General Information of the Protein
Protein ID
PT01102
Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1C
Secondarily
Protein Name
Calcium channel
L type
alpha-1 polypeptide
isoform 1
cardiac muscle
Voltage-gated calcium channel subunit alpha Cav1.2
Gene Name
CACNA1C
Secondarily
Gene Name
CACH2
CACN2
CACNL1A1
CCHL1A1
Sequence
MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRERHVPMCEDLELRRDSGSAGTQAHCLLLRKANPSRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL
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Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Voltage-gated calcium channel
Function
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:23677916, PubMed:30023270, PubMed:30172029, PubMed:34163037). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).
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Uniprot ID
Primary ID:
Q13936

Secondarily ID:
B2RUT3
E9PDJ0
Q13917
Q13918
Q13919
Q13920
Q13921
Q13922
Q13923
Q13924
Q13925
Q13926
Q13927
Q13928
Q13929
Q13930
Q13932
Q13933
Q14743
Q14744
Q15877
Q4VMI7
Q4VMI8
Q4VMI9
Q6PKM7
Q8N6C0
Q99025
Q99241
Q99875
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Ensembl ID
ENSG00000151067
HGNC ID
HGNC:1390
Subcellular Location
Cell membrane
Cell membrane
Sarcolemma
Perikaryon
Postsynaptic density membrane
Cell projection
Dendrite
Cell membrane
Sarcolemma
T-tubule
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0072914
 Compound Info 
US20230414632, Compound I-e
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C20H24N2O6
  1
1
IC50 = 3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0046619
 Compound Info 
Adalat
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C17H18N2O6
  1
1
IC50 = 50 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0454037
 Compound Info 
10-[4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-5-propan-2-yloxycarbonyl-1,4-dihydropyridine-3-carbonyl]oxydecyl-trimethylazanium
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C31H47N4O5+
  1
1
IC50 = 70 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0406371
 Compound Info 
Pinaverium
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C26H41BrNO4+
  1
1
IC50 = 1750 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0002225
 Compound Info 
Doribax
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C15H24N4O6S2
  1
1
IC50 = 1995.26 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0013111
 Compound Info 
ADL 8-2698
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C25H32N2O4
  1
1
IC50 = 5011.87 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0002227
 Compound Info 
SOLIFENACIN
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C23H26N2O2
  1
1
IC50 = 6309.57 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0002231
 Compound Info 
2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phenyl}-5-methyl-7-propyl-3H,4H-imidazo[1,5-a][1,2,4]triazin-4-one
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C23H32N6O4S
  1
1
IC50 = 15848.93 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036382
 Compound Info 
CAS_52-53-9
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C27H38N2O4
  1
1
IC50 = 23500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0271660
 Compound Info 
(R)-1-(Methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxy-phenyl)-2-imidazolidinone
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C20H25N3O5S
  1
1
IC50 > 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0010753
 Compound Info 
N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)piperidin-4-yl]methyl]-3,5-dichlorobenzamide
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C21H32Cl2N4O3
  1
1
IC50 > 31600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0014435
 Compound Info 
(2R)-2-acetylamino-N-benzyl-3-methoxypropanamide
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C13H18N2O3
  1
1
IC50 = 50118.72 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0002211
 Compound Info 
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
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C22H27FN4O2
  1
1
IC50 = 79432.82 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0008168
 Compound Info 
CAS_136434-34-9
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C18H19NOS
  1
1
IC50 = 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0010658
 Compound Info 
5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
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C22H30N6O4S
  1
1
IC50 = 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0013607
 Compound Info 
2-methoxyacetic acid [(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methyl-amino]ethyl]-6-fluoro-1-isopropyl-tetralin-2-yl] ester;hydrate;hydrochloride
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C29H38FN3O3
  1
1 IC50 = 250 nM
Clinical Information about the Protein
Target 1 ( Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) )
Target Type Successful Target
Disease 3 Target-related Diseases  3
1 Alzheimer disease [ICD-11: 8A20]
2 Angina pectoris [ICD-11: BA40]
3 Cardiac failure [ICD-11: BD10-BD13]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 ARC029
 Drug Info 
Phase 3
Alzheimer disease
Discontinued Drug(s) 1 Discontinued Drug  1
1 R-56865
 Drug Info 
Terminated
Angina pectoris
Investigative Drug(s) 1 Investigative Drug  1
1 CPU-228
 Drug Info 
Investigative
Cardiac failure
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT04580 Voltage-dependent L-type calcium channel subunit alpha-1C Rattus norvegicus, Rat
 Protein Info 
PT06039 Voltage-dependent L-type calcium channel subunit alpha-1D Rattus norvegicus, Rat
 Protein Info 
PT06040 Voltage-dependent L-type calcium channel subunit alpha-1C Oryctolagus cuniculus, Rabbit
 Protein Info