General Information of the Compound
Compound ID
CP0374517
Compound Name
3-[4-(4-{2-Cyano-3-[2-(2-ethoxy-ethoxy)-ethoxy]-phenyl}-piperazin-1-yl)-butyl]-1H-indole-5-carbonitrile
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Structure
Formula
C30H37N5O3
Molecular Weight
515.658
Canonical SMILES
CCOCCOCCOc1cccc(N2CCN(CCCCc3c[nH]c4ccc(cc34)C#N)CC2)c1C#N
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InChI
InChI=1S/C30H37N5O3/c1-2-36-16-17-37-18-19-38-30-8-5-7-29(27(30)22-32)35-14-12-34(13-15-35)11-4-3-6-25-23-33-28-10-9-24(21-31)20-26(25)28/h5,7-10,20,23,33H,2-4,6,11-19H2,1H3
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InChIKey
KAWWVHKWESRAHV-UHFFFAOYSA-N
Physicochemical Property
logP
4.48806
Rotatable Bonds
14
Heavy Atom Count
38
Polar Areas
97.54
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11375756
SID: 16469020
ChEMBL ID
CHEMBL186468
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01448, 5-hydroxytryptamine receptor 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 2 nM
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