Protein Information

General Information of the Protein

Protein ID	PT01398
Protein Name	Somatostatin receptor type 4
Gene Name	SSTR4
Sequence	MSAPSTLPPGGEEGLGTAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRHWPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAIFADTRPARGGQAVACNLQWPHPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRFFQRVLCLRCCLLEGAGGAEEEPLDYYATALKSKGGAGCMCPPLPCQQEALQPEPGRKRIPLTRTTTF Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Peptide receptor (family A GPCR) > Short peptide receptor (family A GPCR) > Somatostatin receptor
Function	Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells. Show/Hide
Uniprot ID	Primary ID: P31391 Secondarily ID: Q17RM1 Q17RM3 Q9UIY1 Show/Hide
Ensembl ID	ENSG00000132671
HGNC ID	HGNC:11333
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000051 , BHK-21

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0049566 Compound Info	15-28-Somatostatin-28 Show/Hide	C76H104N18O19S2	1
1	Ki = 1.4 nM Bioactivity Info	TI LI LO TS
CP0059824 Compound Info	1-{3-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-[3-(1H-imidazol-4-yl)-propyl]-thiourea Show/Hide	C22H25BrCl2N6S	1
1	Ki = 6 nM Bioactivity Info	TI LI LO TS
CP0384087 Compound Info	1-{2-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-ethyl}-3-[3-(1H-imidazol-4-yl)-propyl]-urea Show/Hide	C21H23BrCl2N6O	1
1	Ki = 14 nM Bioactivity Info	TI LI LO TS
CP0436780 Compound Info	1-{3-[(5-Bromo-pyridin-2-yl)-naphthalen-1-ylmethyl-amino]-propyl}-3-[3-(1H-imidazol-4-yl)-propyl]-thiourea Show/Hide	C26H29BrN6S	1
1	Ki = 16 nM Bioactivity Info	TI LI LO TS
CP0543778 Compound Info	2N-(4-bromobenzyl)-2N-(3-{1-[3-(1H-4-imidazolyl)propylimino]methylthioamino}propyl)-2-pyridinamine Show/Hide	C22H29BrN6S	1
1	Ki = 50 nM Bioactivity Info	TI LI LO TS
CP0472009 Compound Info	1-{4-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-butyl}-3-[3-(1H-imidazol-4-yl)-propyl]-thiourea Show/Hide	C23H27BrCl2N6S	1
1	Ki = 53 nM Bioactivity Info	TI LI LO TS
CP0502230 Compound Info	1-{2-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-ethyl}-3-[3-(1H-imidazol-4-yl)-propyl]-thiourea Show/Hide	C21H23BrCl2N6S	1
1	Ki = 70 nM Bioactivity Info	TI LI LO TS
CP0409321 Compound Info	1-{4-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-butyl}-3-[2-(1H-imidazol-4-yl)-ethyl]-thiourea Show/Hide	C22H25BrCl2N6S	1
1	Ki = 96 nM Bioactivity Info	TI LI LO TS
CP0376036 Compound Info	1-{3-[(4-Bromo-benzyl)-pyridin-2-yl-amino]-propyl}-3-[3-(pyridin-2-ylamino)-propyl]-thiourea Show/Hide	C24H29BrN6S	1
1	Ki = 113 nM Bioactivity Info	TI LI LO TS
CP0453405 Compound Info	1-{3-[(4-Bromo-benzyl)-pyridin-2-yl-amino]-propyl}-3-[3-(1H-imidazol-4-yl)-propyl]-thiourea Show/Hide	C22H27BrN6S	1
1	Ki = 118 nM Bioactivity Info	TI LI LO TS
CP0460454 Compound Info	1-{5-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-pentyl}-3-[3-(1H-imidazol-4-yl)-propyl]-thiourea Show/Hide	C24H29BrCl2N6S	1
1	Ki = 132 nM Bioactivity Info	TI LI LO TS
CP0859841 Compound Info	1-{2-[(3,4-Dichloro-benzyl)-(5-nitro-pyridin-2-yl)-amino]-ethyl}-3-[3-(1H-imidazol-4-yl)-propyl]-thiourea Show/Hide	C21H23Cl2N7O2S	1
1	Ki = 176 nM Bioactivity Info	TI LI LO TS
CP0502114 Compound Info	1-{3-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-[3-(pyridin-2-ylamino)-propyl]-thiourea Show/Hide	C24H27BrCl2N6S	1
1	Ki = 185 nM Bioactivity Info	TI LI LO TS
CP0508594 Compound Info	4-(1H-Imidazol-4-yl)-piperidine-1-carbothioic acid {2-[(5-bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-ethyl}-amide Show/Hide	C23H25BrCl2N6S	1
1	Ki = 413 nM Bioactivity Info	TI LI LO TS
CP0376417 Compound Info	1-{2-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-ethyl}-3-[2-(1H-imidazol-4-yl)-ethyl]-thiourea Show/Hide	C20H21BrCl2N6S	1
1	Ki = 476 nM Bioactivity Info	TI LI LO TS
CP0452999 Compound Info	1-{2-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-ethyl}-3-(3-pyrrolidin-1-yl-propyl)-thiourea Show/Hide	C22H28BrCl2N5S	1
1	Ki = 477 nM Bioactivity Info	TI LI LO TS
CP0492514 Compound Info	1-{3-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-(3-pyrrolidin-1-yl-propyl)-thiourea Show/Hide	C23H30BrCl2N5S	1
1	Ki = 514 nM Bioactivity Info	TI LI LO TS
CP0460895 Compound Info	1-{4-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-butyl}-3-[3-(1H-imidazol-4-yl)-phenyl]-thiourea Show/Hide	C26H25BrCl2N6S	1
1	Ki = 520 nM Bioactivity Info	TI LI LO TS
CP0418801 Compound Info	1-{2-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-ethyl}-3-(3-dimethylamino-propyl)-thiourea Show/Hide	C20H26BrCl2N5S	1
1	Ki = 803 nM Bioactivity Info	TI LI LO TS
CP0384089 Compound Info	1-(1H-Benzotriazol-5-yl)-3-{2-[(5-bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-ethyl}-thiourea Show/Hide	C21H18BrCl2N7S	1
1	Ki = 1000 nM Bioactivity Info	TI LI LO TS
CP0497826 Compound Info	1-(4-Amino-butyl)-3-{3-[(5-bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-thiourea Show/Hide	C20H26BrCl2N5S	1
1	Ki = 1000 nM Bioactivity Info	TI LI LO TS
CP0418815 Compound Info	1-(1H-Benzoimidazol-2-ylmethyl)-3-{2-[(5-bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-ethyl}-thiourea Show/Hide	C23H21BrCl2N6S	1
1	Ki = 1200 nM Bioactivity Info	TI LI LO TS
CP0376040 Compound Info	1-{4-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-butyl}-3-(3-imidazol-1-yl-propyl)-thiourea Show/Hide	C23H27BrCl2N6S	1
1	Ki = 1400 nM Bioactivity Info	TI LI LO TS
CP0405563 Compound Info	1-{3-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-(2-pyridin-2-yl-ethyl)-thiourea Show/Hide	C23H24BrCl2N5S	1
1	Ki = 1700 nM Bioactivity Info	TI LI LO TS
CP0428437 Compound Info	1-{3-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-(3-imidazol-1-yl-propyl)-thiourea Show/Hide	C22H25BrCl2N6S	1
1	Ki = 1700 nM Bioactivity Info	TI LI LO TS
CP0049568 Compound Info	(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2S,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide Show/Hide	C49H66N10O10S2	1
1	Ki = 1904 nM Bioactivity Info	TI LI LO TS
CP0439738 Compound Info	1-(4-Amino-butyl)-3-{3-[(5-bromo-pyridin-2-yl)-naphthalen-1-ylmethyl-amino]-propyl}-thiourea Show/Hide	C24H30BrN5S	1
1	Ki = 2000 nM Bioactivity Info	TI LI LO TS
CP0151093 Compound Info	(3S,6S,9S,12R,15S,18S)-9-(4-Amino-butyl)-3-benzyl-15-(4-hydroxy-benzyl)-12-(1H-indol-3-ylmethyl)-6-isopropyl-1,18-dimethyl-1,4,7,10,13,16hexaaza-cyclooctadecane-2,5,8,11,14,17-hexaone Show/Hide	C44H56N8O7	1
1	Ki = 3200 nM Bioactivity Info	TI LI LO TS
CP0497811 Compound Info	1-{4-[(3,4-Dichloro-benzyl)-pyridin-2-yl-amino]-butyl}-3-(3-imidazol-1-yl-propyl)-thiourea Show/Hide	C23H28Cl2N6S	1
1	Ki = 4000 nM Bioactivity Info	TI LI LO TS
CP0504926 Compound Info	1-(3-Amino-propyl)-3-{2-[(5-bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-ethyl}-thiourea Show/Hide	C18H22BrCl2N5S	1
1	Ki = 4200 nM Bioactivity Info	TI LI LO TS
CP0409322 Compound Info	1-{4-[(4-Bromo-benzyl)-pyridin-2-yl-amino]-butyl}-3-(3-imidazol-1-yl-propyl)-thiourea Show/Hide	C23H29BrN6S	1
1	Ki = 7000 nM Bioactivity Info	TI LI LO TS
CP0501010 Compound Info	1-{3-[(4-Bromo-benzyl)-pyridin-2-yl-amino]-propyl}-3-(3-imidazol-1-yl-propyl)-thiourea Show/Hide	C22H27BrN6S	1
1	Ki = 7000 nM Bioactivity Info	TI LI LO TS
CP0487457 Compound Info	1-{2-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-ethyl}-3-(4-piperidin-1-yl-phenyl)-thiourea Show/Hide	C26H28BrCl2N5S	1
1	Ki = 15000 nM Bioactivity Info	TI LI LO TS
CP0384017 Compound Info	1-{4-[(4-Bromo-benzyl)-pyridin-2-yl-amino]-butyl}-3-(3-phenyl-propyl)-thiourea Show/Hide	C26H31BrN4S	1
1	Ki = 71000 nM Bioactivity Info	TI LI LO TS
CP0497135 Compound Info	1-{3-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-(4-piperidin-1-yl-phenyl)-thiourea Show/Hide	C27H30BrCl2N5S	1
1	Ki = 71000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL000389 , CHO-DXB11

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000351 , Dede

Cell Line Info

Cell Line ID: CL000050 , HEK293-A

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0049566 Compound Info	15-28-Somatostatin-28 Show/Hide	C76H104N18O19S2	6
1	IC50 = 0.08 nM
2	IC50 = 1.6 nM
3	IC50 = 1.77 nM
4	Ki = 1.7 nM
5	Ki = 1.76 nM
6	Ki < 2 nM
CP0046225 Compound Info	(4R,7S,10S,13S,16S,19S,22S,25R)-25-amino-13-(4-aminobutyl)-7,19,22-tribenzyl-10-[(1R)-1-hydroxyethyl]-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptazacyclohexacosane-4-carboxylic acid Show/Hide	C54H66N10O10S2	1
1	IC50 = 0.7 nM
CP0050675 Compound Info	(4R,7R,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37-{2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-hydroxypropanamido]propanamido]-3-carbamoylpropanamido]-3-hydroxypropanamido]-3-carbamoylpropanoyl]pyrrolidin-2-yl]formamido}propanamido]-4-(methylsulfanyl)butanamido]propanoyl]pyrrolidin-2-yl]formamido}-5-carbamimidamidopentanamido]-4-carboxybutanamido]-5-carbamimidamidopentanamido]hexanamido]propanamido]a Show/Hide	C137H207N41O39S3	4
1	IC50 = 1.6 nM
2	IC50 = 2.2 nM
3	IC50 = 2.6 nM
4	IC50 = 2.9 nM
CP0036365 Compound Info	H-c(Cys3-Phe6-Phe7-DTrp8-Lys9-Thr10-Phe11-Cys14)-OH Show/Hide	C54H66N10O10S2	1
1	IC50 = 1.8 nM
CP0038580 Compound Info	(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37-[[2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-4-amino-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-carboxybutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]propanoyl]amino]acetyl]amino]-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-10,16-bis[(1S)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-2-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecazacyclooctatriacontane-4-carboxylic acid Show/Hide	C137H207N41O39S3	3
1	IC50 = 2.5 nM
2	IC50 = 3.1 nM
3	IC50 = 3.8 nM
CP0049568 Compound Info	(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2S,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide Show/Hide	C49H66N10O10S2	3
1	IC50 = 3 nM
2	Ki = 398 nM
3	Ki > 1000 nM
CP0670712 Compound Info	(S)-methyl 2-(4-(5,7-difluoro-2-phenyl-1H-indol-3-yl)butanamido)-5-guanidinopentanoate Show/Hide	C25H29F2N5O3	1
1	IC50 = 4.2 nM
CP0042009 Compound Info	(4R,7S,10S,13R,16S,19R)-13-((1H-indol-3-yl)methyl)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-19-((R)-2-amino-3-phenylpropanamido)-10-(4-aminobutyl)-16-benzyl-7-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide Show/Hide	C49H65N11O10S2	2
1	IC50 > 1000 nM
2	IC50 > 10000 nM
CP0151093 Compound Info	(3S,6S,9S,12R,15S,18S)-9-(4-Amino-butyl)-3-benzyl-15-(4-hydroxy-benzyl)-12-(1H-indol-3-ylmethyl)-6-isopropyl-1,18-dimethyl-1,4,7,10,13,16hexaaza-cyclooctadecane-2,5,8,11,14,17-hexaone Show/Hide	C44H56N8O7	1
1	IC50 > 1000 nM
CP0059824 Compound Info	1-{3-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-[3-(1H-imidazol-4-yl)-propyl]-thiourea Show/Hide	C22H25BrCl2N6S	1
1	Ki = 17 nM
CP0136960 Compound Info	(4R,7S,10S,13R,16S,19S)-10-(4-aminobutyl)-19-[[(2S)-2-amino-3-(4-chlorophenyl)propanoyl]amino]-N-[(2S)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide Show/Hide	C58H68ClN11O10S2	1
1	Ki > 1000 nM

Clinical Information about the Protein

Target 1 ( Somatostatin receptor type 4 (SSTR4) )

Target Type	Clinical trial Target

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT07339	Somatostatin receptor type 4	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han