Brief Information of the Compound and Protein
Compound Name
5-(phenylethynyl)pyrimidine
    Show/Hide
PubChem ID
CID: 4074142
SID: 16791194
Canonical SMILES
c1ccc(cc1)C#Cc1cncnc1
    Show/Hide
Compound Formula C12H8N2
Compound Structure
Protein Name
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Uniprot ID
P31424
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 486 nM
   TI
   LI
   LO
   TS
CL000050 HEK293-A Homo sapiens (Human)  3
1
IC50 = 480 nM
   TI
   LI
   LO
   TS
2
IC50 = 486 nM
   TI
   LI
   LO
   TS
3
Ki = 125.9 nM
   TI
   LI
   LO
   TS