General Information of the Compound
Compound ID
CP0432753
Compound Name
methyl (2R)-2-[2-[(4-chloro-3-pyridin-2-ylphenyl)carbamoyl]-5-methylquinolin-8-yl]propanoate
    Show/Hide
Structure
Formula
C26H22ClN3O3
Molecular Weight
459.933
Canonical SMILES
COC(=O)[C@H](C)c1ccc(C)c2ccc(nc12)C(=O)Nc1ccc(Cl)c(c1)-c1ccccn1
    Show/Hide
InChI
InChI=1S/C26H22ClN3O3/c1-15-7-9-19(16(2)26(32)33-3)24-18(15)10-12-23(30-24)25(31)29-17-8-11-21(27)20(14-17)22-6-4-5-13-28-22/h4-14,16H,1-3H3,(H,29,31)/t16-/m1/s1
    Show/Hide
InChIKey
XFVHLKZDDHYLSX-MRXNPFEDSA-N
Physicochemical Property
logP
5.78742
Rotatable Bonds
5
Heavy Atom Count
33
Polar Areas
81.18
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 134147491
ChEMBL ID
CHEMBL3949509
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02397, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000426 Shh Light II Mus musculus (Mouse)  1
1
IC50 = 270 nM
   TI
   LI
   LO
   TS