General Information of the Compound
Compound ID
CP0330770
Compound Name
4-[3-(2,4-dimethylanilino)-2-[(2,4-dimethylanilino)-oxomethyl]-3-oxoprop-1-enyl]benzoic acid
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Structure
Formula
C27H26N2O4
Molecular Weight
442.515
Canonical SMILES
Cc1ccc(NC(=O)C(=Cc2ccc(cc2)C(O)=O)C(=O)Nc2ccc(C)cc2C)c(C)c1
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InChI
InChI=1S/C27H26N2O4/c1-16-5-11-23(18(3)13-16)28-25(30)22(15-20-7-9-21(10-8-20)27(32)33)26(31)29-24-12-6-17(2)14-19(24)4/h5-15H,1-4H3,(H,28,30)(H,29,31)(H,32,33)
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InChIKey
QZOHMGLHJDZRBE-UHFFFAOYSA-N
Physicochemical Property
logP
5.27928
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
95.5
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
3
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 4882569
ChEMBL ID
CHEMBL1302460
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06109, Geminin
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000015 SW480 Homo sapiens (Human)  1
1
Potency ~ 18356.4 nM
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Protein ID: PT02997, Isocitrate dehydrogenase [NADP] cytoplasmic
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
Potency ~ 14581 nM
   TI
   LI
   LO
   TS
Protein ID: PT01214, Tyrosine-protein kinase JAK2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  1
1
IC50 = 5462 nM
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   LI
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