General Information of the Compound
Compound ID
CP0050653
Compound Name
(7S,8R,11S)-11-Benzoyl-9-oxo-8-(3-p-tolyl-propyl)-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7-carboxylic acid hydroxyamide
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Structure
Formula
C33H38N2O5
Molecular Weight
542.676
Canonical SMILES
Cc1ccc(CCC[C@@H]2[C@H](CCCCOc3ccc(C[C@H](NC2=O)C(=O)c2ccccc2)cc3)C(=O)NO)cc1
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InChI
InChI=1S/C33H38N2O5/c1-23-13-15-24(16-14-23)8-7-12-28-29(33(38)35-39)11-5-6-21-40-27-19-17-25(18-20-27)22-30(34-32(28)37)31(36)26-9-3-2-4-10-26/h2-4,9-10,13-20,28-30,39H,5-8,11-12,21-22H2,1H3,(H,34,37)(H,35,38)/t28-,29+,30+/m1/s1
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InChIKey
GIGQELYOVAVUIF-NGDRWEMDSA-N
Physicochemical Property
logP
5.22862
Rotatable Bonds
7
Heavy Atom Count
40
Polar Areas
104.73
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 9937188
SID: 14910361
ChEMBL ID
CHEMBL99547
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01058, Disintegrin and metalloproteinase domain-containing protein 17
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 96 nM