General Information of the Cell Line
Cell Line ID
CL000336
Cell Line Name
HEPM
Synonyms
Human Embryonic Palatal Mesenchyme
Category
Finite cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_2486
Tissue Information
Oral cavity
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT04361, Protein smoothened
Compound ID Compound Name Compound Formula
CP0062005
(R)-(3-methyl-4-(4-p-tolylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C27H26N4O
 1
1
IC50 = 0.4 nM
   TI
   LI
   LO
   TS
CP0324862
(R)-(4-(4-(4-chlorophenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H23ClN4O
 1
1
IC50 = 0.7 nM
   TI
   LI
   LO
   TS
CP0436829
(R)-(3-methyl-4-(1-(4-(trifluoromethyl)phenyl)pyrido[3,4-d]pyridazin-4-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H22F3N5O
 1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CP0158739
(R)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H24N4O
 1
1
IC50 = 2.2 nM
   TI
   LI
   LO
   TS
CP0294008
(R)-(4-(4-(4-cyclopropylphenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C29H28N4O
 1
1
IC50 = 2.3 nM
   TI
   LI
   LO
   TS
CP0158733
(R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C27H26N4O2
 1
1
IC50 = 2.7 nM
   TI
   LI
   LO
   TS
CP0061998
(R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C27H23F3N4O
 1
1
IC50 = 2.8 nM
   TI
   LI
   LO
   TS
CP0237452
(R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthalazin-1-yl)benzonitrile
   Show/Hide
C27H23N5O
 1
1
IC50 = 3.1 nM
   TI
   LI
   LO
   TS
CP0062015
(S)-(2-methyl-4-(4-p-tolylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C27H26N4O
 1
1
IC50 = 3.2 nM
   TI
   LI
   LO
   TS
CP0438767
(R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthalazin-1-yl)phenyl acetate
   Show/Hide
C28H26N4O3
 1
1
IC50 = 3.3 nM
   TI
   LI
   LO
   TS
CP0390820
(S)-(2-methyl-4-(4-(4-(trifluoromethyl)phenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C27H23F3N4O
 1
1
IC50 = 3.6 nM
   TI
   LI
   LO
   TS
CP0075317
[4-[4-(4-methylphenyl)phthalazin-1-yl]piperazin-1-yl]-phenylmethanone
   Show/Hide
C26H24N4O
 1
1
IC50 = 4.4 nM
   TI
   LI
   LO
   TS
CP0374211
(R)-2-(4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthalazin-1-yl)phenyl)acetamide
   Show/Hide
C28H27N5O2
 1
1
IC50 = 4.8 nM
   TI
   LI
   LO
   TS
CP0062026
(4-(4-(4-chlorophenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H21ClN4O
 1
1
IC50 = 5.2 nM
   TI
   LI
   LO
   TS
CP0503923
(R)-(4-(4-(4-(dimethylamino)phenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C28H29N5O
 2
1
IC50 = 5.2 nM
   TI
   LI
   LO
   TS
2
IC50 = 5.3 nM
   TI
   LI
   LO
   TS
CP0297663
(S)-(2-methyl-4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H24N4O
 1
1
IC50 = 5.3 nM
   TI
   LI
   LO
   TS
CP0062031
(S)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H24N4O
 2
1
IC50 = 5.3 nM
   TI
   LI
   LO
   TS
2
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0438769
(R)-(3-methyl-4-(1-phenylpyrido[3,4-d]pyridazin-4-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 5.8 nM
   TI
   LI
   LO
   TS
CP0505343
2-chloro-N-[4-(3-phenylphenyl)phenyl]benzamide
   Show/Hide
C25H18ClNO
 1
1
IC50 = 6.4 nM
   TI
   LI
   LO
   TS
CP0301002
(S)-(4-(4-(4-chlorophenyl)phthalazin-1-yl)-2-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H23ClN4O
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0438291
2-chloro-N-[4-(4-phenylpyridin-2-yl)phenyl]benzamide
   Show/Hide
C24H17ClN2O
 1
1
IC50 = 7.2 nM
   TI
   LI
   LO
   TS
CP0062001
(R)-(4-(4-(4-isopropylphenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C29H30N4O
 1
1
IC50 = 7.3 nM
   TI
   LI
   LO
   TS
CP0516443
(R)-(4-(4-(indolin-1-yl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C28H25N5O
 1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0503924
(R)-(4-(4-(1H-pyrrol-1-yl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C24H23N5O
 1
1
IC50 = 8.7 nM
   TI
   LI
   LO
   TS
CP0128039
(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(thiazol-2-yl)methanone
   Show/Hide
C22H19N5OS
 1
1
IC50 = 9.5 nM
   TI
   LI
   LO
   TS
CP0061999
(R)-(4-(4-(4-tert-butylphenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C30H32N4O
 1
1
IC50 = 10.1 nM
   TI
   LI
   LO
   TS
CP0302620
(4-(4-(4-fluorophenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H21FN4O
 1
1
IC50 = 10.8 nM
   TI
   LI
   LO
   TS
CP0158734
(S)-(4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H23FN4O
 1
1
IC50 = 11.8 nM
   TI
   LI
   LO
   TS
CP0436827
(S)-(4-(4-(4-fluorophenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H23FN4O
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0510392
(R)-(3-methyl-4-(4-phenylpyrido[4,3-d]pyridazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0158773
(R)-(2-methyl-4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H24N4O
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0294157
furan-2-yl-[4-(4-phenylphthalazin-1-yl)piperazin-1-yl]methanone
   Show/Hide
C23H20N4O2
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0499249
N-(4-benzamidophenyl)-2-chlorobenzamide
   Show/Hide
C20H15ClN2O2
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0512708
2-chloro-N-[4-(2-hydroxy-2-phenylethyl)phenyl]benzamide
   Show/Hide
C21H18ClNO2
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0062020
[4-[4-(2-methylphenyl)phthalazin-1-yl]piperazin-1-yl]-phenylmethanone
   Show/Hide
C26H24N4O
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0301010
(4-(4-(4-methoxyphenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H24N4O2
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0477750
(R)-(3-methyl-4-(5-phenylpyrido[2,3-d]pyridazin-8-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0062028
(4-(4-(3,4-dichlorophenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H20Cl2N4O
 2
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
2
IC50 = 17.3 nM
   TI
   LI
   LO
   TS
CP0037761
phenyl-[4-(4-phenylphthalazin-1-yl)piperazin-1-yl]methanone
   Show/Hide
C25H22N4O
 1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CP0504620
(R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthalazin-1-yl)benzamide
   Show/Hide
C27H25N5O2
 1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CP0075312
(4-(4-(3-methoxyphenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C26H24N4O2
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0062019
(4-(4-(2-chlorophenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H21ClN4O
 1
1
IC50 = 20.3 nM
   TI
   LI
   LO
   TS
CP0510391
(R)-(3-methyl-4-(4-(4-morpholinophenyl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C30H31N5O2
 1
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
CP0514577
(R)-(3-methyl-4-(4-(pyridin-4-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0399137
2-chloro-N-[4-(2-phenylpyrimidin-4-yl)phenyl]benzamide
   Show/Hide
C23H16ClN3O
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0494208
2-chloro-N-[4-(4-phenyl-1,3-thiazol-2-yl)phenyl]benzamide
   Show/Hide
C22H15ClN2OS
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0511551
2-chloro-N-[4-(5-phenylpyridin-3-yl)phenyl]benzamide
   Show/Hide
C24H17ClN2O
 1
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
CP0460050
2-chloro-N-[4-[4-phenyl-5-(trifluoromethyl)-1,3-oxazol-2-yl]phenyl]benzamide
   Show/Hide
C23H14ClF3N2O2
 1
1
IC50 = 31 nM
   TI
   LI
   LO
   TS
CP0511550
2-chloro-N-[4-(6-phenylpyridin-2-yl)phenyl]benzamide
   Show/Hide
C24H17ClN2O
 1
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
CP0466583
2-chloro-N-[4-(4-phenylpyrimidin-2-yl)phenyl]benzamide
   Show/Hide
C23H16ClN3O
 1
1
IC50 = 37 nM
   TI
   LI
   LO
   TS
CP0499263
2-chloro-N-[4-(5-phenyl-1,3-oxazol-2-yl)phenyl]benzamide
   Show/Hide
C22H15ClN2O2
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0460049
2-chloro-N-[4-(5-methyl-4-phenyl-1,3-oxazol-2-yl)phenyl]benzamide
   Show/Hide
C23H17ClN2O2
 1
1
IC50 = 44 nM
   TI
   LI
   LO
   TS
CP0531058
2-chloro-N-[4-(6-phenylpyrimidin-4-yl)phenyl]benzamide
   Show/Hide
C23H16ClN3O
 1
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
CP0466529
2-chloro-N-[4-[(E)-2-phenylethenyl]phenyl]benzamide
   Show/Hide
C21H16ClNO
 1
1
IC50 = 49 nM
   TI
   LI
   LO
   TS
CP0503921
(R)-(3-methyl-4-(4-(pyridin-2-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 57 nM
   TI
   LI
   LO
   TS
CP0508701
2-chloro-N-[4-(4-phenyl-1,3-oxazol-2-yl)phenyl]benzamide
   Show/Hide
C22H15ClN2O2
 1
1
IC50 = 63 nM
   TI
   LI
   LO
   TS
CP0503922
(R)-(3-methyl-4-(8-phenylpyrido[3,2-d]pyridazin-5-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 66 nM
   TI
   LI
   LO
   TS
CP0374212
(R)-(3-methyl-4-(4-(pyridin-3-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 79 nM
   TI
   LI
   LO
   TS
CP0466528
2-chloro-N-(4-phenacylphenyl)benzamide
   Show/Hide
C21H16ClNO2
 1
1
IC50 = 79 nM
   TI
   LI
   LO
   TS
CP0505438
2-chloro-N-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide
   Show/Hide
C21H14ClN3O2
 1
1
IC50 = 89 nM
   TI
   LI
   LO
   TS
CP0158775
1-(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)ethanone
   Show/Hide
C20H20N4O
 1
1
IC50 = 91 nM
   TI
   LI
   LO
   TS
CP0503341
2-chloro-N-[4-(2-phenylpyridin-4-yl)phenyl]benzamide
   Show/Hide
C24H17ClN2O
 1
1
IC50 = 93 nM
   TI
   LI
   LO
   TS
CP0503342
2-chloro-N-[4-(2-phenyl-1,3-oxazol-4-yl)phenyl]benzamide
   Show/Hide
C22H15ClN2O2
 1
1
IC50 = 93 nM
   TI
   LI
   LO
   TS
CP0075307
(S)-(2-methyl-4-(4-(pyridin-4-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 96 nM
   TI
   LI
   LO
   TS
CP0498749
2-chloro-N-[4-(2-phenyl-1,3-thiazol-4-yl)phenyl]benzamide
   Show/Hide
C22H15ClN2OS
 1
1
IC50 = 109 nM
   TI
   LI
   LO
   TS
CP0294155
(S)-(2-methyl-4-(4-(pyridin-2-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0062022
3-(4-(4-benzoylpiperazin-1-yl)phthalazin-1-yl)benzonitrile
   Show/Hide
C26H21N5O
 1
1
IC50 = 212 nM
   TI
   LI
   LO
   TS
CP0062018
(S)-(2-methyl-4-(4-(pyridin-3-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C25H23N5O
 1
1
IC50 = 213 nM
   TI
   LI
   LO
   TS
CP0035818
(S)-(2-methyl-4-(4-(pyridazin-1(6H)-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C24H24N6O
 1
1
IC50 = 2340 nM
   TI
   LI
   LO
   TS
CP0180062
(S)-(2-methyl-4-(4-(oxazol-2-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C23H21N5O2
 1
1
IC50 = 2700 nM
   TI
   LI
   LO
   TS
CP0374213
(R)-(4-(4-(1H-imidazol-1-yl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C23H22N6O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0388693
(R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthalazin-1-yl)benzoic acid
   Show/Hide
C27H24N4O3
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0400823
(R)-(4-(4-(furan-2-yl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C23H21N5O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0430788
(R)-(4-(4-(pyrimidin-5-yl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone
   Show/Hide
C24H22N6O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0868072
(R)-(3-methyl-4-(4-(pyridazin-1(2H)-yl)phthalazin-1-yl)piperazin-1-yl)(phenyl)methanone
   Show/Hide
C24H24N6O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line