| Compound ID |
Compound Name |
Compound Formula |
|
CP0166540
|
N-benzyl-2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]acetamide
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|
C26H29N3O3
|
3
|
| 1 |
GI50 = 20 nM
|
|
|
| 2 |
IC50 = 6.5 nM
|
|
|
| 3 |
IC50 = 13 nM
|
|
|
|
CP0109656
|
BMCL182776 Compound 1
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|
C24H27ClN4O4
|
2
|
| 1 |
GI50 = 87 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
|
CP0045281
|
AZD0530
Show/Hide
|
C27H32ClN5O5
|
2
|
| 1 |
IC50 = 2.7 nM
|
|
|
| 2 |
IC50 = 76 nM
|
|
|
|
CP0727871
|
N-(5-chlorobenzo[d][1,3]dioxol-4-yl)-7-(2-(pyridin-4-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine
Show/Hide
|
C27H25ClN4O5
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 40 nM
|
|
|
|
CP0110152
|
AZD0530 analogue 15
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|
C27H31ClN4O5
|
2
|
| 1 |
IC50 < 4 nM
|
|
|
| 2 |
IC50 = 65 nM
|
|
|
|
CP0277198
|
AZD0530 analogue 21
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|
C28H36ClN5O4
|
2
|
| 1 |
IC50 < 4 nM
|
|
|
| 2 |
IC50 = 220 nM
|
|
|
|
CP0309960
|
AZD0530 analogue 9
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|
C26H31ClN4O5
|
2
|
| 1 |
IC50 < 4 nM
|
|
|
| 2 |
IC50 = 100 nM
|
|
|
|
CP0332951
|
AZD0530 analogue 25
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|
C28H34ClN5O5
|
2
|
| 1 |
IC50 < 4 nM
|
|
|
| 2 |
IC50 = 50 nM
|
|
|
|
CP0370306
|
AZD0530 analogue 30
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|
C25H29ClN4O4
|
2
|
| 1 |
IC50 < 4 nM
|
|
|
| 2 |
IC50 = 50 nM
|
|
|
|
CP0453655
|
AZD0530 analogue 28
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|
C23H24ClFN4O4
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 70 nM
|
|
|
|
CP0051681
|
AZD0530 analogue 34
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|
C23H25ClN4O4
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 120 nM
|
|
|
|
CP0220846
|
AZD0530 analogue 31
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|
C24H27ClN4O5
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 50 nM
|
|
|
|
CP0511222
|
AZD0530 analogue 37
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|
C23H25ClN4O4
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0293092
|
AZD0530 analogue 18
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|
C27H31ClN4O5
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 80 nM
|
|
|
|
CP0376326
|
AZD0530 analogue 16
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|
C26H29ClN4O5
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 150 nM
|
|
|
|
CP0194245
|
AZD0530 analogue 29
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|
C25H29ClN4O4
|
2
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
IC50 = 100 nM
|
|
|
|
CP0829442
|
N-(5-chloro-1,3-benzodioxol-4-yl)-7-methoxy-5-(piperidin-4-yloxy)quinazolin-4-amine
Show/Hide
|
C21H15ClN4O4
|
2
|
| 1 |
IC50 = 9.5 nM
|
|
|
| 2 |
IC50 = 150 nM
|
|
|
|
CP0163697
|
AZD0530 analogue 35
Show/Hide
|
C23H27ClN4O3
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 530 nM
|
|
|
|
CP0341875
|
AZD0530 analogue 6
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|
C22H23ClN4O4
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 150 nM
|
|
|
|
CP0485907
|
AZD0530 analogue 36
Show/Hide
|
C23H25ClN4O4
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0059916
|
AZD0530 analogue 7
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|
C27H33ClN4O5
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 200 nM
|
|
|
|
CP0194246
|
1-{4-[2-({4-[(5-fluoro-2H-1,3-benzodioxol-4-yl)amino]-5-(propan-2-yloxy)quinazolin-7-yl}oxy)ethyl]piperazin-1-yl}ethan-1-one
Show/Hide
|
C26H30FN5O5
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 200 nM
|
|
|
|
CP0286522
|
AZD0530 analogue 8
Show/Hide
|
C28H35ClN4O4
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 750 nM
|
|
|
|
CP0174033
|
1-(4-(3-(4-(3-chloro-6-methoxypyridin-2-ylamino)-5-isopropoxyquinazolin-7-yloxy)propyl)piperazin-1-yl)ethanone
Show/Hide
|
C26H33ClN6O4
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0344967
|
AZD0530 analogue 5
Show/Hide
|
C22H25ClN4O3
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
IC50 = 500 nM
|
|
|
|
CP0174031
|
N-(3-chloro-6-methoxypyridin-2-yl)-7-(3-morpholin-4-ylpropoxy)-5-propan-2-yloxyquinazolin-4-amine
Show/Hide
|
C24H30ClN5O4
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0255394
|
AZD0530 analogue 10
Show/Hide
|
C25H31ClN4O4
|
3
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
IC50 = 150 nM
|
|
|
| 3 |
IC50 = 180 nM
|
|
|
|
CP0291529
|
AZD0530 analogue 11
Show/Hide
|
C27H32N4O5
|
2
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
IC50 = 300 nM
|
|
|
|
CP0727949
|
N-(5-chlorobenzo[d][1,3]dioxol-4-yl)-5-(pyridin-4-yloxy)quinazolin-4-amine
Show/Hide
|
C20H13ClN4O3
|
2
|
| 1 |
IC50 = 55 nM
|
|
|
| 2 |
IC50 = 600 nM
|
|
|
|
CP0178750
|
1-(4-(2-(4-(3-chloro-6-methoxypyridin-2-ylamino)-5-isopropoxyquinazolin-7-yloxy)ethyl)piperazin-1-yl)ethanone
Show/Hide
|
C25H31ClN6O4
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0302966
|
N-(3-chloro-6-methoxypyridin-2-yl)-7-[3-(4-methylpiperazin-1-yl)propoxy]-5-propan-2-yloxyquinazolin-4-amine
Show/Hide
|
C25H33ClN6O3
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0079915
|
Benzodioxole deriv. 20
Show/Hide
|
C23H25BrN4O5
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0526116
|
AZD0530 analogue 42
Show/Hide
|
C28H34ClN5O5
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0174016
|
N-(3-chloro-6-methoxypyridin-2-yl)-5-propan-2-yloxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine
Show/Hide
|
C24H30ClN5O3
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0178748
|
N-(3-chloro-6-methoxypyridin-2-yl)-7-(3-morpholin-4-ylpropoxy)-5-(oxan-4-yloxy)quinazolin-4-amine
Show/Hide
|
C26H32ClN5O5
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0272327
|
1-(4-(2-(4-(3-chloro-6-methoxypyrazin-2-ylamino)-5-isopropoxyquinazolin-7-yloxy)ethyl)piperazin-1-yl)ethanone
Show/Hide
|
C24H30ClN7O4
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0276783
|
N-(3-chloro-6-methoxypyridin-2-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-propan-2-yloxyquinazolin-4-amine
Show/Hide
|
C24H31ClN6O3
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0285459
|
AZD0530 analogue 20
Show/Hide
|
C25H28ClN5O4
|
2
|
| 1 |
IC50 = 75 nM
|
|
|
| 2 |
IC50 = 630 nM
|
|
|
|
CP0542901
|
AZD0530 analogue 14
Show/Hide
|
C26H30N4O5
|
2
|
| 1 |
IC50 = 80 nM
|
|
|
| 2 |
IC50 = 800 nM
|
|
|
|
CP0309959
|
AZD0530 analogue 17
Show/Hide
|
C27H32N4O5
|
2
|
| 1 |
IC50 = 85 nM
|
|
|
| 2 |
IC50 = 1100 nM
|
|
|
|
CP0295734
|
4-[({4-[(5-chloro-2H-1,3-benzodioxol-4-yl)amino]-6-methoxyquinazolin-7-yl}oxy)methyl]pyridine-2-carbonitrile
Show/Hide
|
C23H16ClN5O4
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0283022
|
AZD0530 analogue 27
Show/Hide
|
C24H27ClN4O4
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0376328
|
AZD0530 analogue 3
Show/Hide
|
C21H21ClN4O3
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
IC50 = 1000 nM
|
|
|
|
CP0182891
|
Benzodioxole deriv. 19
Show/Hide
|
C23H25ClN4O5
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0501134
|
AZD0530 analogue 41
Show/Hide
|
C27H31ClN4O5
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0566595
|
N-[(3-fluorophenyl)methyl]-2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]acetamide
Show/Hide
|
C26H28FN3O3
|
1
|
| 1 |
IC50 = 118 nM
|
|
|
|
CP0036121
|
N-(3-chloro-6-methoxypyridin-2-yl)-5-propan-2-yloxy-7-(2-pyrrolidin-1-ylethoxy)quinazolin-4-amine
Show/Hide
|
C23H28ClN5O3
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0496795
|
N-(3-chloro-6-methoxypyridin-2-yl)-7-(2-morpholin-4-ylethoxy)-5-propan-2-yloxyquinazolin-4-amine
Show/Hide
|
C23H28ClN5O4
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0146333
|
N-(2-chloro-5-methoxypyridin-3-yl)-7-(3-morpholin-4-ylpropoxy)-5-(oxan-4-yloxy)quinazolin-4-amine
Show/Hide
|
C26H32ClN5O5
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0422302
|
AZD0530 analogue 12
Show/Hide
|
C22H24N4O4
|
2
|
| 1 |
IC50 = 150 nM
|
|
|
| 2 |
IC50 = 4500 nM
|
|
|
|
CP0109912
|
N-(2-chloro-5-methoxypyridin-3-yl)-7-(3-morpholin-4-ylpropoxy)-5-propan-2-yloxyquinazolin-4-amine
Show/Hide
|
C24H30ClN5O4
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0344966
|
AZD0530 analogue 4
Show/Hide
|
C23H27ClN4O4
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0497209
|
AZD0530 analogue 22
Show/Hide
|
C17H16ClN3O3
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0571334
|
N-[(3-fluorophenyl)methyl]-2-(5-phenylpyridin-2-yl)acetamide
Show/Hide
|
C20H17FN2O
|
1
|
| 1 |
IC50 = 269 nM
|
|
|
|
CP0135259
|
1-(4-(2-(4-(5-chloro-2-methoxypyrimidin-4-ylamino)-5-isopropoxyquinazolin-7-yloxy)ethyl)piperazin-1-yl)ethanone
Show/Hide
|
C24H30ClN7O4
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0500684
|
AZD0530 analogue 1
Show/Hide
|
C21H23ClN4O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0292172
|
Benzodioxole deriv. 21
Show/Hide
|
C23H25FN4O5
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0111947
|
Benzofuran deriv. 9
Show/Hide
|
C24H25ClN4O4
|
1
|
| 1 |
IC50 = 310 nM
|
|
|
|
CP0124502
|
Methoxy Aniline 5
Show/Hide
|
C23H27ClN4O4
|
1
|
| 1 |
IC50 = 310 nM
|
|
|
|
CP0284392
|
Benzodioxole deriv. 18
Show/Hide
|
C23H26N4O5
|
1
|
| 1 |
IC50 = 310 nM
|
|
|
|
CP0200838
|
Benzofuran deriv. 11
Show/Hide
|
C24H25ClN4O4
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0432010
|
N-[(3-fluorophenyl)methyl]-2-(4-phenylphenyl)acetamide
Show/Hide
|
C21H18FNO
|
1
|
| 1 |
IC50 = 349 nM
|
|
|
|
CP0078087
|
N-(5-chloro-2-methoxypyridin-4-yl)-7-(3-morpholin-4-ylpropoxy)-5-propan-2-yloxyquinazolin-4-amine
Show/Hide
|
C24H30ClN5O4
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
|
CP0123552
|
Indole deriv. 17
Show/Hide
|
C24H26ClN5O3
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0344965
|
AZD0530 analogue 2
Show/Hide
|
C20H20ClN3O3
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0267709
|
Benzodioxole deriv. 25
Show/Hide
|
C22H23ClN4O4
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0376293
|
AZD0530 analogue 26
Show/Hide
|
C22H23ClN4O3
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0686846
|
(2-Chloro-5-methoxy-phenyl)-[6-methoxy-7-(4-methyl-piperazin-1-ylmethoxy)-quinazolin-4-yl]-amine
Show/Hide
|
C22H26ClN5O3
|
1
|
| 1 |
IC50 = 530 nM
|
|
|
|
CP0453654
|
AZD0530 analogue 38
Show/Hide
|
C22H25ClN4O3
|
2
|
| 1 |
IC50 = 540 nM
|
|
|
| 2 |
IC50 = 3000 nM
|
|
|
|
CP0376327
|
AZD0530 analogue 13
Show/Hide
|
C23H26N4O4
|
2
|
| 1 |
IC50 = 570 nM
|
|
|
| 2 |
IC50 = 6400 nM
|
|
|
|
CP0526118
|
AZD0530 analogue 40
Show/Hide
|
C28H36ClN5O4
|
2
|
| 1 |
IC50 = 600 nM
|
|
|
| 2 |
IC50 = 3900 nM
|
|
|
|
CP0183101
|
6-Methoxy-N-(3-methoxyphenyl)-7-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Show/Hide
|
C23H28N4O4
|
1
|
| 1 |
IC50 = 690 nM
|
|
|
|
CP0112075
|
Benzodioxole deriv. 26
Show/Hide
|
C23H25ClN4O5
|
1
|
| 1 |
IC50 = 1160 nM
|
|
|
|
CP0542900
|
AZD0530 analogue 39
Show/Hide
|
C17H16ClN3O3
|
1
|
| 1 |
IC50 = 3700 nM
|
|
|
