Brief Information of the Cell Line and Protein
Cell Line ID: CL000017 , HeLa
Synonyms
HELA
Hela
He La
He-La
HeLa-CCL2
Henrietta Lacks cells
Helacyton gartleri
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0030
Protein ID: PT04417 , Son of sevenless homolog 1
Gene Name SOS1
Organism Homo sapiens, Human
Protein Classification Unclassified protein
Uniprot ID Q07889
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000017  Protein ID: PT04417
 
Compound ID Compound Name Compound Formula
CP0412657
2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclopropylethyl]-8-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)quinazoline-2,4-diamine
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C25H27ClFN5
 1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0412667
2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclopropylethyl]-8-(1,2,3,6-tetrahydropyridin-4-yl)quinazoline-2,4-diamine
   Show/Hide
C24H25ClFN5
 1
1
EC50 = 1800 nM
   TI
   LI
   LO
   TS
CP0471457
8-(azetidin-3-ylmethyl)-2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclopropylethyl]quinazoline-2,4-diamine
   Show/Hide
C23H25ClFN5
 1
1
EC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0412656
8-(aminomethyl)-2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclopropylethyl]quinazoline-2,4-diamine
   Show/Hide
C20H21ClFN5
 1
1
EC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0493021
2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclopropylbutyl]quinazoline-2,4-diamine
   Show/Hide
C21H22ClFN4
 1
1
EC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0450621
8-(2-aminoethyl)-2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclopropylethyl]quinazoline-2,4-diamine
   Show/Hide
C21H23ClFN5
 1
1
EC50 = 2700 nM
   TI
   LI
   LO
   TS
CP0536568
8-(azetidin-3-yl)-2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclopropylethyl]quinazoline-2,4-diamine
   Show/Hide
C22H23ClFN5
 1
1
EC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0519766
[(2S)-1-[6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-piperazin-1-ylbenzimidazol-4-yl]pyrrolidin-2-yl]methanamine
   Show/Hide
C25H32ClFN6
 1
1
EC50 = 3200 nM
   TI
   LI
   LO
   TS
CP0493022
2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclopropylethyl]-8-piperazin-1-ylquinazoline-2,4-diamine
   Show/Hide
C23H26ClFN6
 1
1
EC50 = 4200 nM
   TI
   LI
   LO
   TS
CP0387111
6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-4-(4-methylpiperazin-1-yl)benzimidazole
   Show/Hide
C26H32ClFN6
 1
1
EC50 = 5900 nM
   TI
   LI
   LO
   TS
CP0415807
6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-4-(4-methylpiperazin-1-yl)-2-piperazin-1-ylbenzimidazole
   Show/Hide
C25H32ClFN6
 1
1
EC50 = 6000 nM
   TI
   LI
   LO
   TS
CP0401722
2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclopropylpropyl]quinazoline-2,4-diamine
   Show/Hide
C20H20ClFN4
 1
1
EC50 = 6200 nM
   TI
   LI
   LO
   TS
CP0095962
2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclopropylethyl]quinazoline-2,4-diamine
   Show/Hide
C19H18ClFN4
 1
1
EC50 = 6400 nM
   TI
   LI
   LO
   TS
CP0536533
8-N-(2-aminoethyl)-2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclopropylethyl]quinazoline-2,4,8-triamine
   Show/Hide
C21H24ClFN6
 1
1
EC50 = 6600 nM
   TI
   LI
   LO
   TS
CP0493019
2-N-(3-bromophenyl)-4-N-(furan-2-ylmethyl)quinazoline-2,4-diamine
   Show/Hide
C19H15BrN4O
 1
1
EC50 = 7100 nM
   TI
   LI
   LO
   TS
CP0412664
2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclopropylethyl]-8-N-[2-(dimethylamino)ethyl]quinazoline-2,4,8-triamine
   Show/Hide
C23H28ClFN6
 1
1
EC50 = 7700 nM
   TI
   LI
   LO
   TS
CP0387110
5-[6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]benzimidazol-4-yl]-4-methylpyrimidin-2-amine
   Show/Hide
C26H27ClFN7
 1
1
EC50 = 7800 nM
   TI
   LI
   LO
   TS
CP0429954
6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-piperazin-1-yl-4-(4-propan-2-ylpyrimidin-5-yl)benzimidazole
   Show/Hide
C27H30ClFN6
 1
1
EC50 = 8800 nM
   TI
   LI
   LO
   TS
CP0405322
6-chloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-piperazin-1-ylbenzimidazole
   Show/Hide
C25H28ClFN6
 1
1
EC50 = 9000 nM
   TI
   LI
   LO
   TS
CP0412659
2-N-(3-chlorophenyl)-4-N-(furan-2-ylmethyl)quinazoline-2,4-diamine
   Show/Hide
C19H15ClN4O
 1
1
EC50 = 9700 nM
   TI
   LI
   LO
   TS
CP0410993
6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-4-(4-methylpyrimidin-5-yl)-2-piperazin-1-ylbenzimidazole
   Show/Hide
C25H26ClFN6
 1
1
EC50 = 10200 nM
   TI
   LI
   LO
   TS
CP0387116
6-chloro-4-(2-chlorophenyl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-piperazin-1-ylbenzimidazole
   Show/Hide
C26H25Cl2FN4
 1
1
EC50 = 11000 nM
   TI
   LI
   LO
   TS
CP0410994
6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-4-(4-methylpyrimidin-5-yl)benzimidazole
   Show/Hide
C26H26ClFN6
 1
1
EC50 = 11400 nM
   TI
   LI
   LO
   TS
CP0412653
2-N-(3-chloro-4-fluorophenyl)-4-N-(furan-2-ylmethyl)quinazoline-2,4-diamine
   Show/Hide
C19H14ClFN4O
 1
1
EC50 = 13100 nM
   TI
   LI
   LO
   TS
CP0405324
5-[6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1-[(4-fluorophenyl)methyl]benzimidazol-4-yl]-4-methylpyrimidin-2-amine
   Show/Hide
C24H23ClFN7
 1
1
EC50 = 14000 nM
   TI
   LI
   LO
   TS
CP0410992
6-chloro-4-(2-chlorophenyl)-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]benzimidazole
   Show/Hide
C27H25Cl2FN4
 1
1
EC50 = 14000 nM
   TI
   LI
   LO
   TS
CP0387112
6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-4-(3,5-dimethyl-1H-pyrazol-4-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]benzimidazole
   Show/Hide
C26H28ClFN6
 1
1
EC50 = 14100 nM
   TI
   LI
   LO
   TS
CP0387115
6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-piperazin-1-ylbenzimidazole
   Show/Hide
C20H22ClFN4
 1
1
EC50 = 14500 nM
   TI
   LI
   LO
   TS
CP0401721
2-N-(3-chloro-4-fluorophenyl)-4-N-(cyclopropylmethyl)quinazoline-2,4-diamine
   Show/Hide
C18H16ClFN4
 1
1
EC50 = 16300 nM
   TI
   LI
   LO
   TS
CP0412651
2-furfuryl-[2-(m-toluidino)quinazolin-4-yl]amine;hydrochloride
   Show/Hide
C20H18N4O
 1
1
EC50 = 16400 nM
   TI
   LI
   LO
   TS
CP0387114
1-[(3-chloro-4-fluorophenyl)methyl]-2-piperazin-1-ylbenzimidazole
   Show/Hide
C18H18ClFN4
 1
1
EC50 = 21000 nM
   TI
   LI
   LO
   TS
CP0405321
1-[(3-chloro-4-fluorophenyl)methyl]-5,6-dimethyl-2-piperazin-1-ylbenzimidazole
   Show/Hide
C20H22ClFN4
 1
1
EC50 = 21300 nM
   TI
   LI
   LO
   TS
CP0471455
2-N-(3-chloro-4-fluorophenyl)-4-N-pentan-3-ylquinazoline-2,4-diamine
   Show/Hide
C19H20ClFN4
 1
1
EC50 = 21900 nM
   TI
   LI
   LO
   TS
CP0387118
1-[(3-chloro-4-fluorophenyl)methyl]-5,6-dimethylbenzimidazol-2-amine
   Show/Hide
C16H15ClFN3
 1
1
EC50 = 32200 nM
   TI
   LI
   LO
   TS
CP0387117
6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1-[(4-fluorophenyl)methyl]-4-(4-methylpyrimidin-5-yl)benzimidazole
   Show/Hide
C24H22ClFN6
 1
1
EC50 = 33200 nM
   TI
   LI
   LO
   TS
CP0412655
2-N-(3-chloro-4-fluorophenyl)-4-N-(cyclobutylmethyl)quinazoline-2,4-diamine
   Show/Hide
C19H18ClFN4
 1
1
EC50 = 44200 nM
   TI
   LI
   LO
   TS
CP0401719
2-N-(4-bromophenyl)-4-N-(furan-2-ylmethyl)quinazoline-2,4-diamine
   Show/Hide
C19H15BrN4O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0412652
2-N-(3,5-dichlorophenyl)-4-N-(furan-2-ylmethyl)quinazoline-2,4-diamine
   Show/Hide
C19H14Cl2N4O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0412654
N-[2-(3-chloro-4-fluoroanilino)quinazolin-4-yl]-N-(furan-2-ylmethyl)acetamide
   Show/Hide
C21H16ClFN4O2
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0412658
2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclopropylethyl]-8-morpholin-4-ylquinazoline-2,4-diamine
   Show/Hide
C23H25ClFN5O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0412660
(2-anilinoquinazolin-4-yl)-(2-furfuryl)amine;hydrochloride
   Show/Hide
C19H16N4O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0412662
2-N-(3,5-dimethylphenyl)-4-N-(furan-2-ylmethyl)quinazoline-2,4-diamine
   Show/Hide
C21H20N4O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0412663
2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclobutylpropyl]quinazoline-2,4-diamine
   Show/Hide
C21H22ClFN4
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0450622
2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclopropylethyl]-8-(2-ethoxyethyl)quinazoline-2,4-diamine
   Show/Hide
C23H26ClFN4O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0450623
2-N-(3,4-dichlorophenyl)-4-N-(furan-2-ylmethyl)quinazoline-2,4-diamine
   Show/Hide
C19H14Cl2N4O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0450626
2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclobutylethyl]quinazoline-2,4-diamine
   Show/Hide
C20H20ClFN4
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0458078
2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclopropyl-3-methylbutyl]quinazoline-2,4-diamine
   Show/Hide
C22H24ClFN4
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0458080
2-N-(3-chloro-4-fluorophenyl)-4-N-[(1S)-1-cyclopropylethyl]quinazoline-2,4-diamine
   Show/Hide
C19H18ClFN4
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0466679
2-furfuryl-[2-(p-toluidino)quinazolin-4-yl]amine;hydrochloride
   Show/Hide
C20H18N4O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0471454
1-[3-[[4-(furan-2-ylmethylamino)quinazolin-2-yl]amino]phenyl]ethanol
   Show/Hide
C21H20N4O2
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0471456
2-N-(3-chloro-4-fluorophenyl)-4-N-(2-methylpropyl)quinazoline-2,4-diamine
   Show/Hide
C18H18ClFN4
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0471458
2-N-(3-chloro-4-fluorophenyl)-4-N-[(1R)-1-cyclopropylethyl]-8-(3,6-dihydro-2H-pyran-4-yl)quinazoline-2,4-diamine
   Show/Hide
C24H24ClFN4O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0472108
2-[[2-(3-chloro-4-fluoroanilino)-4-[[(1R)-1-cyclopropylethyl]amino]quinazolin-8-yl]amino]ethanol
   Show/Hide
C21H23ClFN5O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0472110
4-N-(furan-2-ylmethyl)-2-N-(4-methoxyphenyl)quinazoline-2,4-diamine
   Show/Hide
C20H18N4O2
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0493018
2-N-(3-chloro-4-fluorophenyl)-4-N-ethyl-4-N-(furan-2-ylmethyl)quinazoline-2,4-diamine
   Show/Hide
C21H18ClFN4O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0530536
4-N-(furan-2-ylmethyl)-2-N-(3-methoxyphenyl)quinazoline-2,4-diamine
   Show/Hide
C20H18N4O2
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0536529
2-N-(3,4-dimethylphenyl)-4-N-(furan-2-ylmethyl)quinazoline-2,4-diamine
   Show/Hide
C21H20N4O
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0536531
2-N-(3-chloro-4-fluorophenyl)-4-N-(cyclopentylmethyl)quinazoline-2,4-diamine
   Show/Hide
C20H20ClFN4
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0536532
2-N-(3-chloro-4-fluorophenyl)-4-N-[(1S)-1-cyclopropylpropyl]quinazoline-2,4-diamine
   Show/Hide
C20H20ClFN4
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS