Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylacetamido)-5-oxopentylamino)(amino)methylene)ureido)acetate
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 PubChem ID
CID: 10008757
SID: 14988607
Canonical SMILES
CCOC(=O)CNC(=O)NC(N)=NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1
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Compound Formula C32H38N6O6
Compound Structure
Protein Name
 Protein Info 
Neuropeptide Y receptor type 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Neuropeptide Y receptor
Uniprot ID
P25929
Gene Name
NPY1R
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000082 HEL
 Cell Line Info 
Homo sapiens (Human)  10
1
IC50 = 0.05012 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.0631 nM
   TI
   LI
   LO
   TS
3
IC50 = 0.1259 nM
   TI
   LI
   LO
   TS
4
IC50 = 0.1698 nM
   TI
   LI
   LO
   TS
5
IC50 = 0.4266 nM
   TI
   LI
   LO
   TS
6
IC50 = 0.7079 nM
   TI
   LI
   LO
   TS
7
IC50 = 2.754 nM
   TI
   LI
   LO
   TS
8
IC50 = 8.24 nM
   TI
   LI
   LO
   TS
9
Ki = 0.12 nM
   TI
   LI
   LO
   TS
10
Ki = 0.3 nM
   TI
   LI
   LO
   TS
CL000074 SK-N-MC
 Cell Line Info 
Homo sapiens (Human)  6
1
IC50 = 0.1514 nM
   TI
   LI
   LO
   TS
2
Ki = 0.037 nM
   TI
   LI
   LO
   TS
3
Ki = 0.1 nM
   TI
   LI
   LO
   TS
4
Ki = 0.21 nM
   TI
   LI
   LO
   TS
5
Ki = 0.28 nM
   TI
   LI
   LO
   TS
6
Ki = 0.42 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.06 nM