General Information of the Compound
Compound ID
CP0526118
Compound Name
AZD0530 analogue 40
    Show/Hide
Structure
Formula
C28H36ClN5O4
Molecular Weight
542.08
Canonical SMILES
COc1ccc(Cl)c(Nc2ncnc3ccc(OCCCN4CCN(C)CC4)c(OC4CCOCC4)c23)c1
    Show/Hide
InChI
InChI=1S/C28H36ClN5O4/c1-33-11-13-34(14-12-33)10-3-15-37-25-7-6-23-26(27(25)38-20-8-16-36-17-9-20)28(31-19-30-23)32-24-18-21(35-2)4-5-22(24)29/h4-7,18-20H,3,8-17H2,1-2H3,(H,30,31,32)
    Show/Hide
InChIKey
KBCWPJVPGXBFTB-UHFFFAOYSA-N
Physicochemical Property
logP
4.6095
Rotatable Bonds
10
Heavy Atom Count
38
Polar Areas
81.21
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
9
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 11974329
ChEMBL ID
CHEMBL426148
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00879, Proto-oncogene tyrosine-protein kinase Src
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3 Mus musculus (Mouse)  2
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
2
IC50 = 3900 nM
   TI
   LI
   LO
   TS