General Information of the Compound
Compound ID
CP0314996
Compound Name
4-[[2-(4,5-dichloro-6-keto-pyridazin-1-yl)acetyl]amino]benzoic acid ethyl ester
    Show/Hide
Structure
Formula
C15H13Cl2N3O4
Molecular Weight
370.192
Canonical SMILES
CCOC(=O)c1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1
    Show/Hide
InChI
InChI=1S/C15H13Cl2N3O4/c1-2-24-15(23)9-3-5-10(6-4-9)19-12(21)8-20-14(22)13(17)11(16)7-18-20/h3-7H,2,8H2,1H3,(H,19,21)
    Show/Hide
InChIKey
MDJMMLITJGVNQI-UHFFFAOYSA-N
Physicochemical Property
logP
2.3655
Rotatable Bonds
5
Heavy Atom Count
24
Polar Areas
90.29
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 2585205
ChEMBL ID
CHEMBL1605956
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06109, Geminin
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000015 SW480 Homo sapiens (Human)  1
1
Potency ~ 2592.9 nM
   TI
   LI
   LO
   TS
Protein ID: PT02997, Isocitrate dehydrogenase [NADP] cytoplasmic
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
Potency ~ 16360.1 nM
   TI
   LI
   LO
   TS
Protein ID: PT06124, Paired box protein Pax-8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000097 RMG-I Homo sapiens (Human)  1
1
AC50 = 6640 nM
   TI
   LI
   LO
   TS