Brief Information of the Cell Line and Protein
Cell Line ID: CL000336 , HEPM
Synonyms
Human Embryonic Palatal Mesenchyme
Category Finite cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_2486
Protein ID: PT04361 , Protein smoothened
Gene Name SMO
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q99835
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000336  Protein ID: PT04361
 
Compound ID Compound Name Compound Formula
CP0062005
(R)-(3-methyl-4-(4-p-tolylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
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C27H26N4O
 1
1
IC50 = 0.4 nM
   TI
   LI
   LO
   TS
CP0324862
(R)-(4-(4-(4-chlorophenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H23ClN4O
 1
1
IC50 = 0.7 nM
   TI
   LI
   LO
   TS
CP0436829
(R)-(3-methyl-4-(1-(4-(trifluoromethyl)phenyl)pyrido[3,4-d]pyridazin-4-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H22F3N5O
 1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CP0158739
(R)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H24N4O
 1
1
IC50 = 2.2 nM
   TI
   LI
   LO
   TS
CP0294008
(R)-(4-(4-(4-cyclopropylphenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C29H28N4O
 1
1
IC50 = 2.3 nM
   TI
   LI
   LO
   TS
CP0158733
(R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C27H26N4O2
 1
1
IC50 = 2.7 nM
   TI
   LI
   LO
   TS
CP0061998
(R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C27H23F3N4O
 1
1
IC50 = 2.8 nM
   TI
   LI
   LO
   TS
CP0237452
(R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthalazin-1-yl)benzonitrile
   Show/Hide
C27H23N5O
 1
1
IC50 = 3.1 nM
   TI
   LI
   LO
   TS
CP0062015
(S)-(2-methyl-4-(4-p-tolylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C27H26N4O
 1
1
IC50 = 3.2 nM
   TI
   LI
   LO
   TS
CP0438767
(R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthalazin-1-yl)phenyl acetate
   Show/Hide
C28H26N4O3
 1
1
IC50 = 3.3 nM
   TI
   LI
   LO
   TS
CP0390820
(S)-(2-methyl-4-(4-(4-(trifluoromethyl)phenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C27H23F3N4O
 1
1
IC50 = 3.6 nM
   TI
   LI
   LO
   TS
CP0075317
[4-[4-(4-methylphenyl)phthalazin-1-yl]piperazin-1-yl]-phenylmethanone
   Show/Hide
C26H24N4O
 1
1
IC50 = 4.4 nM
   TI
   LI
   LO
   TS
CP0374211
(R)-2-(4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthalazin-1-yl)phenyl)acetamide
   Show/Hide
C28H27N5O2
 1
1
IC50 = 4.8 nM
   TI
   LI
   LO
   TS
CP0062026
(4-(4-(4-chlorophenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H21ClN4O
 1
1
IC50 = 5.2 nM
   TI
   LI
   LO
   TS
CP0503923
(R)-(4-(4-(4-(dimethylamino)phenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C28H29N5O
 2
1
IC50 = 5.2 nM
   TI
   LI
   LO
   TS
2
IC50 = 5.3 nM
   TI
   LI
   LO
   TS
CP0297663
(S)-(2-methyl-4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H24N4O
 1
1
IC50 = 5.3 nM
   TI
   LI
   LO
   TS
CP0062031
(S)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H24N4O
 2
1
IC50 = 5.3 nM
   TI
   LI
   LO
   TS
2
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0438769
(R)-(3-methyl-4-(1-phenylpyrido[3,4-d]pyridazin-4-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 5.8 nM
   TI
   LI
   LO
   TS
CP0505343
2-chloro-N-[4-(3-phenylphenyl)phenyl]benzamide
   Show/Hide
C25H18ClNO
 1
1
IC50 = 6.4 nM
   TI
   LI
   LO
   TS
CP0301002
(S)-(4-(4-(4-chlorophenyl)phthalazin-1-yl)-2-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H23ClN4O
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0438291
2-chloro-N-[4-(4-phenylpyridin-2-yl)phenyl]benzamide
   Show/Hide
C24H17ClN2O
 1
1
IC50 = 7.2 nM
   TI
   LI
   LO
   TS
CP0062001
(R)-(4-(4-(4-isopropylphenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C29H30N4O
 1
1
IC50 = 7.3 nM
   TI
   LI
   LO
   TS
CP0516443
(R)-(4-(4-(indolin-1-yl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C28H25N5O
 1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0503924
(R)-(4-(4-(1H-pyrrol-1-yl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C24H23N5O
 1
1
IC50 = 8.7 nM
   TI
   LI
   LO
   TS
CP0128039
(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(thiazol-2-yl)methanone
   Show/Hide
C22H19N5OS
 1
1
IC50 = 9.5 nM
   TI
   LI
   LO
   TS
CP0061999
(R)-(4-(4-(4-tert-butylphenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C30H32N4O
 1
1
IC50 = 10.1 nM
   TI
   LI
   LO
   TS
CP0302620
(4-(4-(4-fluorophenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H21FN4O
 1
1
IC50 = 10.8 nM
   TI
   LI
   LO
   TS
CP0158734
(S)-(4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H23FN4O
 1
1
IC50 = 11.8 nM
   TI
   LI
   LO
   TS
CP0436827
(S)-(4-(4-(4-fluorophenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H23FN4O
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0510392
(R)-(3-methyl-4-(4-phenylpyrido[4,3-d]pyridazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0158773
(R)-(2-methyl-4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H24N4O
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0294157
furan-2-yl-[4-(4-phenylphthalazin-1-yl)piperazin-1-yl]methanone
   Show/Hide
C23H20N4O2
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0499249
N-(4-benzamidophenyl)-2-chlorobenzamide
   Show/Hide
C20H15ClN2O2
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0512708
2-chloro-N-[4-(2-hydroxy-2-phenylethyl)phenyl]benzamide
   Show/Hide
C21H18ClNO2
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0062020
[4-[4-(2-methylphenyl)phthalazin-1-yl]piperazin-1-yl]-phenylmethanone
   Show/Hide
C26H24N4O
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0301010
(4-(4-(4-methoxyphenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H24N4O2
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0477750
(R)-(3-methyl-4-(5-phenylpyrido[2,3-d]pyridazin-8-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0062028
(4-(4-(3,4-dichlorophenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H20Cl2N4O
 2
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
2
IC50 = 17.3 nM
   TI
   LI
   LO
   TS
CP0037761
phenyl-[4-(4-phenylphthalazin-1-yl)piperazin-1-yl]methanone
   Show/Hide
C25H22N4O
 1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CP0504620
(R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthalazin-1-yl)benzamide
   Show/Hide
C27H25N5O2
 1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CP0075312
(4-(4-(3-methoxyphenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H24N4O2
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0062019
(4-(4-(2-chlorophenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H21ClN4O
 1
1
IC50 = 20.3 nM
   TI
   LI
   LO
   TS
CP0510391
(R)-(3-methyl-4-(4-(4-morpholinophenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C30H31N5O2
 1
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
CP0514577
(R)-(3-methyl-4-(4-(pyridin-4-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0399137
2-chloro-N-[4-(2-phenylpyrimidin-4-yl)phenyl]benzamide
   Show/Hide
C23H16ClN3O
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0494208
2-chloro-N-[4-(4-phenyl-1,3-thiazol-2-yl)phenyl]benzamide
   Show/Hide
C22H15ClN2OS
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0511551
2-chloro-N-[4-(5-phenylpyridin-3-yl)phenyl]benzamide
   Show/Hide
C24H17ClN2O
 1
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
CP0460050
2-chloro-N-[4-[4-phenyl-5-(trifluoromethyl)-1,3-oxazol-2-yl]phenyl]benzamide
   Show/Hide
C23H14ClF3N2O2
 1
1
IC50 = 31 nM
   TI
   LI
   LO
   TS
CP0511550
2-chloro-N-[4-(6-phenylpyridin-2-yl)phenyl]benzamide
   Show/Hide
C24H17ClN2O
 1
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
CP0466583
2-chloro-N-[4-(4-phenylpyrimidin-2-yl)phenyl]benzamide
   Show/Hide
C23H16ClN3O
 1
1
IC50 = 37 nM
   TI
   LI
   LO
   TS
CP0499263
2-chloro-N-[4-(5-phenyl-1,3-oxazol-2-yl)phenyl]benzamide
   Show/Hide
C22H15ClN2O2
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0460049
2-chloro-N-[4-(5-methyl-4-phenyl-1,3-oxazol-2-yl)phenyl]benzamide
   Show/Hide
C23H17ClN2O2
 1
1
IC50 = 44 nM
   TI
   LI
   LO
   TS
CP0531058
2-chloro-N-[4-(6-phenylpyrimidin-4-yl)phenyl]benzamide
   Show/Hide
C23H16ClN3O
 1
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
CP0466529
2-chloro-N-[4-[(E)-2-phenylethenyl]phenyl]benzamide
   Show/Hide
C21H16ClNO
 1
1
IC50 = 49 nM
   TI
   LI
   LO
   TS
CP0503921
(R)-(3-methyl-4-(4-(pyridin-2-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 57 nM
   TI
   LI
   LO
   TS
CP0508701
2-chloro-N-[4-(4-phenyl-1,3-oxazol-2-yl)phenyl]benzamide
   Show/Hide
C22H15ClN2O2
 1
1
IC50 = 63 nM
   TI
   LI
   LO
   TS
CP0503922
(R)-(3-methyl-4-(8-phenylpyrido[3,2-d]pyridazin-5-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 66 nM
   TI
   LI
   LO
   TS
CP0374212
(R)-(3-methyl-4-(4-(pyridin-3-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 79 nM
   TI
   LI
   LO
   TS
CP0466528
2-chloro-N-(4-phenacylphenyl)benzamide
   Show/Hide
C21H16ClNO2
 1
1
IC50 = 79 nM
   TI
   LI
   LO
   TS
CP0505438
2-chloro-N-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide
   Show/Hide
C21H14ClN3O2
 1
1
IC50 = 89 nM
   TI
   LI
   LO
   TS
CP0158775
1-(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)ethanone
   Show/Hide
C20H20N4O
 1
1
IC50 = 91 nM
   TI
   LI
   LO
   TS
CP0503341
2-chloro-N-[4-(2-phenylpyridin-4-yl)phenyl]benzamide
   Show/Hide
C24H17ClN2O
 1
1
IC50 = 93 nM
   TI
   LI
   LO
   TS
CP0503342
2-chloro-N-[4-(2-phenyl-1,3-oxazol-4-yl)phenyl]benzamide
   Show/Hide
C22H15ClN2O2
 1
1
IC50 = 93 nM
   TI
   LI
   LO
   TS
CP0075307
(S)-(2-methyl-4-(4-(pyridin-4-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 96 nM
   TI
   LI
   LO
   TS
CP0498749
2-chloro-N-[4-(2-phenyl-1,3-thiazol-4-yl)phenyl]benzamide
   Show/Hide
C22H15ClN2OS
 1
1
IC50 = 109 nM
   TI
   LI
   LO
   TS
CP0294155
(S)-(2-methyl-4-(4-(pyridin-2-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0062022
3-(4-(4-benzoylpiperazin-1-yl)phthalazin-1-yl)benzonitrile
   Show/Hide
C26H21N5O
 1
1
IC50 = 212 nM
   TI
   LI
   LO
   TS
CP0062018
(S)-(2-methyl-4-(4-(pyridin-3-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 213 nM
   TI
   LI
   LO
   TS
CP0035818
(S)-(2-methyl-4-(4-(pyridazin-1(6H)-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C24H24N6O
 1
1
IC50 = 2340 nM
   TI
   LI
   LO
   TS
CP0180062
(S)-(2-methyl-4-(4-(oxazol-2-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C23H21N5O2
 1
1
IC50 = 2700 nM
   TI
   LI
   LO
   TS
CP0374213
(R)-(4-(4-(1H-imidazol-1-yl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C23H22N6O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0388693
(R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthalazin-1-yl)benzoic acid
   Show/Hide
C27H24N4O3
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0400823
(R)-(4-(4-(furan-2-yl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C23H21N5O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0430788
(R)-(4-(4-(pyrimidin-5-yl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C24H22N6O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0868072
(R)-(3-methyl-4-(4-(pyridazin-1(2H)-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C24H24N6O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS