| Compound ID |
Compound Name |
Compound Formula |
|
CP0577026
|
(3-phenoxyazetidin-1-yl)-[(3S)-3-phenyl-3,4-dihydropyrazol-2-yl]methanone
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|
C19H19N3O2
|
1
|
| 1 |
EC50 = 0.5 nM
|
|
|
|
CP0579386
|
[(3S)-3-(3,5-difluorophenyl)-3,4-dihydropyrazol-2-yl]-[3-(2-fluorophenoxy)azetidin-1-yl]methanone
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|
C19H16F3N3O2
|
1
|
| 1 |
EC50 = 3.1 nM
|
|
|
|
CP0579413
|
[(3S)-3-(3,5-difluorophenyl)-3,4-dihydropyrazol-2-yl]-(3-phenoxyazetidin-1-yl)methanone
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|
C19H17F2N3O2
|
1
|
| 1 |
EC50 = 3.8 nM
|
|
|
|
CP0570583
|
[(3S)-3-(4-chlorophenyl)-3,4-dihydropyrazol-2-yl]-[(2S,3S)-3-(4-fluorophenoxy)-2-methylazetidin-1-yl]methanone
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|
C20H19ClFN3O2
|
1
|
| 1 |
EC50 < 5.1 nM
|
|
|
|
CP0534815
|
[1-[(3S)-3-(3,5-difluorophenyl)-3,4-dihydropyrazole-2-carbonyl]azetidin-3-yl]-phenylmethanone
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|
C20H17F2N3O2
|
1
|
| 1 |
EC50 = 5.6 nM
|
|
|
|
CP0577756
|
[3-(4-bromophenyl)sulfanylazetidin-1-yl]-[(3S)-3-(3,5-difluorophenyl)-3,4-dihydropyrazol-2-yl]methanone
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|
C19H16BrF2N3OS
|
1
|
| 1 |
EC50 = 5.9 nM
|
|
|
|
CP0432286
|
1-[3-[5-(3-aminophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
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|
C27H19F4N5O
|
2
|
| 1 |
IC50 = 1.3 nM
|
|
|
| 2 |
IC50 = 32 nM
|
|
|
|
CP0421166
|
1-[3-[5-(4-ethylsulfonylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
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|
C29H22F4N4O3S
|
2
|
| 1 |
IC50 = 3.2 nM
|
|
|
| 2 |
IC50 = 10 nM
|
|
|
|
CP0432283
|
1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[3-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]urea
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|
C26H17F4N5O
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 7.9 nM
|
|
|
|
CP0430033
|
1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[3-[5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]urea
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|
C24H16F4N6O
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
|
CP0430036
|
1-(3-methoxyphenyl)-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]urea
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|
C27H22N4O2
|
2
|
| 1 |
IC50 = 6.3 nM
|
|
|
| 2 |
IC50 = 32 nM
|
|
|
|
CP0020770
|
3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[3-(trifluoromethyl)phenyl]urea
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|
C20H14F3N5O2
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 20 nM
|
|
|
|
CP0237070
|
1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea
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|
C23H23N5O2
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
|
CP0421164
|
1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-ethylphenyl)urea
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|
C21H19N5O2
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 25 nM
|
|
|
|
CP0431779
|
1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]urea
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|
C23H16F4N4O
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 320 nM
|
|
|
|
CP0432265
|
3-[3-[3-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]benzamide
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|
C28H19F4N5O2
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
|
CP0432266
|
1-(3-acetylphenyl)-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]urea
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|
C28H22N4O2
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 13 nM
|
|
|
|
CP0469192
|
1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[3-[5-(3-methylsulfonylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]urea
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|
C28H20F4N4O3S
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 63 nM
|
|
|
|
CP0018963
|
3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]urea
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|
C20H13F4N5O2
|
2
|
| 1 |
IC50 = 13 nM
|
|
|
| 2 |
IC50 = 63 nM
|
|
|
|
CP0392870
|
1-(3-methylphenyl)-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]urea
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|
C27H22N4O
|
2
|
| 1 |
IC50 = 13 nM
|
|
|
| 2 |
IC50 = 20 nM
|
|
|
|
CP0457354
|
1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
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|
C23H16F4N4O
|
2
|
| 1 |
IC50 = 13 nM
|
|
|
| 2 |
IC50 = 130 nM
|
|
|
|
CP0420725
|
1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea
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|
C20H20N6O3
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
IC50 = 32 nM
|
|
|
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CP0430037
|
1-(3-nitrophenyl)-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]urea
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|
C26H19N5O3
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0451715
|
1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea
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|
C23H17F3N4O
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 25 nM
|
|
|
|
CP0432287
|
1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-[3-fluoro-5-(trifluoromethyl)phenyl]urea
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|
C23H16F4N4O
|
2
|
| 1 |
IC50 = 25 nM
|
|
|
| 2 |
IC50 = 160 nM
|
|
|
|
CP0029124
|
3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[3,5-bis(trifluoromethyl)phenyl]urea
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|
C21H13F6N5O2
|
2
|
| 1 |
IC50 = 32 nM
|
|
|
| 2 |
IC50 = 320 nM
|
|
|
|
CP0432282
|
1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[4-chloro-3-(trifluoromethyl)phenyl]urea
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|
C20H13ClF3N5O2
|
2
|
| 1 |
IC50 = 32 nM
|
|
|
| 2 |
IC50 = 160 nM
|
|
|
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CP0431708
|
1-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea
Show/Hide
|
C27H19F3N4O
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0439848
|
1-[3-[5-(4-aminophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Show/Hide
|
C27H19F4N5O
|
2
|
| 1 |
IC50 = 32 nM
|
|
|
| 2 |
IC50 = 50 nM
|
|
|
|
CP0432262
|
1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-[4-chloro-3-(trifluoromethyl)phenyl]urea
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|
C23H16ClF3N4O
|
2
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
IC50 = 160 nM
|
|
|
|
CP0420697
|
1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[3-fluoro-5-(trifluoromethyl)phenyl]urea
Show/Hide
|
C20H13F4N5O2
|
2
|
| 1 |
IC50 = 63 nM
|
|
|
| 2 |
IC50 = 130 nM
|
|
|
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CP0458311
|
1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]urea
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|
C27H18F4N4O
|
2
|
| 1 |
IC50 = 80 nM
|
|
|
| 2 |
IC50 = 200 nM
|
|
|
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CP0172608
|
3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-naphthalen-2-ylurea
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|
C23H17N5O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
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CP0386311
|
1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]urea
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|
C20H13F4N5O2
|
2
|
| 1 |
IC50 = 160 nM
|
|
|
| 2 |
IC50 = 500 nM
|
|
|
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CP0442480
|
1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-chlorophenyl)urea
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|
C19H14ClN5O2
|
2
|
| 1 |
IC50 = 160 nM
|
|
|
| 2 |
IC50 = 200 nM
|
|
|
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CP0430035
|
1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-3-(trifluoromethyl)phenyl]urea
Show/Hide
|
C20H13F4N5O2
|
2
|
| 1 |
IC50 = 200 nM
|
|
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| 2 |
IC50 = 250 nM
|
|
|
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CP0439847
|
1-phenyl-3-(3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)urea
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|
C26H20N4O
|
2
|
| 1 |
IC50 = 400 nM
|
|
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| 2 |
IC50 = 1300 nM
|
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CP0386312
|
1-cyclopentyl-3-[3-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]urea
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|
C25H24N4O
|
2
|
| 1 |
IC50 = 500 nM
|
|
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| 2 |
IC50 = 2000 nM
|
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CP0432284
|
1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-[2-chloro-5-(trifluoromethyl)phenyl]urea
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|
C23H16ClF3N4O
|
2
|
| 1 |
IC50 = 630 nM
|
|
|
| 2 |
IC50 = 3200 nM
|
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|
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CP0264510
|
3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-chloro-5-(trifluoromethyl)phenyl]urea
Show/Hide
|
C20H13ClF3N5O2
|
2
|
| 1 |
IC50 = 2500 nM
|
|
|
| 2 |
IC50 > 10000 nM
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CP0421171
|
1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-[2-fluoro-3-(trifluoromethyl)phenyl]urea
Show/Hide
|
C23H16F4N4O
|
2
|
| 1 |
IC50 = 4000 nM
|
|
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| 2 |
IC50 > 10000 nM
|
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|
