Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hydroxybenzyl)pentanamide
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 PubChem ID
CID: 5311023
SID: 14907625
Canonical SMILES
NC(N)=NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1
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Compound Formula C27H31N5O3
Compound Structure
Protein Name
 Protein Info 
Neuropeptide Y receptor type 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Neuropeptide Y receptor
Uniprot ID
P25929
Gene Name
NPY1R
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000082 HEL
 Cell Line Info 
Homo sapiens (Human)  4
1
IC50 = 10.23 nM
   TI
   LI
   LO
   TS
2
IC50 = 11.75 nM
   TI
   LI
   LO
   TS
3
IC50 = 16.22 nM
   TI
   LI
   LO
   TS
4
Ki = 1.5 nM
   TI
   LI
   LO
   TS
CL000125 MCB3901
 Cell Line Info 
Mesocricetus auratus (Golden hamster)  1
1
Ki = 2315 nM
   TI
   LI
   LO
   TS
CL000074 SK-N-MC
 Cell Line Info 
Homo sapiens (Human)  9
1
IC50 = 3.631 nM
   TI
   LI
   LO
   TS
2
IC50 = 3.981 nM
   TI
   LI
   LO
   TS
3
Kd = 2.1 nM
   TI
   LI
   LO
   TS
4
Ki = 1 nM
   TI
   LI
   LO
   TS
5
Ki = 1.3 nM
   TI
   LI
   LO
   TS
6
Ki = 1.5 nM
   TI
   LI
   LO
   TS
7
Ki = 2 nM
   TI
   LI
   LO
   TS
8
Ki = 5.1 nM
   TI
   LI
   LO
   TS
9
Ki = 14.9 nM
   TI
   LI
   LO
   TS