Brief Information of the Compound and Protein
Compound Name
2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine
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PubChem ID
CID: 44551660
SID: 87234681
Canonical SMILES
COc1cc2ncnc(-n3nc(nc3N)-c3ccccn3)c2cc1OC
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Compound Formula C17H15N7O2
Compound Structure
Protein Name
Serine-protein kinase ATM
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
Atypical protein kinase group
>
Atypical protein kinase PIKK family
Uniprot ID
Q13315
Gene Name
ATM
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000007 HT-29 Homo sapiens (Human)  1
1
IC50 = 3420 nM
   TI
   LI
   LO
   TS
CL000083 MCF-7 Homo sapiens (Human)  2
1
IC50 = 400 nM
   TI
   LI
   LO
   TS
2
IC50 = 480 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 12.9 nM
2 IC50 = 20 nM
3 IC50 = 21 nM
4 IC50 = 370 nM