General Information of the Protein
Protein ID
PT04580
Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1C
Secondarily
Protein Name
Calcium channel
L type
alpha-1 polypeptide
isoform 1
cardiac muscle
Rat brain class C
Voltage-gated calcium channel subunit alpha Cav1.2
Gene Name
CACNA1C
Secondarily
Gene Name
Cach2
Cacn2
Cacnl1a1
Cchl1a1
Sequence
MIRAFAQPSTPPYQPLSSCLSEDTERKFKGKVVHEAQLNCFYISPGGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWLAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGGTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEDKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISCWRCVRLLRIFKITRYWNSLSNLVASLLNSLRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFISPNYILLNLFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEVMEKPAVEESKEEKIELKSITADGESPPTTKINMDDLQPSENEDKSPHSNPDTAGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAESKGNYITYKTGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLPRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDSRSNFPQTFATQRPLHINKTGNNQADTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRFPHPAGYSSTVSTVEGHGPPLSPAVRVQEAAWKLSSKRCHSRESQGATVSQDMFPDETRSSVRLSEEVEYCSEPSLLSTDILSYQDDENRQLTCLEEDKREIQPCPKRSFLRSASLGRRASFHLECLKRQKDQGGDISQKTALPLHLVHHQALAVAGLSPLLQRSHSPSTFPRPRPTPPVTPGSRGRPLQPIPTLRLEGAESSEKLNSSFPSIHCSSWSEETTACSGGSSMARRARPVSLTVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMENAADNILSGGAQQSPNGTLLPFVNCRDPGQDRAVVPEDESCVYALGRGRSEEALPDSRSYVSNL
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Organism
Rattus norvegicus, Rat
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Voltage-gated calcium channel
Function
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (Probable) (PubMed:15140941, PubMed:15170217). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart (By similarity). Required for normal heart development and normal regulation of heart rhythm (By similarity). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (By similarity). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (By similarity).
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Uniprot ID
Primary ID:
P22002

Secondarily ID:
P27733
P27734
Q62816
Q63271
Q64178
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Ensembl ID
ENSG00000151067
Subcellular Location
Cell membrane
Cell membrane
Sarcolemma
Perikaryon
Postsynaptic density membrane
Cell projection
Dendrite
Cell membrane
Sarcolemma
T-tubule
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000238 , A7r5
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0013607
 Compound Info 
2-methoxyacetic acid [(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methyl-amino]ethyl]-6-fluoro-1-isopropyl-tetralin-2-yl] ester;hydrate;hydrochloride
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C29H38FN3O3
  1
1
IC50 = 1100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0923188
 Compound Info 
2-[1-[2-[4-fluoro-2-(2-methoxyethoxy)phenyl]ethyl]piperidin-4-yl]-N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]acetamide
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C28H38F2N2O3
  1
1
IC50 = 1900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0873392
 Compound Info 
2-[1-[2-[3-fluoro-2-(2-methoxyethoxy)phenyl]ethyl]piperidin-4-yl]-N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]acetamide
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C28H38F2N2O3
  1
1
IC50 = 2100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0873393
 Compound Info 
2-[1-[2-[5-fluoro-2-(2-methoxyethoxy)phenyl]ethyl]piperidin-4-yl]-N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]acetamide
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C28H38F2N2O3
  1
1
IC50 = 3100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0941579
 Compound Info 
2-[1-[2-[2-fluoro-6-(2-methoxyethoxy)phenyl]ethyl]piperidin-4-yl]-N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]acetamide
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C28H38F2N2O3
  1
1
IC50 = 3100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0926518
 Compound Info 
N-[2-(4-fluorophenyl)-3-methylbutyl]-1-(2-phenylethyl)piperidine-4-carboxamide
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C25H33FN2O
  1
1
IC50 = 3900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0468566
 Compound Info 
N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(2-phenylethyl)piperidine-4-carboxamide
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C26H35FN2O
  1
1
IC50 = 4400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0865043
 Compound Info 
1-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]-3-[1-(2-phenylethyl)piperidin-4-yl]urea
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C24H32FN3O
  1
1
IC50 = 5000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0952239
 Compound Info 
N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]-2-[1-[2-(2-methoxyphenyl)ethyl]piperidin-4-yl]acetamide
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C26H35FN2O2
  1
1
IC50 = 6800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0900988
 Compound Info 
N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]-2-[1-(2-phenylethyl)piperidin-4-yl]acetamide
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C25H33FN2O
  1
1
IC50 = 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01102 Voltage-dependent L-type calcium channel subunit alpha-1C Homo sapiens, Human
 Protein Info 
PT06039 Voltage-dependent L-type calcium channel subunit alpha-1D Rattus norvegicus, Rat
 Protein Info 
PT06040 Voltage-dependent L-type calcium channel subunit alpha-1C Oryctolagus cuniculus, Rabbit
 Protein Info