(S)-(4-fluorophenyl)(3-(3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone

(S)-(2,4-difluorophenyl)(3-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone

3-chloro-N-(3-fluorophenyl)benzamide

5-(2-p-tolylethynyl)pyrimidine

5-(2-(4-chlorophenyl)ethynyl)pyrimidine

4-(2-(pyrimidin-5-yl)ethynyl)benzaldehyde

5-(2-(4-ethylphenyl)ethynyl)pyrimidine

3-(6-Methyl-pyridin-2-ylethynyl)-benzonitrile

3-Fluoro-5-cyano-1-(2-methylthiazol-4-ylethynyl)benzene

2-Phenyl-5-(2-methylthiazol-4ylethynyl)pyridine

3-(2-(6-methylpyridin-2-yl)ethynyl)-5-fluorobenzonitrile

3-Phenyl-1-(2-methylthiazol-4-ylethynyl)benzene

2-Phenyl-5-(6-methylpyridin-2-ylethynyl)benzonitrile

3-methoxy-5-[2-(6-methylpyridin-2-yl)ethynyl]benzonitrile

1-(Pyridin-3-yl)-2-fluoro-4-(2-methylthiazol-4ylethynyl)benzene

2-Methyl-6-(phenylethynyl)pyridine

3-Cyano-4-(4'-fluorophenyl)-N-(6-methylpyridin-2-yl)-benzamid

1-Fluoro-3-(pyridin-3-yl)-5-(2-methylthiazol-4ylethynyl)benzene

2-(Pyridin-3-yl)-5-(2-methylthiazol-4ylethynyl)pyridine

2-(3-Fluorophenyl)-5-(6-methylpyridin-2-ylethynyl)benzonitrile

5-(2-m-tolylethynyl)pyrimidine

2-(4-Fluorophenyl)-5-(6-methylpyridin-2-ylethynyl)benzonitrile

N-(5-fluoropyridin-2-yl)-6-(5-fluoropyridin-3-yl)oxyquinoline-8-carboxamide

6-[2-(3-cyano-5-fluorophenyl)ethynyl]pyridine-2-carbonitrile

US8796295, Table 2: Compound: 3

N-(5-fluoropyridin-2-yl)-6-methyl-4-pyrimidin-5-yloxypyridine-2-carboxamide

5-((6-Methylpyridin-2-yl)ethynyl)nicotinonitrile

2-methyl-4-(pyridin-3-ylethynyl)thiazole

3-Cyano-4-phenyl-N-(6-methylpyridin-2-yl)-benzamide

6-[2-(3-cyanophenyl)ethynyl]pyridine-2-carbonitrile

N-(5-fluoropyridin-2-yl)-6-(5-fluoropyridin-3-yl)oxy-[1,2,4]triazolo[1,5-a]pyridine-8-carboxamide

3-Cyano-5-fluoro-N-(6-methylpyridin-2-yl)-benzamide

3-Cyano-4'-(3-fluorophenyl)-N-(6-methylpyridin-2-yl)-benzamide

3-[2-[6-(hydroxymethyl)pyridin-2-yl]ethynyl]benzonitrile

5-(2-(3-chlorophenyl)ethynyl)pyrimidine

N-(3-chlorophenyl)-3-cyano-5-fluorobenzamide

3-fluoro-5-[2-[6-(hydroxymethyl)pyridin-2-yl]ethynyl]benzonitrile

3-cyano-5-fluoro-N-(4-methylthiazol-2-yl)benzamide

3-(1,3-dioxoisoindolin-2-yl)-N-(2-hydroxyphenyl)benzamide

3-[2-(6-ethylpyridin-2-yl)ethynyl]benzonitrile

3-fluoro-5-[2-(6-fluoropyridin-2-yl)ethynyl]benzonitrile

5-(2-Methylquinolin-7-yl)-2-phenylnicotinonitrile

N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-5-bromofuran-2-carboxamide

4-(3,5-Difluorophenyl)-N-(6-methylpyrindin-2-yl)picolinamide

4-bromo-N-(6-pyrimidin-5-yloxypyrazin-2-yl)pyridine-2-carboxamide

3-cyano-5-fluoro-N-m-tolylbenzamide

5-[2-(6-methoxypyridin-2-yl)ethynyl]pyridine-3-carbonitrile

3-[2-(6-fluoropyridin-2-yl)ethynyl]benzonitrile

3-[2-(6-acetylpyridin-2-yl)ethynyl]-5-fluorobenzonitrile

N-(6-chloropyridin-2-yl)-3-cyano-5-fluorobenzamide

2-Methoxymethoxy-5-(2-methylquinolin-7-yl)benzonitrile

3-[2-(6-acetylpyridin-2-yl)ethynyl]benzonitrile

3-[2-(6-methoxypyridin-2-yl)ethynyl]benzonitrile

3-cyano-N-(3-ethynylphenyl)-5-fluorobenzamide

N-(3-chloro-2-fluorophenyl)-3-cyano-5-fluorobenzamide

5-(2-(4-fluoro-3-methylphenyl)ethynyl)pyrimidine

N-(3-chloro-4-fluorophenyl)-3-cyano-5-fluorobenzamide

3-fluoro-5-[2-(6-methoxypyridin-2-yl)ethynyl]benzonitrile

5-(2-(3-(trifluoromethyl)phenyl)ethynyl)pyrimidine

5-(phenylethynyl)pyrimidine

3-cyano-N-(3-cyanophenyl)-5-fluorobenzamide

3-cyano-N-(6-methylpyridin-2-yl)benzamide

6-[2-(5-cyanopyridin-3-yl)ethynyl]pyridine-2-carbonitrile

3-cyano-N-(6-ethylpyridin-2-yl)-5-fluorobenzamide

3-cyano-5-fluoro-N-(3-(trifluoromethyl)phenyl)benzamide

3-cyano-N-(4,5-dimethylthiazol-2-yl)-5-fluorobenzamide

3-Cyano-N-(6-methylpyridin-2-yl)-4-(naphthalen-1-yl)-benzamide

5-(2-Methylquinolin-7-yl)-2-(4-fluorophenyl)benzonitrile

3-[2-(6-butylpyridin-2-yl)ethynyl]benzonitrile

3-cyano-5-fluoro-N-(5-methylthiazol-2-yl)benzamide

N-[3-[(3-chlorobenzoyl)amino]phenyl]-2-methoxybenzamide

3-cyano-N-(4-cyclopropylthiazol-2-yl)-5-fluorobenzamide

3-(1,3-dioxoisoindolin-2-yl)-N-(2-fluorophenyl)benzamide

5-(2-Methylquinolin-7-yl)-2-phenylbenzonitrile

3-(1,3-dioxoisoindolin-2-yl)-N-(pyridin-2-yl)benzamide

5-(2-Methylquinolin-7-yl)-2-(pyridin-3-yl)benzonitrile

2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide

3-cyano-5-fluoro-N-(6-methoxypyridin-2-yl)benzamide

N-(3-chlorophenyl)-3-(1,3-dioxoisoindol-2-yl)benzamide

N-[3-[(3-cyanobenzoyl)amino]phenyl]-2-methoxybenzamide

N-(3-chloro-5-fluorophenyl)-3-cyano-5-fluorobenzamide

3-chloro-N-(6-methylpyridin-2-yl)benzamide

3-cyano-5-fluoro-N-(3-fluorophenyl)benzamide

3-chloro-N-(3-(cyclopropanecarboxamido)phenyl)benzamide

2-chloro-N-(3-(3-chlorobenzamido)phenyl)benzamide

3-cyano-5-fluoro-N-(pyridin-2-yl)benzamide

2-Chloro-5-(2-methylquinolin-7-yl)nicotinonitrile

N-(3,5-dimethoxyphenyl)-3-(1,3-dioxoisoindol-2-yl)benzamide

N-(5-chloro-2-fluorophenyl)-3-cyano-5-fluorobenzamide

N-[3-[(3-chlorobenzoyl)amino]phenyl]furan-2-carboxamide

3-cyano-N-(3-ethylphenyl)-5-fluorobenzamide

3-chloro-N-(3-(cyclobutanecarboxamido)phenyl)benzamide

3-cyano-5-fluoro-N-phenylbenzamide

3-chloro-N-(3-isobutyramidophenyl)benzamide

5-(2-(3,5-difluorophenyl)ethynyl)pyrimidine

N-[3-[(3-fluorobenzoyl)amino]phenyl]-2-methoxybenzamide

2-Phenyl-4-(2-methylbenzo[d]thiazol-5-yl)benzonitrile

3-(1,3-dioxoisoindolin-2-yl)-N-(3-hydroxyphenyl)benzamide

5-Biphenyl-4-ylethynyl-pyrimidine

2-Cyano-4-(2-methylbenzo[d]thiazol-5-yl)phenyl trifluoromethanesulfonate

N-(3-acetamidophenyl)-3-chlorobenzamide

(S)-cyclobutyl(3-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone

5-Chloro-2-(2-methylquinolin-7-yl)benzonitrile

4'-fluoro-4-(2-methylbenzo[d]thiazol-5-yl)biphenyl-2-carbonitrile

2-Benzoxy-5-(2-methylbenzo[d]thiazol-5-yl)benzonitrile

2-Benzoxy-5-(2-methylquinolin-7-yl)benzonitrile

2-Hydroxy-5-(2-methylquinolin-7-yl)benzonitrile

2-(Pyridin-3-yl)-4-(2-methylbenzo[d]thiazol-5-yl)benzonitrile

3-cyano-5-fluoro-N-(4-methylpyridin-2-yl)benzamide

3-cyano-5-fluoro-N-(thiazol-2-yl)benzamide

3-cyano-5-fluoro-N-(4-fluorophenyl)benzamide

3-cyano-5-fluoro-N-(1-methyl-1H-pyrazol-3-yl)benzamide

N-(4-tert-butyl-1,3-thiazol-2-yl)-3-cyano-5-fluorobenzamide

N-(2-adamantyl)-3-cyano-5-fluorobenzamide

3-cyano-5-fluoro-N-(6-(trifluoromethyl)pyridin-2-yl)benzamide

3-cyano-5-fluoro-N-(3-methoxyphenyl)benzamide

1-adamantyl-[(2R)-2-methyl-4-pyridin-2-ylpiperazin-1-yl]methanone

1-adamantyl-[(3R)-3-methyl-4-pyridin-2-ylpiperazin-1-yl]methanone

3-chloro-N-(3-fluoropyridin-2-yl)-5-(pyrimidin-5-yloxy)benzamide

3-(pyridin-3-yloxy)-N-(pyrimidin-4-yl)benzamide

3-fluoro-N-(3-fluoropyridin-2-yl)-5-(pyrimidin-5-yloxy)benzamide

N-(2-methylpyridin-4-yl)-3-(pyridin-3-yloxy)benzamide

3-(pyridin-3-yloxy)-N-(thiazol-2-yl)benzamide

US8569308, 137

N-[6-(5-fluoropyridin-3-yl)oxypyrazin-2-yl]-4-methyl-1,3-thiazole-2-carboxamide

N-[6-(5-fluoropyridin-3-yl)oxypyrazin-2-yl]-1,3-thiazole-2-carboxamide

N-(6-pyrimidin-5-yloxypyrazin-2-yl)thiophene-3-carboxamide

3-chloro-5-fluoro-N-[6-(5-fluoropyridin-3-yl)oxypyrazin-2-yl]benzamide

N-(6-pyrimidin-5-yloxypyrazin-2-yl)thiophene-2-carboxamide

N-(6-pyrimidin-5-yloxypyrazin-2-yl)benzamide

3-(dimethylamino)-N-[6-(5-fluoropyridin-3-yl)oxypyrazin-2-yl]benzamide

N-[6-(5-fluoropyridin-3-yl)oxypyrazin-2-yl]pyridine-2-carboxamide

N-(6-pyrimidin-5-yloxypyrazin-2-yl)-1,3-thiazole-4-carboxamide

6-[difluoro(pyrimidin-5-yl)methyl]-N-(4-methylpyridin-2-yl)quinoline-8-carboxamide

N-(6-fluoropyridin-2-yl)-6-(pyrimidine-5-carbonyl)quinoline-8-carboxamide

6-[hydroxy(pyridin-3-yl)methyl]-N-(4-methyl-1,3-thiazol-2-yl)quinoline-8-carboxamide

2-methoxy-N-(3-(3-(trifluoromethyl)benzamido)phenyl)benzamide

5-(2-(2,5-dimethylphenyl)ethynyl)pyrimidine

3-chloro-N-(3-(3-methylbenzamido)phenyl)benzamide

N-[3-[(4-chlorobenzoyl)amino]phenyl]-2-methoxybenzamide

3,5-dichloro-N-(3-(2-methoxybenzamido)phenyl)benzamide

3-chloro-N-(3-(cyclohexanecarboxamido)phenyl)benzamide

3,4-dichloro-N-(3-(2-methoxybenzamido)phenyl)benzamide

N-[3-[(4-fluorobenzoyl)amino]phenyl]-2-methoxybenzamide

N-[3-(cyclohexanecarbonylamino)phenyl]-2-methoxybenzamide

N-[3-(cyclobutanecarbonylamino)phenyl]-2-methoxybenzamide

3-chloro-N-(3-(4-fluorobenzamido)phenyl)benzamide

3-chloro-N-(3-(cyclopentanecarboxamido)phenyl)benzamide

N-(3-acetamidophenyl)-2-methoxybenzamide

2-methoxy-N-(3-(2-methoxyacetamido)phenyl)benzamide

3-chloro-N-(3-(2-phenylcyclopropanecarboxamido)phenyl)benzamide

2-chloro-N-(3-(2-methoxybenzamido)phenyl)benzamide

Adamantane-1-carboxylic acid [3-(2-methoxy-benzoylamino)-phenyl]-amide

N-[3-[(3-chlorobenzoyl)amino]phenyl]-1,3-benzodioxole-5-carboxamide

3-chloro-N-(3-(2-methoxyacetamido)phenyl)benzamide

3-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorophenyl)benzamide

N-[3-[(2-methoxybenzoyl)amino]phenyl]-1,3-benzodioxole-5-carboxamide

3,4-dichloro-N-(3-(3-chlorobenzamido)phenyl)benzamide

3-chloro-N-(3-(3-(trifluoromethyl)benzamido)phenyl)benzamide

3-chloro-N-(3-(2-phenylacetamido)phenyl)benzamide

Adamantane-1-carboxylic acid [3-(3-chloro-benzoylamino)-phenyl]-amide

3-(1,3-dioxoisoindolin-2-yl)-N-(pyridin-3-yl)benzamide

3-chloro-N-[3-[(3-chlorobenzoyl)amino]phenyl]benzamide

3-(1,3-dioxoisoindolin-2-yl)-N-(2-methoxyphenyl)benzamide

3-chloro-N-(3-(3-fluorobenzamido)phenyl)benzamide

N-cyclopropyl-3-(1,3-dioxoisoindol-2-yl)benzamide