Brief Information of the Cell Line and Protein
Cell Line ID: CL000040 , THP-1
Synonyms
THP1
THP 1
THPI
THP-1(ATCC)
THP-1-O
O-THP-1
Tohoku Hospital Pediatrics-1
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0006
Protein ID: PT01058 , Disintegrin and metalloproteinase domain-containing protein 17
Gene Name ADAM17
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P78536
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000040  Protein ID: PT01058
 
Compound ID Compound Name Compound Formula
CP0063416
(7S,8R,11S)-9-Oxo-8-[3-(3,4,5-trimethoxy-phenyl)-propyl]-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide
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C30H41N3O8
 1
1
IC50 = 140 nM
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CP0214161
(7S,8R,11S)-8-[3-(3,4-dimethoxy-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide
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C29H39N3O7
 1
1
IC50 = 180 nM
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CP0068570
(7S,8R,11S)-8-[3-(3-isopropyl-5-methyl-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide
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C31H43N3O5
 1
1
IC50 = 220 nM
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CP0094685
(7S,8R,11S)-8-[3-(3,5-Bis-trifluoromethyl-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide
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C29H33F6N3O5
 1
1
IC50 = 300 nM
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CP0061136
(7S,8R,11S)-8-[3-(4-ethoxy-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide
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C29H39N3O6
 1
1
IC50 = 400 nM
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CP0109554
(7S,8R,11S)-8-(3-naphthalen-1-yl-propyl)-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide
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C31H37N3O5
 1
1
IC50 = 440 nM
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CP0206165
(7S,8R,11S)-8-[3-(4-chloro-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide
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C27H34ClN3O5
 1
1
IC50 = 440 nM
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CP0076614
(S)-2,2-Dimethyl-4-[4-(3,4,5-trimethoxy-phenoxy)-benzenesulfonyl]-thiomorpholine-3-carboxylic acid hydroxyamide
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C22H28N2O8S2
 1
1
IC50 = 550 nM
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CP0077428
(7S,8R,11S)-11-benzoyl-8-[3-(3,5-dimethoxy-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7-carboxylic acid hydroxyamide
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C34H40N2O7
 1
1
IC50 = 2900 nM
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CP0077433
(7S,8R,11S)-11-benzoyl-9-oxo-8-[3-(3,4,5-trimethoxy-phenyl)-propyl]-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7-carboxylic acid hydroxyamide
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C35H42N2O8
 1
1
IC50 = 3500 nM
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CP0068569
(7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide
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C29H39N3O7
 1
1
IC50 = 4100 nM
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CP0068572
(S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesulfonyl]-thiomorpholine-3-carboxylic acid hydroxyamide
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C18H21N3O5S2
 1
1
IC50 = 8600 nM
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CP0068568
(7S,8R,11S)-11-Benzoyl-8-{3-[3-methoxy-5-(2-methoxy-ethoxy)-phenyl]-propyl}-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7-carboxylic acid hydroxyamide
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C36H44N2O8
 1
1
IC50 = 15000 nM
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CP0109621
N-hydroxy-2-methyl-3-[4-(3,4,5-trimethoxyphenoxy)phenyl]sulfonylpropanamide
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C19H23NO8S
 1
1
IC50 = 41000 nM
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CP0050653
(7S,8R,11S)-11-Benzoyl-9-oxo-8-(3-p-tolyl-propyl)-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7-carboxylic acid hydroxyamide
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C33H38N2O5
 1
1
IC50 > 5000 nM
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CP0196222
(7S,8R,11S)-11-Benzoyl-8-[3-(3,5-dibromo-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7-carboxylic acid hydroxyamide
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C32H34Br2N2O5
 1
1
IC50 > 5000 nM
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