Brief Information of the Cell Line and Protein
Cell Line ID: CL000426 , Shh Light II
Synonyms
Shh-Light II
Shh Light 2
Shh LIGHT 2
Shh Light2
Shh-Light2
Shh-L2
Category Spontaneously immortalized cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_2721
Protein ID: PT02397 , Protein smoothened
Gene Name SMO
Organism Mus musculus, Mouse
Protein Classification Membrane receptor
Uniprot ID P56726
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000426  Protein ID: PT02397
 
Compound ID Compound Name Compound Formula
CP0270436
(2R)-N-[4-chloro-3-(1-methylbenzimidazol-2-yl)phenyl]-2-[(5R,8S)-2,5-dimethyl-5,6,7,8-tetrahydroquinolin-8-yl]propanamide
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C28H29ClN4O
 4
1
EC50 = 24.35 nM
   TI
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2
EC50 = 47 nM
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3
EC50 = 136.6 nM
   TI
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4
IC50 = 9.53 nM
   TI
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CP0068085
2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide
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C19H14Cl2N2O3S
 1
1
IC50 = 39.2 nM
   TI
   LI
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CP0566824
(2R)-N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-2-[(5R,8S)-2,5-dimethyl-5,6,7,8-tetrahydroquinolin-8-yl]propanamide
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C27H27ClN4O
 1
1
IC50 = 45.9 nM
   TI
   LI
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CP0518008
(2R)-N-[4-chloro-3-[1-methyl-6-(trifluoromethoxy)benzimidazol-2-yl]phenyl]-2-[(5R,8S)-2,5-dimethyl-5,6,7,8-tetrahydroquinolin-8-yl]propanamide
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C29H28ClF3N4O2
 1
1
IC50 = 52.6 nM
   TI
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CP0558050
(2R)-N-[4-chloro-3-[1-methyl-5-(trifluoromethoxy)benzimidazol-2-yl]phenyl]-2-[(5R,8S)-2,5-dimethyl-5,6,7,8-tetrahydroquinolin-8-yl]propanamide
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C29H28ClF3N4O2
 1
1
IC50 = 84.5 nM
   TI
   LI
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   TS
CP0445996
(2R)-N-(4-chloro-3-pyridin-2-ylphenyl)-2-[(5R,8S)-5-methyl-2-(morpholin-4-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-yl]propanamide
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C29H33ClN4O2
 1
1
IC50 = 155 nM
   TI
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CP0455534
(1R,4S,5R,8S,9S,12R)-N-(4-chloro-3-pyridin-2-ylphenyl)-1,5,9-trimethyl-10,13,14,15-tetraoxatetracyclo[9.3.1.04,12.08,12]pentadecane-9-carboxamide
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C26H29ClN2O5
 1
1
IC50 = 180 nM
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CP0432755
N-(4-chloro-3-pyridin-2-ylphenyl)-2-[(1S,4S,5R,8S,9R,10R,12R,13R)-1,5,9-trimethyl-11,14,15-trioxatetracyclo[10.2.1.04,13.08,13]pentadecan-10-yl]acetamide
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C28H33ClN2O4
 1
1
IC50 = 184 nM
   TI
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CP0131462
(2R)-N-(4-chloro-3-pyridin-2-ylphenyl)-2-[(5R,8S)-2,5-dimethyl-5,6,7,8-tetrahydroquinolin-8-yl]propanamide
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C25H26ClN3O
 1
1
IC50 = 212 nM
   TI
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   TS
CP0562449
(2R)-N-[4-chloro-3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl]-2-[(5R,8S)-2,5-dimethyl-5,6,7,8-tetrahydroquinolin-8-yl]propanamide
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C25H27ClN4O2
 1
1
IC50 = 220 nM
   TI
   LI
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   TS
CP0562308
N-(4-chloro-3-pyridin-2-ylphenyl)-2-[(1R,4S,5R,8S,9R,10R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]acetamide
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C28H33ClN2O5
 1
1
IC50 = 241 nM
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CP0551409
(2R)-N-[3-(1,3-benzoxazol-2-yl)-4-chlorophenyl]-2-[(5R,8S)-2,5-dimethyl-5,6,7,8-tetrahydroquinolin-8-yl]propanamide
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C27H26ClN3O2
 1
1
IC50 = 243 nM
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CP0388908
(2R)-N-[4-chloro-3-[5-(2-methylpyrazol-3-yl)-1,3,4-thiadiazol-2-yl]phenyl]-2-[(5R,8S)-2,5-dimethyl-5,6,7,8-tetrahydroquinolin-8-yl]propanamide
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C26H27ClN6OS
 1
1
IC50 = 265 nM
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CP0432753
methyl (2R)-2-[2-[(4-chloro-3-pyridin-2-ylphenyl)carbamoyl]-5-methylquinolin-8-yl]propanoate
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C26H22ClN3O3
 1
1
IC50 = 270 nM
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CP0445917
(2R)-N-[3-(1,3-benzothiazol-2-yl)-4-chlorophenyl]-2-[(5R,8S)-2,5-dimethyl-5,6,7,8-tetrahydroquinolin-8-yl]propanamide
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C27H26ClN3OS
 1
1
IC50 = 282 nM
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CP0558051
(2R)-2-[(1R,4R,4aS,8aS)-4-methyl-7-oxo-2,3,4,4a,5,6,8,8a-octahydro-1H-naphthalen-1-yl]-N-(4-chloro-3-pyridin-2-ylphenyl)propanamide
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C25H29ClN2O2
 1
1
IC50 = 290 nM
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CP0566850
(2R)-2-[(4aS,5R,8R,8aS)-5-methyl-1-phenyl-4,4a,5,6,7,8,8a,9-octahydrobenzo[f]indazol-8-yl]-N-(4-chloro-3-pyridin-2-ylphenyl)propanamide
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C32H33ClN4O
 1
1
IC50 = 327 nM
   TI
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CP0566849
(2R)-2-[(6aS,7R,10R,10aS)-5,10-dimethyl-6,6a,7,8,9,10,10a,11-octahydrobenzo[b]carbazol-7-yl]-N-(4-chloro-3-pyridin-2-ylphenyl)propanamide
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C32H34ClN3O
 1
1
IC50 = 476 nM
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CP0543467
(2R)-N-[4-chloro-3-[5-(2-methylpyrazol-3-yl)-1,3,4-oxadiazol-2-yl]phenyl]-2-[(5R,8S)-2,5-dimethyl-5,6,7,8-tetrahydroquinolin-8-yl]propanamide
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C26H27ClN6O2
 1
1
IC50 = 588 nM
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CP0388909
(2R)-2-[(5R,8S)-2,5-dimethyl-5,6,7,8-tetrahydroquinolin-8-yl]-N-[2-methyl-3-[4-(trifluoromethoxy)phenyl]phenyl]propanamide
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C28H29F3N2O2
 1
1
IC50 = 1000 nM
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CP0432754
(2R)-2-[(4aS,5R,8R,8aS)-2,8-dimethyl-4,4a,5,6,7,8,8a,9-octahydrobenzo[f][1,3]benzothiazol-5-yl]-N-(4-chloro-3-pyridin-2-ylphenyl)propanamide
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C27H30ClN3OS
 1
1
IC50 > 1000 nM
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CP0510632
(2R)-2-[(4aS,5R,8R,8aS)-2-acetamido-8-methyl-4,4a,5,6,7,8,8a,9-octahydrobenzo[f][1,3]benzothiazol-5-yl]-N-(4-chloro-3-pyridin-2-ylphenyl)propanamide
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C28H31ClN4O2S
 1
1
IC50 > 1000 nM
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CP0510633
(2R)-2-[(1R,4R,4aS,8aS)-7-hydroxy-4-methyl-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-1-yl]-N-(4-chloro-3-pyridin-2-ylphenyl)propanamide
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C25H31ClN2O2
 1
1
IC50 > 1000 nM
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CP0543468
(2R)-N-[4-chloro-3-[5-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-2-yl]phenyl]-2-[(5R,8S)-2,5-dimethyl-5,6,7,8-tetrahydroquinolin-8-yl]propanamide
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C31H37ClN4O2
 1
1
IC50 > 1000 nM
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CP0562307
(2R)-N-[4-chloro-3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2-[(5R,8S)-2,5-dimethyl-5,6,7,8-tetrahydroquinolin-8-yl]propanamide
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C23H25ClN4O2
 1
1
IC50 > 1000 nM
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CP0564637
(2R)-2-[(1R,4R,4aR,8aR)-4-methyl-7-oxo-2,3,4,4a,8,8a-hexahydro-1H-naphthalen-1-yl]-N-(4-chloro-3-pyridin-2-ylphenyl)propanamide
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C25H27ClN2O2
 1
1
IC50 > 1000 nM
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CP0564638
(2R)-2-[(1S,4R,4aS)-4-methyl-7-oxo-2,3,4,4a,5,6-hexahydro-1H-naphthalen-1-yl]-N-(4-chloro-3-pyridin-2-ylphenyl)propanamide
   Show/Hide
C25H27ClN2O2
 1
1
IC50 > 1000 nM
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