General Information of the Compound
Compound ID
CP0259647
Compound Name
3-butyl-8-[(4,5-dichloro-6-keto-pyridazin-1-yl)methyl]-7-propyl-xanthine
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Structure
Formula
C17H20Cl2N6O3
Molecular Weight
427.292
Canonical SMILES
CCCCn1c2nc(Cn3ncc(Cl)c(Cl)c3=O)n(CCC)c2c(=O)[nH]c1=O
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InChI
InChI=1S/C17H20Cl2N6O3/c1-3-5-7-24-14-13(15(26)22-17(24)28)23(6-4-2)11(21-14)9-25-16(27)12(19)10(18)8-20-25/h8H,3-7,9H2,1-2H3,(H,22,26,28)
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InChIKey
UOCKBSLTEWMSDN-UHFFFAOYSA-N
Physicochemical Property
logP
2.0082
Rotatable Bonds
7
Heavy Atom Count
28
Polar Areas
107.57
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 4216259
ChEMBL ID
CHEMBL1531245
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06109, Geminin
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000015 SW480 Homo sapiens (Human)  1
1
Potency ~ 7307.8 nM
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Protein ID: PT02997, Isocitrate dehydrogenase [NADP] cytoplasmic
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
Potency ~ 8199.5 nM
   TI
   LI
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   TS
Protein ID: PT06124, Paired box protein Pax-8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000097 RMG-I Homo sapiens (Human)  1
1
AC50 = 6680 nM
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