General Information of the Protein
Protein ID
PT01215
Protein Name
C-C chemokine receptor type 3
Secondarily
Protein Name
Eosinophil eotaxin receptor
Gene Name
CCR3
Secondarily
Gene Name
CMKBR3
Sequence
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CC chemokine receptor
Function
Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15 (PubMed:7622448, PubMed:8642344, PubMed:8676064). Subsequently transduces a signal by increasing the intracellular calcium ions level (PubMed:8676064). In addition acts as a possible functional receptor for NARS1 (PubMed:30171954).
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Uniprot ID
Primary ID:
P51677

Secondarily ID:
B3KVQ1
F5GWL6
Q15748
Q2YDB9
Q86WD2
Q8TDP6
Q9ULY8
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Ensembl ID
ENSG00000183625
HGNC ID
HGNC:1604
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000795 , 300-19
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0090447
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(2-hydroxy-4-methylbenzoyl)piperidin-4-ylidene]acetamide
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C30H32FN3O3
  1
1
IC50 = 0.98 nM
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CP0102939
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(2-hydroxybenzoyl)piperidin-4-ylidene]acetamide
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C29H30FN3O3
  2
1
IC50 = 1 nM
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2
IC50 = 8.4 nM
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CP0452198
 Compound Info 
2-[1-(1,3-Benzodioxol-5-ylcarbonyl)piperidin-4-ylidene]-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide
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C30H30FN3O4
  1
1
IC50 = 1.6 nM
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CP0492671
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(4-methoxybenzoyl)piperidin-4-ylidene]acetamide
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C30H32FN3O3
  1
1
IC50 = 1.8 nM
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CP0398965
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(2-hydroxy-4-methoxybenzoyl)piperidin-4-ylidene]acetamide
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C30H32FN3O4
  1
1
IC50 = 3.3 nM
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CP0540187
 Compound Info 
2-[1-(3,4-Dimethoxybenzoyl)piperidin-4-ylidene]-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide
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C31H34FN3O4
  1
1
IC50 = 3.6 nM
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CP0421459
 Compound Info 
2-(1-Benzoylpiperidin-4-ylidene)-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide
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C29H30FN3O2
  1
1
IC50 = 4.4 nM
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CP0492672
 Compound Info 
2-[1-(2-Fluorobenzoyl)piperidin-4-ylidene]-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide
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C29H29F2N3O2
  1
1
IC50 = 4.8 nM
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CP0404911
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(3-hydroxybenzoyl)piperidin-4-ylidene]acetamide
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C29H30FN3O3
  1
1
IC50 = 5 nM
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CP0404912
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(2-methoxybenzoyl)piperidin-4-ylidene]acetamide
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C30H32FN3O3
  1
1
IC50 = 5.1 nM
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CP0504827
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(4-hydroxybenzoyl)piperidin-4-ylidene]acetamide
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C29H30FN3O3
  1
1
IC50 = 5.1 nM
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CP0398966
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(3-methoxybenzoyl)piperidin-4-ylidene]acetamide
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C30H32FN3O3
  1
1
IC50 = 5.8 nM
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CP0452197
 Compound Info 
2-[1-(4-Fluoro-2-hydroxybenzoyl)piperidin-4-ylidene]-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide
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C29H29F2N3O3
  1
1
IC50 = 6 nM
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CP0506155
 Compound Info 
2-[1-(4-Chloro-2-hydroxybenzoyl)piperidin-4-ylidene]-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide
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C29H29ClFN3O3
  1
1
IC50 = 7.5 nM
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CP0799907
 Compound Info 
2-(Azepan-1-ylcarbonyl)-N-{(3-exo)-8-[(6-fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}benzamide
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C32H36FN3O2
  1
1
IC50 = 12 nM
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CP0504828
 Compound Info 
(R)-2-(1-(3-fluorobenzoyl)piperidin-4-ylidene)-N-(1-((6-fluoronaphthalen-2-yl)methyl)pyrrolidin-3-yl)acetamide
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C29H29F2N3O2
  1
1
IC50 = 12 nM
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CP0844223
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-3-(piperidin-1-ylcarbonyl)isonicotinamide
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C30H33FN4O2
  1
1
IC50 = 13 nM
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CP0506156
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(2-hydroxy-5-methoxybenzoyl)piperidin-4-ylidene]acetamide
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C30H32FN3O4
  1
1
IC50 = 14 nM
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CP0067400
 Compound Info 
Biphenyl-2-carboxylic acid [(1R,5R)-8-(6-fluoro-naphthalen-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide
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C31H29FN2O
  1
1
IC50 = 20 nM
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CP0421458
 Compound Info 
2-[1-(4-Fluorobenzoyl)piperidin-4-ylidene]-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide
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C29H29F2N3O2
  1
1
IC50 = 22 nM
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CP0666454
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-3-(piperidin-1-ylcarbonyl)isonicotinamide 1-oxide
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C30H33FN4O3
  1
1
IC50 = 23 nM
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CP0828774
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-(piperidin-1-ylcarbonyl)benzamide
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C31H34FN3O2
  1
1
IC50 = 23 nM
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CP0681149
 Compound Info 
4-(8-((6-fluoronaphthalen-2-yl)methyl)-8-azabicyclo[3.2.1]octan-3-ylcarbamoyl)-3-(piperidine-1-carbonyl)pyridine 1-oxide
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C30H33FN4O3
  1
1
IC50 = 23 nM
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CP0746384
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-pyridin-3-ylbenzamide
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C30H28FN3O
  1
1
IC50 = 29 nM
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CP0435153
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]-2-phenylbenzamide
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C29H27FN2O
  1
1
IC50 = 38 nM
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CP0504001
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(2-hydroxy-3-methoxybenzoyl)piperidin-4-ylidene]acetamide
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C30H32FN3O4
  1
1
IC50 = 38 nM
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CP0806516
 Compound Info 
N-Cyclohexyl-N'-{(3-exo)-8-[(6-fluoro-2-naphthyl)-methyl]-8-azabicyclo[3.2.1]oct-3-yl}-N-methylphthalamide
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C33H38FN3O2
  1
1
IC50 = 44 nM
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CP0480383
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(2-hydroxy-6-methoxybenzoyl)piperidin-4-ylidene]acetamide
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C30H32FN3O4
  1
1
IC50 = 45 nM
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CP0799901
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-pyridin-2-ylbenzamide
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C30H28FN3O
  1
1
IC50 = 57 nM
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CP0806517
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-4-(piperidin-1-ylcarbonyl)nicotinamide
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C30H33FN4O2
  1
1
IC50 = 85 nM
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CP0677445
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-(1,3-thiazol-2-yl)benzamide
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C28H26FN3OS
  1
1
IC50 = 89 nM
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CP0828771
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-pyrimidin-5-ylbenzamidefumarate
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C33H31FN4O5
  1
1
IC50 = 93 nM
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CP0464185
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]-2-phenoxybenzamide
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C29H27FN2O2
  1
1
IC50 = 95 nM
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CP0787219
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-(piperidin-1-ylcarbonyl)nicotinamide
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C30H33FN4O2
  1
1
IC50 = 98 nM
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CP0421460
 Compound Info 
(2E)-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}-3-phenylacrylamide
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C24H23FN2O
  1
1
IC50 = 100 nM
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CP0646105
 Compound Info 
2-(Cyclohexyloxy)-N-{(3-exo)-8-[(6-fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}benzamide
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C31H35FN2O2
  1
1
IC50 = 118 nM
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CP0755468
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-3-(piperidin-1-ylcarbonyl)pyridine-2-carboxamide
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C30H33FN4O2
  1
1
IC50 = 131 nM
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CP0404913
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-phenylbenzamide
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C28H25FN2O
  1
1
IC50 = 140 nM
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CP0430815
 Compound Info 
2-(1-Acetylpiperidin-4-ylidene)-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide
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C24H28FN3O2
  1
1
IC50 = 160 nM
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CP0398969
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-phenylacetamide
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C23H23FN2O
  1
1
IC50 = 170 nM
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CP0904404
 Compound Info 
N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}-2-(4-phenoxycyclohexylidene)acetamide
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C29H31FN2O2
  1
1
IC50 = 210 nM
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CP0785159
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-(1H-imidazol-1-yl)benzamide
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C28H27FN4O
  1
1
IC50 = 217 nM
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CP0828772
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-(1H-pyrrol-1-yl)benzamide
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C29H28FN3O
  1
1
IC50 = 221 nM
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CP0716643
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-(pyrrolidin-1-ylcarbonyl)benzamide
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C30H32FN3O2
  1
1
IC50 = 225 nM
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CP0492673
 Compound Info 
4-Fluoro-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]-pyrrolidin-3-yl}benzamide
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C22H20F2N2O
  1
1
IC50 = 230 nM
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CP0430816
 Compound Info 
1-(benzenesulfonyl)-3-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]urea
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C22H22FN3O3S
  1
1
IC50 = 250 nM
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CP0828773
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-piperidin-1-ylbenzamide
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C30H34FN3O
  1
1
IC50 = 279 nM
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CP0456034
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]-2-phenylacetamide
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C24H25FN2O
  1
1
IC50 = 300 nM
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CP0492674
 Compound Info 
[1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-(2-phenylphenyl)methanone
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C28H24FNO
  1
1
IC50 = 320 nM
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CP0772632
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-[(4-methylpiperazin-1-yl)carbonyl]benzamide
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C31H35FN4O2
  1
1
IC50 = 482 nM
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CP0404914
 Compound Info 
(rac)-N-{1-[(6-Fluoro-2-naphthyl)methyl]piperidin-3-yl}-biphenyl-2-carboxamide
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C29H27FN2O
  1
1
IC50 = 550 nM
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CP0435155
 Compound Info 
N-benzyl-1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-amine
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C23H25FN2
  1
1
IC50 = 600 nM
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CP0787218
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-pyridin-4-ylbenzamide
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C30H28FN3O
  1
1
IC50 = 613 nM
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CP0490535
 Compound Info 
4-fluoro-N-(1-((6-fluoronaphthalen-2-yl)methyl)piperidin-4-yl)benzamide
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C23H22F2N2O
  1
1
IC50 = 640 nM
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CP0435154
 Compound Info 
3-fluoro-N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]benzamide
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C23H22F2N2O
  1
1
IC50 = 670 nM
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CP0844222
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-(morpholin-4-ylcarbonyl)benzamide
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C30H32FN3O3
  1
1
IC50 = 679 nM
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CP0371933
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]-2-methoxybenzamide
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C24H25FN2O2
  1
1
IC50 = 720 nM
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CP0490537
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]-N-methylbenzamide
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C24H25FN2O
  1
1
IC50 = 810 nM
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CP0490539
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]benzenesulfonamide
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C22H23FN2O2S
  1
1
IC50 = 830 nM
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CP0540188
 Compound Info 
(2E)-3-(1-Benzoylpiperidin-4-yl)-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acrylamide
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C30H32FN3O2
  1
1
IC50 = 900 nM
 Bioactivity Info 
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CP0513670
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]-3-phenoxybenzamide
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C29H27FN2O2
  1
1
IC50 = 1100 nM
 Bioactivity Info 
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CP0283763
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]benzamide
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C23H23FN2O
  1
1
IC50 = 1300 nM
 Bioactivity Info 
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CP0551862
 Compound Info 
1-[(6-fluoronaphthalen-2-yl)methyl]-N-phenylpiperidine-4-carboxamide
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C23H23FN2O
  1
1
IC50 = 1700 nM
 Bioactivity Info 
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CP0504829
 Compound Info 
1-(benzenesulfonyl)-3-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]urea
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C23H24FN3O3S
  1
1
IC50 = 2000 nM
 Bioactivity Info 
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CP0505194
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]-4-methoxybenzamide
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C24H25FN2O2
  1
1
IC50 = 2400 nM
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CP0514124
 Compound Info 
N-[(3S)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-phenylbenzamide
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C28H25FN2O
  1
1
IC50 = 2500 nM
 Bioactivity Info 
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CP0454043
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]-4-methylpiperidin-4-yl]-2-phenylbenzamide
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C30H29FN2O
  1
1
IC50 = 2800 nM
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CP0513671
 Compound Info 
2-fluoro-N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]benzamide
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C23H22F2N2O
  1
1
IC50 = 2900 nM
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CP0458537
 Compound Info 
N-[1-[(E)-3-(4-fluorophenyl)prop-2-enyl]piperidin-4-yl]benzamide
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C21H23FN2O
  1
1
IC50 = 3400 nM
 Bioactivity Info 
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CP0458359
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]-3-methoxybenzamide
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C24H25FN2O2
  1
1
IC50 = 3500 nM
 Bioactivity Info 
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CP0510759
 Compound Info 
[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl] N-phenylcarbamate
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C23H23FN2O2
  1
1
IC50 = 4800 nM
 Bioactivity Info 
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CP0398968
 Compound Info 
(2E)-N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}-3-phenylacrylamide
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C25H25FN2O
  1
1
IC50 = 9700 nM
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Cell Line ID: CL000011 , CHO
 Cell Line Info 
Cell Line ID: CL001029 , CHO CCR3/2
 Cell Line Info 
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Cell Line ID: CL000002 , K-562
 Cell Line Info 
Cell Line ID: CL000752 , PBMC iPSC #1
 Cell Line Info 
Cell Line ID: CL000808 , Y3-Ag 1.2.3
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0094763
 Compound Info 
1-((2R,3S)-4-((S)-3-(4-fluorobenzyl)piperidin-1-yl)-3-hydroxybutan-2-yl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenyl)urea
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C25H32FN7O2
  1
1 IC50 = 0.3 nM
CP0036478
 Compound Info 
1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)cyclohexyl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenyl)urea
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C28H36FN7O
  2
1 IC50 = 0.5 nM
2 IC50 = 2 nM
CP0059520
 Compound Info 
1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)cyclohexyl)-3-(5-acetyl-4-methylthiazol-2-yl)urea
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C26H35FN4O2S
  1
1 IC50 = 0.5 nM
CP0131315
 Compound Info 
1-((E)-1-Cyclooct-1-enyl)methyl-4-[(2,7-dichloro-9H-xanthene-9-carbonyl)-amino]-1-ethyl-piperidinium; iodide
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C30H37Cl2IN2O2
  1
1 IC50 = 0.58 nM
CP0263957
 Compound Info 
1-(3-((S)-3-(4-fluorobenzyl)piperidin-1-yl)propyl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenyl)urea
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C24H30FN7O
  1
1 IC50 = 0.6 nM
CP0035037
 Compound Info 
1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)cyclohexyl)-3-(3-acetylphenyl)urea
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C28H36FN3O2
  2
1 IC50 = 0.8 nM
2 IC50 = 2 nM
CP0243337
 Compound Info 
(S)-1-(3-(3-(4-fluorobenzyl)piperidin-1-yl)propyl)-3-(3,5-diacetylphenyl)urea
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C26H32FN3O3
  1
1 IC50 = 1.2 nM
CP0294093
 Compound Info 
1-((3S,4S)-4-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)-1-methylpiperidin-3-yl)-3-(5-acetyl-4-methylthiazol-2-yl)urea
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C26H36FN5O2S
  1
1 IC50 = 1.2 nM
CP0113627
 Compound Info 
1-(3-((S)-3-(4-fluorobenzyl)piperidin-1-yl)propyl)-3-(3-methyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl)urea
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C25H32FN7O
  1
1 IC50 = 1.5 nM
CP0228253
 Compound Info 
2-(6-Amino-benzothiazol-2-ylsulfanyl)-N-[1-(3,4-dichloro-benzyl)-piperidin-4-yl]-acetamide
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C21H22Cl2N4OS2
  1
1 IC50 = 2.3 nM
CP0049932
 Compound Info 
(S)-1-(3-(3-(4-fluorobenzyl)piperidin-1-yl)propyl)-3-(3-acetylphenyl)urea
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C24H30FN3O2
  1
1 IC50 = 2.5 nM
CP0307123
 Compound Info 
1-(3-((S)-3-(4-fluorobenzyl)piperidin-1-yl)propyl)-3-(3-acetyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl)urea
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C26H32FN7O2
  1
1 IC50 = 2.6 nM
CP0183536
 Compound Info 
(S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-phenyl)-propionic acid methyl ester
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C21H18N2O5
  2
1 IC50 = 5 nM
2 IC50 = 7 nM
CP0270497
 Compound Info 
4-[4-(3,4-dichlorophenoxy)piperidin-1-yl]-N-(4-methylphenyl)sulfonylpiperidine-1-carboxamide
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C24H29Cl2N3O4S
  1
1 IC50 = 8.1 nM
CP0194068
 Compound Info 
1-(3-Acetyl-phenyl)-3-{3-[4-(4-fluoro-benzyl)-piperidin-1-yl]-propyl}-urea
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C24H30FN3O2
  1
1 IC50 = 10 nM
CP0085008
 Compound Info 
2-(Benzothiazol-2-ylsulfanyl)-N-[1-(3,4-dichloro-benzyl)-piperidin-4-yl]-acetamide
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C21H21Cl2N3OS2
  1
1 IC50 = 32 nM
CP0086677
 Compound Info 
6-[2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]indol-1-yl]pyridine-3-carboxylic acid
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C30H31F2N3O2S
  2
1 IC50 = 40 nM
2 IC50 = 531.8 nM
Clinical Information about the Protein
Target 1 ( CCR3 messenger RNA (CCR3 mRNA) )
Target Type Clinical trial Target
Target 2 ( C-C chemokine receptor type 3 (CCR3) )
Target Type Discontinued Target
Disease 1 Target-related Disease  1
1 Parkinson disease [ICD-11: 8A00.0]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 AKST4290
 Drug Info 
Phase 2
Parkinson disease