N-(2-ethoxyethyl)-N-[(2S)-2-hydroxy-3-(6-oxospiro[3,4,7,8-tetrahydropyrano[3,2-f]isoindole-2,3'-piperidine]-1'-yl)propyl]-2,6-dimethylbenzenesulfonamide

N-(2-ethoxyethyl)-N-[(2S)-2-hydroxy-3-spiro[8,9-dihydro-3H-pyrano[3,2-e]indazole-7,3'-piperidine]-1'-ylpropyl]-2,6-dimethylbenzenesulfonamide

(2S)-2-[3-fluoro-4-(trifluoromethyl)phenyl]-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-[(1-hydroxy-2-methylpropan-2-yl)amino]propan-1-one

(2S)-3-(cyclopropylmethylamino)-2-[3-fluoro-4-(trifluoromethyl)phenyl]-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-[(1-hydroxy-2-methylpropan-2-yl)amino]propan-1-one

2-(4-chloro-3-fluorobenzyl)-3-(isopropylamino)-1-(4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

(2S)-3-(tert-butylamino)-2-[3-fluoro-4-(trifluoromethyl)phenyl]-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylmethylamino)propan-1-one

(2S)-2-(4-chlorophenyl)-1-[4-[(5R)-5-(fluoromethyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

(S)-2-(4-chlorobenzyl)-3-(isopropylamino)-1-(4-((S)-5-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-[(4-methoxycyclohexyl)amino]propan-1-one

(S)-2-(4-chlorobenzyl)-3-(isopropylamino)-1-(4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

(2S)-2-(4-chloro-3-fluorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-[methyl(propan-2-yl)amino]propan-1-one

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-fluoro-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

2-(4-chlorobenzyl)-3-(isopropylamino)-1-(4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

(R)-2-amino-3-(4-fluorophenyl)-1-(4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

(R)-2-amino-3-(4-chloro-3-fluorophenyl)-1-(4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

(2S)-2-(4-chlorophenyl)-1-[4-[(5S)-5-ethenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

2-(4-chlorobenzyl)-1-(4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)-3-(pyrrolidin-1-yl)propan-1-one

(2S)-2-(4-chlorophenyl)-3-(cyclopropylmethylamino)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one

N-(2-ethoxyethyl)-N-[(2S)-2-hydroxy-3-[2-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,9-diazaspiro[4.5]decan-9-yl]propyl]-2,6-dimethylbenzenesulfonamide

(R)-2-amino-3-(4-chlorophenyl)-1-(4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(oxan-4-ylamino)propan-1-one

(2S)-2-(4-chlorophenyl)-3-(4-fluoropiperidin-1-yl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one

3-(isopropylamino)-1-(4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)-2-(4-methylbenzyl)propan-1-one

(2S)-2-(4-chloro-3-fluorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-[(2S)-pyrrolidin-2-yl]ethanone

3-(1-aminocyclopropyl)-2-(4-chloro-3-fluorobenzyl)-1-(4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

(2S)-2-(4-chlorophenyl)-1-[4-[(5R)-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

(2R)-2-amino-3-(4-chlorophenyl)-1-(4-(5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

N-(2-ethoxyethyl)-N-[(2S)-2-hydroxy-3-[2-(3-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-yl)-2,9-diazaspiro[4.5]decan-9-yl]propyl]-2,6-dimethylbenzenesulfonamide

2-(4-chloro-3-fluorobenzyl)-3-(isopropylamino)-1-(4-((S)-5-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

(2S)-2-(4-chlorophenyl)-3-(cyclohexylamino)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(2-methoxyethylamino)propan-1-one

4-amino-2-(4-chlorobenzyl)-4-methyl-1-(4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)pentan-1-one

(+/-)-N-(3-(2-(6-amino-5-cyclopropylpyrimidin-4-yl)-2,7-diazaspiro[4.5]decan-7-yl)-2-hydroxypropyl)-N-(2-ethoxyethyl)-2,6-dimethylbenzenesulfonamide

N-[(2S)-3-[(5R)-2-(6-amino-5-cyclopropylpyrimidin-4-yl)-2,9-diazaspiro[4.5]decan-9-yl]-2-hydroxypropyl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-[(2S)-piperidin-2-yl]ethanone

4-amino-2-(4-chloro-3-fluorobenzyl)-4-methyl-1-(4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)pentan-1-one

4-amino-2-(4-chloro-3-fluorobenzyl)-4-methyl-1-(4-((S)-5-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-4-yl)piperazin-1-yl)pentan-1-one

(R)-2-amino-3-(3,4-difluorophenyl)-1-(4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

(2S)-3-amino-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-[4-(trifluoromethyl)phenyl]propan-1-one

(R)-2-amino-3-(4-chlorophenyl)-1-(4-((S)-5-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

(S)-2-((R)-2-(6-amino-5-cyclopropylpyrimidin-4-yl)-2,7-diazaspiro[4.5]decan-7-yl)-1-((S)-1-(2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)ethanol

N-[(2S)-3-[2-(5-cyclopropylpyrimidin-4-yl)-2,9-diazaspiro[4.5]decan-9-yl]-2-hydroxypropyl]-N-(2-ethoxyethyl)-2,6-dimethylbenzenesulfonamide

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7S)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

2-(3,4-difluorobenzyl)-3-(isopropylamino)-1-(4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

(2S)-2-(4-chlorophenyl)-1-[4-[(5R)-5-(hydroxymethyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-2-[(3R)-morpholin-3-yl]ethanone

N-[(2S)-3-[(5R)-2-(6-amino-5-cyclopropylpyrimidin-4-yl)-2,9-diazaspiro[4.5]decan-9-yl]-2-hydroxypropyl]-2,6-dimethylbenzenesulfonamide

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7S)-7-fluoro-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

3-(isopropylamino)-1-(4-((S)-5-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-4-yl)piperazin-1-yl)-2-(4-methylbenzyl)propan-1-one

N-[(2S)-3-[(5R)-2-(6-amino-5-cyclopropylpyrimidin-4-yl)-2,9-diazaspiro[4.5]decan-9-yl]-2-hydroxypropyl]-2-methylbenzenesulfonamide

(S)-N-(2-ethoxyethyl)-N-(2-hydroxy-3-(9-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,9-diazaspiro[5.5]undecan-2-yl)propyl)-2,6-dimethylbenzenesulfonamide

(2R)-2-amino-3-(4-chlorophenyl)-1-(4-(5-ethyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

(2S)-2-(4-chlorophenyl)-3-(2-fluoroethylamino)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one

(2S)-3-amino-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one

(R)-2-amino-3-(4-fluorophenyl)-1-(4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

N-[(2S)-3-[(5R)-2-(6-amino-5-cyclopropylpyrimidin-4-yl)-2,9-diazaspiro[4.5]decan-9-yl]-2-hydroxypropyl]-2-chlorobenzenesulfonamide

N-[(2S)-3-[(5R)-2-(6-amino-5-cyclopropylpyrimidin-4-yl)-2,9-diazaspiro[4.5]decan-9-yl]-2-hydroxypropyl]-2-bromobenzenesulfonamide

N-[(2S)-3-[(5R)-2-(6-amino-5-cyclopropylpyrimidin-4-yl)-2,9-diazaspiro[4.5]decan-9-yl]-2-hydroxypropyl]-4-fluoro-2-methylbenzenesulfonamide

1'-((S)-3-(N-(2-ethoxyethyl)-2,6-dimethylphenylsulfonamido)-2-hydroxypropyl)spiro[chroman-2,3'-piperidine]-6-carboxamide

(S)-2-((R)-2-(6-amino-5-cyclopropylpyrimidin-4-yl)-2,7-diazaspiro[4.5]decan-7-yl)-1-((R)-1-(2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)ethanol

N-(2-ethoxyethyl)-N-[(2S)-2-hydroxy-3-(2-quinazolin-4-yl-2,9-diazaspiro[4.5]decan-9-yl)propyl]-2,6-dimethylbenzenesulfonamide

2-(1-aminocyclopropyl)-3-(4-chlorophenyl)-1-(4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

N-[(2S)-3-(6-cyanospiro[3,4-dihydrochromene-2,3'-piperidine]-1'-yl)-2-hydroxypropyl]-N-(2-ethoxyethyl)-2,6-dimethylbenzenesulfonamide

N-(2-ethoxyethyl)-N-[(2S)-2-hydroxy-3-(6-hydroxyspiro[3,4-dihydrochromene-2,3'-piperidine]-1'-yl)propyl]-2,6-dimethylbenzenesulfonamide

N-(2-ethoxyethyl)-N-[(2S)-2-hydroxy-3-[2-(3-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-yl)-2,7-diazaspiro[4.4]nonan-7-yl]propyl]-2,6-dimethylbenzenesulfonamide

(2R)-2-amino-3-(indolin-3-yl)-1-(4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

(R)-2-amino-3-(4-chlorophenyl)-1-(4-(5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

N-(2-ethoxyethyl)-N-[(2S)-3-(6-fluorospiro[3,4-dihydrochromene-2,3'-piperidine]-1'-yl)-2-hydroxypropyl]-2,6-dimethylbenzenesulfonamide

N-(2-ethoxyethyl)-N-[(2S)-2-hydroxy-3-(6-hydroxyspiro[3,4-dihydrochromene-2,3'-piperidine]-1'-yl)propyl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide

(2S)-2-(4-chlorophenyl)-1-[4-[(5R)-7,7-difluoro-5-methyl-5,6-dihydrocyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

(R)-2-((R)-2-(6-amino-5-cyclopropylpyrimidin-4-yl)-2,7-diazaspiro[4.5]decan-7-yl)-1-((S)-1-(2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)ethanol

N-[(2S)-3-[(5R)-2-(6-amino-5-cyclopropylpyrimidin-4-yl)-2,9-diazaspiro[4.5]decan-9-yl]-2-hydroxypropyl]-2-fluorobenzenesulfonamide

N-(2-ethoxyethyl)-N-[(2S)-2-hydroxy-3-(6-hydroxy-4-oxospiro[3H-chromene-2,3'-piperidine]-1'-yl)propyl]-2,6-dimethylbenzenesulfonamide

N-[(2S)-3-[(5R)-2-(6-amino-5-cyclopropylpyrimidin-4-yl)-2,9-diazaspiro[4.5]decan-9-yl]-2-hydroxypropyl]-2,4-dimethylbenzenesulfonamide

(R)-2-amino-3-(4-chlorophenyl)-1-(4-((R)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one

N-[(2S)-2-hydroxy-3-(6-hydroxy-4-oxospiro[3H-chromene-2,3'-piperidine]-1'-yl)propyl]-3,5-dimethyl-N-(2-propan-2-yloxyethyl)-1,2-oxazole-4-sulfonamide

(R)-2-Amino-3-(4-chloro-phenyl)-1-[4-(6,6-dioxo-6,7-dihydro-5H-6lambda*6*-thieno[3,4-d]pyrimidin-4-yl)-pi perazin-1-yl]-propan-1-one

N-(2-ethoxyethyl)-N-[(2S)-2-hydroxy-3-(6-hydroxy-4-oxospiro[3H-chromene-2,3'-piperidine]-1'-yl)propyl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide

N-[(2S)-2-hydroxy-3-(6-hydroxy-4-oxospiro[3H-chromene-2,3'-piperidine]-1'-yl)propyl]-3,5-dimethyl-N-pentyl-1,2-oxazole-4-sulfonamide

N-[(2S)-2-hydroxy-3-(6-hydroxy-4-oxospiro[3H-chromene-2,3'-piperidine]-1'-yl)propyl]-N-(2-methoxyethyl)-3,5-dimethyl-1,2-oxazole-4-sulfonamide

N-(2-ethoxyethyl)-2-fluoro-N-[(2S)-2-hydroxy-3-(6-hydroxy-4-oxospiro[3H-chromene-2,3'-piperidine]-1'-yl)propyl]benzenesulfonamide

N-(2-ethoxyethyl)-N-[(2S)-2-hydroxy-3-(6-hydroxy-4-oxospiro[3H-chromene-2,3'-piperidine]-1'-yl)propyl]-2-methylbenzenesulfonamide

3-chloro-N-(2-ethoxyethyl)-N-((2S)-2-hydroxy-3-(6-hydroxy-4-oxospiro[chroman-2,3'-piperidine]-1'-yl)propyl)benzenesulfonamide

N-[(2R)-2-hydroxy-3-(6-hydroxy-4-oxospiro[3H-chromene-2,3'-piperidine]-1'-yl)propyl]-N-(2-methoxyethyl)-3,5-dimethyl-1,2-oxazole-4-sulfonamide

N-(2-ethoxyethyl)-N-[(2S)-2-hydroxy-3-(6-hydroxy-4-oxospiro[3H-chromene-2,3'-piperidine]-1'-yl)propyl]-2-(trifluoromethyl)benzenesulfonamide

N-cyclohexyl-N-[(2S)-2-hydroxy-3-(6-hydroxy-4-oxospiro[3H-chromene-2,3'-piperidine]-1'-yl)propyl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide

2-chloro-N-(2-ethoxyethyl)-N-((2S)-2-hydroxy-3-(6-hydroxy-4-oxospiro[chroman-2,3'-piperidine]-1'-yl)propyl)benzenesulfonamide

N-(2-ethoxyethyl)-N-[(2S)-2-hydroxy-3-(6-hydroxy-4-oxospiro[3H-chromene-2,3'-piperidine]-1'-yl)propyl]-2-methoxybenzenesulfonamide

2-cyano-N-(2-ethoxyethyl)-N-((2S)-2-hydroxy-3-(6-hydroxy-4-oxospiro[chroman-2,3'-piperidine]-1'-yl)propyl)benzenesulfonamide

4-chloro-N-(2-ethoxyethyl)-N-((2S)-2-hydroxy-3-(6-hydroxy-4-oxospiro[chroman-2,3'-piperidine]-1'-yl)propyl)benzenesulfonamide