Brief Information of the Cell Line and Protein
Cell Line ID: CL000063 , Hep-G2
Synonyms
HEP-G2
Hep G2
HEP G2
HepG2
HEPG2
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0027
Protein ID: PT02011 , 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene Name HMGCR
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P04035
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000063  Protein ID: PT02011
 
Compound ID Compound Name Compound Formula
CP0875614
(racemic)Sodium salt of 7-[4-(4-Fluoro-phenyl)-2-isopropyl-1-phenyl-1H-pyrrol-3-yl]-3,5-dihydroxy-heptanoic acid
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C26H29FNNaO4
 1
1
IC50 < 0.01 nM
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CP0895187
Sodium salt of 7-[4-(4-Fluoro-phenyl)-2-isopropyl-1-phenyl-1H-pyrrol-3-yl]-3,5-dihydroxy-hept-6-enoic acid
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C26H27FNNaO4
 1
1
IC50 = 0.014 nM
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CP0846107
Sodium salt of 7-[1-Cyclohexyl-4-(4-fluoro-phenyl)-2-isopropyl-1H-pyrrol-3-yl]-3,5-dihydroxy-heptanoic acid
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C26H35FNNaO4
 1
1
IC50 = 0.018 nM
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CP0879672
Sodium salt of 7-[4-(4-Fluoro-phenyl)-1,2-diisopropyl-1H-pyrrol-3-yl]-3,5-dihydroxy-hept-6-enoic acid
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C23H29FNNaO4
 1
1
IC50 = 0.05 nM
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CP0501270
sodium;(E,3R,5R)-7-[1-cyclohexyl-4-(4-fluorophenyl)-2-propan-2-ylpyrrol-3-yl]-3,5-dihydroxyhept-6-enoate
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C26H33FNNaO4
 1
1
IC50 = 0.106 nM
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CP0861138
Sodium salt of 7-[4-(4-Fluoro-phenyl)-1-isopropyl-2-methyl-1H-pyrrol-3-yl]-3,5-dihydroxy-heptanoic acid
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C21H27FNNaO4
 1
1
IC50 = 0.27 nM
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CP0658528
Sodium salt 6-[4'-fluoro-5-(4-fluoro-phenylsulfanyl)-3-isopropyl-biphenyl-2-yloxy]-3,5-dihydroxy-hexanoate
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C27H27F2NaO5S
 1
1
IC50 = 0.5 nM
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CP0859327
Sodium salt of 7-[4-(4-Fluoro-phenyl)-2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl]-3,5-dihydroxy-heptanoic acid
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C25H27FNNaO4
 1
1
IC50 = 0.57 nM
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CP0416701
sodium;(E,3R,5R)-7-[4-(4-fluorophenyl)-2-methyl-1-phenylpyrrol-3-yl]-3,5-dihydroxyhept-6-enoate
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C24H23FNNaO4
 1
1
IC50 = 0.83 nM
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CP0536865
6-(4'-Fluoro-3,5-diisopropyl-biphenyl-2-yloxymethyl)-4-hydroxy-tetrahydro-pyran-2-one
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C24H29FO4
 1
1
IC50 = 1.8 nM
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CP0674757
Sodium salt 6-(4'-Fluoro-6-hydroxy-2,4,5-triisopropyl-biphenyl-3-yloxy)-3,5-dihydroxy-hexanoic acid anion; Sodium acetyl
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C29H39FNa2O8
 1
1
IC50 = 4.1 nM
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CP0304062
(E)-6-{2-[4-(4-Fluoro-phenyl)-2,6-diisopropyl-pyrimidin-5-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one
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C23H27FN2O3
 1
1
IC50 = 4.8 nM
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CP0918465
Sodium salt of 7-[4-(4-Fluoro-phenyl)-2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl]-3,5-dihydroxy-hept-6-enoic acid
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C25H25FNNaO4
 1
1
IC50 = 5 nM
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CP0295551
(E)-6-{2-[4-(4-Fluoro-phenyl)-6-isopropyl-2-phenyl-pyrimidin-5-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one
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C26H25FN2O3
 1
1
IC50 = 5 nM
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CP0311274
(E)-6-{2-[2-tert-Butyl-4-(4-fluoro-phenyl)-6-phenyl-pyridin-3-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one
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C27H26FNO3
 1
1
IC50 = 5 nM
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CP0656587
Sodium salt 6-(4'-fluoro-5-hydroxy-3,4,6-triisopropyl-biphenyl-2-yloxy)-3,5-dihydroxy-hexanoate
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C27H36FNaO6
 1
1
IC50 = 5.6 nM
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CP0916157
Sodium salt of 7-[4-(4-Fluoro-phenyl)-1-isopropyl-2-methyl-1H-pyrrol-3-yl]-3,5-dihydroxy-hept-6-enoic acid
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C21H25FNNaO4
 1
1
IC50 = 6 nM
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CP0056914
(E)-6-{2-[4,6-Bis-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one
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C27H25F2NO3
 1
1
IC50 = 7.5 nM
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CP0194903
(E)-6-{2-[6-Cyclohexyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one
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C27H32FNO3
 1
1
IC50 = 9.5 nM
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CP0462978
(E)-6-{2-[2-(4-Fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one
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C27H26FNO3
 1
1
IC50 = 10 nM
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CP0524202
sodium;(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
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C25H39O6-
 1
1
IC50 = 12 nM
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CP0321544
(E)-6-{2-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one
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C26H24F2N2O3
 1
1
IC50 = 18 nM
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CP0111125
(E)-6-{2-[6-(2,5-Dimethyl-phenyl)-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one
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C29H30FNO3
 1
1
IC50 = 20 nM
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CP0163533
(E)-6-{2-[4-(4-Fluoro-phenyl)-2,6-diisopropyl-pyridin-3-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one
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C25H30FNO3
 1
1
IC50 = 20 nM
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CP0092025
(E)-6-{2-[2-Cyclohexyl-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one
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C26H31FN2O3
 1
1
IC50 = 26 nM
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CP0946212
methyl 7-[3,8-dimethyl-10-[1-methyl-(1S)-propylcarbonyloxy]-(1R,2S,3S,8R,10S)-bicyclo[4.4.0]deca-4,6-dien-2-yl]-3,5-dihydroxy-(3R,5R)-sodium heptanoate
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C24H37NaO6
 1
1
IC50 = 29 nM
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CP0736650
Sodium salt 6-(4'-fluoro-3,5-diisopropyl-biphenyl-2-yloxy)-3,5-dihydroxy-hexanoate
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C24H30FNaO5
 1
1
IC50 = 30 nM
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CP0005348
LOVASTATIN
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C24H36O5
 2
1
IC50 = 37 nM
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2
IC50 = 50 nM
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CP0063684
(E)-6-{2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-methyl-pyridin-3-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one
   Show/Hide
C22H24FNO3
 1
1
IC50 = 50 nM
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CP0794416
Sodium salt 6-(4,4''-difluoro-5'-isopropyl-[1,1',3',1'']terphenyl-4'-yloxy)-3,5-dihydroxy-hexanoate
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C27H27F2NaO5
 1
1
IC50 = 55 nM
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CP0063801
(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-methyl-6-phenylpyridin-3-yl]ethenyl]-4-hydroxyoxan-2-one
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C25H22FNO3
 1
1
IC50 = 90 nM
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CP0678062
Sodium salt 6-(5-cyclohexylmethyl-3-isopropyl-biphenyl-4-yloxy)-3,5-dihydroxy-hexanoate
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C28H37NaO5
 1
1
IC50 = 100 nM
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CP0162817
(E)-4-Hydroxy-6-{2-[2-isopropyl-4-(4-methoxy-phenyl)-6-phenyl-pyridin-3-yl]-vinyl}-tetrahydro-pyran-2-one
   Show/Hide
C28H29NO4
 1
1
IC50 = 150 nM
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CP0691369
Sodium salt 6-[2-(4-fluoro-phenyl)-4-isopropyl-quinolin-3-yloxy]-3,5-dihydroxy-hexanoate
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C24H25FNNaO5
 1
1
IC50 = 250 nM
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CP0193874
6-{2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-4-hydroxy-tetrahydro-pyran-2-one
   Show/Hide
C27H28FNO3
 1
1
IC50 = 370 nM
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CP0501215
2-Methyl-butyric acid 3-hydroxy-8-[2-(4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester
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C23H36O6
 1
1
IC50 = 1400 nM
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CP0192776
(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2,6-dimethylpyridin-3-yl]ethenyl]-4-hydroxyoxan-2-one
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C20H20FNO3
 1
1
IC50 = 2000 nM
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CP0916435
Sodium salt 3,5-dihydroxy-7-[6-hydroxy-2-methyl-8-(2-methyl-butyryloxy)-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl]-heptanoate
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C23H37NaO7
 1
1
IC50 = 2220 nM
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CP0741425
Sodium salt 6-[2,4-dichloro-6-(cyclohexyl-difluoro-methyl)-phenoxy]-3,5-dihydroxy-hexanoate
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C19H23Cl2F2NaO5
 1
1
IC50 = 2500 nM
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CP0670655
Sodium salt 6-{3-[bis-(4-fluoro-phenyl)-methyl]-1-isopropyl-naphthalen-2-yloxy}-3,5-dihydroxy-hexanoate
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C32H31F2NaO5
 1
1
IC50 = 3500 nM
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CP0359386
(4R,6S)-6-[(Z)-2-[4-(4-fluorophenyl)-2-methyl-6-phenylpyridin-3-yl]ethenyl]-4-hydroxyoxan-2-one
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C25H22FNO3
 1
1
IC50 = 5000 nM
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CP0271837
6-[2-(Chloro-cyclohexyl-methyl)-4,6-dimethyl-phenoxymethyl]-4-hydroxy-tetrahydro-pyran-2-one
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C21H29ClO4
 1
1
IC50 = 6500 nM
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CP0774833
Sodium salt 6-{3-[bis-(4-fluoro-phenyl)-methyl]-1-methyl-naphthalen-2-yloxy}-3,5-dihydroxy-hexanoate
   Show/Hide
C30H27F2NaO5
 1
1
IC50 = 20000 nM
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CP0841332
Sodium salt 6-(5-tert-butyl-4'-fluoro-3-isopropyl-biphenyl-2-yloxy)-3,5-dihydroxy-hexanoate
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C25H32FNaO5
 1
1
IC50 > 500 nM
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CP0745081
6-[4-{1-[4-[5-carboxylato-2,4-dihydroxy-(2R,4R)-pentyloxy]-3-(4-fluorophenyl)-5-isopropylphenylsulfanyl]-1-methylethylsulfanyl}-2-(4-fluorophenyl)-6-isopropylphenoxy]-3,5-dihydroxy-(3R,5R)-hexanoate;2Sodium ion
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C45H52F2Na2O10S2
 1
1
IC50 > 1000 nM
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CP0838106
Disodium salt; 6-{4'-Fluoro-5-[1-(4'-fluoro-6-hydroxy-5-isopropyl-biphenyl-3-ylsulfanyl)-1-methyl-ethylsulfanyl]-3-isopropyl-biphenyl-2-yloxy}-3,5-dihydroxy-hexanoic acid
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C39H42F2Na2O6S2
 1
1
IC50 > 1700 nM
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CP0272197
(E)-6-{2-[2-Cyclohexyl-4-(4-fluoro-phenyl)-6-phenyl-pyridin-3-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one
   Show/Hide
C30H30FNO3
 1
1
IC50 > 5000 nM
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CP0684969
Sodium salt 6-[2-(4-fluoro-phenyl)-4-methyl-quinolin-3-yloxy]-3,5-dihydroxy-hexanoate
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C22H21FNNaO5
 1
1
IC50 > 5000 nM
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CP0839492
Sodium salt 3,5-dihydroxy-6-(2-methyl-4-phenyl-quinolin-3-yloxy)-hexanoate
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C22H22NNaO5
 1
1
IC50 > 5000 nM
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