Brief Information of the Cell Line and Protein
Cell Line ID: CL000082 , HEL
Synonyms
Hel
GM06141
GM06141B
Human ErythroLeukemia
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0001
Protein ID: PT02259 , Neuropeptide Y receptor type 1
Gene Name NPY1R
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P25929
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000082  Protein ID: PT02259
 
Compound ID Compound Name Compound Formula
CP0382183
(R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylacetamido)-5-oxopentylamino)(amino)methylene)ureido)acetate
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C32H38N6O6
 10
1
IC50 = 0.05012 nM
   TI
   LI
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2
IC50 = 0.0631 nM
   TI
   LI
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3
IC50 = 0.1259 nM
   TI
   LI
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4
IC50 = 0.1698 nM
   TI
   LI
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5
IC50 = 0.4266 nM
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   LI
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6
IC50 = 0.7079 nM
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7
IC50 = 2.754 nM
   TI
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8
IC50 = 8.24 nM
   TI
   LI
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9
Ki = 0.12 nM
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10
Ki = 0.3 nM
   TI
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   TS
CP0562221
(2R)-5-[[amino-[2-[(2-fluoroacetyl)amino]ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
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C34H39F4N7O7
 1
1
IC50 = 0.05495 nM
   TI
   LI
   LO
   TS
CP0551789
(2R)-5-[[amino-[2-[(2-bromoacetyl)amino]ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C34H39BrF3N7O7
 1
1
IC50 = 0.06166 nM
   TI
   LI
   LO
   TS
CP0567542
(2R)-5-[[amino-[2-(2-methylpropanoylamino)ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
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C36H44F3N7O7
 1
1
IC50 = 0.06607 nM
   TI
   LI
   LO
   TS
CP0553601
(2R)-5-[[amino-[2-[(2-chloroacetyl)amino]ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
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C34H39ClF3N7O7
 1
1
IC50 = 0.07943 nM
   TI
   LI
   LO
   TS
CP0560329
(2R)-5-[[amino-[2-[(2-hydroxyacetyl)amino]ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C34H40F3N7O8
 1
1
IC50 = 0.0912 nM
   TI
   LI
   LO
   TS
CP0181598
(R)-1-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylacetamido)-5-oxopentylamino)(amino)methylene)-3-ethylurea
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C30H36N6O4
 7
1
IC50 = 0.1 nM
   TI
   LI
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   TS
2
IC50 = 0.1202 nM
   TI
   LI
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3
IC50 = 0.2399 nM
   TI
   LI
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4
IC50 = 0.4786 nM
   TI
   LI
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5
IC50 = 1.23 nM
   TI
   LI
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6
IC50 = 8 nM
   TI
   LI
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   TS
7
Ki = 0.24 nM
   TI
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   TS
CP0403846
ethyl 3-[[N'-[(4R)-4-[(2,2-diphenylacetyl)amino]-5-[(4-hydroxyphenyl)methylamino]-5-oxopentyl]carbamimidoyl]carbamoylamino]propanoate
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C33H40N6O6
 8
1
IC50 = 0.1 nM
   TI
   LI
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2
IC50 = 0.1047 nM
   TI
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3
IC50 = 0.1514 nM
   TI
   LI
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4
IC50 = 0.1622 nM
   TI
   LI
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5
IC50 = 0.3311 nM
   TI
   LI
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6
IC50 = 0.5129 nM
   TI
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   TS
7
IC50 = 1.445 nM
   TI
   LI
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8
Ki = 0.3 nM
   TI
   LI
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   TS
CP0382200
(2R)-5-[[amino-[2-(propanoylamino)ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
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C37H43F6N7O9
 8
1
IC50 = 0.1 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.1288 nM
   TI
   LI
   LO
   TS
3
IC50 = 0.1698 nM
   TI
   LI
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   TS
4
IC50 = 0.4169 nM
   TI
   LI
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5
IC50 = 0.871 nM
   TI
   LI
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6
IC50 = 2.399 nM
   TI
   LI
   LO
   TS
7
IC50 = 7.61 nM
   TI
   LI
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   TS
8
Ki = 0.1 nM
   TI
   LI
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   TS
CP0551784
(2R)-5-[[amino-[2-[(2,2-difluoroacetyl)amino]ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
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C34H38F5N7O7
 1
1
IC50 = 0.1096 nM
   TI
   LI
   LO
   TS
CP0565084
(2R)-5-[[amino-[2-[(2,2,2-trifluoroacetyl)amino]ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
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C34H37F6N7O7
 1
1
IC50 = 0.1259 nM
   TI
   LI
   LO
   TS
CP0552786
(2R)-5-[[amino-[2-(prop-2-enoylamino)ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
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C35H40F3N7O7
 1
1
IC50 = 0.1862 nM
   TI
   LI
   LO
   TS
CP0385636
(2R)-5-[[amino-[(1-methyltriazol-4-yl)methylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C34H38F3N9O6
 6
1
IC50 = 0.195 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.2188 nM
   TI
   LI
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3
IC50 = 0.3467 nM
   TI
   LI
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4
IC50 = 0.871 nM
   TI
   LI
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5
IC50 = 1.698 nM
   TI
   LI
   LO
   TS
6
IC50 = 4.266 nM
   TI
   LI
   LO
   TS
CP0553604
N-[2-[[N'-[(4R)-4-[(2,2-diphenylacetyl)amino]-5-[(4-hydroxyphenyl)methylamino]-5-oxopentyl]carbamimidoyl]carbamoylamino]ethyl]cyclopropanecarboxamide;2,2,2-trifluoroacetic acid
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C36H42F3N7O7
 1
1
IC50 = 0.2399 nM
   TI
   LI
   LO
   TS
CP0553605
N-[2-[[N'-[(4R)-4-[(2,2-diphenylacetyl)amino]-5-[(4-hydroxyphenyl)methylamino]-5-oxopentyl]carbamimidoyl]carbamoylamino]ethyl]cyclobutanecarboxamide;2,2,2-trifluoroacetic acid
   Show/Hide
C37H44F3N7O7
 1
1
IC50 = 0.2399 nM
   TI
   LI
   LO
   TS
CP0553607
(2R)-5-[[amino-[2-[(2-aminoacetyl)amino]ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C34H41F3N8O7
 1
1
IC50 = 0.2818 nM
   TI
   LI
   LO
   TS
CP0553603
(2R)-5-[[amino-[2-(3-bromopropanoylamino)ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C35H41BrF3N7O7
 1
1
IC50 = 0.4074 nM
   TI
   LI
   LO
   TS
CP0511921
(2R)-5-[[amino-[2-(3-chloropropanoylamino)ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C35H41ClF3N7O7
 1
1
IC50 = 0.5888 nM
   TI
   LI
   LO
   TS
CP0551788
N-[2-[[N'-[(4R)-4-[(2,2-diphenylacetyl)amino]-5-[(4-hydroxyphenyl)methylamino]-5-oxopentyl]carbamimidoyl]carbamoylamino]ethyl]cyclopentanecarboxamide;2,2,2-trifluoroacetic acid
   Show/Hide
C38H46F3N7O7
 1
1
IC50 = 7.586 nM
   TI
   LI
   LO
   TS
CP0084655
(R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hydroxybenzyl)pentanamide
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C27H31N5O3
 4
1
IC50 = 10.23 nM
   TI
   LI
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   TS
2
IC50 = 11.75 nM
   TI
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3
IC50 = 16.22 nM
   TI
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4
Ki = 1.5 nM
   TI
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CP0551785
N-[2-[[N'-[(4R)-4-[(2,2-diphenylacetyl)amino]-5-[(4-hydroxyphenyl)methylamino]-5-oxopentyl]carbamimidoyl]carbamoylamino]ethyl]benzamide;2,2,2-trifluoroacetic acid
   Show/Hide
C39H42F3N7O7
 1
1
IC50 = 11.48 nM
   TI
   LI
   LO
   TS
CP0551787
(2R)-5-[[amino-[2-(2,2-dimethylpropanoylamino)ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C37H46F3N7O7
 1
1
IC50 = 14.45 nM
   TI
   LI
   LO
   TS
CP0551786
N-[2-[[N'-[(4R)-4-[(2,2-diphenylacetyl)amino]-5-[(4-hydroxyphenyl)methylamino]-5-oxopentyl]carbamimidoyl]carbamoylamino]ethyl]-4-fluorobenzamide;2,2,2-trifluoroacetic acid
   Show/Hide
C39H41F4N7O7
 1
1
IC50 = 16.22 nM
   TI
   LI
   LO
   TS
CP0155302
BIBP3226
   Show/Hide
C27H31N5O3
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0551790
N-[2-[[N'-[(4R)-4-[(2,2-diphenylacetyl)amino]-5-[(4-hydroxyphenyl)methylamino]-5-oxopentyl]carbamimidoyl]carbamoylamino]ethyl]cyclohexanecarboxamide;2,2,2-trifluoroacetic acid
   Show/Hide
C39H48F3N7O7
 1
1
IC50 = 30.9 nM
   TI
   LI
   LO
   TS
CP0458887
2-Diphenylacetylamino-5-guanidino-pentanoic acid [1-(4-hydroxy-phenyl)-ethyl]-amide
   Show/Hide
C28H33N5O3
 1
1
IC50 = 60 nM
   TI
   LI
   LO
   TS
CP0403975
2-[2-(4-Chloro-phenyl)-2-phenyl-acetylamino]-5-guanidino-pentanoic acid benzylamide
   Show/Hide
C27H30ClN5O2
 1
1
IC50 = 81 nM
   TI
   LI
   LO
   TS
CP0551791
(2R)-5-[[amino-[2-[(2-phenylacetyl)amino]ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C40H44F3N7O7
 1
1
IC50 = 95.5 nM
   TI
   LI
   LO
   TS
CP0489006
2-[2,2-Bis-(4-chloro-phenyl)-acetylamino]-5-guanidino-pentanoic acid benzylamide
   Show/Hide
C27H29Cl2N5O2
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0510580
2-Diphenylacetylamino-5-guanidino-pentanoic acid benzylamide
   Show/Hide
C27H31N5O2
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0894056
2-Diphenylacetylamino-5-guanidino-pentanoic acid ((R)-1-phenyl-ethyl)-amide
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C28H33N5O2
 1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0403793
N-[5-(diaminomethylideneamino)-1-(7-hydroxy-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-1-oxopentan-2-yl]-2,2-diphenylacetamide
   Show/Hide
C30H35N5O3
 1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0562222
(2R)-5-[[amino-[2-[(2-cyclohexylacetyl)amino]ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C40H50F3N7O7
 1
1
IC50 = 457.09 nM
   TI
   LI
   LO
   TS
CP0551792
(2R)-5-[[amino-[2-[(2,2-diphenylacetyl)amino]ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;2,2,2-trifluoroacetic acid
   Show/Hide
C46H48F3N7O7
 1
1
IC50 = 524.81 nM
   TI
   LI
   LO
   TS
CP0377492
2-Diphenylacetylamino-5-guanidino-pentanoic acid ((S)-2-hydroxy-1-phenyl-ethyl)-amide
   Show/Hide
C28H33N5O3
 1
1
IC50 = 900 nM
   TI
   LI
   LO
   TS
CP0451294
2-Diphenylacetylamino-5-guanidino-pentanoic acid (5-hydroxy-indan-1-yl)-amide
   Show/Hide
C29H33N5O3
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0500473
2-(4-Chloro-phenyl)-N-[4-guanidino-1-(1,3,4,5-tetrahydro-benzo[c]azepine-2-carbonyl)-butyl]-2-phenyl-acetamide
   Show/Hide
C30H34ClN5O2
 1
1
IC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0458948
2-Diphenylacetylamino-5-guanidino-pentanoic acid (S)-indan-1-ylamide
   Show/Hide
C29H33N5O2
 1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0537601
N-[5-(diaminomethylideneamino)-1-oxo-1-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)pentan-2-yl]-2,2-diphenylacetamide
   Show/Hide
C30H35N5O2
 1
1
IC50 = 2200 nM
   TI
   LI
   LO
   TS
CP0847362
2-Diphenylacetylamino-5-guanidino-pentanoic acid ((S)-1-phenyl-ethyl)-amide
   Show/Hide
C28H33N5O2
 1
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0377257
2-[2-(4-Chloro-phenyl)-2-phenyl-acetylamino]-5-guanidino-pentanoic acid (S)-indan-1-ylamide
   Show/Hide
C29H32ClN5O2
 1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0440697
2-Diphenylacetylamino-5-guanidino-pentanoic acid (pyridin-2-ylmethyl)-amide
   Show/Hide
C26H30N6O2
 1
1
IC50 = 3750 nM
   TI
   LI
   LO
   TS
CP0397276
2-Diphenylacetylamino-5-guanidino-pentanoic acid ((R)-carbamoyl-phenyl-methyl)-amide
   Show/Hide
C28H32N6O3
 1
1
IC50 = 4600 nM
   TI
   LI
   LO
   TS
CP0404642
2-Diphenylacetylamino-5-guanidino-pentanoic acid ((S)-carbamoyl-phenyl-methyl)-amide
   Show/Hide
C28H32N6O3
 1
1
IC50 = 7500 nM
   TI
   LI
   LO
   TS
CP0501350
2-Diphenylacetylamino-5-guanidino-pentanoic acid [(R)-carbamoyl-(4-hydroxy-phenyl)-methyl]-amide
   Show/Hide
C28H32N6O4
 1
1
IC50 = 8100 nM
   TI
   LI
   LO
   TS
CP0507443
2-[2,2-Bis-(4-chloro-phenyl)-acetylamino]-5-guanidino-pentanoic acid (S)-indan-1-ylamide
   Show/Hide
C29H31Cl2N5O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0439620
2-Diphenylacetylamino-5-guanidino-pentanoic acid (2-pyridin-2-yl-ethyl)-amide
   Show/Hide
C27H32N6O2
 1
1
IC50 = 11500 nM
   TI
   LI
   LO
   TS
CP0397504
2-Biphenyl-4-yl-N-{1-(7-hydroxy-1,3,4,5-tetrahydro-benzo[c]azepine-2-carbonyl)-4-[N'-(3-phenyl-propyl)-guanidino]-butyl}-acetamide
   Show/Hide
C39H45N5O3
 1
1
IC50 = 11900 nM
   TI
   LI
   LO
   TS
CP0397577
2,2-Bis-(4-chloro-phenyl)-N-[4-guanidino-1-(1,3,4,5-tetrahydro-benzo[c]azepine-2-carbonyl)-butyl]-acetamide
   Show/Hide
C30H33Cl2N5O2
 1
1
IC50 = 12000 nM
   TI
   LI
   LO
   TS
CP0510733
2-Diphenylacetylamino-5-guanidino-pentanoic acid (R)-indan-1-ylamide
   Show/Hide
C29H33N5O2
 1
1
IC50 = 21000 nM
   TI
   LI
   LO
   TS
CP0461119
2-(2-Biphenyl-4-yl-acetylamino)-5-guanidino-pentanoic acid benzylamide
   Show/Hide
C27H31N5O2
 1
1
IC50 = 21800 nM
   TI
   LI
   LO
   TS
CP0461121
2-Diphenylacetylamino-5-guanidino-pentanoic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide
   Show/Hide
C28H33N5O3
 1
1
IC50 = 22300 nM
   TI
   LI
   LO
   TS
CP0536933
N-[5-(diaminomethylideneamino)-1-oxo-1-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)pentan-2-yl]-2,2,2-triphenylacetamide
   Show/Hide
C36H39N5O2
 1
1
IC50 = 51000 nM
   TI
   LI
   LO
   TS
CP0410726
2-Biphenyl-4-yl-N-[4-guanidino-1-(1,3,4,5-tetrahydro-benzo[c]azepine-2-carbonyl)-butyl]-acetamide
   Show/Hide
C30H35N5O2
 1
1
IC50 = 76000 nM
   TI
   LI
   LO
   TS
CP0055951
(4S)-5-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S,3S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-[[2-[[(2S)-1-[(2S)-4-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxypropanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-oxopentanoic acid
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C189H285N55O57S
 1
1
Ki = 0.5 nM
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CP0382185
(4S)-5-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S,3R)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2R)-1-[[(2R)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-[[2-[[(2S)-1-[(2S)-4-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxypropanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-oxopentanoic acid
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C190H287N55O57
 1
1
Ki = 0.6 nM
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CP0375180
(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]butanediamide
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C75H124N26O17
 1
1
Ki = 281 nM
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CP0334304
(4S)-5-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(1S)-1-amino-2-(4-hydroxyphenyl)ethyl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-aminopropanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-4-oxobutanoyl]amino]propanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoic acid
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C184H287N53O53S2
 1
1
Ki = 440 nM
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CP0375159
(2S)-2-[[(2S)-2-[[(2S,3R)-2-acetamido-3-hydroxybutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide
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C33H56N12O8
 1
1
Ki > 1000 nM
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CP0375160
(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-carbamimidamidopentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(1S,2R)-2-[[(2S)-1-[[(1S,2R)-2-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]cyclobutyl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]cyclobutyl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]butanediamide
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C76H120N28O16
 1
1
Ki > 1000 nM
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CP0375161
(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-N-[(2S)-1-[[(2S,3S)-1-[[(1S,2R)-2-[[(2S)-1-[[(1S,2R)-2-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]cyclopentyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]cyclopentyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]butanediamide
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C78H123N25O16
 1
1
Ki > 1000 nM
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CP0375162
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-amino-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pentanediamide
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C75H120N26O18
 1
1
Ki > 1000 nM
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CP0375179
(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-amino-4-oxobutanoyl]amino]-N-[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(1S,2R)-2-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]cyclobutyl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]butanediamide
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C73H119N27O18
 1
1
Ki > 1000 nM
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CP0386806
(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-carbamimidamidopentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-N-[(2S)-1-[[(2S,3S)-1-[[(1R,3S)-3-[[(2S)-1-[[(1R,3S)-3-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-2,2-dimethylcyclobutyl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]-2,2-dimethylcyclobutyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]butanediamide
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C80H127N25O16
 1
1
Ki > 1000 nM
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CP0386808
(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-carbamimidamidopentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-N-[(2S)-1-[[(2S,3S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]butanediamide
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C76H123N25O17
 1
1
Ki > 1000 nM
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CP0386811
(1R,2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]cyclopentane-1-carboxamide
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C38H56N12O8
 1
1
Ki > 1000 nM
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CP0395195
(1R,2S)-2-[[(2S)-2-[[(2S,3R)-2-acetamido-3-hydroxybutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]cyclopentane-1-carboxamide
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C33H54N12O8
 1
1
Ki > 1000 nM
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CP0420154
(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(1S,2R)-2-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]cyclopentyl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]butanediamide
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C76H126N26O17
 1
1
Ki > 1000 nM
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CP0420318
(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide
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C38H58N12O8
 1
1
Ki > 1000 nM
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CP0429059
(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-N-[(2S)-1-[[(2S,3S)-1-[[(2S,3R)-1-[[(2S)-1-[[(1S,3R)-3-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]-2,2-dimethylcyclobutyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]butanediamide
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C77H123N25O17
 1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS
CP0434504
(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-N-[(2S)-1-[[(2S,3S)-1-[[(2S,3R)-1-[[(2S)-1-[[(1S,2R)-2-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]cyclopentyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]butanediamide
   Show/Hide
C76H121N25O17
 1
1
Ki > 1000 nM
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   LI
   LO
   TS
CP0469093
(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(1S,2R)-2-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]cyclobutyl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]butanediamide
   Show/Hide
C75H124N26O17
 1
1
Ki > 1000 nM
   TI
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   LO
   TS
CP0476460
(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-carbamimidamidopentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-N-[(2S)-1-[[(2S,3S)-1-[[(2S,3R)-1-[[(2S)-1-[[(1S,2R)-2-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]cyclobutyl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]butanediamide
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C75H119N25O17
 1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS