General Information of the Compound
Compound ID
CP0295761
Compound Name
6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-9H-purin-2-amine
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Structure
Formula
C11H6N8O3S
Molecular Weight
330.289
Canonical SMILES
Nc1nc(Sc2ccc([N+]([O-])=O)c3nonc23)c2[nH]cnc2n1
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InChI
InChI=1S/C11H6N8O3S/c12-11-15-9-8(13-3-14-9)10(16-11)23-5-2-1-4(19(20)21)6-7(5)18-22-17-6/h1-3H,(H3,12,13,14,15,16)
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InChIKey
NPXXCZXQTLRXTP-UHFFFAOYSA-N
Physicochemical Property
logP
1.5307
Rotatable Bonds
3
Heavy Atom Count
23
Polar Areas
162.54
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
10
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 3246652
SID: 16585836
ChEMBL ID
CHEMBL515505
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06109, Geminin
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000015 SW480 Homo sapiens (Human)  1
1
Potency ~ 2592.9 nM
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   LI
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Protein ID: PT02997, Isocitrate dehydrogenase [NADP] cytoplasmic
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
Potency ~ 4610.9 nM
   TI
   LI
   LO
   TS
Protein ID: PT06124, Paired box protein Pax-8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000097 RMG-I Homo sapiens (Human)  1
1
AC50 = 2170 nM
   TI
   LI
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   TS