Protein Information

General Information of the Protein

Protein ID	PT06040
Protein Name	Voltage-dependent L-type calcium channel subunit alpha-1C
Secondarily Protein Name	Calcium channel L type alpha-1 polypeptide isoform 1 cardiac muscle Smooth muscle calcium channel blocker receptor Voltage-gated calcium channel subunit alpha Cav1.2
Gene Name	CACNA1C
Secondarily Gene Name	CACH2 CACN2 CACNL1A1 CCHL1A1
Sequence	MLRALVQPATPAYQPLPSHLSAETESTCKGTVVHEAQLNHFYISPGGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGVADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKVMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEVVGKPALEEAKEEKIELKSITADGESPPTTKINMDDLQPNESEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPHNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDSRSAFPQTFTTQRPLHISKAGNNQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGSPLSPAVRAQEAAWKLSSKRCHSQESQIAMACQEGASQDDNYDVRIGEDAECCSEPSLLSTEMLSYQDDENRQLAPPEEEKRDIRLSPKKGFLRSASLGRRASFHLECLKRQKNQGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPTSLPRPCATPPATPGSRGWPPQPIPTLRLEGADSSEKLNSSFPSIHCGSWSGENSPCRGDSSAARRARPVSLTVPSQAGAQGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDLTIEEMENAADDILSGGARQSPNGTLLPFVNRRDPGRDRAGQNEQDASGACAPGCGQSEEALADRRAGVSSL Show/Hide
Organism	Oryctolagus cuniculus, Rabbit
Protein Classification	Ion channel > Voltage-gated ion channel > Voltage-gated calcium channel
Function	Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:2474130, PubMed:2169433, PubMed:8232554, PubMed:9502794, PubMed:9278523, PubMed:15615847, PubMed:17525370, PubMed:21127204, PubMed:22928916, PubMed:23145875, PubMed:29363593, PubMed:22649239). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (PubMed:23145875). Plays an important role in excitation-contraction coupling in the heart (PubMed:17525370, PubMed:22928916, PubMed:23145875). Required for normal heart development and normal regulation of heart rhythm (By similarity). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (By similarity). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). Show/Hide
Uniprot ID	Primary ID: P15381 Secondarily ID: Q03716 Q28676 Q99243 Show/Hide
Ensembl ID	ENSG00000151067
Subcellular Location	Cell membrane Cell membrane Sarcolemma Perikaryon Postsynaptic density membrane Cell projection Dendrite Cell membrane Sarcolemma T-tubule

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000006 , HEK293

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0920840 Compound Info	3-methyl 5-(3-phenylbutyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C26H28N2O6	1
1	IC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0845477 Compound Info	3-(3,4-difluorobenzyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C23H20F2N2O6	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0889559 Compound Info	diethyl 2,6-dimethyl-4-(2-(methylthio)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H25NO4S	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0905845 Compound Info	3-(4-chlorophenethyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C24H23ClN2O6	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0913785 Compound Info	dimethyl 2,6-dimethyl-4-(2-(methylthio)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C18H21NO4S	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0932398 Compound Info	3-allyl 5-methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H20N2O6	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0861281 Compound Info	3-(2-(benzyloxy)ethyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C25H26N2O7	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0920253 Compound Info	3-methyl 5-(3-phenoxypropyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C25H26N2O7	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0845479 Compound Info	3-methyl 5-(4-phenylbutyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C26H28N2O6	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0852182 Compound Info	diethyl 2-(chloromethyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H21ClN2O6	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0858666 Compound Info	3-ethyl 5-(2-(methacryloyloxy)ethyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C23H26N2O8	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0859552 Compound Info	diethyl 2-(acetoxymethyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C21H24N2O8	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0896955 Compound Info	3-methyl 5-(2,4,6-trichlorobenzyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C23H19Cl3N2O6	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0901012 Compound Info	3-cyclohex-2-enyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C22H24N2O6	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0860952 Compound Info	3-benzo[d][1,3]dioxol-5-ylmethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C24H22N2O8	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0919510 Compound Info	3-ethyl 5-methyl 6-(methoxymethyl)-2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H22N2O7	1
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0845481 Compound Info	diethyl 4-(2,3-difluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H21F2NO4	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0901009 Compound Info	3-allyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H20N2O6	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0849994 Compound Info	3-methyl 5-(2,2,2-trifluoroethyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C18H17F3N2O6	1
1	IC50 = 16 nM Bioactivity Info	TI LI LO TS
CP0914991 Compound Info	3-ethyl 5-(2-methoxyethyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H24N2O7	1
1	IC50 = 16 nM Bioactivity Info	TI LI LO TS
CP0845480 Compound Info	3-(4-(4-methoxyphenyl)butyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C27H30N2O7	1
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0929910 Compound Info	diethyl 2-methyl-4-(3-nitrophenyl)-6-propyl-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C21H26N2O6	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0845478 Compound Info	3-(2-(2-chlorophenoxy)ethyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C24H23ClN2O7	1
1	IC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0849989 Compound Info	3-furan-2-ylmethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C21H20N2O7	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0905847 Compound Info	diethyl 2-butyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C22H28N2O6	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0929913 Compound Info	diethyl 4-(2,4-difluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H21F2NO4	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0860951 Compound Info	diethyl 2-(2-cyanovinyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C21H21N3O6	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0861280 Compound Info	3-(3-fluorobenzyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C23H21FN2O6	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0901010 Compound Info	3-methyl 5-(3-methylbut-3-enyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C21H24N2O6	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0845476 Compound Info	3-benzyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C23H22N2O6	1
1	IC50 = 25 nM Bioactivity Info	TI LI LO TS
CP0920688 Compound Info	3-allyl 5-ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H22N2O6	1
1	IC50 = 25 nM Bioactivity Info	TI LI LO TS
CP0916506 Compound Info	3-(2-cyanoethyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H19N3O6	1
1	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0920251 Compound Info	3-(2-chloroethyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C18H19ClN2O6	1
1	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0847189 Compound Info	3-cyclopropylmethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H22N2O6	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0847190 Compound Info	3-methyl 5-thiophen-2-ylmethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C21H20N2O6S	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0861279 Compound Info	3-but-3-ynyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H20N2O6	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0915930 Compound Info	Pranidipine Show/Hide	C25H24N2O6	1
1	IC50 = 37 nM Bioactivity Info	TI LI LO TS
CP0858667 Compound Info	3-ethyl 5-pentyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C22H28N2O6	1
1	IC50 = 49 nM Bioactivity Info	TI LI LO TS
CP0861277 Compound Info	diethyl 2-(hydroxymethyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H22N2O7	1
1	IC50 = 49 nM Bioactivity Info	TI LI LO TS
CP0861276 Compound Info	R-(-)-3-(2-cyanoethyl)5-ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H21N3O6	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0859562 Compound Info	3-(4-methoxybenzyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C24H24N2O7	1
1	IC50 = 51 nM Bioactivity Info	TI LI LO TS
CP0889560 Compound Info	S-(+)-3-(2-cyanoethyl)5-ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H21N3O6	1
1	IC50 = 51 nM Bioactivity Info	TI LI LO TS
CP0915935 Compound Info	3-(3,5-dinitrobenzyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C23H20N4O10	1
1	IC50 = 55 nM Bioactivity Info	TI LI LO TS
CP0847191 Compound Info	3-biphenyl-4-ylmethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C29H26N2O6	1
1	IC50 = 69 nM Bioactivity Info	TI LI LO TS
CP0905848 Compound Info	3-(2,3-dihydro-1H-inden-2-yl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C25H24N2O6	1
1	IC50 = 72 nM Bioactivity Info	TI LI LO TS
CP0916507 Compound Info	3-(3,3-diphenylpropyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C31H30N2O6	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0223810 Compound Info	Dynacirc Show/Hide	C19H21N3O5	1
1	IC50 = 107 nM Bioactivity Info	TI LI LO TS
CP0901011 Compound Info	3-methyl 5-(2-nitropropyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H21N3O8	1
1	IC50 = 108 nM Bioactivity Info	TI LI LO TS
CP0915936 Compound Info	3-(3,4-dimethoxybenzyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C25H26N2O8	1
1	IC50 = 112 nM Bioactivity Info	TI LI LO TS
CP0896954 Compound Info	dimethyl 2-(methoxymethyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C18H20N2O7	1
1	IC50 = 115 nM Bioactivity Info	TI LI LO TS
CP0859532 Compound Info	3-ethyl 5-(4-nitrobenzyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C24H23N3O8	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0859686 Compound Info	S-(+)-3-(2-cyanoethyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H19N3O6	1
1	IC50 = 143 nM Bioactivity Info	TI LI LO TS
CP0851856 Compound Info	1-isopropyl 5-methyl4-methyl-6-(3-nitrophenyl)-2-thioxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C17H19N3O6S	1
1	IC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0859685 Compound Info	diethyl 2-(benzoyloxymethyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C26H26N2O8	1
1	IC50 = 210 nM Bioactivity Info	TI LI LO TS
CP0861374 Compound Info	R-(-)-3-(2-cyanoethyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H19N3O6	1
1	IC50 = 262 nM Bioactivity Info	TI LI LO TS
CP0859561 Compound Info	(E/Z)-diethyl 2-(3-methoxy-3-oxoprop-1-enyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C22H24N2O8	1
1	IC50 = 313 nM Bioactivity Info	TI LI LO TS
CP0952522 Compound Info	rac-1-Methyl5-isopropyl4-methyl-6-(3-nitrophenyl)-2-thioxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C17H19N3O6S	1
1	IC50 = 350 nM Bioactivity Info	TI LI LO TS
CP0901008 Compound Info	3-methyl 5-(2-(2,2,2-trifluoroacetamido)ethyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H20F3N3O7	1
1	IC50 = 410 nM Bioactivity Info	TI LI LO TS
CP0892083 Compound Info	3-Isopropyl 5-methyl 2-amino-6-methyl-4-(3-nitrophenyl)-4H-pyran-3,5-dicarboxylate Show/Hide	C18H20N2O7	1
1	IC50 = 410 nM Bioactivity Info	TI LI LO TS
CP0405907 Compound Info	propan-2-yl 6-methyl-2-methylsulfanyl-4-(3-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylate Show/Hide	C16H19N3O4S	1
1	IC50 = 420 nM Bioactivity Info	TI LI LO TS
CP0924353 Compound Info	diethyl 2-(diethoxymethyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C23H30N2O8	1
1	IC50 = 460 nM Bioactivity Info	TI LI LO TS
CP0559137 Compound Info	propan-2-yl 6-methyl-3-(2-methylpropanoyl)-4-(3-nitrophenyl)-2-oxo-1,4-dihydropyrimidine-5-carboxylate Show/Hide	C19H23N3O6	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0857922 Compound Info	(-)-(R)-5-isopropyl 1-methyl 4-methyl-6-(3-nitrophenyl)-2-thioxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C17H19N3O6S	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0851857 Compound Info	3-Ethyl 5-methyl 2-amino-6-methyl-4-(3-nitrophenyl)-4H-pyran-3,5-dicarboxylate Show/Hide	C17H18N2O7	1
1	IC50 = 580 nM Bioactivity Info	TI LI LO TS
CP0912097 Compound Info	diethyl 2,4,6-trimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H25NO4	1
1	IC50 = 630 nM Bioactivity Info	TI LI LO TS
CP0913798 Compound Info	diethyl 2-methyl-4-(3-nitrophenyl)-6-((4-phenylpiperazin-1-yl)methyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C29H34N4O6	1
1	IC50 = 630 nM Bioactivity Info	TI LI LO TS
CP0857921 Compound Info	rac-1,5-Diisopropyl4-methyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydro-pyrimidine-1,5(6H)-dicarboxylate Show/Hide	C19H23N3O7	1
1	IC50 = 640 nM Bioactivity Info	TI LI LO TS
CP0861282 Compound Info	2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(3,5-dimethyl-adamantan-1-ylmethyl) ester 5-methyl ester Show/Hide	C29H36N2O6	1
1	IC50 = 685 nM Bioactivity Info	TI LI LO TS
CP0851855 Compound Info	3,5-diisopropyl 2-amino-6-methyl-4-(3-nitrophenyl)-4h-pyran-3,5-dicarboxylate Show/Hide	C20H24N2O7	1
1	IC50 = 860 nM Bioactivity Info	TI LI LO TS
CP0861278 Compound Info	5-(methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid Show/Hide	C16H16N2O6	1
1	IC50 = 900 nM Bioactivity Info	TI LI LO TS
CP0434136 Compound Info	3-O-methyl 5-O-propan-2-yl 2-methoxycarbonylsulfanyl-6-methyl-4-(3-nitrophenyl)-4H-pyrimidine-3,5-dicarboxylate Show/Hide	C19H21N3O8S	1
1	IC50 = 1020 nM Bioactivity Info	TI LI LO TS
CP0857442 Compound Info	(-)-(R)-diisopropyl 4-methyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C19H23N3O7	1
1	IC50 = 1020 nM Bioactivity Info	TI LI LO TS
CP0861378 Compound Info	3-allyl 5-ethyl 2,6-dimethyl-4-(naphthalen-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C24H25NO4	1
1	IC50 = 1306 nM Bioactivity Info	TI LI LO TS
CP0920832 Compound Info	2,4,6-Trimethyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester Show/Hide	C18H21NO4	1
1	IC50 = 1470 nM Bioactivity Info	TI LI LO TS
CP0913783 Compound Info	4-(2,3-difluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile Show/Hide	C15H11F2N3	1
1	IC50 = 1610 nM Bioactivity Info	TI LI LO TS
CP0859528 Compound Info	3-ethyl 5-methyl 6-(methoxymethyl)-2-methyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H22N2O7	1
1	IC50 = 1760 nM Bioactivity Info	TI LI LO TS
CP0397647 Compound Info	5-O-methyl 3-O-propan-2-yl 6-methyl-2-methylimino-4-(3-nitrophenyl)-1,4-dihydropyrimidine-3,5-dicarboxylate Show/Hide	C18H22N4O6	1
1	IC50 = 1810 nM Bioactivity Info	TI LI LO TS
CP0898244 Compound Info	1,5-Diisopropyl4-isopropyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C21H27N3O7	1
1	IC50 = 1930 nM Bioactivity Info	TI LI LO TS
CP0864312 Compound Info	diethyl 2-methyl-4-(3-nitrophenyl)-6-(4-nitrostyryl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C26H25N3O8	1
1	IC50 = 1940 nM Bioactivity Info	TI LI LO TS
CP0852209 Compound Info	ethyl 5-acetyl-2,6-dimethyl-4-(naphthalen-2-yl)-1,4-dihydropyridine-3-carboxylate Show/Hide	C22H23NO3	1
1	IC50 = 2217 nM Bioactivity Info	TI LI LO TS
CP0918005 Compound Info	(S)-1-(4-Chlorophenethyl)-3-(2,2-dimethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 2300 nM Bioactivity Info	TI LI LO TS
CP0857920 Compound Info	(-)-(R)-5-isopropyl 1-methyl 4-methyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C17H19N3O7	1
1	IC50 = 2360 nM Bioactivity Info	TI LI LO TS
CP0465374 Compound Info	3-O-methyl 5-O-propan-2-yl 6-methyl-2-methylimino-4-(3-nitrophenyl)-1,4-dihydropyrimidine-3,5-dicarboxylate Show/Hide	C18H22N4O6	1
1	IC50 = 2450 nM Bioactivity Info	TI LI LO TS
CP0861744 Compound Info	rac-1-Methyl 5-isopropyl4-methyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C17H19N3O7	1
1	IC50 = 2480 nM Bioactivity Info	TI LI LO TS
CP0880340 Compound Info	1-Isopropyl5-methyl4-methyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C17H19N3O7	1
1	IC50 = 2480 nM Bioactivity Info	TI LI LO TS
CP0918004 Compound Info	1-(3,5-Bis(trifluoromethyl)phenethyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H18F6N2O3	1
1	IC50 = 2600 nM Bioactivity Info	TI LI LO TS
CP0857253 Compound Info	(+/-)-endo-1-(bicyclo[2.2.1]heptan-2-yl)-3-(2-(3-chlorophenyl)-2-methylpropyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C21H25ClN2O3	1
1	IC50 = 2800 nM Bioactivity Info	TI LI LO TS
CP0851873 Compound Info	(+)-(S)-diisopropyl 4-methyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C19H23N3O7	1
1	IC50 = 3070 nM Bioactivity Info	TI LI LO TS
CP0854691 Compound Info	(R)-1-(2,2-Dimethylcyclopentyl)-3-(3-(trifluoromethyl)phenethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H23F3N2O3	1
1	IC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0465373 Compound Info	methyl 6-methyl-2-methylsulfanyl-4-(3-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylate Show/Hide	C14H15N3O4S	1
1	IC50 = 3290 nM Bioactivity Info	TI LI LO TS
CP0948372 Compound Info	1-Cyclopentyl-3-(3,5-dichlorophenethyl)pyrimidine-2,4,6-(1H,3H,5H)-trione Show/Hide	C17H18Cl2N2O3	1
1	IC50 = 3300 nM Bioactivity Info	TI LI LO TS
CP0845897 Compound Info	1-Cyclopentyl-3-(3,4-dichlorophenethyl)pyrimidine-2,4,6-(1H,3H,5H)-trione Show/Hide	C17H18Cl2N2O3	1
1	IC50 = 3400 nM Bioactivity Info	TI LI LO TS
CP0917508 Compound Info	(S)-1-(3-Chlorophenethyl)-3-(2,2-dimethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 3500 nM Bioactivity Info	TI LI LO TS
CP0917512 Compound Info	cis-1-(3-chlorophenethyl)-3-((1R,2S)-2-methylcyclohexyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 3700 nM Bioactivity Info	TI LI LO TS
CP0918001 Compound Info	1-(3,5-Bis(trifluoromethyl)phenethyl-3-((+/-)-endonorbornyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C21H20F6N2O3	1
1	IC50 = 3800 nM Bioactivity Info	TI LI LO TS
CP0863212 Compound Info	1-(1-(4-Chlorophenyl)propan-2-yl)-3-((+/-)-endo-norbornyl)pyrimidine-2,4,6-(1H,3H,5H)-trione Show/Hide	C20H23ClN2O3	1
1	IC50 = 4100 nM Bioactivity Info	TI LI LO TS
CP0876347 Compound Info	1-Cyclopentyl-3-(2-methyl-2-(3-(trifluoromethyl)phenyl)-propyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H23F3N2O3	1
1	IC50 = 4200 nM Bioactivity Info	TI LI LO TS
CP0387751 Compound Info	5-O-ethyl 3-O-methyl 2-methyl-6-(2-methylpropanoylamino)-4-(3-nitrophenyl)-4H-pyran-3,5-dicarboxylate Show/Hide	C21H24N2O8	1
1	IC50 = 4230 nM Bioactivity Info	TI LI LO TS
CP0909384 Compound Info	1-(2(3,5-Dichlorophenyl)ethyl)-3-((+/-)-endo-norbornyl)-pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H20Cl2N2O3	1
1	IC50 = 4600 nM Bioactivity Info	TI LI LO TS
CP0899533 Compound Info	1-cyclopentyl-3-(3,3-diphenylpropyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C24H26N2O3	1
1	IC50 = 4700 nM Bioactivity Info	TI LI LO TS
CP0910448 Compound Info	(R)-1-(3-chlorophenethyl)-3-(2,2-dimethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 4700 nM Bioactivity Info	TI LI LO TS
CP0397646 Compound Info	3-O-ethyl 5-O-methyl 2-acetamido-6-methyl-4-(3-nitrophenyl)-4H-pyran-3,5-dicarboxylate Show/Hide	C19H20N2O8	1
1	IC50 = 4750 nM Bioactivity Info	TI LI LO TS
CP0857458 Compound Info	(R)-1-(4-chlorophenethyl)-3-(2,2-dimethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 4800 nM Bioactivity Info	TI LI LO TS
CP0876346 Compound Info	1-(2-(3-Chlorophenyl)propyl)-3-((+/-)-endo-norbornyl)-pyrimidine-2,4,6-(1H,3H,5H)-trione Show/Hide	C20H23ClN2O3	1
1	IC50 = 5100 nM Bioactivity Info	TI LI LO TS
CP0938640 Compound Info	cis-1-(4-Chlorophenethyl)-3-((1S,2R)-2-methylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 5100 nM Bioactivity Info	TI LI LO TS
CP0857455 Compound Info	1-(2-([1,1'-Biphenyl]-4-yl)ethyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C23H24N2O3	1
1	IC50 = 5400 nM Bioactivity Info	TI LI LO TS
CP0405906 Compound Info	3-O-methyl 5-O-propan-2-yl 6-methyl-2-methylsulfanyl-4-(3-nitrophenyl)-4H-pyrimidine-3,5-dicarboxylate Show/Hide	C18H21N3O6S	1
1	IC50 = 5540 nM Bioactivity Info	TI LI LO TS
CP0407423 Compound Info	5-O-methyl 3-O-propan-2-yl 2-acetamido-6-methyl-4-(3-nitrophenyl)-4H-pyran-3,5-dicarboxylate Show/Hide	C20H22N2O8	1
1	IC50 = 6110 nM Bioactivity Info	TI LI LO TS
CP0440146 Compound Info	1-O,3-O-dimethyl 5-O-propan-2-yl 6-methyl-4-(3-nitrophenyl)-2-oxo-4H-pyrimidine-1,3,5-tricarboxylate Show/Hide	C19H21N3O9	1
1	IC50 = 6130 nM Bioactivity Info	TI LI LO TS
CP0914259 Compound Info	(R)-1-Cyclopentyl-3-(1-(naphthalen-1-yl)ethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C21H22N2O3	1
1	IC50 = 6150 nM Bioactivity Info	TI LI LO TS
CP0917514 Compound Info	cis-(1S,3R)-3-fluorophenethyl 3-(3-(3-chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentanecarboxylate Show/Hide	C26H26ClFN2O5	1
1	IC50 = 6700 nM Bioactivity Info	TI LI LO TS
CP0929215 Compound Info	1-(2-(4-Chlorophenyl)propyl)-3-((+/-)-endo-norbornyl)pyrimidine-2,4,6-(1H,3H,5H)-trione Show/Hide	C20H23ClN2O3	1
1	IC50 = 8000 nM Bioactivity Info	TI LI LO TS
CP0929217 Compound Info	1-Cyclopentyl-3-(2,2-diphenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C23H24N2O3	1
1	IC50 = 8100 nM Bioactivity Info	TI LI LO TS
CP0899531 Compound Info	1-(4-chlorophenethyl)-3-((1R,2S)-2-methylcyclohexyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 8300 nM Bioactivity Info	TI LI LO TS
CP0857457 Compound Info	cis-(1S,3R)-isopropyl 3-(3-(3-chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentanecarboxylate Show/Hide	C21H25ClN2O5	1
1	IC50 = 8500 nM Bioactivity Info	TI LI LO TS
CP0858777 Compound Info	cis-1-(3-chlorophenethyl)-3-((1R,2S)-2-methylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 9300 nM Bioactivity Info	TI LI LO TS
CP0860966 Compound Info	(+)-(S)-5-isopropyl 1-methyl 4-methyl-6-(3-nitrophenyl)-2-thioxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C17H19N3O6S	1
1	IC50 = 9870 nM Bioactivity Info	TI LI LO TS
CP0863216 Compound Info	cis-1-(4-chlorophenethyl)-3-((1R,2S)-2-methylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0876353 Compound Info	(R)-1-(3-Chlorophenethyl)-3-(1-(naphthalen-1-yl)ethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C24H21ClN2O3	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0876586 Compound Info	1-Isopropyl5-methyl4-isopropyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C19H23N3O7	1
1	IC50 = 10400 nM Bioactivity Info	TI LI LO TS
CP0891593 Compound Info	(1-(3-(3-Chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentyl)methyl isobutyrate Show/Hide	C22H27ClN2O5	1
1	IC50 = 10600 nM Bioactivity Info	TI LI LO TS
CP0876585 Compound Info	6-Methyl-5-(isopropyloxycarbonyl)-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-thione Show/Hide	C15H17N3O4S	1
1	IC50 = 10700 nM Bioactivity Info	TI LI LO TS
CP0860203 Compound Info	5-Methoxy-6-methyl-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one Show/Hide	C13H13N3O5	1
1	IC50 = 11670 nM Bioactivity Info	TI LI LO TS
CP0845872 Compound Info	1-(2-(3-Chlorophenyl)-2-methylpropyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 12600 nM Bioactivity Info	TI LI LO TS
CP0845900 Compound Info	(1R,2S)-Ethyl 2-(3-(3-chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentane carboxylate Show/Hide	C20H23ClN2O5	1
1	IC50 = 12600 nM Bioactivity Info	TI LI LO TS
CP0863214 Compound Info	(1S,2S)-2-(3-(3-Chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentyl isobutyrate Show/Hide	C21H25ClN2O5	1
1	IC50 = 12900 nM Bioactivity Info	TI LI LO TS
CP0845904 Compound Info	cis-1-(3-Chlorophenethyl)-3-((1S,2R)-2-methylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 13000 nM Bioactivity Info	TI LI LO TS
CP0916622 Compound Info	1-(3-Chlorophenethyl)-3-((1S,2R,3S)-2,3-dimethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 13200 nM Bioactivity Info	TI LI LO TS
CP0857967 Compound Info	Methyl3-(4-chlorophenyl)-2-(3-cyclopentyl-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)propanoate Show/Hide	C19H21ClN2O5	1
1	IC50 = 13400 nM Bioactivity Info	TI LI LO TS
CP0497653 Compound Info	1-O,3-O-diethyl 5-O-methyl 6-methyl-4-(3-nitrophenyl)-2-oxo-4H-pyrimidine-1,3,5-tricarboxylate Show/Hide	C19H21N3O9	1
1	IC50 = 13920 nM Bioactivity Info	TI LI LO TS
CP0860965 Compound Info	1-Ethyl 5-methyl4-isopropyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C18H21N3O7	1
1	IC50 = 14840 nM Bioactivity Info	TI LI LO TS
CP0845903 Compound Info	1-(3-Chlorophenethyl)-3-(3-ethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0374923 Compound Info	5-O-methyl 3-O-propan-2-yl 6-methyl-2-methylsulfanyl-4-(3-nitrophenyl)-4H-pyrimidine-3,5-dicarboxylate Show/Hide	C18H21N3O6S	1
1	IC50 = 16130 nM Bioactivity Info	TI LI LO TS
CP0938665 Compound Info	1-Cyclopentyl-3-(2,3-dihydro-1H-inden-2-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H20N2O3	1
1	IC50 = 16400 nM Bioactivity Info	TI LI LO TS
CP0876350 Compound Info	1-(4-(Benzyloxy)phenethyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C24H26N2O4	1
1	IC50 = 18700 nM Bioactivity Info	TI LI LO TS
CP0946409 Compound Info	1-Cyclopentyl-3-(1,2,3,4-tetrahydronaphthalen-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H22N2O3	1
1	IC50 = 20000 nM Bioactivity Info	TI LI LO TS
CP0482487 Compound Info	1-[2-(4-chlorophenyl)ethyl]-3-(3-methylcyclopentyl)-1,3-diazinane-2,4,6-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 20400 nM Bioactivity Info	TI LI LO TS
CP0876348 Compound Info	1-(2-(3-Chlorophenyl)propyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 20700 nM Bioactivity Info	TI LI LO TS
CP0881135 Compound Info	1-(3-Chlorophenethyl)-3-((+/-)-trans-2-methylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 21000 nM Bioactivity Info	TI LI LO TS
CP0880339 Compound Info	(+)-(S)-5-isopropyl 1-methyl 4-methyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C17H19N3O7	1
1	IC50 = 21740 nM Bioactivity Info	TI LI LO TS
CP0925570 Compound Info	1-Cyclopentyl-3-(3-phenylpropyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H22N2O3	1
1	IC50 = 21900 nM Bioactivity Info	TI LI LO TS
CP0917510 Compound Info	1-(4-Chlorophenethyl)-3-((+/-)-trans-2-methylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 23000 nM Bioactivity Info	TI LI LO TS
CP0857456 Compound Info	cis-(1R,2S)-2-(3-(3-Chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentyl acetate Show/Hide	C19H21ClN2O5	1
1	IC50 = 23400 nM Bioactivity Info	TI LI LO TS
CP0929218 Compound Info	1-Cyclopentyl-3-(2,3-dihydro-1H-inden-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H20N2O3	1
1	IC50 = 24800 nM Bioactivity Info	TI LI LO TS
CP0876355 Compound Info	1-(3-chlorophenethyl)-3-(pentan-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C17H21ClN2O3	1
1	IC50 = 25500 nM Bioactivity Info	TI LI LO TS
CP0848480 Compound Info	1-(4-Chlorophenethyl)-3-(3,3-dimethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 26000 nM Bioactivity Info	TI LI LO TS
CP0913143 Compound Info	1-(4-chlorophenethyl)-3-((1S,2S,3S,5R)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C22H27ClN2O3	1
1	IC50 = 28000 nM Bioactivity Info	TI LI LO TS
CP0940964 Compound Info	rac-1-(4-Chlorophenethyl)-3-(3-ethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 29000 nM Bioactivity Info	TI LI LO TS
CP0854699 Compound Info	(1-(3-(3-Chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentyl)methyl acetate Show/Hide	C20H23ClN2O5	1
1	IC50 = 29100 nM Bioactivity Info	TI LI LO TS
CP0891584 Compound Info	1-(4-Chlorophenethyl)-3-(4-methylcyclohexyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 30000 nM Bioactivity Info	TI LI LO TS
CP0912093 Compound Info	5-(ethoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic formic anhydride Show/Hide	C18H18N2O7	1
1	IC50 = 33300 nM Bioactivity Info	TI LI LO TS
CP0876467 Compound Info	methyl 1-(3-(3-Chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentanecarboxylate Show/Hide	C19H21ClN2O5	1
1	IC50 = 33400 nM Bioactivity Info	TI LI LO TS
CP0848478 Compound Info	(S)-benzyl3-(3-(3-Chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)pyrrolidine-1-carboxylate Show/Hide	C24H24ClN3O5	1
1	IC50 = 33900 nM Bioactivity Info	TI LI LO TS
CP0891551 Compound Info	1-(3-Chlorophenethyl)-3-((1S,2S)-2-methoxycyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O4	1
1	IC50 = 34600 nM Bioactivity Info	TI LI LO TS
CP0891586 Compound Info	1-(3-Chlorophenethyl)-3-(3-methylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 38000 nM Bioactivity Info	TI LI LO TS
CP0845896 Compound Info	(R)-1-(3-Chlorophenethyl)-3-((tetrahydrofuran-2-yl)methyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C17H19ClN2O4	1
1	IC50 = 41000 nM Bioactivity Info	TI LI LO TS
CP0891585 Compound Info	1-(3-Chlorophenethyl)-3-(3,3-dimethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 43000 nM Bioactivity Info	TI LI LO TS
CP0938663 Compound Info	(R)-methyl 2-(3-cyclopentyl-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)-3-phenylpropanoate Show/Hide	C19H22N2O5	1
1	IC50 = 44300 nM Bioactivity Info	TI LI LO TS
CP0858776 Compound Info	1-(3-Chlorophenethyl)-3-(4-methylcyclohexyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 46000 nM Bioactivity Info	TI LI LO TS
CP0848664 Compound Info	1-(3-Chlorobenzyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C16H17ClN2O3	1
1	IC50 = 46700 nM Bioactivity Info	TI LI LO TS
CP0845895 Compound Info	cis-1-(3-Chlorophenethyl)-3-(((1R,2S,5R)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)methyl)pyrimi-dine-2,4,6(1H,3H,5H)-trione Show/Hide	C22H27ClN2O3	1
1	IC50 = 47000 nM Bioactivity Info	TI LI LO TS
CP0848476 Compound Info	trans-(1S,2S)-2-(3-(3-Chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentyl acetate Show/Hide	C19H21ClN2O5	1
1	IC50 = 48100 nM Bioactivity Info	TI LI LO TS
CP0955871 Compound Info	N-(4-chlorophenethyl)-N'-(+/-)-endo-norbornylpyrimidine-2,4,6-(1H,3H,5H)-trione Show/Hide	C19H21ClN2O3	1
1	IC50 = 50000 nM Bioactivity Info	TI LI LO TS
CP0863213 Compound Info	1-(4-Chlorobenzyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C16H17ClN2O3	1
1	IC50 = 51700 nM Bioactivity Info	TI LI LO TS
CP0917509 Compound Info	1-((1S,2R,4R)-Bicyclo[2.2.1]heptan-2-yl)-3-(4-chlorophenethyl)-pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H21ClN2O3	1
1	IC50 = 54000 nM Bioactivity Info	TI LI LO TS
CP0851872 Compound Info	6-Methyl-5-(methoxycarbonyl)-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-thione Show/Hide	C13H13N3O4S	1
1	IC50 = 54970 nM Bioactivity Info	TI LI LO TS
CP0374921 Compound Info	methyl 3-(2-methylpropanoyl)-4-(3-nitrophenyl)-2-oxo-6-propan-2-yl-1,4-dihydropyrimidine-5-carboxylate Show/Hide	C19H23N3O6	1
1	IC50 = 56580 nM Bioactivity Info	TI LI LO TS
CP0938664 Compound Info	1-Cyclopentyl-3-(4-isopropylphenethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H26N2O3	1
1	IC50 = 57600 nM Bioactivity Info	TI LI LO TS
CP0876584 Compound Info	6-Methyl-5-(isopropyloxycarbonyl)-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one Show/Hide	C15H17N3O5	1
1	IC50 = 58100 nM Bioactivity Info	TI LI LO TS
CP0854692 Compound Info	(+)-endo-1-((1S,2R,4R)-Bicyclo[2.2.1]heptan-2-yl)-3-(3-(trifluoromethyl)phenethyl)-pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H21F3N2O3	1
1	IC50 = 76600 nM Bioactivity Info	TI LI LO TS
CP0409855 Compound Info	1-[2-(3-chlorophenyl)ethyl]-3-[(3S)-pyrrolidin-3-yl]-1,3-diazinane-2,4,6-trione Show/Hide	C16H18ClN3O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0845901 Compound Info	1-(3-Chlorophenethyl)-3-((1S,2S)-2-hydroxycyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C17H19ClN2O4	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0845902 Compound Info	(R)-1-(4-Chlorophenethyl)-3-((tetrahydrofuran-2-yl)methyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C17H19ClN2O4	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0848479 Compound Info	1-((1R,2S,4S)-Bicyclo[2.2.1]heptan-2-yl)-3-(4-chlorophenethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H21ClN2O3	1
1	IC50 = 100000 nM Bioactivity Info	TI LI LO TS
CP0848629 Compound Info	1-((+/-)-exo-Norbornyl)-3-(3-(trifluoromethyl)phenethyl)-pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H21F3N2O3	1
1	IC50 = 100000 nM Bioactivity Info	TI LI LO TS
CP0857965 Compound Info	1-((1R,2S,4S)-Bicyclo[2.2.1]heptan-2-yl)-3-(3-chlorophenethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H21ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0858773 Compound Info	cis-(1S,3R)-3-(3-(3-chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentanecarboxylic acid Show/Hide	C18H19ClN2O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0858774 Compound Info	1-(3-Chlorophenethyl)-3-((1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C22H27ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0858775 Compound Info	1-(3-Chlorophenethyl)-3-((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C22H27ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0860614 Compound Info	1-(4-Chlorophenethyl)-3-((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C22H27ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0863215 Compound Info	1-(4-Chlorophenethyl)-3-((1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C22H27ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0876357 Compound Info	(R)-1-(4-Chlorophenethyl)-3-(1-cyclohexylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H25ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0891583 Compound Info	cis-1-(4-Chlorophenethyl)-3-(((1R,2S,5R)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)methyl)pyrimi-dine-2,4,6(1H,3H,5H)-trione Show/Hide	C22H27ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0909385 Compound Info	1-Cyclopentyl-3-(3-(trifluoromethyl)phenyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C16H15F3N2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0910445 Compound Info	1-(3-chlorophenethyl)-3-((1S,2S,3S,5R)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C22H27ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0910446 Compound Info	1-((1S,2R,4R)-Bicyclo[2.2.1]heptan-2-yl)-3-(3-chlorophenethyl)-pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H21ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0912860 Compound Info	(S)-1-(4-Chlorophenethyl)-3-(1-cyclohexylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H25ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0917507 Compound Info	(S)-N-(3-chlorophenethyl)-N-(1-cyclohexylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H25ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0917511 Compound Info	(R)-1-(3-Chlorophenethyl)-3-(1-cyclohexylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H25ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0918002 Compound Info	1-((1-(4-Chlorophenyl)cyclopropyl)methyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H21ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0925569 Compound Info	(-)-endo-1-((1R,2S,4S)-Bicyclo-[2.2.1]heptan-2-yl)-3-(3-(trifluoromethyl)phenethyl)-pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H21F3N2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0929216 Compound Info	(S)-Methyl 2-(3-cyclopentyl-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)-3-phenylpropanoate Show/Hide	C19H22N2O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0938641 Compound Info	N-(3-chlorophenethyl)-N'-cyclopentylpyrimidine-2,4,6-trione Show/Hide	C17H19ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0857919 Compound Info	6-Isopropyl-5-(methoxycarbonyl)-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one Show/Hide	C15H17N3O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0374255 Compound Info	diethyl 2,6-dimethyl-4-(3-nitrophenyl)-4H-pyran-3,5-dicarboxylate Show/Hide	C19H21NO7	1
1	IC50 > 4000 nM Bioactivity Info	TI LI LO TS
CP0919512 Compound Info	ethyl 2-methyl-4-(3-nitrophenyl)-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate Show/Hide	C17H16N2O6	1
1	IC50 > 4000 nM Bioactivity Info	TI LI LO TS

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT01102	Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens, Human	Protein Info
PT04580	Voltage-dependent L-type calcium channel subunit alpha-1C	Rattus norvegicus, Rat	Protein Info
PT06039	Voltage-dependent L-type calcium channel subunit alpha-1D	Rattus norvegicus, Rat	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han