Brief Information of the Compound and Protein
Compound Name
2-(4-Fluorophenyl)-5-(6-methylpyridin-2-ylethynyl)benzonitrile
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PubChem ID
CID: 44573869
Canonical SMILES
Fc1ccc(cc1)-c1ccc(cc1C#N)C#Cc1ccccn1
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Compound Formula C20H11FN2
Compound Structure
Protein Name
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
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Family C G protein-coupled receptor
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Small molecule receptor (family C GPCR)
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Neurotransmitter receptor (family C GPCR)
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Metabotropic glutamate receptor
Uniprot ID
P31424
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
Ki = 3 nM
   TI
   LI
   LO
   TS
CL000050 HEK293-A Homo sapiens (Human)  1
1
IC50 = 7.19 nM
   TI
   LI
   LO
   TS