Compound Info	4-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzofuran-2-carboxylic acid amide Show/Hide	C26H27N5O2	1
1	IC50 = 1.4 nM Bioactivity Info	TI LI LO TS
CP0445505 Compound Info	3-{4-[4-(1H-Indol-5-yl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C25H27N5	1
1	IC50 = 1.6 nM Bioactivity Info	TI LI LO TS
CP0498042 Compound Info	7-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzofuran-2-carboxylic acid amide Show/Hide	C26H27N5O2	1
1	IC50 = 1.9 nM Bioactivity Info	TI LI LO TS
CP0442225 Compound Info	5-Methoxy-3-(4-{4-[4-(2-methoxy-ethoxy)-phenyl]-piperazin-1-yl}-butyl)-1H-indole Show/Hide	C26H35N3O3	1
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0497840 Compound Info	4-{4-[4-(5-Methoxy-1H-indol-3-yl)-butyl]-piperazin-1-yl}-phenol Show/Hide	C23H29N3O2	1
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0522607 Compound Info	5-Ethoxy-3-{4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole Show/Hide	C25H33N3O2	1
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0551766 Compound Info	3-[4-(4-Chroman-6-yl-piperazin-1-yl)-butyl]-5-methoxy-1H-indole Show/Hide	C26H33N3O2	1
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0374517 Compound Info	3-[4-(4-{2-Cyano-3-[2-(2-ethoxy-ethoxy)-ethoxy]-phenyl}-piperazin-1-yl)-butyl]-1H-indole-5-carbonitrile Show/Hide	C30H37N5O3	1
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0480695 Compound Info	3-{4-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C23H25FN4	1
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0499952 Compound Info	3-[4-(4-Benzo[1,2,5]thiadiazol-5-yl-piperazin-1-yl)-butyl]-1H-indole-5-carbonitrile Show/Hide	C23H24N6S	1
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0420104 Compound Info	N-[4-[4-[4-(5-methoxy-1H-indol-3-yl)butyl]piperazin-1-yl]phenyl]acetamide Show/Hide	C25H32N4O2	1
1	IC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0445648 Compound Info	5-{4-[4-(5-Fluoro-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzofuran-2-carboxylic acid amide Show/Hide	C25H27FN4O2	1
1	IC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0499242 Compound Info	5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzo[b]thiophene-2-carboxylic acid amide Show/Hide	C26H27N5OS	1
1	IC50 = 3.1 nM Bioactivity Info	TI LI LO TS
CP0382385 Compound Info	5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-2,3-dihydro-benzofuran-2-carboxylic acid amide Show/Hide	C26H29N5O2	1
1	IC50 = 3.2 nM Bioactivity Info	TI LI LO TS
CP0495106 Compound Info	5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzofuran-4-carboxylic acid amide Show/Hide	C26H27N5O2	1
1	IC50 = 3.3 nM Bioactivity Info	TI LI LO TS
CP0485963 Compound Info	5-Methoxy-3-{4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole Show/Hide	C24H31N3O2	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0494601 Compound Info	3-[4-(4-Benzo[1,3]dioxol-5-yl-piperazin-1-yl)-butyl]-5-methoxy-1H-indole Show/Hide	C24H29N3O3	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0395077 Compound Info	3-{4-[4-(2,3-Dihydro-benzofuran-5-yl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C25H28N4O	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0435548 Compound Info	3-[4-(4-Benzo[1,3]dioxol-5-yl-piperazin-1-yl)-butyl]-5-fluoro-1H-indole Show/Hide	C23H26FN3O2	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0501484 Compound Info	3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid Show/Hide	C25H29N3O4	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0495105 Compound Info	6-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzofuran-2-carboxylic acid amide Show/Hide	C26H27N5O2	1
1	IC50 = 4.4 nM Bioactivity Info	TI LI LO TS
CP0368089 Compound Info	3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-piperazin-1-yl]-butyl}-5-fluoro-1H-indole Show/Hide	C24H28FN3O2	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0485027 Compound Info	5-{4-[4-(5-Fluoro-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzofuran-2-carbonitrile Show/Hide	C25H25FN4O	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0499238 Compound Info	3-[4-(4-Chroman-6-yl-piperazin-1-yl)-butyl]-1H-indole-5-carbonitrile Show/Hide	C26H30N4O	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0435546 Compound Info	3-{4-[4-(2-Cyano-3-methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C25H27N5O	1
1	IC50 = 5.6 nM Bioactivity Info	TI LI LO TS
CP0486042 Compound Info	3-{4-[4-(4-Hydroxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C23H26N4O	1
1	IC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0440079 Compound Info	2-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzamide Show/Hide	C24H27N5O	1
1	IC50 = 6.4 nM Bioactivity Info	TI LI LO TS
CP0374512 Compound Info	3-{4-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid methyl ester Show/Hide	C25H31N3O3	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0490724 Compound Info	3-{4-[4-(4-Cyano-2-methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C25H27N5O	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0497451 Compound Info	3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-piperazin-1-yl]-butyl}-1H-indole Show/Hide	C24H29N3O2	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0059583 Compound Info	1,1-Dioxo-2-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-butyl]-1,2-dihydro-1lambda6-benzo[d]isothiazol-3-one Show/Hide	C19H23N5O3S	1
1	IC50 = 8.2 nM Bioactivity Info	TI LI LO TS
CP0382384 Compound Info	3-[4-(4-Benzofuran-5-yl-piperazin-1-yl)-butyl]-1H-indole-5-carbonitrile Show/Hide	C25H26N4O	1
1	IC50 = 8.7 nM Bioactivity Info	TI LI LO TS
CP0497345 Compound Info	3-{4-[4-(3,4-Dimethoxy-phenyl)-piperazin-1-yl]-butyl}-5-methoxy-1H-indole Show/Hide	C25H33N3O3	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0491995 Compound Info	4-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-phthalonitrile Show/Hide	C25H24N6	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0408654 Compound Info	5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-1H-indole-2-carboxylic acid amide Show/Hide	C26H28N6O	1
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0486034 Compound Info	3-{4-[4-(4-Cyano-3-methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C25H27N5O	1
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0035411 Compound Info	5-Methoxy-3-[4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]-1H-indole Show/Hide	C24H28N2O	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0485959 Compound Info	5-Methoxy-3-[4-(4-phenyl-piperazin-1-yl)-butyl]-1H-indole Show/Hide	C23H29N3O	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0509617 Compound Info	3-[4-(4-Phenyl-piperidin-1-yl)-butyl]-1H-indole-5-carboxylic acid methyl ester Show/Hide	C25H30N2O2	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0420105 Compound Info	2,2-Dimethyl-propionic acid 4-{4-[4-(5-methoxy-1H-indol-3-yl)-butyl]-piperazin-1-yl}-phenyl ester Show/Hide	C28H37N3O3	1
1	IC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0551764 Compound Info	3-{4-[4-(4-Benzyloxy-phenyl)-piperazin-1-yl]-butyl}-5-methoxy-1H-indole Show/Hide	C30H35N3O2	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0486420 Compound Info	3-{4-[4-(5-Chloro-2-methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C24H27ClN4O	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0526002 Compound Info	5-Benzyloxy-3-{4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole Show/Hide	C30H35N3O2	1
1	IC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0392390 Compound Info	3-{4-[4-(4-Cyano-3,5-difluoro-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C24H23F2N5	1
1	IC50 = 36 nM Bioactivity Info	TI LI LO TS
CP0506272 Compound Info	3-[4-(4-Phenyl-piperazin-1-yl)-butyl]-1H-indole-5-carboxylic acid Show/Hide	C23H27N3O2	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0521131 Compound Info	3-[4-(4-Phenyl-piperazin-1-yl)-butyl]-1H-indole-5-carboxylic acid methyl ester Show/Hide	C24H29N3O2	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0198134 Compound Info	5-Chloro-3-{4-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-piperazin-1-yl]-butyl}-1H-indole Show/Hide	C24H28ClN3O2	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0374516 Compound Info	2-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-isophthalonitrile Show/Hide	C25H24N6	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0464617 Compound Info	4-{4-[4-(5-Fluoro-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzonitrile Show/Hide	C23H25FN4	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0491985 Compound Info	5-Methoxy-3-{4-[4-(4-methoxy-3,5-dimethyl-phenyl)-piperazin-1-yl]-butyl}-1H-indole Show/Hide	C26H35N3O2	1
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0495101 Compound Info	3-{4-[4-(3,4-Dimethoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C25H30N4O2	1
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0501483 Compound Info	3-(4-{4-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-piperazin-1-yl}-butyl)-5-methoxy-1H-indole Show/Hide	C29H43N3O2Si	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0374511 Compound Info	5-Cyclopentyloxy-3-{4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole Show/Hide	C28H37N3O2	1
1	IC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0435694 Compound Info	3-[4-(4-Phenyl-piperidin-1-yl)-butyl]-1H-indole-5-carboxylic acid Show/Hide	C24H28N2O2	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0509746 Compound Info	4-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzamide Show/Hide	C24H27N5O	1
1	IC50 = 118 nM Bioactivity Info	TI LI LO TS
CP0391233 Compound Info	3-{4-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-butyl}-5-pentyloxy-1H-indole Show/Hide	C28H39N3O2	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0442307 Compound Info	5-Methoxy-3-{4-[4-(3,4,5-trimethoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole Show/Hide	C26H35N3O4	1
1	IC50 = 333 nM Bioactivity Info	TI LI LO TS
CP0435547 Compound Info	3-{4-[4-(3-Cyano-4-hydroxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile Show/Hide	C24H25N5O	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0487163 Compound Info	3-[4-(4-Phenyl-piperazin-1-yl)-butyl]-1H-indole-5-carbonitrile Show/Hide	C23H26N4	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0374866 Compound Info	(8R)-8-[3-phenylpropyl(propyl)amino]-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C25H30N2O	1
1	Ki < 0.02 nM Bioactivity Info	TI LI LO TS
CP0392154 Compound Info	8-(Phenethyl-propyl-amino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C24H28N2O	1
1	Ki = 0.04 nM Bioactivity Info	TI LI LO TS
CP0462232 Compound Info	8-Pyrrolidin-1-yl-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C17H20N2O	1
1	Ki = 0.07 nM Bioactivity Info	TI LI LO TS
CP0424195 Compound Info	8-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C22H26N2OS	1
1	Ki = 0.1 nM Bioactivity Info	TI LI LO TS
CP0052478 Compound Info	(+/-)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H26N2O	1
1	Ki = 0.2 nM Bioactivity Info	TI LI LO TS
CP0221880 Compound Info	(S)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H26N2O	1
1	Ki = 0.2 nM Bioactivity Info	TI LI LO TS
CP0276816 Compound Info	(R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H26N2O	1
1	Ki = 0.2 nM Bioactivity Info	TI LI LO TS
CP0498856 Compound Info	4,4-dimethyl-1-[4-[propyl-[(8R)-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl]amino]butyl]piperidine-2,6-dione Show/Hide	C26H37N3O2	1
1	Ki = 0.2 nM Bioactivity Info	TI LI LO TS
CP0497718 Compound Info	8-Azepan-1-yl-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H24N2O	1
1	Ki = 0.24 nM Bioactivity Info	TI LI LO TS
CP0425117 Compound Info	8-(Allyl-propyl-amino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H24N2O	1
1	Ki = 0.3 nM Bioactivity Info	TI LI LO TS
CP0207911 Compound Info	1-((3aR,9bS)-3-Propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indol-9-yl)-ethanone Show/Hide	C17H23NO	1
1	Ki = 0.4 nM Bioactivity Info	TI LI LO TS
CP0037227 Compound Info	7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol Show/Hide	C16H25NO	1
1	Ki = 0.5 nM Bioactivity Info	TI LI LO TS
CP0378553 Compound Info	8-[(3-Phenyl-propyl)-propyl-amino]-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C25H30N2O	1
1	Ki = 0.6 nM Bioactivity Info	TI LI LO TS
CP0380900 Compound Info	(8R)-8-[4-(4,4-dimethyl-2,6-dioxopiperidin-1-yl)butyl-propylamino]-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C27H37N3O3	1
1	Ki = 0.6 nM Bioactivity Info	TI LI LO TS
CP0428818 Compound Info	8-(Cyclopropylmethyl-propyl-amino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C20H26N2O	1
1	Ki = 0.6 nM Bioactivity Info	TI LI LO TS
CP0509166 Compound Info	N-propyl-N-(2-thiophen-2-ylethyl)-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C21H26N2S	1
1	Ki = 0.6 nM Bioactivity Info	TI LI LO TS
CP0292584 Compound Info	1-((3aR,9bS)-3-Propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indol-9-yl)-butan-1-one Show/Hide	C19H27NO	1
1	Ki = 0.7 nM Bioactivity Info	TI LI LO TS
CP0380845 Compound Info	8-(Methyl-propyl-amino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C17H22N2O	1
1	Ki = 0.7 nM Bioactivity Info	TI LI LO TS
CP0467378 Compound Info	N-(2-phenylethyl)-N-propyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C23H28N2	1
1	Ki = 0.7 nM Bioactivity Info	TI LI LO TS
CP0376303 Compound Info	8-Pyrrolidin-1-yl-6,7,8,9-tetrahydro-3H-benzo[e]indole Show/Hide	C16H20N2	1
1	Ki = 0.8 nM Bioactivity Info	TI LI LO TS
CP0448144 Compound Info	8-{[3-(3-Chloro-phenoxy)-propyl]-propyl-amino}-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C25H29ClN2O2	1
1	Ki = 0.8 nM Bioactivity Info	TI LI LO TS
CP0186734 Compound Info	(3aR,9bS)-3-Allyl-9-bromo-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole Show/Hide	C15H18BrN	1
1	Ki = 1 nM Bioactivity Info	TI LI LO TS
CP0448143 Compound Info	8-Propylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C16H20N2O	1
1	Ki = 1 nM Bioactivity Info	TI LI LO TS
CP0416467 Compound Info	(8R)-8-[2-methylpropyl(propyl)amino]-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C20H28N2O	1
1	Ki = 1.1 nM Bioactivity Info	TI LI LO TS
CP0106709 Compound Info	2-Methyl-1-((3aR,9bS)-3-propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indol-9-yl)-propan-1-one Show/Hide	C19H27NO	1
1	Ki = 1.2 nM Bioactivity Info	TI LI LO TS
CP0378377 Compound Info	8-{[3-(2-Methoxy-phenyl)-propyl]-propyl-amino}-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C26H32N2O2	1
1	Ki = 1.2 nM Bioactivity Info	TI LI LO TS
CP0216619 Compound Info	(8S)-N,N-dipropyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C18H26N2	1
1	Ki = 1.4 nM Bioactivity Info	TI LI LO TS
CP0343649 Compound Info	(3aR,9bS)-3-Allyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid amide Show/Hide	C16H20N2O	1
1	Ki = 1.5 nM Bioactivity Info	TI LI LO TS
CP0437569 Compound Info	(8S)-8-[4-(4,4-dimethyl-2,6-dioxopiperidin-1-yl)butyl-propylamino]-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde;hydrate Show/Hide	C27H37N3O3	1
1	Ki = 1.5 nM Bioactivity Info	TI LI LO TS
CP0509509 Compound Info	(8R)-8-(dimethylamino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C15H18N2O	1
1	Ki = 1.5 nM Bioactivity Info	TI LI LO TS
CP0192883 Compound Info	(3aR,9bS)-3-Propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid amide Show/Hide	C16H22N2O	1
1	Ki = 1.9 nM Bioactivity Info	TI LI LO TS
CP0378588 Compound Info	4,4-Dimethyl-1-{4-[propyl-(6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-amino]-butyl}-piperidine-2,6-dione Show/Hide	C26H37N3O2	1
1	Ki = 1.9 nM Bioactivity Info	TI LI LO TS
CP0428133 Compound Info	Benzyl-propyl-(6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-amine Show/Hide	C22H26N2	1
1	Ki = 1.9 nM Bioactivity Info	TI LI LO TS
CP0104673 Compound Info	(3aR,9bS)-3-Propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid allylamide Show/Hide	C19H26N2O	1
1	Ki = 2.2 nM Bioactivity Info	TI LI LO TS
CP0381324 Compound Info	N-(cyclopropylmethyl)-N-propyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C19H26N2	1
1	Ki = 2.5 nM Bioactivity Info	TI LI LO TS
CP0401280 Compound Info	8-(Benzyl-propyl-amino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C23H26N2O	1
1	Ki = 2.7 nM Bioactivity Info	TI LI LO TS
CP0376302 Compound Info	8-{[4-(4,4-Dimethyl-2,6-dioxo-piperidin-1-yl)-butyl]-propyl-amino}-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C27H37N3O3	1
1	Ki = 2.8 nM Bioactivity Info	TI LI LO TS
CP0392682 Compound Info	N-[3-(2-methoxyphenyl)propyl]-N-propyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C25H32N2O	1
1	Ki = 2.9 nM Bioactivity Info	TI LI LO TS
CP0001238 Compound Info	14C-5-hydroxy tryptamine creatinine disulfate Show/Hide	C10H12N2O	1
1	Ki = 3 nM Bioactivity Info	TI LI LO TS
CP0382288 Compound Info	N-propyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C15H20N2	1
1	Ki = 3.2 nM Bioactivity Info	TI LI LO TS
CP0258010 Compound Info	(+/-)-Dipropyl-(6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-amine Show/Hide	C18H26N2	1
1	Ki = 3.3 nM Bioactivity Info	TI LI LO TS
CP0432290 Compound Info	(3-Phenyl-propyl)-(6,7,8,9-tetrahydro-3H-benzo[e]indol-8-ylmethyl)-amine Show/Hide	C22H26N2	1
1	Ki = 3.4 nM Bioactivity Info	TI LI LO TS
CP0378469 Compound Info	(8R)-N-(2-methylpropyl)-N-propyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C19H28N2	1
1	Ki = 3.6 nM Bioactivity Info	TI LI LO TS
CP0150376 Compound Info	(3aR,9bS)-3-(3-Fluoro-propyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid amide Show/Hide	C16H21FN2O	1
1	Ki = 3.9 nM Bioactivity Info	TI LI LO TS
CP0428161 Compound Info	Allyl-propyl-(6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-amine Show/Hide	C18H24N2	1
1	Ki = 4.6 nM Bioactivity Info	TI LI LO TS
CP0211159 Compound Info	(3aR,9bS)-9-Bromo-3-(3-fluoro-propyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole Show/Hide	C15H19BrFN	1
1	Ki = 4.7 nM Bioactivity Info	TI LI LO TS
CP0343622 Compound Info	(3aR,9bS)-9-Bromo-3-cyclopropylmethyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole Show/Hide	C16H20BrN	1
1	Ki = 4.7 nM Bioactivity Info	TI LI LO TS
CP0056626 Compound Info	(8R)-N,N-dipropyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C18H26N2	1
1	Ki = 5.2 nM Bioactivity Info	TI LI LO TS
CP0316240 Compound Info	(3aR,9bS)-3-Cyclopropylmethyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid amide Show/Hide	C17H22N2O	1
1	Ki = 8.3 nM Bioactivity Info	TI LI LO TS
CP0197920 Compound Info	(3aR,9bS)-9-Bromo-3-ethyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole Show/Hide	C14H18BrN	1
1	Ki = 11 nM Bioactivity Info	TI LI LO TS
CP0071154 Compound Info	2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamine Show/Hide	C13H18N2O	1
1	Ki = 11 nM Bioactivity Info	TI LI LO TS
CP0079907 Compound Info	(3aR,9bS)-9-Bromo-3-(3-chloro-propyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole Show/Hide	C15H19BrClN	1
1	Ki = 12 nM Bioactivity Info	TI LI LO TS
CP0419374 Compound Info	N-[3-(3-chlorophenoxy)propyl]-N-propyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C24H29ClN2O	1
1	Ki = 12 nM Bioactivity Info	TI LI LO TS
CP0405371 Compound Info	N-methyl-N-propyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C16H22N2	1
1	Ki = 14 nM Bioactivity Info	TI LI LO TS
CP0297911 Compound Info	(3aR,9bS)-3-(3-Chloro-propyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid amide Show/Hide	C16H21ClN2O	1
1	Ki = 15 nM Bioactivity Info	TI LI LO TS
CP0064163 Compound Info	(8R)-N,N-dimethyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C14H18N2	1
1	Ki = 15 nM Bioactivity Info	TI LI LO TS
CP0271827 Compound Info	(+/-)-Dimethyl-(6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-amine Show/Hide	C14H18N2	1
1	Ki = 15 nM Bioactivity Info	TI LI LO TS
CP0393050 Compound Info	8-Azepan-1-yl-6,7,8,9-tetrahydro-3H-benzo[e]indole Show/Hide	C18H24N2	1
1	Ki = 15 nM Bioactivity Info	TI LI LO TS
CP0480515 Compound Info	(8S)-8-(dimethylamino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C15H18N2O	1
1	Ki = 18 nM Bioactivity Info	TI LI LO TS
CP0237350 Compound Info	(3aR,9bS)-3-Propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid benzylamide Show/Hide	C23H28N2O	1
1	Ki = 22 nM Bioactivity Info	TI LI LO TS
CP0050932 Compound Info	(3aR,9bS)-3-Ethyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid amide Show/Hide	C15H20N2O	1
1	Ki = 23 nM Bioactivity Info	TI LI LO TS
CP0334921 Compound Info	(3aR,9bS)-9-Bromo-3-methyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole Show/Hide	C13H16BrN	1
1	Ki = 24 nM Bioactivity Info	TI LI LO TS
CP0316062 Compound Info	(3aR,9bS)-9-Bromo-3-but-3-enyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole Show/Hide	C16H20BrN	1
1	Ki = 34 nM Bioactivity Info	TI LI LO TS
CP0312683 Compound Info	(3aR,9bS)-3-Methyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid amide Show/Hide	C14H18N2O	1
1	Ki = 41 nM Bioactivity Info	TI LI LO TS
CP0050979 Compound Info	(3aR,9bS)-3-Isobutyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid amide Show/Hide	C17H24N2O	1
1	Ki = 42 nM Bioactivity Info	TI LI LO TS
CP0376310 Compound Info	8-Dipropylaminomethyl-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C20H28N2O	1
1	Ki = 42 nM Bioactivity Info	TI LI LO TS
CP0211158 Compound Info	(3aR,9bS)-9-Bromo-3-butyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole Show/Hide	C16H22BrN	1
1	Ki = 45 nM Bioactivity Info	TI LI LO TS
CP0182360 Compound Info	(3aR,9bS)-3-Prop-2-ynyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid amide Show/Hide	C16H18N2O	1
1	Ki = 48 nM Bioactivity Info	TI LI LO TS
CP0220979 Compound Info	(3aR,9bS)-3-Propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid propylamide Show/Hide	C19H28N2O	1
1	Ki = 52 nM Bioactivity Info	TI LI LO TS
CP0040671 Compound Info	8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C23H26FN3O2	1
1	Ki = 58 nM Bioactivity Info	TI LI LO TS
CP0185134 Compound Info	(3aR,9bS)-3-But-3-enyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid amide Show/Hide	C17H22N2O	1
1	Ki = 82 nM Bioactivity Info	TI LI LO TS
CP0312231 Compound Info	(3aR,9bS)-3-Butyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid amide Show/Hide	C17H24N2O	1
1	Ki = 83 nM Bioactivity Info	TI LI LO TS
CP0526741 Compound Info	(3aR,9bS)-9-Bromo-3-(2-methoxy-ethyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole Show/Hide	C15H20BrNO	1
1	Ki = 97 nM Bioactivity Info	TI LI LO TS
CP0316072 Compound Info	(3aR,9bS)-3-(2-Methoxy-ethyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid amide Show/Hide	C16H22N2O2	1
1	Ki = 129 nM Bioactivity Info	TI LI LO TS
CP0044323 Compound Info	(8S)-N,N-dimethyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C14H18N2	1
1	Ki = 137 nM Bioactivity Info	TI LI LO TS
CP0479467 Compound Info	(R)-2-Methoxyaporphin-11-yl pentanoate Show/Hide	C23H27NO3	1
1	Ki = 151 nM Bioactivity Info	TI LI LO TS
CP0509975 Compound Info	3-Benzyl-8-[4-(4-fluoro-phenyl)-4-oxo-butyl]-1-methyl-1,3,8-triaza-spiro[4.5]decan-4-one Show/Hide	C25H30FN3O2	1
1	Ki = 265 nM Bioactivity Info	TI LI LO TS
CP0237257 Compound Info	(3aR,9bS)-9-Bromo-3-(3-methyl-but-2-enyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole Show/Hide	C17H22BrN	1
1	Ki = 266 nM Bioactivity Info	TI LI LO TS
CP0218726 Compound Info	(3aR,9bS)-3-(3-Methyl-but-2-enyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid amide Show/Hide	C18H24N2O	1
1	Ki = 271 nM Bioactivity Info	TI LI LO TS
CP0101476 Compound Info	(3aR,9bS)-3-Propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-9-carboxylic acid dipropylamide Show/Hide	C22H34N2O	1
1	Ki = 434 nM Bioactivity Info	TI LI LO TS
CP0410531 Compound Info	8-[(3-chlorophenyl)methylamino]-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Show/Hide	C24H25ClN2O	1
1	Ki = 479 nM Bioactivity Info	TI LI LO TS
CP0424413 Compound Info	(R)-11-Amino-2-methoxyaporphine Show/Hide	C18H20N2O	1
1	Ki = 640 nM Bioactivity Info	TI LI LO TS
CP0870861 Compound Info	(+/-)-1-phenyl-6-m-tolyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide Show/Hide	C23H24BrNO2	1
1	Ki = 736 nM Bioactivity Info	TI LI LO TS
CP0870860 Compound Info	(+/-)-1,6-Diphenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide Show/Hide	C22H22BrNO2	1
1	Ki = 775 nM Bioactivity Info	TI LI LO TS
CP0875703 Compound Info	(+/-)-6-(naphthalen-2-yl)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide Show/Hide	C26H24BrNO2	1
1	Ki = 1083 nM Bioactivity Info	TI LI LO TS
CP0278253 Compound Info	4-Cyclohexylamino-1-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperidine-4-carboxylic acid amide Show/Hide	C22H32FN3O2	1
1	Ki = 1610 nM Bioactivity Info	TI LI LO TS
CP0461410 Compound Info	(R)-2,11-Diaminoaporphine Show/Hide	C17H19N3	1
1	Ki = 2300 nM Bioactivity Info	TI LI LO TS
CP0063768 Compound Info	8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1-isopropyl-1,3,8-triaza-spiro[4.5]decan-4-one Show/Hide	C20H28FN3O2	1
1	Ki = 2340 nM Bioactivity Info	TI LI LO TS
CP0277875 Compound Info	8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-3-isopropyl-1-methyl-1,3,8-triaza-spiro[4.5]decan-4-one Show/Hide	C21H30FN3O2	1
1	Ki = 6300 nM Bioactivity Info	TI LI LO TS
CP0102266 Compound Info	1-Ethyl-8-[4-(4-fluoro-phenyl)-4-oxo-butyl]-1,3,8-triaza-spiro[4.5]decan-4-one Show/Hide	C19H26FN3O2	1
1	Ki = 7960 nM Bioactivity Info	TI LI LO TS
CP0460496 Compound Info	C,C,C-Trifluoro-N-[3-((S)-1-propyl-piperidin-3-yl)-phenyl]-methanesulfonamide Show/Hide	C15H21F3N2O2S	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0059946 Compound Info	8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,3-dimethyl-1,3,8-triaza-spiro[4.5]decan-4-one Show/Hide	C19H26FN3O2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0063089 Compound Info	8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1-methyl-1,3,8-triaza-spiro[4.5]decan-4-one Show/Hide	C18H24FN3O2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0113075 Compound Info	3-Butyl-8-[4-(4-fluoro-phenyl)-4-oxo-butyl]-1-methyl-1,3,8-triaza-spiro[4.5]decan-4-one Show/Hide	C22H32FN3O2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0202170 Compound Info	8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1-methyl-3-propyl-1,3,8-triaza-spiro[4.5]decan-4-one Show/Hide	C21H30FN3O2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0217185 Compound Info	1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-4-isopropylamino-piperidine-4-carboxylic acid amide Show/Hide	C19H28FN3O2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0307324 Compound Info	8-[3-(4-Fluoro-phenoxy)-propyl]-1-methyl-3-propyl-1,3,8-triaza-spiro[4.5]decan-4-one Show/Hide	C20H30FN3O2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0392231 Compound Info	3-Ethyl-8-[4-(4-fluoro-phenyl)-4-oxo-butyl]-1-methyl-1,3,8-triaza-spiro[4.5]decan-4-one Show/Hide	C20H28FN3O2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0392232 Compound Info	1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-4-methylamino-piperidine-4-carboxylic acid amide Show/Hide	C17H24FN3O2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0430583 Compound Info	8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,3,8-triaza-spiro[4.5]decan-4-one Show/Hide	C17H22FN3O2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0050995 Compound Info	(6aR)-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol Show/Hide	C19H21NO	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0235380 Compound Info	Acetic acid (R)-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-yl ester Show/Hide	C21H23NO2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0320610 Compound Info	11-valeryloxynoraporphine Show/Hide	C24H29NO2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0372853 Compound Info	11-Heptanoyloxy-N-n-propylnoraporphine Show/Hide	C26H33NO2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0372855 Compound Info	11-Hexanoyloxy-N-n-propylnoraporphine Show/Hide	C25H31NO2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0372857 Compound Info	Bis[N-propylnoraporphin-11-O-yl]succinate Show/Hide	C42H44N2O4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0467392 Compound Info	11-[2-(Benzyloxycarbonylamino)acetyloxy]-N-npropylnoraporphine Show/Hide	C29H30N2O4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0474888 Compound Info	11-Butyryloxy-N-n-propylnoraporphine Show/Hide	C23H27NO2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0491417 Compound Info	11-Propionyloxy-N-n-propylnoraporphine Show/Hide	C22H25NO2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0510086 Compound Info	Bis(N-propylnoraporphin-11-O-yl) glutamate Show/Hide	C43H46N2O4	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0456677 Compound Info	N-propyl-N-(6,7,8,9-tetrahydro-3H-benzo[e]indol-8-ylmethyl)propan-1-amine Show/Hide	C19H28N2	1
1	Ki > 200 nM Bioactivity Info	TI LI LO TS
CP0400236 Compound Info	3-methyl-8-[(2-methylphenyl)methylamino]-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Show/Hide	C25H28N2O	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0410530 Compound Info	8-amino-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Show/Hide	C17H20N2O	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0424268 Compound Info	3-methyl-8-[(4-methylphenyl)methylamino]-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Show/Hide	C25H28N2O	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0426632 Compound Info	3-methyl-8-(3-methylphenyl)-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Show/Hide	C24H25NO	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0443432 Compound Info	7-amino-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol Show/Hide	C17H20N2O	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0443434 Compound Info	8-(benzylamino)-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Show/Hide	C24H26N2O	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0443435 Compound Info	8-(4-hydroxyphenyl)-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Show/Hide	C23H23NO2	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0509154 Compound Info	3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Show/Hide	C17H19NO	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0509167 Compound Info	3-methyl-8-[(3-methylphenyl)methylamino]-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Show/Hide	C25H28N2O	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0159608 Compound Info	3-[4-(4-Chroman-6-yl-piperazin-1-yl)-butyl]-1H-indole-5-carboxylic acid amide Show/Hide	C26H32N4O2	1
1	ED50 = 0.07 nM
CP0037227 Compound Info	7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol Show/Hide	C16H25NO	14
1	IC50 = 1.1 nM
2	IC50 = 2.1 nM
3	IC50 = 3 nM
4	IC50 = 8.06 nM
5	Kd = 2.5 nM
6	Ki = 0.47 nM
7	Ki = 0.5 nM
8	Ki = 1 nM
9	Ki = 1.2 nM
10	Ki = 1.44 nM
11	Ki = 1.59 nM
12	Ki = 2.1 nM
13	Ki = 4.3 nM
14	Ki = 8.7 nM
CP0001238 Compound Info	14C-5-hydroxy tryptamine creatinine disulfate Show/Hide	C10H12N2O	4
1	IC50 = 2.6 nM
2	IC50 = 5.2 nM
3	Ki = 1.585 nM
4	Ki = 1.7 nM
CP0052478 Compound Info	(+/-)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H26N2O	1
1	Ki = 1.3 nM
CP0276816 Compound Info	(R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H26N2O	1
1	Ki = 1.4 nM
CP0043151 Compound Info	8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbonitrile Show/Hide	C19H25N3	1
1	Ki = 1.8 nM
CP0221880 Compound Info	(S)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H26N2O	1
1	Ki = 2 nM
CP0065057 Compound Info	(R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbonitrile Show/Hide	C19H25N3	1
1	Ki = 2.7 nM
CP0099933 Compound Info	(S)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbonitrile Show/Hide	C19H25N3	1
1	Ki = 2.9 nM
CP0059583 Compound Info	1,1-Dioxo-2-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-butyl]-1,2-dihydro-1lambda6-benzo[d]isothiazol-3-one Show/Hide	C19H23N5O3S	1
1	Ki = 3.4 nM
CP0056626 Compound Info	(8R)-N,N-dipropyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C18H26N2	1
1	Ki = 7 nM
CP0071154 Compound Info	2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamine Show/Hide	C13H18N2O	2
1	Ki = 7.8 nM
2	Ki = 69 nM
CP0258010 Compound Info	(+/-)-Dipropyl-(6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-amine Show/Hide	C18H26N2	1
1	Ki = 12 nM
CP0348071 Compound Info	(1-Chloro-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine Show/Hide	C18H25ClN2	1
1	Ki = 12.6 nM
CP0216619 Compound Info	(8S)-N,N-dipropyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C18H26N2	1
1	Ki = 14 nM
CP0064163 Compound Info	(8R)-N,N-dimethyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C14H18N2	1
1	Ki = 25 nM
CP0040671 Compound Info	8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C23H26FN3O2	2
1	Ki = 30 nM
2	Ki = 49 nM
CP0050995 Compound Info	(6aR)-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol Show/Hide	C19H21NO	1
1	Ki = 40 nM
CP0271827 Compound Info	(+/-)-Dimethyl-(6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-amine Show/Hide	C14H18N2	1
1	Ki = 66 nM
CP0216553 Compound Info	N,N-dipropyl-1-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C20H27F3N2	1
1	Ki = 182 nM
CP0044323 Compound Info	(8S)-N,N-dimethyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C14H18N2	1
1	Ki = 190 nM

Similar Protein(s) and Bioactivity Statistics

90% Identity

Protein ID	Protein Name	Protein Organism
PT01723	5-hydroxytryptamine receptor 1A	Mus musculus, Mouse	Protein Info

50% Identity

Protein ID	Protein Name	Protein Organism
PT00819	5-hydroxytryptamine receptor 1A	Homo sapiens, Human	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han