| Compound ID |
Compound Name |
Compound Formula |
|
CP0374519
|
N-cycloheptyl-7-methoxy-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-4-amine
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|
C25H37N5O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0417402
|
C-014C
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|
C22H32N4O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0399036
|
2-(1,4'-Bipiperidine-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine
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|
C27H41N5O2
|
3
|
| 1 |
IC50 = 18 nM
|
|
|
| 2 |
IC50 = 73 nM
|
|
|
| 3 |
IC50 = 140 nM
|
|
|
|
CP0460669
|
N-cycloheptyl-2-[4-[cyclopentyl(methyl)amino]piperidin-1-yl]-6,7-dimethoxyquinazolin-4-amine
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|
C28H43N5O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0311718
|
N-cycloheptyl-6,7-dimethoxy-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-4-amine
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|
C26H39N5O2
|
3
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
IC50 = 70 nM
|
|
|
| 3 |
IC50 = 200 nM
|
|
|
|
CP0399358
|
(1'-{4-[(4-Chlorophenyl)amino]-6,7-dimethoxyquinazolin-2-yl}-1,4'-bipiperidin-3-yl)methanol
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|
C27H34ClN5O3
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
IC50 = 23 nM
|
|
|
|
CP0179371
|
N-(4-chlorophenyl)-6,7-dimethoxy-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-4-amine
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|
C25H30ClN5O2
|
2
|
| 1 |
IC50 = 24 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
|
CP0462299
|
[1-[1-[4-(cycloheptylamino)-6,7-dimethoxyquinazolin-2-yl]piperidin-4-yl]piperidin-3-yl]methanol
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|
C28H43N5O3
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
IC50 = 100 nM
|
|
|
|
CP0480246
|
N-cycloheptyl-6-methoxy-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-4-amine
Show/Hide
|
C25H37N5O
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0384581
|
N-cycloheptyl-2-[4-(4-fluoropiperidin-1-yl)piperidin-1-yl]-6,7-dimethoxyquinazolin-4-amine
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|
C27H40FN5O2
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0490272
|
1'-{4-[(4-Chlorophenyl)amino]-6,7-dimethoxyquinazolin-2-yl}-1,4'-bipiperidin-3-ol
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|
C26H32ClN5O3
|
2
|
| 1 |
IC50 = 48 nM
|
|
|
| 2 |
IC50 = 85 nM
|
|
|
|
CP0467631
|
N-(4-chlorophenyl)-6,7-dimethoxy-2-[4-[3-(methoxymethyl)piperidin-1-yl]piperidin-1-yl]quinazolin-4-amine
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|
C28H36ClN5O3
|
2
|
| 1 |
IC50 = 52 nM
|
|
|
| 2 |
IC50 = 64 nM
|
|
|
|
CP0459609
|
1'-(4-{[2-(4-Chlorophenyl)ethyl]amino}-6,7-dimethoxyquinazolin-2-yl)-1,40-bipiperidin-3-yl]methanol
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|
C29H38ClN5O3
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0399034
|
(1'-{4-[(4-Chlorobenzyl)amino]-6,7-dimethoxyquinazolin-2-yl}-1,4'-bipiperidin-3-yl)methanol
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|
C28H36ClN5O3
|
2
|
| 1 |
IC50 = 87 nM
|
|
|
| 2 |
IC50 = 450 nM
|
|
|
|
CP0459485
|
N-(4-chlorophenyl)-6,7-dimethoxy-2-[4-(3-methoxypiperidin-1-yl)piperidin-1-yl]quinazolin-4-amine
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|
C27H34ClN5O3
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
IC50 = 510 nM
|
|
|
|
CP0468430
|
[4-[1-[4-(4-chloroanilino)-6,7-dimethoxyquinazolin-2-yl]piperidin-4-yl]morpholin-2-yl]methanol
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|
C26H32ClN5O4
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
IC50 = 620 nM
|
|
|
|
CP0459608
|
[1-[1-[4-[3-(4-chlorophenyl)propylamino]-6,7-dimethoxyquinazolin-2-yl]piperidin-4-yl]piperidin-3-yl]methanol
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|
C30H40ClN5O3
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0384582
|
N-cyclooctyl-6,7-dimethoxy-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-4-amine
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|
C27H41N5O2
|
2
|
| 1 |
IC50 = 200 nM
|
|
|
| 2 |
IC50 = 1200 nM
|
|
|
|
CP0417413
|
N-cycloheptyl-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-4-amine
Show/Hide
|
C24H35N5
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0438817
|
N-cycloheptyl-6,7-dimethoxy-2-(4-propan-2-ylpiperazin-1-yl)quinazolin-4-amine
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|
C24H37N5O2
|
2
|
| 1 |
IC50 = 220 nM
|
|
|
| 2 |
IC50 = 660 nM
|
|
|
|
CP0374428
|
N-cycloheptyl-2-[4-(dimethylamino)piperidin-1-yl]-6,7-dimethoxyquinazolin-4-amine
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|
C24H37N5O2
|
2
|
| 1 |
IC50 = 260 nM
|
|
|
| 2 |
IC50 = 730 nM
|
|
|
|
CP0384584
|
N-cyclohexyl-6,7-dimethoxy-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-4-amine
Show/Hide
|
C25H37N5O2
|
2
|
| 1 |
IC50 = 480 nM
|
|
|
| 2 |
IC50 = 1900 nM
|
|
|
|
CP0374427
|
N-cycloheptyl-2-(1-cyclohexylpiperidin-4-yl)-6,7-dimethoxyquinazolin-4-amine
Show/Hide
|
C28H42N4O2
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0374450
|
N-cycloheptyl-2-(4-cyclohexylpiperazin-1-yl)-6,7-dimethoxyquinazolin-4-amine
Show/Hide
|
C27H41N5O2
|
1
|
| 1 |
IC50 = 550 nM
|
|
|
|
CP0399037
|
[1-[1-[4-(4-chlorophenyl)-6,7-dimethoxyquinazolin-2-yl]piperidin-4-yl]piperidin-3-yl]methanol
Show/Hide
|
C27H33ClN4O3
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
