Brief Information of the Cell Line and Protein
Cell Line ID: CL000262 , MT-2
Synonyms
MT2
MT-2J
MT-2Org
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_2631
Protein ID: PT00005 , Reverse transcriptase/RNaseH
Gene Name POL
Organism Human immunodeficiency virus 1
Protein Classification Enzyme
Uniprot ID Q72547
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000262  Protein ID: PT00005
 
Compound ID Compound Name Compound Formula
CP0458501
8-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]-4-fluorophenoxy]-6-fluoroindolizine-2-carbonitrile
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C21H14F2N4O4
 2
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
2
EC50 = 250 nM
   TI
   LI
   LO
   TS
CP0458498
5-chloro-7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]-4-fluorophenoxy]-8-methylnaphthalene-2-carbonitrile
   Show/Hide
C24H17ClFN3O4
 2
1
EC50 = 27 nM
   TI
   LI
   LO
   TS
2
EC50 = 500 nM
   TI
   LI
   LO
   TS
CP0543423
7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]-4-fluorophenoxy]-5,8-dimethylnaphthalene-2-carbonitrile
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C25H20FN3O4
 2
1
EC50 = 28 nM
   TI
   LI
   LO
   TS
2
EC50 = 410 nM
   TI
   LI
   LO
   TS
CP0567211
7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]-4-fluorophenoxy]-5-fluoro-8-methylnaphthalene-2-carbonitrile
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C24H17F2N3O4
 2
1
EC50 = 31 nM
   TI
   LI
   LO
   TS
2
EC50 = 980 nM
   TI
   LI
   LO
   TS
CP0455025
8-chloro-7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]-5-methylnaphthalene-2-carbonitrile
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C24H18ClN3O4
 2
1
EC50 = 42 nM
   TI
   LI
   LO
   TS
2
EC50 = 120 nM
   TI
   LI
   LO
   TS
CP0419690
5-chloro-7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]-8-methylnaphthalene-2-carbonitrile
   Show/Hide
C24H18ClN3O4
 2
1
EC50 = 58 nM
   TI
   LI
   LO
   TS
2
EC50 = 280 nM
   TI
   LI
   LO
   TS
CP0432732
7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]-5-fluoro-8-methylnaphthalene-2-carbonitrile
   Show/Hide
C24H18FN3O4
 2
1
EC50 = 60 nM
   TI
   LI
   LO
   TS
2
EC50 = 890 nM
   TI
   LI
   LO
   TS
CP0432736
7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]-5,8-dimethylnaphthalene-2-carbonitrile
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C25H21N3O4
 2
1
EC50 = 62 nM
   TI
   LI
   LO
   TS
2
EC50 = 150 nM
   TI
   LI
   LO
   TS
CP0477771
8-chloro-7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]-4-fluorophenoxy]-5-fluoronaphthalene-2-carbonitrile
   Show/Hide
C23H14ClF2N3O4
 2
1
EC50 = 72 nM
   TI
   LI
   LO
   TS
2
EC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0386306
8-chloro-7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]-5-fluoronaphthalene-2-carbonitrile
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C23H15ClFN3O4
 2
1
EC50 = 90 nM
   TI
   LI
   LO
   TS
2
EC50 = 310 nM
   TI
   LI
   LO
   TS
CP0458497
7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]-8-methyl-5-propan-2-ylnaphthalene-2-carbonitrile
   Show/Hide
C27H25N3O4
 2
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
2
EC50 = 400 nM
   TI
   LI
   LO
   TS
CP0432737
7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]-5-ethyl-8-methylnaphthalene-2-carbonitrile
   Show/Hide
C26H23N3O4
 2
1
EC50 = 150 nM
   TI
   LI
   LO
   TS
2
EC50 = 300 nM
   TI
   LI
   LO
   TS
CP0533274
7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]-5-ethoxy-8-methylnaphthalene-2-carbonitrile
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C26H23N3O5
 2
1
EC50 = 200 nM
   TI
   LI
   LO
   TS
2
EC50 = 800 nM
   TI
   LI
   LO
   TS
CP0385250
7-[4-chloro-2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]-5-fluoro-8-methylnaphthalene-2-carbonitrile
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C24H17ClFN3O4
 2
1
EC50 = 330 nM
   TI
   LI
   LO
   TS
2
EC50 > 100 nM
   TI
   LI
   LO
   TS
CP0432738
7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]-8-methyl-5-propylnaphthalene-2-carbonitrile
   Show/Hide
C27H25N3O4
 2
1
EC50 = 630 nM
   TI
   LI
   LO
   TS
2
EC50 = 990 nM
   TI
   LI
   LO
   TS
CP0551454
7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]-5-methoxy-8-methylnaphthalene-2-carbonitrile
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C25H21N3O5
 2
1
EC50 = 670 nM
   TI
   LI
   LO
   TS
2
EC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0386307
7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]-5-(methoxymethyl)-8-methylnaphthalene-2-carbonitrile
   Show/Hide
C26H23N3O5
 2
1
EC50 = 690 nM
   TI
   LI
   LO
   TS
2
EC50 = 790 nM
   TI
   LI
   LO
   TS
CP0432739
7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]-5,6,8-trimethylnaphthalene-2-carbonitrile
   Show/Hide
C26H23N3O4
 2
1
EC50 = 790 nM
   TI
   LI
   LO
   TS
2
EC50 > 100 nM
   TI
   LI
   LO
   TS
CP0432733
7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]-5-methylnaphthalene-2-carbonitrile
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C24H19N3O4
 2
1
EC50 = 800 nM
   TI
   LI
   LO
   TS
2
EC50 = 2900 nM
   TI
   LI
   LO
   TS
CP0419691
5-chloro-7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]naphthalene-2-carbonitrile
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C23H16ClN3O4
 1
1
EC50 = 890 nM
   TI
   LI
   LO
   TS
CP0454572
5-(cyclopropylmethyl)-7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]-8-methylnaphthalene-2-carbonitrile
   Show/Hide
C28H25N3O4
 2
1
EC50 = 900 nM
   TI
   LI
   LO
   TS
2
EC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0386310
5-chloro-7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]-4-fluorophenoxy]naphthalene-2-carbonitrile
   Show/Hide
C23H15ClFN3O4
 2
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
2
EC50 = 4100 nM
   TI
   LI
   LO
   TS
CP0386309
7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]-4-fluorophenoxy]naphthalene-2-carbonitrile
   Show/Hide
C23H16FN3O4
 2
1
EC50 = 1200 nM
   TI
   LI
   LO
   TS
2
EC50 = 9400 nM
   TI
   LI
   LO
   TS
CP0464151
7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]-4-fluorophenoxy]-8-fluoro-5-methylnaphthalene-2-carbonitrile
   Show/Hide
C24H17F2N3O4
 2
1
EC50 = 1200 nM
   TI
   LI
   LO
   TS
2
EC50 = 3800 nM
   TI
   LI
   LO
   TS
CP0386308
7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]-6,8-dimethylnaphthalene-2-carbonitrile
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C25H21N3O4
 2
1
EC50 = 1700 nM
   TI
   LI
   LO
   TS
2
EC50 > 100 nM
   TI
   LI
   LO
   TS
CP0432734
7-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]naphthalene-2-carbonitrile
   Show/Hide
C23H17N3O4
 2
1
EC50 = 2600 nM
   TI
   LI
   LO
   TS
2
EC50 = 4000 nM
   TI
   LI
   LO
   TS
CP0385251
6-[2-[2-(2,4-dioxopyrimidin-1-yl)ethoxy]phenoxy]naphthalene-2-carbonitrile
   Show/Hide
C23H17N3O4
 2
1
EC50 = 5600 nM
   TI
   LI
   LO
   TS
2
EC50 > 100 nM
   TI
   LI
   LO
   TS
CP0393763
methyl N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-[[4-(1,3-thiazol-5-yl)phenyl]methyl]amino]-1-phenylbutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
   Show/Hide
C35H48N6O7S
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0477083
((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N'-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-N-(4-thiazol-5-yl-benzyl)-hydrazino]-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
   Show/Hide
C35H48N6O7S
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0383122
methyl N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[[[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]amino]-(3-methylbutyl)amino]-1-phenylbutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
   Show/Hide
C29H49N5O7
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0393762
methyl N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-[[4-(1,3-thiazol-2-yl)phenyl]methyl]amino]-1-phenylbutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
   Show/Hide
C35H48N6O7S
 1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0461114
methyl N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-[(4-pyridin-2-ylphenyl)methyl]amino]-1-phenylbutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
   Show/Hide
C37H50N6O7
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0448357
((S)-1-{(1S,2S)-1-Benzyl-3-[N'-((S)-2-ethoxycarbonylamino-3-methyl-butyryl)-N-(4-thiazol-5-yl-benzyl)-hydrazino]-2-hydroxy-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
   Show/Hide
C36H50N6O7S
 1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0086074
Atazanavir
   Show/Hide
C38H52N6O7
 1
1
IC50 = 26 nM
   TI
   LI
   LO
   TS
CP0402881
((S)-1-{N'-[(2S,3S)-2-Hydroxy-3-((S)-2-methoxycarbonylamino-3,3-dimethyl-butyrylamino)-4-phenyl-butyl]-N'-[4-(2-methyl-2H-tetrazol-5-yl)-benzyl]-hydrazinocarbonyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
   Show/Hide
C35H51N9O7
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0377882
((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N'-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-N-(4-pyridin-2-yl-benzyl)-hydrazino]-propylcarbamoyl}-2-methyl-butyl)-carbamic acid methyl ester
   Show/Hide
C37H50N6O7
 1
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
CP0374662
methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3-methyl-1-oxobutan-2-yl]carbamate
   Show/Hide
C36H48N6O7
 1
1
IC50 = 29 nM
   TI
   LI
   LO
   TS
CP0407134
((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N'-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-N-(4-pyridin-2-yl-benzyl)-hydrazino]-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
   Show/Hide
C37H50N6O7
 1
1
IC50 = 31 nM
   TI
   LI
   LO
   TS
CP0477154
methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]amino]-4-phenylbutyl]-2-[[4-(1,3-thiazol-5-yl)phenyl]methyl]hydrazinyl]-3-methyl-1-oxobutan-2-yl]carbamate
   Show/Hide
C34H46N6O7S
 1
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
CP0470011
methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[[4-(1,3-thiazol-2-yl)phenyl]methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
   Show/Hide
C36H50N6O7S
 1
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
CP0402651
methyl N-[(2S)-1-[[(2S,3S)-4-[[[(2S)-2-(ethoxycarbonylamino)-3-methylbutanoyl]amino]-[(4-pyridin-2-ylphenyl)methyl]amino]-3-hydroxy-1-phenylbutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
   Show/Hide
C37H50N6O7
 1
1
IC50 = 34 nM
   TI
   LI
   LO
   TS
CP0377953
((S)-1-{N'-Biphenyl-4-ylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinocarbonyl}-2-methyl-propyl)-carbamic acid methyl ester
   Show/Hide
C37H49N5O7
 1
1
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0378062
((S)-1-{N'-(4-Diethylamino-benzyl)-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3,3-dimethyl-butyrylamino)-4-phenyl-butyl]-hydrazinocarbonyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
   Show/Hide
C37H58N6O7
 1
1
IC50 = 41 nM
   TI
   LI
   LO
   TS
CP0393864
methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[[4-(1,3-thiazol-5-yl)phenyl]methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
   Show/Hide
C36H50N6O7S
 1
1
IC50 = 41 nM
   TI
   LI
   LO
   TS
CP0041607
(AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
   Show/Hide
C10H13N5O4
 1
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
CP0377608
((S)-1-{N'-Biphenyl-4-ylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinocarbonyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
   Show/Hide
C38H51N5O7
 1
1
IC50 = 51 nM
   TI
   LI
   LO
   TS
CP0461863
((S)-1-{N'-Biphenyl-4-ylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3,3-dimethyl-butyrylamino)-4-phenyl-butyl]-hydrazinocarbonyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
   Show/Hide
C39H53N5O7
 1
1
IC50 = 58 nM
   TI
   LI
   LO
   TS
CP0407108
((S)-1-{N'-[4-(2-tert-Butyl-2H-tetrazol-5-yl)-benzyl]-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3,3-dimethyl-butyrylamino)-4-phenyl-butyl]-hydrazinocarbonyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
   Show/Hide
C38H57N9O7
 1
1
IC50 = 72 nM
   TI
   LI
   LO
   TS
CP0374661
((S)-1-{(1S,2S)-1-Benzyl-3-[N-biphenyl-4-ylmethyl-N'-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-hydrazino]-2-hydroxy-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
   Show/Hide
C38H51N5O7
 1
1
IC50 = 85 nM
   TI
   LI
   LO
   TS
CP0407058
CGP 53820 analog
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C33H55N5O7
 1
1
IC50 = 177 nM
   TI
   LI
   LO
   TS
CP0036865
Atripla
   Show/Hide
C9H14N5O4P
 1
1
IC50 = 380 nM
   TI
   LI
   LO
   TS
CP0440844
9-[(2R,5S)-3-fluoro-5-methoxy-2,5-dihydrofuran-2-yl]purin-6-amine
   Show/Hide
C10H10FN5O2
 1
1
IC50 = 400 nM
   TI
   LI
   LO
   TS
CP0457171
[(2R,5R)-5-(6-aminopurin-9-yl)-2,5-dihydrofuran-2-yl]oxymethylphosphonic acid
   Show/Hide
C10H12N5O5P
 1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0377875
[(2R,5R)-5-(6-aminopurin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl]oxymethylphosphonic acid
   Show/Hide
C10H11FN5O5P
 1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS