Protein Information

General Information of the Protein

Protein ID	PT06039
Protein Name	Voltage-dependent L-type calcium channel subunit alpha-1D
Secondarily Protein Name	Calcium channel L type alpha-1 polypeptide isoform 2 Rat brain class D Voltage-gated calcium channel subunit alpha Cav1.3
Gene Name	CACNA1D
Secondarily Gene Name	Cach3 Cacn4 Cacnl1a2 Cchl1a2
Sequence	MMMMMMMKKMQHQRQQQEDHANEANYARGTRLPISGEGPTSQPNSSKQTVLSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVDWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIASGLLLHPNASVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCAANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGETQGCCGSLWCWWKRRGAAKTGPSGCRRWGQAISKSKLRSHGAREALCVCRCSLESLVKLWTSRFSAHLQAAYVRPYSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLKLFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEEAEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEDSKPEEEDVFKRNGALLGNYVNHVNSDRRESLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGDLEHVSENGHYSYKHDRELQRRSSIKRTRYYETYIRSESGDEQLPTIFREDPEIHGYFRDPRCFGEQEYFSSEECCEDDSSPTWSRQNYSYYNRYPGSSMDFERPRGYHHPQGFLEDDDSPIGYDSRRSPRRRLLPPTPPSHRRSSFNFECLRRQNSQDDVLPSPALPHRAALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVDRSESMDQVNGSLPSLHRSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGSVCPRANGDMGPISHRQDYELQDFGPGYSDEEPDPGREEEDLADEMICITTL Show/Hide
Organism	Rattus norvegicus, Rat
Protein Classification	Ion channel > Voltage-gated ion channel > Voltage-gated calcium channel
Function	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Show/Hide
Uniprot ID	Primary ID: P27732 Secondarily ID: O09022 O09023 O09024 Q01542 Q62691 Q62815 Q63491 Q63492 Show/Hide
Ensembl ID	ENSG00000157388
Subcellular Location	Membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000006 , HEK293

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0845481 Compound Info	diethyl 4-(2,3-difluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H21F2NO4	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0858666 Compound Info	3-ethyl 5-(2-(methacryloyloxy)ethyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C23H26N2O8	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0901012 Compound Info	3-cyclohex-2-enyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C22H24N2O6	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0932398 Compound Info	3-allyl 5-methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H20N2O6	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0920253 Compound Info	3-methyl 5-(3-phenoxypropyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C25H26N2O7	1
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0920840 Compound Info	3-methyl 5-(3-phenylbutyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C26H28N2O6	1
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0861281 Compound Info	3-(2-(benzyloxy)ethyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C25H26N2O7	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0845476 Compound Info	3-benzyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C23H22N2O6	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0849989 Compound Info	3-furan-2-ylmethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C21H20N2O7	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0889559 Compound Info	diethyl 2,6-dimethyl-4-(2-(methylthio)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H25NO4S	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0901009 Compound Info	3-allyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H20N2O6	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0920688 Compound Info	3-allyl 5-ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H22N2O6	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0845477 Compound Info	3-(3,4-difluorobenzyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C23H20F2N2O6	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0905847 Compound Info	diethyl 2-butyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C22H28N2O6	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0847189 Compound Info	3-cyclopropylmethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H22N2O6	1
1	IC50 = 21 nM Bioactivity Info	TI LI LO TS
CP0849994 Compound Info	3-methyl 5-(2,2,2-trifluoroethyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C18H17F3N2O6	1
1	IC50 = 21 nM Bioactivity Info	TI LI LO TS
CP0860952 Compound Info	3-benzo[d][1,3]dioxol-5-ylmethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C24H22N2O8	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0920251 Compound Info	3-(2-chloroethyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C18H19ClN2O6	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0847190 Compound Info	3-methyl 5-thiophen-2-ylmethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C21H20N2O6S	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0861280 Compound Info	3-(3-fluorobenzyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C23H21FN2O6	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0896955 Compound Info	3-methyl 5-(2,4,6-trichlorobenzyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C23H19Cl3N2O6	1
1	IC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0861279 Compound Info	3-but-3-ynyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H20N2O6	1
1	IC50 = 35 nM Bioactivity Info	TI LI LO TS
CP0913785 Compound Info	dimethyl 2,6-dimethyl-4-(2-(methylthio)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C18H21NO4S	1
1	IC50 = 35 nM Bioactivity Info	TI LI LO TS
CP0859552 Compound Info	diethyl 2-(acetoxymethyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C21H24N2O8	1
1	IC50 = 37 nM Bioactivity Info	TI LI LO TS
CP0915930 Compound Info	Pranidipine Show/Hide	C25H24N2O6	1
1	IC50 = 37 nM Bioactivity Info	TI LI LO TS
CP0845479 Compound Info	3-methyl 5-(4-phenylbutyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C26H28N2O6	1
1	IC50 = 38 nM Bioactivity Info	TI LI LO TS
CP0845480 Compound Info	3-(4-(4-methoxyphenyl)butyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C27H30N2O7	1
1	IC50 = 38 nM Bioactivity Info	TI LI LO TS
CP0905845 Compound Info	3-(4-chlorophenethyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C24H23ClN2O6	1
1	IC50 = 39 nM Bioactivity Info	TI LI LO TS
CP0915935 Compound Info	3-(3,5-dinitrobenzyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C23H20N4O10	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0905848 Compound Info	3-(2,3-dihydro-1H-inden-2-yl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C25H24N2O6	1
1	IC50 = 43 nM Bioactivity Info	TI LI LO TS
CP0860951 Compound Info	diethyl 2-(2-cyanovinyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C21H21N3O6	1
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0861277 Compound Info	diethyl 2-(hydroxymethyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H22N2O7	1
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0845478 Compound Info	3-(2-(2-chlorophenoxy)ethyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C24H23ClN2O7	1
1	IC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0901010 Compound Info	3-methyl 5-(3-methylbut-3-enyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C21H24N2O6	1
1	IC50 = 47 nM Bioactivity Info	TI LI LO TS
CP0852182 Compound Info	diethyl 2-(chloromethyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H21ClN2O6	1
1	IC50 = 53 nM Bioactivity Info	TI LI LO TS
CP0929913 Compound Info	diethyl 4-(2,4-difluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H21F2NO4	1
1	IC50 = 58 nM Bioactivity Info	TI LI LO TS
CP0847191 Compound Info	3-biphenyl-4-ylmethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C29H26N2O6	1
1	IC50 = 74 nM Bioactivity Info	TI LI LO TS
CP0916506 Compound Info	3-(2-cyanoethyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H19N3O6	1
1	IC50 = 78 nM Bioactivity Info	TI LI LO TS
CP0859562 Compound Info	3-(4-methoxybenzyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C24H24N2O7	1
1	IC50 = 79 nM Bioactivity Info	TI LI LO TS
CP0914991 Compound Info	3-ethyl 5-(2-methoxyethyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H24N2O7	1
1	IC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0919510 Compound Info	3-ethyl 5-methyl 6-(methoxymethyl)-2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H22N2O7	1
1	IC50 = 96 nM Bioactivity Info	TI LI LO TS
CP0929910 Compound Info	diethyl 2-methyl-4-(3-nitrophenyl)-6-propyl-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C21H26N2O6	1
1	IC50 = 105 nM Bioactivity Info	TI LI LO TS
CP0901011 Compound Info	3-methyl 5-(2-nitropropyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H21N3O8	1
1	IC50 = 111 nM Bioactivity Info	TI LI LO TS
CP0915936 Compound Info	3-(3,4-dimethoxybenzyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C25H26N2O8	1
1	IC50 = 117 nM Bioactivity Info	TI LI LO TS
CP0858667 Compound Info	3-ethyl 5-pentyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C22H28N2O6	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0861276 Compound Info	R-(-)-3-(2-cyanoethyl)5-ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H21N3O6	1
1	IC50 = 137 nM Bioactivity Info	TI LI LO TS
CP0859532 Compound Info	3-ethyl 5-(4-nitrobenzyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C24H23N3O8	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0859685 Compound Info	diethyl 2-(benzoyloxymethyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C26H26N2O8	1
1	IC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0889560 Compound Info	S-(+)-3-(2-cyanoethyl)5-ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H21N3O6	1
1	IC50 = 211 nM Bioactivity Info	TI LI LO TS
CP0859561 Compound Info	(E/Z)-diethyl 2-(3-methoxy-3-oxoprop-1-enyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C22H24N2O8	1
1	IC50 = 213 nM Bioactivity Info	TI LI LO TS
CP0223810 Compound Info	Dynacirc Show/Hide	C19H21N3O5	1
1	IC50 = 221 nM Bioactivity Info	TI LI LO TS
CP0916507 Compound Info	3-(3,3-diphenylpropyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C31H30N2O6	1
1	IC50 = 270 nM Bioactivity Info	TI LI LO TS
CP0896954 Compound Info	dimethyl 2-(methoxymethyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C18H20N2O7	1
1	IC50 = 350 nM Bioactivity Info	TI LI LO TS
CP0861374 Compound Info	R-(-)-3-(2-cyanoethyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H19N3O6	1
1	IC50 = 399 nM Bioactivity Info	TI LI LO TS
CP0857442 Compound Info	(-)-(R)-diisopropyl 4-methyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C19H23N3O7	1
1	IC50 = 510 nM Bioactivity Info	TI LI LO TS
CP0901008 Compound Info	3-methyl 5-(2-(2,2,2-trifluoroacetamido)ethyl)2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H20F3N3O7	1
1	IC50 = 550 nM Bioactivity Info	TI LI LO TS
CP0952522 Compound Info	rac-1-Methyl5-isopropyl4-methyl-6-(3-nitrophenyl)-2-thioxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C17H19N3O6S	1
1	IC50 = 550 nM Bioactivity Info	TI LI LO TS
CP0857922 Compound Info	(-)-(R)-5-isopropyl 1-methyl 4-methyl-6-(3-nitrophenyl)-2-thioxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C17H19N3O6S	1
1	IC50 = 560 nM Bioactivity Info	TI LI LO TS
CP0859686 Compound Info	S-(+)-3-(2-cyanoethyl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H19N3O6	1
1	IC50 = 589 nM Bioactivity Info	TI LI LO TS
CP0913798 Compound Info	diethyl 2-methyl-4-(3-nitrophenyl)-6-((4-phenylpiperazin-1-yl)methyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C29H34N4O6	1
1	IC50 = 610 nM Bioactivity Info	TI LI LO TS
CP0924353 Compound Info	diethyl 2-(diethoxymethyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C23H30N2O8	1
1	IC50 = 615 nM Bioactivity Info	TI LI LO TS
CP0857921 Compound Info	rac-1,5-Diisopropyl4-methyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydro-pyrimidine-1,5(6H)-dicarboxylate Show/Hide	C19H23N3O7	1
1	IC50 = 660 nM Bioactivity Info	TI LI LO TS
CP0859528 Compound Info	3-ethyl 5-methyl 6-(methoxymethyl)-2-methyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C19H22N2O7	1
1	IC50 = 790 nM Bioactivity Info	TI LI LO TS
CP0851856 Compound Info	1-isopropyl 5-methyl4-methyl-6-(3-nitrophenyl)-2-thioxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C17H19N3O6S	1
1	IC50 = 880 nM Bioactivity Info	TI LI LO TS
CP0861278 Compound Info	5-(methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid Show/Hide	C16H16N2O6	1
1	IC50 = 930 nM Bioactivity Info	TI LI LO TS
CP0559137 Compound Info	propan-2-yl 6-methyl-3-(2-methylpropanoyl)-4-(3-nitrophenyl)-2-oxo-1,4-dihydropyrimidine-5-carboxylate Show/Hide	C19H23N3O6	1
1	IC50 = 990 nM Bioactivity Info	TI LI LO TS
CP0434136 Compound Info	3-O-methyl 5-O-propan-2-yl 2-methoxycarbonylsulfanyl-6-methyl-4-(3-nitrophenyl)-4H-pyrimidine-3,5-dicarboxylate Show/Hide	C19H21N3O8S	1
1	IC50 = 1110 nM Bioactivity Info	TI LI LO TS
CP0913783 Compound Info	4-(2,3-difluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile Show/Hide	C15H11F2N3	1
1	IC50 = 1150 nM Bioactivity Info	TI LI LO TS
CP0845897 Compound Info	1-Cyclopentyl-3-(3,4-dichlorophenethyl)pyrimidine-2,4,6-(1H,3H,5H)-trione Show/Hide	C17H18Cl2N2O3	1
1	IC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0851855 Compound Info	3,5-diisopropyl 2-amino-6-methyl-4-(3-nitrophenyl)-4h-pyran-3,5-dicarboxylate Show/Hide	C20H24N2O7	1
1	IC50 = 1390 nM Bioactivity Info	TI LI LO TS
CP0918004 Compound Info	1-(3,5-Bis(trifluoromethyl)phenethyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H18F6N2O3	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0948372 Compound Info	1-Cyclopentyl-3-(3,5-dichlorophenethyl)pyrimidine-2,4,6-(1H,3H,5H)-trione Show/Hide	C17H18Cl2N2O3	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0918005 Compound Info	(S)-1-(4-Chlorophenethyl)-3-(2,2-dimethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 1700 nM Bioactivity Info	TI LI LO TS
CP0918001 Compound Info	1-(3,5-Bis(trifluoromethyl)phenethyl-3-((+/-)-endonorbornyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C21H20F6N2O3	1
1	IC50 = 1800 nM Bioactivity Info	TI LI LO TS
CP0892083 Compound Info	3-Isopropyl 5-methyl 2-amino-6-methyl-4-(3-nitrophenyl)-4H-pyran-3,5-dicarboxylate Show/Hide	C18H20N2O7	1
1	IC50 = 1820 nM Bioactivity Info	TI LI LO TS
CP0405907 Compound Info	propan-2-yl 6-methyl-2-methylsulfanyl-4-(3-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylate Show/Hide	C16H19N3O4S	1
1	IC50 = 1860 nM Bioactivity Info	TI LI LO TS
CP0917509 Compound Info	1-((1S,2R,4R)-Bicyclo[2.2.1]heptan-2-yl)-3-(4-chlorophenethyl)-pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H21ClN2O3	1
1	IC50 = 1900 nM Bioactivity Info	TI LI LO TS
CP0857920 Compound Info	(-)-(R)-5-isopropyl 1-methyl 4-methyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C17H19N3O7	1
1	IC50 = 1910 nM Bioactivity Info	TI LI LO TS
CP0374255 Compound Info	diethyl 2,6-dimethyl-4-(3-nitrophenyl)-4H-pyran-3,5-dicarboxylate Show/Hide	C19H21NO7	1
1	IC50 = 1925 nM Bioactivity Info	TI LI LO TS
CP0851873 Compound Info	(+)-(S)-diisopropyl 4-methyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C19H23N3O7	1
1	IC50 = 1960 nM Bioactivity Info	TI LI LO TS
CP0910446 Compound Info	1-((1S,2R,4R)-Bicyclo[2.2.1]heptan-2-yl)-3-(3-chlorophenethyl)-pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H21ClN2O3	1
1	IC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0864312 Compound Info	diethyl 2-methyl-4-(3-nitrophenyl)-6-(4-nitrostyryl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C26H25N3O8	1
1	IC50 = 2055 nM Bioactivity Info	TI LI LO TS
CP0848479 Compound Info	1-((1R,2S,4S)-Bicyclo[2.2.1]heptan-2-yl)-3-(4-chlorophenethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H21ClN2O3	1
1	IC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0854692 Compound Info	(+)-endo-1-((1S,2R,4R)-Bicyclo[2.2.1]heptan-2-yl)-3-(3-(trifluoromethyl)phenethyl)-pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H21F3N2O3	1
1	IC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0917508 Compound Info	(S)-1-(3-Chlorophenethyl)-3-(2,2-dimethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0912097 Compound Info	diethyl 2,4,6-trimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C20H25NO4	1
1	IC50 = 2140 nM Bioactivity Info	TI LI LO TS
CP0861378 Compound Info	3-allyl 5-ethyl 2,6-dimethyl-4-(naphthalen-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C24H25NO4	1
1	IC50 = 2161 nM Bioactivity Info	TI LI LO TS
CP0876347 Compound Info	1-Cyclopentyl-3-(2-methyl-2-(3-(trifluoromethyl)phenyl)-propyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H23F3N2O3	1
1	IC50 = 2200 nM Bioactivity Info	TI LI LO TS
CP0857253 Compound Info	(+/-)-endo-1-(bicyclo[2.2.1]heptan-2-yl)-3-(2-(3-chlorophenyl)-2-methylpropyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C21H25ClN2O3	1
1	IC50 = 2300 nM Bioactivity Info	TI LI LO TS
CP0920832 Compound Info	2,4,6-Trimethyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester Show/Hide	C18H21NO4	1
1	IC50 = 2310 nM Bioactivity Info	TI LI LO TS
CP0852209 Compound Info	ethyl 5-acetyl-2,6-dimethyl-4-(naphthalen-2-yl)-1,4-dihydropyridine-3-carboxylate Show/Hide	C22H23NO3	1
1	IC50 = 2315 nM Bioactivity Info	TI LI LO TS
CP0845872 Compound Info	1-(2-(3-Chlorophenyl)-2-methylpropyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 2400 nM Bioactivity Info	TI LI LO TS
CP0848629 Compound Info	1-((+/-)-exo-Norbornyl)-3-(3-(trifluoromethyl)phenethyl)-pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H21F3N2O3	1
1	IC50 = 2400 nM Bioactivity Info	TI LI LO TS
CP0876346 Compound Info	1-(2-(3-Chlorophenyl)propyl)-3-((+/-)-endo-norbornyl)-pyrimidine-2,4,6-(1H,3H,5H)-trione Show/Hide	C20H23ClN2O3	1
1	IC50 = 2400 nM Bioactivity Info	TI LI LO TS
CP0910448 Compound Info	(R)-1-(3-chlorophenethyl)-3-(2,2-dimethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0854691 Compound Info	(R)-1-(2,2-Dimethylcyclopentyl)-3-(3-(trifluoromethyl)phenethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H23F3N2O3	1
1	IC50 = 2700 nM Bioactivity Info	TI LI LO TS
CP0909384 Compound Info	1-(2(3,5-Dichlorophenyl)ethyl)-3-((+/-)-endo-norbornyl)-pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H20Cl2N2O3	1
1	IC50 = 2700 nM Bioactivity Info	TI LI LO TS
CP0851857 Compound Info	3-Ethyl 5-methyl 2-amino-6-methyl-4-(3-nitrophenyl)-4H-pyran-3,5-dicarboxylate Show/Hide	C17H18N2O7	1
1	IC50 = 2720 nM Bioactivity Info	TI LI LO TS
CP0863216 Compound Info	cis-1-(4-chlorophenethyl)-3-((1R,2S)-2-methylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 2800 nM Bioactivity Info	TI LI LO TS
CP0861744 Compound Info	rac-1-Methyl 5-isopropyl4-methyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C17H19N3O7	1
1	IC50 = 2960 nM Bioactivity Info	TI LI LO TS
CP0925569 Compound Info	(-)-endo-1-((1R,2S,4S)-Bicyclo-[2.2.1]heptan-2-yl)-3-(3-(trifluoromethyl)phenethyl)-pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H21F3N2O3	1
1	IC50 = 3000 nM Bioactivity Info	TI LI LO TS
CP0916622 Compound Info	1-(3-Chlorophenethyl)-3-((1S,2R,3S)-2,3-dimethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 3090 nM Bioactivity Info	TI LI LO TS
CP0938640 Compound Info	cis-1-(4-Chlorophenethyl)-3-((1S,2R)-2-methylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0465374 Compound Info	3-O-methyl 5-O-propan-2-yl 6-methyl-2-methylimino-4-(3-nitrophenyl)-1,4-dihydropyrimidine-3,5-dicarboxylate Show/Hide	C18H22N4O6	1
1	IC50 = 3250 nM Bioactivity Info	TI LI LO TS
CP0929215 Compound Info	1-(2-(4-Chlorophenyl)propyl)-3-((+/-)-endo-norbornyl)pyrimidine-2,4,6-(1H,3H,5H)-trione Show/Hide	C20H23ClN2O3	1
1	IC50 = 3400 nM Bioactivity Info	TI LI LO TS
CP0857965 Compound Info	1-((1R,2S,4S)-Bicyclo[2.2.1]heptan-2-yl)-3-(3-chlorophenethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H21ClN2O3	1
1	IC50 = 3500 nM Bioactivity Info	TI LI LO TS
CP0863212 Compound Info	1-(1-(4-Chlorophenyl)propan-2-yl)-3-((+/-)-endo-norbornyl)pyrimidine-2,4,6-(1H,3H,5H)-trione Show/Hide	C20H23ClN2O3	1
1	IC50 = 3600 nM Bioactivity Info	TI LI LO TS
CP0848480 Compound Info	1-(4-Chlorophenethyl)-3-(3,3-dimethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 3700 nM Bioactivity Info	TI LI LO TS
CP0891586 Compound Info	1-(3-Chlorophenethyl)-3-(3-methylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 3700 nM Bioactivity Info	TI LI LO TS
CP0917512 Compound Info	cis-1-(3-chlorophenethyl)-3-((1R,2S)-2-methylcyclohexyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 3700 nM Bioactivity Info	TI LI LO TS
CP0899533 Compound Info	1-cyclopentyl-3-(3,3-diphenylpropyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C24H26N2O3	1
1	IC50 = 4100 nM Bioactivity Info	TI LI LO TS
CP0876348 Compound Info	1-(2-(3-Chlorophenyl)propyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 4200 nM Bioactivity Info	TI LI LO TS
CP0397647 Compound Info	5-O-methyl 3-O-propan-2-yl 6-methyl-2-methylimino-4-(3-nitrophenyl)-1,4-dihydropyrimidine-3,5-dicarboxylate Show/Hide	C18H22N4O6	1
1	IC50 = 4220 nM Bioactivity Info	TI LI LO TS
CP0917507 Compound Info	(S)-N-(3-chlorophenethyl)-N-(1-cyclohexylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H25ClN2O3	1
1	IC50 = 4300 nM Bioactivity Info	TI LI LO TS
CP0898244 Compound Info	1,5-Diisopropyl4-isopropyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C21H27N3O7	1
1	IC50 = 4310 nM Bioactivity Info	TI LI LO TS
CP0857455 Compound Info	1-(2-([1,1'-Biphenyl]-4-yl)ethyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C23H24N2O3	1
1	IC50 = 4400 nM Bioactivity Info	TI LI LO TS
CP0914259 Compound Info	(R)-1-Cyclopentyl-3-(1-(naphthalen-1-yl)ethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C21H22N2O3	1
1	IC50 = 4600 nM Bioactivity Info	TI LI LO TS
CP0880340 Compound Info	1-Isopropyl5-methyl4-methyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C17H19N3O7	1
1	IC50 = 4600 nM Bioactivity Info	TI LI LO TS
CP0857458 Compound Info	(R)-1-(4-chlorophenethyl)-3-(2,2-dimethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 4700 nM Bioactivity Info	TI LI LO TS
CP0861282 Compound Info	2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(3,5-dimethyl-adamantan-1-ylmethyl) ester 5-methyl ester Show/Hide	C29H36N2O6	1
1	IC50 = 5070 nM Bioactivity Info	TI LI LO TS
CP0929217 Compound Info	1-Cyclopentyl-3-(2,2-diphenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C23H24N2O3	1
1	IC50 = 5200 nM Bioactivity Info	TI LI LO TS
CP0845904 Compound Info	cis-1-(3-Chlorophenethyl)-3-((1S,2R)-2-methylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 5500 nM Bioactivity Info	TI LI LO TS
CP0374923 Compound Info	5-O-methyl 3-O-propan-2-yl 6-methyl-2-methylsulfanyl-4-(3-nitrophenyl)-4H-pyrimidine-3,5-dicarboxylate Show/Hide	C18H21N3O6S	1
1	IC50 = 5580 nM Bioactivity Info	TI LI LO TS
CP0891585 Compound Info	1-(3-Chlorophenethyl)-3-(3,3-dimethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 5600 nM Bioactivity Info	TI LI LO TS
CP0955871 Compound Info	N-(4-chlorophenethyl)-N'-(+/-)-endo-norbornylpyrimidine-2,4,6-(1H,3H,5H)-trione Show/Hide	C19H21ClN2O3	1
1	IC50 = 5600 nM Bioactivity Info	TI LI LO TS
CP0440146 Compound Info	1-O,3-O-dimethyl 5-O-propan-2-yl 6-methyl-4-(3-nitrophenyl)-2-oxo-4H-pyrimidine-1,3,5-tricarboxylate Show/Hide	C19H21N3O9	1
1	IC50 = 5880 nM Bioactivity Info	TI LI LO TS
CP0899531 Compound Info	1-(4-chlorophenethyl)-3-((1R,2S)-2-methylcyclohexyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 6100 nM Bioactivity Info	TI LI LO TS
CP0938641 Compound Info	N-(3-chlorophenethyl)-N'-cyclopentylpyrimidine-2,4,6-trione Show/Hide	C17H19ClN2O3	1
1	IC50 = 6300 nM Bioactivity Info	TI LI LO TS
CP0940964 Compound Info	rac-1-(4-Chlorophenethyl)-3-(3-ethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 6700 nM Bioactivity Info	TI LI LO TS
CP0917510 Compound Info	1-(4-Chlorophenethyl)-3-((+/-)-trans-2-methylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 7000 nM Bioactivity Info	TI LI LO TS
CP0845903 Compound Info	1-(3-Chlorophenethyl)-3-(3-ethylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 7300 nM Bioactivity Info	TI LI LO TS
CP0858777 Compound Info	cis-1-(3-chlorophenethyl)-3-((1R,2S)-2-methylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 7300 nM Bioactivity Info	TI LI LO TS
CP0918002 Compound Info	1-((1-(4-Chlorophenyl)cyclopropyl)methyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H21ClN2O3	1
1	IC50 = 7300 nM Bioactivity Info	TI LI LO TS
CP0857967 Compound Info	Methyl3-(4-chlorophenyl)-2-(3-cyclopentyl-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)propanoate Show/Hide	C19H21ClN2O5	1
1	IC50 = 7500 nM Bioactivity Info	TI LI LO TS
CP0925570 Compound Info	1-Cyclopentyl-3-(3-phenylpropyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H22N2O3	1
1	IC50 = 7600 nM Bioactivity Info	TI LI LO TS
CP0876357 Compound Info	(R)-1-(4-Chlorophenethyl)-3-(1-cyclohexylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H25ClN2O3	1
1	IC50 = 8100 nM Bioactivity Info	TI LI LO TS
CP0912860 Compound Info	(S)-1-(4-Chlorophenethyl)-3-(1-cyclohexylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H25ClN2O3	1
1	IC50 = 8300 nM Bioactivity Info	TI LI LO TS
CP0917511 Compound Info	(R)-1-(3-Chlorophenethyl)-3-(1-cyclohexylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H25ClN2O3	1
1	IC50 = 9700 nM Bioactivity Info	TI LI LO TS
CP0917514 Compound Info	cis-(1S,3R)-3-fluorophenethyl 3-(3-(3-chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentanecarboxylate Show/Hide	C26H26ClFN2O5	1
1	IC50 = 9700 nM Bioactivity Info	TI LI LO TS
CP0482487 Compound Info	1-[2-(4-chlorophenyl)ethyl]-3-(3-methylcyclopentyl)-1,3-diazinane-2,4,6-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 9800 nM Bioactivity Info	TI LI LO TS
CP0387751 Compound Info	5-O-ethyl 3-O-methyl 2-methyl-6-(2-methylpropanoylamino)-4-(3-nitrophenyl)-4H-pyran-3,5-dicarboxylate Show/Hide	C21H24N2O8	1
1	IC50 = 9950 nM Bioactivity Info	TI LI LO TS
CP0397646 Compound Info	3-O-ethyl 5-O-methyl 2-acetamido-6-methyl-4-(3-nitrophenyl)-4H-pyran-3,5-dicarboxylate Show/Hide	C19H20N2O8	1
1	IC50 = 10030 nM Bioactivity Info	TI LI LO TS
CP0876586 Compound Info	1-Isopropyl5-methyl4-isopropyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C19H23N3O7	1
1	IC50 = 10070 nM Bioactivity Info	TI LI LO TS
CP0857457 Compound Info	cis-(1S,3R)-isopropyl 3-(3-(3-chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentanecarboxylate Show/Hide	C21H25ClN2O5	1
1	IC50 = 10400 nM Bioactivity Info	TI LI LO TS
CP0465373 Compound Info	methyl 6-methyl-2-methylsulfanyl-4-(3-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylate Show/Hide	C14H15N3O4S	1
1	IC50 = 10620 nM Bioactivity Info	TI LI LO TS
CP0405906 Compound Info	3-O-methyl 5-O-propan-2-yl 6-methyl-2-methylsulfanyl-4-(3-nitrophenyl)-4H-pyrimidine-3,5-dicarboxylate Show/Hide	C18H21N3O6S	1
1	IC50 = 10670 nM Bioactivity Info	TI LI LO TS
CP0876353 Compound Info	(R)-1-(3-Chlorophenethyl)-3-(1-(naphthalen-1-yl)ethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C24H21ClN2O3	1
1	IC50 = 10800 nM Bioactivity Info	TI LI LO TS
CP0881135 Compound Info	1-(3-Chlorophenethyl)-3-((+/-)-trans-2-methylcyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O3	1
1	IC50 = 11000 nM Bioactivity Info	TI LI LO TS
CP0891584 Compound Info	1-(4-Chlorophenethyl)-3-(4-methylcyclohexyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 11000 nM Bioactivity Info	TI LI LO TS
CP0876355 Compound Info	1-(3-chlorophenethyl)-3-(pentan-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C17H21ClN2O3	1
1	IC50 = 11700 nM Bioactivity Info	TI LI LO TS
CP0891593 Compound Info	(1-(3-(3-Chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentyl)methyl isobutyrate Show/Hide	C22H27ClN2O5	1
1	IC50 = 11900 nM Bioactivity Info	TI LI LO TS
CP0845900 Compound Info	(1R,2S)-Ethyl 2-(3-(3-chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentane carboxylate Show/Hide	C20H23ClN2O5	1
1	IC50 = 12000 nM Bioactivity Info	TI LI LO TS
CP0860966 Compound Info	(+)-(S)-5-isopropyl 1-methyl 4-methyl-6-(3-nitrophenyl)-2-thioxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C17H19N3O6S	1
1	IC50 = 12800 nM Bioactivity Info	TI LI LO TS
CP0407423 Compound Info	5-O-methyl 3-O-propan-2-yl 2-acetamido-6-methyl-4-(3-nitrophenyl)-4H-pyran-3,5-dicarboxylate Show/Hide	C20H22N2O8	1
1	IC50 = 13620 nM Bioactivity Info	TI LI LO TS
CP0863214 Compound Info	(1S,2S)-2-(3-(3-Chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentyl isobutyrate Show/Hide	C21H25ClN2O5	1
1	IC50 = 13700 nM Bioactivity Info	TI LI LO TS
CP0912093 Compound Info	5-(ethoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic formic anhydride Show/Hide	C18H18N2O7	1
1	IC50 = 13900 nM Bioactivity Info	TI LI LO TS
CP0497653 Compound Info	1-O,3-O-diethyl 5-O-methyl 6-methyl-4-(3-nitrophenyl)-2-oxo-4H-pyrimidine-1,3,5-tricarboxylate Show/Hide	C19H21N3O9	1
1	IC50 = 13930 nM Bioactivity Info	TI LI LO TS
CP0938665 Compound Info	1-Cyclopentyl-3-(2,3-dihydro-1H-inden-2-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H20N2O3	1
1	IC50 = 14400 nM Bioactivity Info	TI LI LO TS
CP0876585 Compound Info	6-Methyl-5-(isopropyloxycarbonyl)-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-thione Show/Hide	C15H17N3O4S	1
1	IC50 = 15840 nM Bioactivity Info	TI LI LO TS
CP0863213 Compound Info	1-(4-Chlorobenzyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C16H17ClN2O3	1
1	IC50 = 17900 nM Bioactivity Info	TI LI LO TS
CP0863215 Compound Info	1-(4-Chlorophenethyl)-3-((1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C22H27ClN2O3	1
1	IC50 = 18000 nM Bioactivity Info	TI LI LO TS
CP0860203 Compound Info	5-Methoxy-6-methyl-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one Show/Hide	C13H13N3O5	1
1	IC50 = 18890 nM Bioactivity Info	TI LI LO TS
CP0946409 Compound Info	1-Cyclopentyl-3-(1,2,3,4-tetrahydronaphthalen-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H22N2O3	1
1	IC50 = 19700 nM Bioactivity Info	TI LI LO TS
CP0929218 Compound Info	1-Cyclopentyl-3-(2,3-dihydro-1H-inden-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H20N2O3	1
1	IC50 = 19900 nM Bioactivity Info	TI LI LO TS
CP0913143 Compound Info	1-(4-chlorophenethyl)-3-((1S,2S,3S,5R)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C22H27ClN2O3	1
1	IC50 = 22000 nM Bioactivity Info	TI LI LO TS
CP0860965 Compound Info	1-Ethyl 5-methyl4-isopropyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C18H21N3O7	1
1	IC50 = 24470 nM Bioactivity Info	TI LI LO TS
CP0891551 Compound Info	1-(3-Chlorophenethyl)-3-((1S,2S)-2-methoxycyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C18H21ClN2O4	1
1	IC50 = 30300 nM Bioactivity Info	TI LI LO TS
CP0876467 Compound Info	methyl 1-(3-(3-Chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentanecarboxylate Show/Hide	C19H21ClN2O5	1
1	IC50 = 32700 nM Bioactivity Info	TI LI LO TS
CP0876350 Compound Info	1-(4-(Benzyloxy)phenethyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C24H26N2O4	1
1	IC50 = 34100 nM Bioactivity Info	TI LI LO TS
CP0858776 Compound Info	1-(3-Chlorophenethyl)-3-(4-methylcyclohexyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C19H23ClN2O3	1
1	IC50 = 35000 nM Bioactivity Info	TI LI LO TS
CP0880339 Compound Info	(+)-(S)-5-isopropyl 1-methyl 4-methyl-6-(3-nitrophenyl)-2-oxo-2,3-dihydropyrimidine-1,5(6H)-dicarboxylate Show/Hide	C17H19N3O7	1
1	IC50 = 35100 nM Bioactivity Info	TI LI LO TS
CP0857456 Compound Info	cis-(1R,2S)-2-(3-(3-Chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentyl acetate Show/Hide	C19H21ClN2O5	1
1	IC50 = 38600 nM Bioactivity Info	TI LI LO TS
CP0938664 Compound Info	1-Cyclopentyl-3-(4-isopropylphenethyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C20H26N2O3	1
1	IC50 = 39000 nM Bioactivity Info	TI LI LO TS
CP0854699 Compound Info	(1-(3-(3-Chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentyl)methyl acetate Show/Hide	C20H23ClN2O5	1
1	IC50 = 39300 nM Bioactivity Info	TI LI LO TS
CP0845895 Compound Info	cis-1-(3-Chlorophenethyl)-3-(((1R,2S,5R)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)methyl)pyrimi-dine-2,4,6(1H,3H,5H)-trione Show/Hide	C22H27ClN2O3	1
1	IC50 = 40000 nM Bioactivity Info	TI LI LO TS
CP0848664 Compound Info	1-(3-Chlorobenzyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C16H17ClN2O3	1
1	IC50 = 43000 nM Bioactivity Info	TI LI LO TS
CP0876584 Compound Info	6-Methyl-5-(isopropyloxycarbonyl)-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one Show/Hide	C15H17N3O5	1
1	IC50 = 46620 nM Bioactivity Info	TI LI LO TS
CP0848478 Compound Info	(S)-benzyl3-(3-(3-Chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)pyrrolidine-1-carboxylate Show/Hide	C24H24ClN3O5	1
1	IC50 = 50300 nM Bioactivity Info	TI LI LO TS
CP0938663 Compound Info	(R)-methyl 2-(3-cyclopentyl-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)-3-phenylpropanoate Show/Hide	C19H22N2O5	1
1	IC50 = 55000 nM Bioactivity Info	TI LI LO TS
CP0409855 Compound Info	1-[2-(3-chlorophenyl)ethyl]-3-[(3S)-pyrrolidin-3-yl]-1,3-diazinane-2,4,6-trione Show/Hide	C16H18ClN3O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0845896 Compound Info	(R)-1-(3-Chlorophenethyl)-3-((tetrahydrofuran-2-yl)methyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C17H19ClN2O4	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0845901 Compound Info	1-(3-Chlorophenethyl)-3-((1S,2S)-2-hydroxycyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C17H19ClN2O4	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0845902 Compound Info	(R)-1-(4-Chlorophenethyl)-3-((tetrahydrofuran-2-yl)methyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C17H19ClN2O4	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0848476 Compound Info	trans-(1S,2S)-2-(3-(3-Chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentyl acetate Show/Hide	C19H21ClN2O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0858773 Compound Info	cis-(1S,3R)-3-(3-(3-chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)cyclopentanecarboxylic acid Show/Hide	C18H19ClN2O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0858774 Compound Info	1-(3-Chlorophenethyl)-3-((1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C22H27ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0858775 Compound Info	1-(3-Chlorophenethyl)-3-((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C22H27ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0860614 Compound Info	1-(4-Chlorophenethyl)-3-((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C22H27ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0891583 Compound Info	cis-1-(4-Chlorophenethyl)-3-(((1R,2S,5R)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)methyl)pyrimi-dine-2,4,6(1H,3H,5H)-trione Show/Hide	C22H27ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0909385 Compound Info	1-Cyclopentyl-3-(3-(trifluoromethyl)phenyl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C16H15F3N2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0910445 Compound Info	1-(3-chlorophenethyl)-3-((1S,2S,3S,5R)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione Show/Hide	C22H27ClN2O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0929216 Compound Info	(S)-Methyl 2-(3-cyclopentyl-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)-3-phenylpropanoate Show/Hide	C19H22N2O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0374921 Compound Info	methyl 3-(2-methylpropanoyl)-4-(3-nitrophenyl)-2-oxo-6-propan-2-yl-1,4-dihydropyrimidine-5-carboxylate Show/Hide	C19H23N3O6	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0851872 Compound Info	6-Methyl-5-(methoxycarbonyl)-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-thione Show/Hide	C13H13N3O4S	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0857919 Compound Info	6-Isopropyl-5-(methoxycarbonyl)-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one Show/Hide	C15H17N3O5	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0919512 Compound Info	ethyl 2-methyl-4-(3-nitrophenyl)-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate Show/Hide	C17H16N2O6	1
1	IC50 > 4000 nM Bioactivity Info	TI LI LO TS

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT01102	Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens, Human	Protein Info
PT04580	Voltage-dependent L-type calcium channel subunit alpha-1C	Rattus norvegicus, Rat	Protein Info
PT06040	Voltage-dependent L-type calcium channel subunit alpha-1C	Oryctolagus cuniculus, Rabbit	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han