Brief Information of the Cell Line and Protein
Cell Line ID: CL000795 , 300-19
 Cell Line Info 
Synonyms
300.19
Category Cancer cell line
Organism
Mus musculus (Mouse)
Protein ID: PT01215 , C-C chemokine receptor type 3
 Protein Info 
Gene Name CCR3
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P51677
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000795
 Cell Line Info 
 Protein ID: PT01215
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0090447
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(2-hydroxy-4-methylbenzoyl)piperidin-4-ylidene]acetamide
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C30H32FN3O3
  1
1
IC50 = 0.98 nM
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CP0102939
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(2-hydroxybenzoyl)piperidin-4-ylidene]acetamide
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C29H30FN3O3
  2
1
IC50 = 1 nM
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2
IC50 = 8.4 nM
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CP0452198
 Compound Info 
2-[1-(1,3-Benzodioxol-5-ylcarbonyl)piperidin-4-ylidene]-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide
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C30H30FN3O4
  1
1
IC50 = 1.6 nM
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CP0492671
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(4-methoxybenzoyl)piperidin-4-ylidene]acetamide
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C30H32FN3O3
  1
1
IC50 = 1.8 nM
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CP0398965
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(2-hydroxy-4-methoxybenzoyl)piperidin-4-ylidene]acetamide
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C30H32FN3O4
  1
1
IC50 = 3.3 nM
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CP0540187
 Compound Info 
2-[1-(3,4-Dimethoxybenzoyl)piperidin-4-ylidene]-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide
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C31H34FN3O4
  1
1
IC50 = 3.6 nM
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CP0421459
 Compound Info 
2-(1-Benzoylpiperidin-4-ylidene)-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide
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C29H30FN3O2
  1
1
IC50 = 4.4 nM
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CP0492672
 Compound Info 
2-[1-(2-Fluorobenzoyl)piperidin-4-ylidene]-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide
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C29H29F2N3O2
  1
1
IC50 = 4.8 nM
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CP0404911
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(3-hydroxybenzoyl)piperidin-4-ylidene]acetamide
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C29H30FN3O3
  1
1
IC50 = 5 nM
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CP0404912
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(2-methoxybenzoyl)piperidin-4-ylidene]acetamide
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C30H32FN3O3
  1
1
IC50 = 5.1 nM
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CP0504827
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(4-hydroxybenzoyl)piperidin-4-ylidene]acetamide
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C29H30FN3O3
  1
1
IC50 = 5.1 nM
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CP0398966
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(3-methoxybenzoyl)piperidin-4-ylidene]acetamide
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C30H32FN3O3
  1
1
IC50 = 5.8 nM
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CP0452197
 Compound Info 
2-[1-(4-Fluoro-2-hydroxybenzoyl)piperidin-4-ylidene]-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide
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C29H29F2N3O3
  1
1
IC50 = 6 nM
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CP0506155
 Compound Info 
2-[1-(4-Chloro-2-hydroxybenzoyl)piperidin-4-ylidene]-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide
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C29H29ClFN3O3
  1
1
IC50 = 7.5 nM
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CP0799907
 Compound Info 
2-(Azepan-1-ylcarbonyl)-N-{(3-exo)-8-[(6-fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}benzamide
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C32H36FN3O2
  1
1
IC50 = 12 nM
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CP0504828
 Compound Info 
(R)-2-(1-(3-fluorobenzoyl)piperidin-4-ylidene)-N-(1-((6-fluoronaphthalen-2-yl)methyl)pyrrolidin-3-yl)acetamide
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C29H29F2N3O2
  1
1
IC50 = 12 nM
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CP0844223
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-3-(piperidin-1-ylcarbonyl)isonicotinamide
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C30H33FN4O2
  1
1
IC50 = 13 nM
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CP0506156
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(2-hydroxy-5-methoxybenzoyl)piperidin-4-ylidene]acetamide
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C30H32FN3O4
  1
1
IC50 = 14 nM
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CP0067400
 Compound Info 
Biphenyl-2-carboxylic acid [(1R,5R)-8-(6-fluoro-naphthalen-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide
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C31H29FN2O
  1
1
IC50 = 20 nM
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CP0421458
 Compound Info 
2-[1-(4-Fluorobenzoyl)piperidin-4-ylidene]-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide
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C29H29F2N3O2
  1
1
IC50 = 22 nM
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CP0666454
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-3-(piperidin-1-ylcarbonyl)isonicotinamide 1-oxide
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C30H33FN4O3
  1
1
IC50 = 23 nM
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CP0828774
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-(piperidin-1-ylcarbonyl)benzamide
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C31H34FN3O2
  1
1
IC50 = 23 nM
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CP0681149
 Compound Info 
4-(8-((6-fluoronaphthalen-2-yl)methyl)-8-azabicyclo[3.2.1]octan-3-ylcarbamoyl)-3-(piperidine-1-carbonyl)pyridine 1-oxide
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C30H33FN4O3
  1
1
IC50 = 23 nM
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CP0746384
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-pyridin-3-ylbenzamide
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C30H28FN3O
  1
1
IC50 = 29 nM
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CP0435153
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]-2-phenylbenzamide
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C29H27FN2O
  1
1
IC50 = 38 nM
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CP0504001
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(2-hydroxy-3-methoxybenzoyl)piperidin-4-ylidene]acetamide
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C30H32FN3O4
  1
1
IC50 = 38 nM
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CP0806516
 Compound Info 
N-Cyclohexyl-N'-{(3-exo)-8-[(6-fluoro-2-naphthyl)-methyl]-8-azabicyclo[3.2.1]oct-3-yl}-N-methylphthalamide
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C33H38FN3O2
  1
1
IC50 = 44 nM
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CP0480383
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(2-hydroxy-6-methoxybenzoyl)piperidin-4-ylidene]acetamide
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C30H32FN3O4
  1
1
IC50 = 45 nM
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CP0799901
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-pyridin-2-ylbenzamide
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C30H28FN3O
  1
1
IC50 = 57 nM
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CP0806517
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-4-(piperidin-1-ylcarbonyl)nicotinamide
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C30H33FN4O2
  1
1
IC50 = 85 nM
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CP0677445
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-(1,3-thiazol-2-yl)benzamide
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C28H26FN3OS
  1
1
IC50 = 89 nM
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CP0828771
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-pyrimidin-5-ylbenzamidefumarate
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C33H31FN4O5
  1
1
IC50 = 93 nM
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CP0464185
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]-2-phenoxybenzamide
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C29H27FN2O2
  1
1
IC50 = 95 nM
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CP0787219
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-(piperidin-1-ylcarbonyl)nicotinamide
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C30H33FN4O2
  1
1
IC50 = 98 nM
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CP0421460
 Compound Info 
(2E)-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}-3-phenylacrylamide
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C24H23FN2O
  1
1
IC50 = 100 nM
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CP0646105
 Compound Info 
2-(Cyclohexyloxy)-N-{(3-exo)-8-[(6-fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}benzamide
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C31H35FN2O2
  1
1
IC50 = 118 nM
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CP0755468
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-3-(piperidin-1-ylcarbonyl)pyridine-2-carboxamide
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C30H33FN4O2
  1
1
IC50 = 131 nM
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CP0404913
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-phenylbenzamide
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C28H25FN2O
  1
1
IC50 = 140 nM
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CP0430815
 Compound Info 
2-(1-Acetylpiperidin-4-ylidene)-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acetamide
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C24H28FN3O2
  1
1
IC50 = 160 nM
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CP0398969
 Compound Info 
N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-phenylacetamide
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C23H23FN2O
  1
1
IC50 = 170 nM
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CP0904404
 Compound Info 
N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}-2-(4-phenoxycyclohexylidene)acetamide
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C29H31FN2O2
  1
1
IC50 = 210 nM
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CP0785159
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-(1H-imidazol-1-yl)benzamide
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C28H27FN4O
  1
1
IC50 = 217 nM
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CP0828772
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-(1H-pyrrol-1-yl)benzamide
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C29H28FN3O
  1
1
IC50 = 221 nM
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CP0716643
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-(pyrrolidin-1-ylcarbonyl)benzamide
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C30H32FN3O2
  1
1
IC50 = 225 nM
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CP0492673
 Compound Info 
4-Fluoro-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]-pyrrolidin-3-yl}benzamide
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C22H20F2N2O
  1
1
IC50 = 230 nM
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CP0430816
 Compound Info 
1-(benzenesulfonyl)-3-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]urea
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C22H22FN3O3S
  1
1
IC50 = 250 nM
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CP0828773
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-piperidin-1-ylbenzamide
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C30H34FN3O
  1
1
IC50 = 279 nM
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CP0456034
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]-2-phenylacetamide
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C24H25FN2O
  1
1
IC50 = 300 nM
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CP0492674
 Compound Info 
[1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-(2-phenylphenyl)methanone
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C28H24FNO
  1
1
IC50 = 320 nM
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CP0772632
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-[(4-methylpiperazin-1-yl)carbonyl]benzamide
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C31H35FN4O2
  1
1
IC50 = 482 nM
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CP0404914
 Compound Info 
(rac)-N-{1-[(6-Fluoro-2-naphthyl)methyl]piperidin-3-yl}-biphenyl-2-carboxamide
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C29H27FN2O
  1
1
IC50 = 550 nM
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CP0435155
 Compound Info 
N-benzyl-1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-amine
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C23H25FN2
  1
1
IC50 = 600 nM
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CP0787218
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-pyridin-4-ylbenzamide
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C30H28FN3O
  1
1
IC50 = 613 nM
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CP0490535
 Compound Info 
4-fluoro-N-(1-((6-fluoronaphthalen-2-yl)methyl)piperidin-4-yl)benzamide
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C23H22F2N2O
  1
1
IC50 = 640 nM
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CP0435154
 Compound Info 
3-fluoro-N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]benzamide
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C23H22F2N2O
  1
1
IC50 = 670 nM
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CP0844222
 Compound Info 
N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-(morpholin-4-ylcarbonyl)benzamide
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C30H32FN3O3
  1
1
IC50 = 679 nM
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CP0371933
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]-2-methoxybenzamide
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C24H25FN2O2
  1
1
IC50 = 720 nM
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CP0490537
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]-N-methylbenzamide
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C24H25FN2O
  1
1
IC50 = 810 nM
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CP0490539
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]benzenesulfonamide
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C22H23FN2O2S
  1
1
IC50 = 830 nM
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CP0540188
 Compound Info 
(2E)-3-(1-Benzoylpiperidin-4-yl)-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}acrylamide
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C30H32FN3O2
  1
1
IC50 = 900 nM
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CP0513670
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]-3-phenoxybenzamide
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C29H27FN2O2
  1
1
IC50 = 1100 nM
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CP0283763
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]benzamide
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C23H23FN2O
  1
1
IC50 = 1300 nM
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CP0551862
 Compound Info 
1-[(6-fluoronaphthalen-2-yl)methyl]-N-phenylpiperidine-4-carboxamide
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C23H23FN2O
  1
1
IC50 = 1700 nM
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CP0504829
 Compound Info 
1-(benzenesulfonyl)-3-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]urea
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C23H24FN3O3S
  1
1
IC50 = 2000 nM
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CP0505194
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]-4-methoxybenzamide
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C24H25FN2O2
  1
1
IC50 = 2400 nM
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CP0514124
 Compound Info 
N-[(3S)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-phenylbenzamide
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C28H25FN2O
  1
1
IC50 = 2500 nM
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CP0454043
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]-4-methylpiperidin-4-yl]-2-phenylbenzamide
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C30H29FN2O
  1
1
IC50 = 2800 nM
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CP0513671
 Compound Info 
2-fluoro-N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]benzamide
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C23H22F2N2O
  1
1
IC50 = 2900 nM
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CP0458537
 Compound Info 
N-[1-[(E)-3-(4-fluorophenyl)prop-2-enyl]piperidin-4-yl]benzamide
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C21H23FN2O
  1
1
IC50 = 3400 nM
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CP0458359
 Compound Info 
N-[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl]-3-methoxybenzamide
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C24H25FN2O2
  1
1
IC50 = 3500 nM
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CP0510759
 Compound Info 
[1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-yl] N-phenylcarbamate
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C23H23FN2O2
  1
1
IC50 = 4800 nM
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CP0398968
 Compound Info 
(2E)-N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}-3-phenylacrylamide
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C25H25FN2O
  1
1
IC50 = 9700 nM
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