| Compound ID |
Compound Name |
Compound Formula |
|
CP0497632
|
US9428503, 67
Show/Hide
|
C29H35N5O3
|
1
|
| 1 |
IC50 < 0.0525 nM
|
|
|
|
CP0457001
|
US9428503, 26
Show/Hide
|
C27H33N5O3
|
1
|
| 1 |
IC50 = 0.152 nM
|
|
|
|
CP0393906
|
US9428503, 28
Show/Hide
|
C28H33N5O3
|
2
|
| 1 |
IC50 = 0.17 nM
|
|
|
| 2 |
IC50 = 0.176 nM
|
|
|
|
CP0246126
|
US9428503, 33
Show/Hide
|
C29H35N5O3
|
1
|
| 1 |
IC50 = 0.2 nM
|
|
|
|
CP0476588
|
US9428503, 68
Show/Hide
|
C27H32FN5O3
|
1
|
| 1 |
IC50 = 0.208 nM
|
|
|
|
CP0406927
|
US9428503, 65
Show/Hide
|
C30H38N6O2
|
1
|
| 1 |
IC50 = 0.22 nM
|
|
|
|
CP0474997
|
US9428503, 59
Show/Hide
|
C28H33N5O3
|
1
|
| 1 |
IC50 = 0.233 nM
|
|
|
|
CP0483520
|
US9428503, 29
Show/Hide
|
C28H33N5O3
|
1
|
| 1 |
IC50 = 0.238 nM
|
|
|
|
CP0228362
|
US9428503, 5
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|
C25H29N5O3
|
1
|
| 1 |
IC50 = 0.24 nM
|
|
|
|
CP0472915
|
US9428503, 2
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|
C26H31N5O3
|
2
|
| 1 |
IC50 = 0.249 nM
|
|
|
| 2 |
IC50 = 0.25 nM
|
|
|
|
CP0472916
|
US9428503, 42
Show/Hide
|
C25H29N5O3
|
2
|
| 1 |
IC50 = 0.249 nM
|
|
|
| 2 |
IC50 = 0.25 nM
|
|
|
|
CP0164887
|
US9428503, 38
Show/Hide
|
C27H31N5O3
|
2
|
| 1 |
IC50 = 0.29 nM
|
|
|
| 2 |
IC50 = 0.292 nM
|
|
|
|
CP0483519
|
US9428503, 21
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|
C26H30FN5O3
|
1
|
| 1 |
IC50 = 0.301 nM
|
|
|
|
CP0451373
|
US9428503, 58
Show/Hide
|
C27H31N5O2
|
1
|
| 1 |
IC50 = 0.31 nM
|
|
|
|
CP0518509
|
US9428503, 63
Show/Hide
|
C27H32FN5O3
|
1
|
| 1 |
IC50 = 0.31 nM
|
|
|
|
CP0480889
|
US9428503, 25
Show/Hide
|
C27H33N5O3
|
1
|
| 1 |
IC50 = 0.315 nM
|
|
|
|
CP0492967
|
US9428503, 69
Show/Hide
|
C27H32FN5O3
|
1
|
| 1 |
IC50 = 0.324 nM
|
|
|
|
CP0145046
|
US9428503, 17
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|
C26H31N5O3
|
2
|
| 1 |
IC50 = 0.329 nM
|
|
|
| 2 |
IC50 = 0.33 nM
|
|
|
|
CP0457022
|
US9428503, 66
Show/Hide
|
C29H35N5O3
|
1
|
| 1 |
IC50 = 0.334 nM
|
|
|
|
CP0457020
|
US9428503, 20
Show/Hide
|
C26H30FN5O3
|
1
|
| 1 |
IC50 = 0.365 nM
|
|
|
|
CP0480890
|
US9428503, 27
Show/Hide
|
C28H32FN5O3
|
1
|
| 1 |
IC50 = 0.418 nM
|
|
|
|
CP0481097
|
US9428503, 57
Show/Hide
|
C28H33N5O2
|
1
|
| 1 |
IC50 = 0.434 nM
|
|
|
|
CP0474995
|
US9428503, 15
Show/Hide
|
C27H31N5O3
|
1
|
| 1 |
IC50 = 0.447 nM
|
|
|
|
CP0497631
|
US9428503, 55
Show/Hide
|
C28H33N5O3
|
1
|
| 1 |
IC50 = 0.493 nM
|
|
|
|
CP0545151
|
4-[[(1S)-1-(1,4-dimethylpyrazol-3-yl)ethyl]amino]-6-[6-(3-pyrrolidin-1-ylpropoxy)pyridin-3-yl]cinnoline-3-carboxamide
Show/Hide
|
C28H34N8O2
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0561658
|
US9428503, 62
Show/Hide
|
C27H32FN5O3
|
1
|
| 1 |
IC50 = 0.507 nM
|
|
|
|
CP0476587
|
US9428503, 45
Show/Hide
|
C25H29N5O3
|
1
|
| 1 |
IC50 < 0.534 nM
|
|
|
|
CP0457000
|
US9428503, 22
Show/Hide
|
C26H30FN5O3
|
1
|
| 1 |
IC50 = 0.552 nM
|
|
|
|
CP0512612
|
US9428503, 61
Show/Hide
|
C28H32FN5O3
|
1
|
| 1 |
IC50 = 0.554 nM
|
|
|
|
CP0451943
|
US9428503, 41
Show/Hide
|
C25H29N5O3
|
1
|
| 1 |
IC50 = 0.555 nM
|
|
|
|
CP0491473
|
US9428503, 23
Show/Hide
|
C28H32FN5O3
|
1
|
| 1 |
IC50 = 0.563 nM
|
|
|
|
CP0480891
|
US9428503, 40
Show/Hide
|
C25H29N5O3
|
1
|
| 1 |
IC50 = 0.567 nM
|
|
|
|
CP0127298
|
US9428503, 1
Show/Hide
|
C26H31N5O3
|
2
|
| 1 |
IC50 = 0.57 nM
|
|
|
| 2 |
IC50 = 0.575 nM
|
|
|
|
CP0861326
|
US9428503, 35
Show/Hide
|
C27H31N5O3
|
1
|
| 1 |
IC50 = 0.589 nM
|
|
|
|
CP0474996
|
US9428503, 43
Show/Hide
|
C25H29N5O3
|
1
|
| 1 |
IC50 = 0.592 nM
|
|
|
|
CP0563158
|
US9428503, 24
Show/Hide
|
C28H32FN5O3
|
1
|
| 1 |
IC50 = 0.69 nM
|
|
|
|
CP0483112
|
US9428503, 54
Show/Hide
|
C28H33N5O3
|
1
|
| 1 |
IC50 = 0.715 nM
|
|
|
|
CP0483512
|
US9428503, 51
Show/Hide
|
C25H28FN5O2
|
1
|
| 1 |
IC50 = 0.722 nM
|
|
|
|
CP0457004
|
US9428503, 64
Show/Hide
|
C30H38N6O2
|
1
|
| 1 |
IC50 = 0.741 nM
|
|
|
|
CP0068686
|
US9428503, 18
Show/Hide
|
C26H30FN5O3
|
2
|
| 1 |
IC50 = 0.76 nM
|
|
|
| 2 |
IC50 = 0.765 nM
|
|
|
|
CP0164865
|
US9428503, 8
Show/Hide
|
C26H30FN5O3
|
2
|
| 1 |
IC50 = 0.78 nM
|
|
|
| 2 |
IC50 = 0.782 nM
|
|
|
|
CP0451370
|
US9428503, 47
Show/Hide
|
C29H34FN5O3
|
2
|
| 1 |
IC50 = 0.799 nM
|
|
|
| 2 |
IC50 = 1.1 nM
|
|
|
|
CP0545150
|
6-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-4-[[(1S)-1-(1,4-dimethylpyrazol-3-yl)ethyl]amino]cinnoline-3-carboxamide
Show/Hide
|
C26H32N8O2
|
1
|
| 1 |
IC50 = 0.9 nM
|
|
|
|
CP0145048
|
US9428503, 16
Show/Hide
|
C26H31N5O3
|
2
|
| 1 |
IC50 = 0.935 nM
|
|
|
| 2 |
IC50 = 0.94 nM
|
|
|
|
CP0451374
|
US9428503, 7
Show/Hide
|
C27H33N5O3
|
1
|
| 1 |
IC50 = 0.96 nM
|
|
|
|
CP0457026
|
US9428503, 10
Show/Hide
|
C26H30FN5O3
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0483063
|
US9428503, 48
Show/Hide
|
C26H29F2N5O3
|
1
|
| 1 |
IC50 = 1.02 nM
|
|
|
|
CP0907953
|
US9428503, 12
Show/Hide
|
C25H29N5O3
|
1
|
| 1 |
IC50 = 1.03 nM
|
|
|
|
CP0438312
|
US9428503, 6
Show/Hide
|
C26H30FN5O3
|
2
|
| 1 |
IC50 = 1.05 nM
|
|
|
| 2 |
IC50 = 1.1 nM
|
|
|
|
CP0474994
|
US9428503, 14
Show/Hide
|
C26H29N5O3
|
1
|
| 1 |
IC50 = 1.05 nM
|
|
|
|
CP0474823
|
US9428503, 44
Show/Hide
|
C25H29N5O3
|
1
|
| 1 |
IC50 = 1.07 nM
|
|
|
|
CP0445207
|
US9428503, 31
Show/Hide
|
C29H35N5O3
|
1
|
| 1 |
IC50 = 1.09 nM
|
|
|
|
CP0451372
|
US9428503, 53
Show/Hide
|
C29H34FN5O3
|
2
|
| 1 |
IC50 = 1.1 nM
|
|
|
| 2 |
IC50 = 1.2 nM
|
|
|
|
CP0474081
|
4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]-6-[6-(3-pyrrolidin-1-ylpropoxy)pyridin-3-yl]cinnoline-3-carboxamide
Show/Hide
|
C27H32N8O2
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0518510
|
US9428503, 30
Show/Hide
|
C28H33N5O3
|
1
|
| 1 |
IC50 = 1.12 nM
|
|
|
|
CP0476585
|
US9428503, 11
Show/Hide
|
C26H30FN5O3
|
1
|
| 1 |
IC50 = 1.14 nM
|
|
|
|
CP0483521
|
US9428503, 37
Show/Hide
|
C29H35N5O3
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0457002
|
US9428503, 39
Show/Hide
|
C27H31N5O3
|
1
|
| 1 |
IC50 = 1.33 nM
|
|
|
|
CP0457021
|
US9428503, 49
Show/Hide
|
C25H28FN5O3
|
1
|
| 1 |
IC50 = 1.34 nM
|
|
|
|
CP0483523
|
US9428503, 50
Show/Hide
|
C25H28FN5O3
|
1
|
| 1 |
IC50 = 1.44 nM
|
|
|
|
CP0457005
|
US9428503, 71
Show/Hide
|
C27H32FN5O3
|
1
|
| 1 |
IC50 = 1.45 nM
|
|
|
|
CP0081675
|
US9428503, 4
Show/Hide
|
C24H27N5O3
|
2
|
| 1 |
IC50 = 1.46 nM
|
|
|
| 2 |
IC50 = 1.5 nM
|
|
|
|
CP0427439
|
8-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-3-methyl-1-(oxan-4-yl)imidazo[4,5-c][1,5]naphthyridin-2-one
Show/Hide
|
C25H30N6O3
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0483510
|
US9428503, 32
Show/Hide
|
C29H35N5O3
|
1
|
| 1 |
IC50 = 1.78 nM
|
|
|
|
CP0456091
|
4-[[(1S)-1-(oxan-4-yl)ethyl]amino]-6-[6-(3-pyrrolidin-1-ylpropoxy)pyridin-3-yl]cinnoline-3-carboxamide
Show/Hide
|
C28H36N6O3
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0123998
|
6-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamide
Show/Hide
|
C26H34N6O3
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0457024
|
US9428503, 3
Show/Hide
|
C27H32FN5O3
|
1
|
| 1 |
IC50 = 2.03 nM
|
|
|
|
CP0512613
|
US9428503, 70
Show/Hide
|
C27H32FN5O3
|
1
|
| 1 |
IC50 = 2.43 nM
|
|
|
|
CP0438311
|
US9428503, 19
Show/Hide
|
C26H29F2N5O3
|
2
|
| 1 |
IC50 = 2.6 nM
|
|
|
| 2 |
IC50 = 2.62 nM
|
|
|
|
CP0189386
|
6-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-N-methyl-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamide
Show/Hide
|
C27H36N6O3
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0507339
|
US9428503, 36
Show/Hide
|
C28H33N5O3
|
1
|
| 1 |
IC50 = 3.01 nM
|
|
|
|
CP0474824
|
US9428503, 56
Show/Hide
|
C27H31N5O3
|
1
|
| 1 |
IC50 = 3.02 nM
|
|
|
|
CP0497634
|
US9428503, 46
Show/Hide
|
C25H29N5O2
|
1
|
| 1 |
IC50 = 3.15 nM
|
|
|
|
CP0476586
|
US9428503, 13
Show/Hide
|
C25H29N5O3
|
1
|
| 1 |
IC50 = 3.22 nM
|
|
|
|
CP0480888
|
US9428503, 9
Show/Hide
|
C24H26FN5O3
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0474083
|
6-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-4-[[(1S)-1-(1,4-dimethylpyrazol-3-yl)ethyl]amino]-N-methylcinnoline-3-carboxamide
Show/Hide
|
C27H34N8O2
|
1
|
| 1 |
IC50 = 3.9 nM
|
|
|
|
CP0547086
|
6-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]cinnoline-3-carboxamide
Show/Hide
|
C25H30N8O2
|
1
|
| 1 |
IC50 = 3.9 nM
|
|
|
|
CP0451371
|
US9428503, 52
Show/Hide
|
C24H26FN5O3
|
1
|
| 1 |
IC50 = 4.76 nM
|
|
|
|
CP0470735
|
N,N-dimethyl-3-[5-[3-methyl-1-(oxan-4-yl)-2-oxoimidazo[4,5-c]quinolin-8-yl]pyridin-2-yl]oxypropan-1-amine oxide
Show/Hide
|
C26H31N5O4
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0235616
|
8-[6-[2-(dimethylamino)ethylamino]pyridin-3-yl]-7-fluoro-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-one
Show/Hide
|
C25H29FN6O2
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0438314
|
4-(dimethylamino)-N-[5-[7-fluoro-1-(3-methoxycyclobutyl)-3-methyl-2-oxoimidazo[4,5-c]quinolin-8-yl]pyridin-2-yl]butanamide
Show/Hide
|
C27H31FN6O3
|
1
|
| 1 |
IC50 = 8.2 nM
|
|
|
|
CP0474725
|
4-(2-ethylbutylamino)-7-fluoro-6-[2-(2-pyrrolidin-1-ylethylamino)pyrimidin-5-yl]quinoline-3-carboxamide
Show/Hide
|
C26H34FN7O
|
1
|
| 1 |
IC50 = 8.6 nM
|
|
|
|
CP0362301
|
4-[[(1S)-1-(1,4-dimethylpyrazol-3-yl)ethyl]amino]-7-fluoro-6-[6-(methoxymethyl)pyridin-3-yl]quinoline-3-carboxamide
Show/Hide
|
C24H25FN6O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0518461
|
US9428503, CN102372711A: Compound 4
Show/Hide
|
C24H25N5O4
|
1
|
| 1 |
IC50 = 11.2 nM
|
|
|
|
CP0259634
|
7-fluoro-4-[[(1S)-1-(4-fluoro-1-methylpyrazol-3-yl)ethyl]amino]-6-[6-(methoxymethyl)pyridin-3-yl]quinoline-3-carboxamide
Show/Hide
|
C23H22F2N6O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0427440
|
8-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-3-methyl-1-(oxan-4-yl)imidazo[4,5-c]cinnolin-2-one
Show/Hide
|
C25H30N6O3
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0164862
|
8-[6-[2-(dimethylamino)ethoxy]pyridin-3-yl]-7-fluoro-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-one
Show/Hide
|
C25H28FN5O3
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0529511
|
US9428503, CN102372711A: Compound 5
Show/Hide
|
C24H25N5O3
|
1
|
| 1 |
IC50 = 26.5 nM
|
|
|
|
CP0180777
|
7-fluoro-6-[6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]quinoline-3-carboxamide
Show/Hide
|
C23H23FN6O2
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0552478
|
6-[6-[2-(dimethylamino)ethoxy]pyridin-3-yl]-4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]cinnoline-3-carboxamide
Show/Hide
|
C24H28N8O2
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0236325
|
4-(2-ethylbutylamino)-6-[6-(methylsulfonylmethyl)pyridin-3-yl]quinoline-3-carboxamide
Show/Hide
|
C23H28N4O3S
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0456093
|
4-[[(1S)-1-(1,4-dimethylpyrazol-3-yl)ethyl]amino]-6-[6-(methoxymethyl)pyridin-3-yl]cinnoline-3-carboxamide
Show/Hide
|
C23H25N7O2
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0234614
|
4-(2-ethylbutylamino)-6-[6-(methoxymethyl)pyridin-3-yl]quinoline-3-carboxamide
Show/Hide
|
C23H28N4O2
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0180776
|
6-[6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]quinoline-3-carboxamide
Show/Hide
|
C24H28N4O3
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0474082
|
6-[6-[2-(dimethylamino)ethoxy]pyridin-3-yl]-N-methyl-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamide
Show/Hide
|
C26H34N6O3
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0364431
|
4-(2-ethylbutylamino)-6-(6-methylpyridin-3-yl)quinoline-3-carboxamide
Show/Hide
|
C22H26N4O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0362300
|
7-fluoro-6-[6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]quinoline-3-carboxamide
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C24H27FN4O3
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1
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| 1 |
IC50 = 52 nM
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CP0387521
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6-[6-[2-(dimethylamino)ethylamino]pyridin-3-yl]-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamide
Show/Hide
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C25H33N7O2
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1
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| 1 |
IC50 = 61 nM
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CP0180778
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6-[2-fluoro-6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]quinoline-3-carboxamide
Show/Hide
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C23H23FN6O2
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1
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| 1 |
IC50 = 63 nM
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CP0234610
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4-(2-ethylbutylamino)-6-[4-(methylsulfonylmethyl)phenyl]quinoline-3-carboxamide
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C24H29N3O3S
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1
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| 1 |
IC50 = 70 nM
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CP0537597
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7-fluoro-6-[2-fluoro-6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]quinoline-3-carboxamide
Show/Hide
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C23H22F2N6O2
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1
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| 1 |
IC50 = 73 nM
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CP0558413
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4-(2-ethylbutylamino)-6-pyridin-3-ylquinoline-3-carboxamide
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C21H24N4O
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1
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| 1 |
IC50 = 73 nM
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CP0495550
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US9428503, CN102399218A: Compound 114
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C23H23N5O4S
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1
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| 1 |
IC50 = 74.1 nM
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CP0180774
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4-(2-ethylbutylamino)-6-[6-(hydroxymethyl)pyridin-3-yl]quinoline-3-carboxamide
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C22H26N4O2
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1
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| 1 |
IC50 = 87 nM
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CP0164868
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7-fluoro-1-(3-methoxycyclobutyl)-8-[6-(methoxymethyl)pyridin-3-yl]-3-methylimidazo[4,5-c]quinolin-2-one
Show/Hide
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C23H23FN4O3
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1
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| 1 |
IC50 = 100 nM
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CP0234613
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4-[[(1R)-1-(4-chlorophenyl)ethyl]amino]-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
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C23H19ClN4O
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1
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| 1 |
IC50 = 109 nM
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CP0362355
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4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
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C21H20N6O
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1
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| 1 |
IC50 = 124 nM
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CP0413610
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US9428503, CN102372711A: Compound 1
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C22H23N5O2
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1
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| 1 |
IC50 = 125 nM
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CP0548185
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N-[2-(dimethylamino)ethyl]-5-[7-fluoro-1-(3-methoxycyclobutyl)-3-methyl-2-oxoimidazo[4,5-c]quinolin-8-yl]pyridine-2-carboxamide
Show/Hide
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C26H29FN6O3
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1
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| 1 |
IC50 = 130 nM
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CP0556348
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4-(cyclohexylamino)-6-pyridin-3-ylquinoline-3-carboxamide
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C21H22N4O
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1
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| 1 |
IC50 = 132 nM
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CP0413611
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US9428503, CN102399218A: Compound 62
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C21H17N5O
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1
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| 1 |
IC50 = 135 nM
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CP0364430
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4-(cyclopentylamino)-6-pyridin-3-ylquinoline-3-carboxamide
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C20H20N4O
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1
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| 1 |
IC50 = 137 nM
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CP0542830
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CHEMBL4176135
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C22H21FN4O3
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1
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| 1 |
IC50 = 140 nM
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CP0456092
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6-[6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamide
Show/Hide
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C23H27N5O3
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1
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| 1 |
IC50 = 140 nM
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CP0180814
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2-morpholin-4-yl-6-(9H-thioxanthen-4-yl)pyran-4-one
Show/Hide
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C22H19NO3S
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1
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| 1 |
IC50 = 149 nM
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CP0164867
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7-fluoro-1-(3-methoxycyclobutyl)-8-[6-(methoxymethyl)pyridin-3-yl]-3-methylimidazo[4,5-c]quinolin-2-one
Show/Hide
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C23H23FN4O3
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1
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| 1 |
IC50 = 160 nM
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CP0232291
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7-fluoro-1-(3-methoxycyclobutyl)-3-methyl-8-[6-(methylsulfonylmethyl)pyridin-3-yl]imidazo[4,5-c]quinolin-2-one
Show/Hide
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C23H23FN4O4S
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1
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| 1 |
IC50 = 160 nM
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CP0180772
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4-[[(1S)-1-(oxan-4-yl)ethyl]amino]-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
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C22H24N4O2
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1
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| 1 |
IC50 = 168 nM
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CP0406920
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US9428503, CN102399218A: Compound 64
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C18H16N6O
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1
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| 1 |
IC50 = 216 nM
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CP0164863
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8-[6-[2-(dimethylamino)ethyl-methylamino]pyridin-3-yl]-7-fluoro-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-one
Show/Hide
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C26H31FN6O2
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1
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| 1 |
IC50 = 230 nM
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CP0438313
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7-fluoro-8-[6-(hydroxymethyl)pyridin-3-yl]-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-one
Show/Hide
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C22H21FN4O3
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1
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| 1 |
IC50 = 230 nM
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CP0235599
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7-fluoro-1-(4-methoxycyclohexyl)-8-[6-(methoxymethyl)pyridin-3-yl]-3-methylimidazo[4,5-c]quinolin-2-one
Show/Hide
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C25H27FN4O3
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1
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| 1 |
IC50 = 240 nM
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CP0429517
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6-[6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]cinnoline-3-carboxamide
Show/Hide
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C22H23N7O2
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1
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| 1 |
IC50 = 260 nM
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CP0456094
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6-[6-(methoxymethyl)pyridin-3-yl]-N-methyl-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamide
Show/Hide
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C24H29N5O3
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1
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| 1 |
IC50 = 330 nM
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CP0412368
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3-methyl-1-(oxan-4-yl)-8-pyridin-3-ylimidazo[4,5-c]quinolin-2-one
Show/Hide
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C21H20N4O2
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1
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| 1 |
IC50 = 360 nM
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CP0145049
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8-[6-(methoxymethyl)pyridin-3-yl]-3-methyl-1-(oxan-4-yl)imidazo[4,5-c]quinolin-2-one
Show/Hide
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C23H24N4O3
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1
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| 1 |
IC50 = 370 nM
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CP0537595
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4-(2-ethylbutylamino)-6-[4-(methoxymethyl)phenyl]quinoline-3-carboxamide
Show/Hide
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C24H29N3O2
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1
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| 1 |
IC50 = 373 nM
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CP0480277
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4-(2-ethylbutylamino)-6-pyridin-4-ylquinoline-3-carboxamide
Show/Hide
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C21H24N4O
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1
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| 1 |
IC50 = 418 nM
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CP0164866
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7-fluoro-8-[6-(methoxymethyl)pyridin-3-yl]-3-methyl-1-(oxan-4-yl)imidazo[4,5-c]quinolin-2-one
Show/Hide
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C23H23FN4O3
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1
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| 1 |
IC50 = 450 nM
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CP0265668
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4-(cyclohexylmethylamino)-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
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C22H24N4O
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1
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| 1 |
IC50 = 456 nM
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CP0164864
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7-fluoro-8-[6-(methoxymethyl)pyridin-3-yl]-3-methyl-1-[(1S)-1-(oxan-4-yl)ethyl]imidazo[4,5-c]quinolin-2-one
Show/Hide
|
C25H27FN4O3
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1
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| 1 |
IC50 = 490 nM
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CP0402721
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US9428503, CN102399218A: Compound 94
Show/Hide
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C20H20N6O2
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1
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| 1 |
IC50 = 494 nM
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CP0534989
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4-(2-ethylbutylamino)-6-(1-methylpyrazol-4-yl)quinoline-3-carboxamide
Show/Hide
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C20H25N5O
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1
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| 1 |
IC50 = 525 nM
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CP0549742
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4-(2-ethylbutylamino)-6-pyridazin-3-ylquinoline-3-carboxamide
Show/Hide
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C20H23N5O
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1
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| 1 |
IC50 = 571 nM
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CP0561273
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7-fluoro-4-(oxan-4-ylamino)-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
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C20H19FN4O2
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1
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| 1 |
IC50 = 606 nM
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CP0473945
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4-[[(1R)-1-(oxan-4-yl)ethyl]amino]-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
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C22H24N4O2
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1
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| 1 |
IC50 = 730 nM
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CP0180782
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6-cyano-4-(2-ethylbutylamino)quinoline-3-carboxamide
Show/Hide
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C17H20N4O
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1
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| 1 |
IC50 = 820 nM
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CP0473927
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4-(2-ethylbutylamino)-6-pyridazin-4-ylquinoline-3-carboxamide
Show/Hide
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C20H23N5O
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1
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| 1 |
IC50 = 908 nM
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CP0164861
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4-(oxan-4-ylamino)-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
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C20H20N4O2
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2
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| 1 |
IC50 = 950 nM
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| 2 |
IC50 = 954 nM
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CP0259633
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4-[[(1R)-1-(1-methylpyrazol-3-yl)ethyl]amino]-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
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C21H20N6O
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1
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| 1 |
IC50 = 1130 nM
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CP0016003
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2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one
Show/Hide
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C21H17NO3S2
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1
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| 1 |
IC50 = 1220 nM
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CP0472913
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1-(oxan-4-yl)-8-pyridin-3-yl-3H-imidazo[4,5-c]quinolin-2-one
Show/Hide
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C20H18N4O2
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1
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| 1 |
IC50 = 1600 nM
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CP0563148
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US9428503, CN102399218A: Compound 60
Show/Hide
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C22H25N5O3
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1
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| 1 |
IC50 = 1760 nM
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CP0180773
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4-(2-ethylbutylamino)-6-pyrimidin-5-ylquinoline-3-carboxamide
Show/Hide
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C20H23N5O
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1
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| 1 |
IC50 = 1840 nM
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CP0571634
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9-[(3R,4R)-4-fluoropyrrolidin-3-yl]-7-methyl-2-[(7-methylquinolin-6-yl)amino]purin-8-one
Show/Hide
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C20H20FN7O
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1
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| 1 |
IC50 = 2600 nM
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CP0446983
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4-(oxan-4-ylmethylamino)-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
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C21H22N4O2
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1
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| 1 |
IC50 = 3230 nM
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CP0362356
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7-chloro-4-(oxan-4-ylamino)-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
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C20H19ClN4O2
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1
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| 1 |
IC50 = 3250 nM
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CP0180813
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2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine
Show/Hide
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C17H15N7O2
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1
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| 1 |
IC50 = 3420 nM
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CP0508027
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US9428503, CN102399218A: Compound 61
Show/Hide
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C21H18N6O
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1
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| 1 |
IC50 = 3460 nM
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CP0180775
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4-(2-ethylbutylamino)-8-methyl-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
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C22H26N4O
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1
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| 1 |
IC50 = 6000 nM
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CP0491233
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4-cyclopentylsulfanyl-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
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C20H19N3OS
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1
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| 1 |
IC50 = 9700 nM
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CP0180780
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4-[[(1R)-1-(4-chlorophenyl)ethyl]amino]-6-cyanoquinoline-3-carboxamide
Show/Hide
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C19H15ClN4O
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1
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| 1 |
IC50 = 14400 nM
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CP0473312
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7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one
Show/Hide
|
C18H20N8O2
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1
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| 1 |
IC50 = 17900 nM
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CP0470728
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8-[6-[3-(4-hydroxypiperidin-1-yl)propoxy]pyridin-3-yl]-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-one
Show/Hide
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C29H35N5O4
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1
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| 1 |
IC50 = 27000 nM
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CP0427456
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1-(3-methoxycyclobutyl)-3-methyl-8-[6-(3-morpholin-4-ylpropoxy)pyridin-3-yl]imidazo[4,5-c]quinolin-2-one
Show/Hide
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C28H33N5O4
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1
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| 1 |
IC50 > 28000 nM
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CP0068243
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(3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine
Show/Hide
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C21H24N4O3S
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1
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| 1 |
IC50 > 30000 nM
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CP0538859
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1-(oxan-4-yl)-3-propan-2-yl-8-pyridin-3-ylimidazo[4,5-c]quinolin-2-one
Show/Hide
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C23H24N4O2
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1
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| 1 |
IC50 > 30000 nM
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CP0068244
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(3R)-3-methyl-4-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrimidin-4-yl]morpholine
Show/Hide
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C20H23N5O3S
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1
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| 1 |
IC50 > 30000 nM
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CP0068245
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N-methyl-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine
Show/Hide
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C21H26N6O3S
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1
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| 1 |
IC50 > 30000 nM
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CP0669285
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US8552004, 2.03
Show/Hide
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C21H27N7O2S
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1
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| 1 |
IC50 > 30000 nM
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CP0808811
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CERALASERTIB
Show/Hide
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C20H24N6O2S
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1
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| 1 |
IC50 > 30000 nM
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CP0362298
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8-chloro-4-(oxan-4-ylamino)-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
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C20H19ClN4O2
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1
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| 1 |
IC50 > 30000 nM
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CP0364433
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4-(2-ethylbutylamino)-2-methyl-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
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C22H26N4O
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1
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| 1 |
IC50 > 30000 nM
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CP0446981
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4-[[(1R)-1-(4-chlorophenyl)ethyl]amino]-6-pyridin-3-ylquinoline-3-carboxylic acid
Show/Hide
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C23H18ClN3O2
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1
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| 1 |
IC50 > 30000 nM
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CP0446982
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4-[[(1R)-1-(4-chlorophenyl)ethyl]amino]-N-methyl-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
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C24H21ClN4O
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1
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| 1 |
IC50 > 30000 nM
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CP0491228
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8-fluoro-4-(oxan-4-ylamino)-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
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C20H19FN4O2
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1
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| 1 |
IC50 > 30000 nM
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CP0491230
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4-(2-ethylbutoxy)-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
|
C21H23N3O2
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1
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| 1 |
IC50 > 30000 nM
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CP0558418
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5-fluoro-4-(oxan-4-ylamino)-6-pyridin-3-ylquinoline-3-carboxamide
Show/Hide
|
C20H19FN4O2
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1
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| 1 |
IC50 > 30000 nM
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CP0559691
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N-[(1R)-1-(4-chlorophenyl)ethyl]-6-pyridin-3-ylquinolin-4-amine
Show/Hide
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C22H18ClN3
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1
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| 1 |
IC50 > 30000 nM
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