General Information of the Compound
| Compound ID |
CP0014938
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| Compound Name |
(5-fluorouracil)5-Fluoro-1H-pyrimidine-2,4-dione
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| Synonyms |
Adrucil
1-fluoro-1h-pyrimidine-2,4-dione
2,4(1H,3H)-Pyrimidinedione, 5-fluoro-
2,4-Dihydroxy-5-fluoropyrimidine
2,4-Dioxo-5-fluoropryimidine
2,4-Dioxo-5-fluoropyrimidine
5 FU Lederle
5 FU medac
5 Fluorouracil
5 Fluorouracil biosyn
5 HU Hexal
5-FU
5-FU (TN)
5-FU Lederle
5-FU medac
5-Faracil
5-Fluor-2,4(1H,3H)-pyrimidindion
5-Fluor-2,4(1H,3H)-pyrimidindion [Czech]
5-Fluor-2,4-dihydroxypyrimidin
5-Fluor-2,4-dihydroxypyrimidin [Czech]
5-Fluor-2,4-pyrimidindiol
5-Fluor-2,4-pyrimidindiol [Czech]
5-Fluoracil
5-Fluoracil [German]
5-Fluoracyl
5-Fluoro-2,4(1H,3H)-pyrimidinedione
5-Fluoro-2,4-pyrimidinedione
5-Fluoropyrimidin-2,4-diol
5-Fluoropyrimidine-2,4-dione
5-Fluorouracil
5-Fluorouracil-biosyn
5-Fluoruracil
5-Fluoruracil [German]
5-Ftouracyl
5-HU Hexal
5-fluoro uracil
5-fluoro-1H-pyrimidine-2,4-dione
5-fluoropyrimidine-2,4(1H,3H)-dione
51-21-8
5FU
Adrucil
Adrucil (TN)
Allergan Brand of Fluorouracil
Arumel
Biosyn Brand of Fluorouracil
CSP Brand of Fluorouracil
Carac
Carac (TN)
Carzonal
Cinco FU
Dakota Brand of Fluorouracil
Dakota, Fluorouracile
Dermatech Brand of Fluorouracil
Dermik Brandof Fluorouracil
Effluderm
Effluderm (free base)
Efudex
Efudex (TN)
Efudix
Efurix
F 6627
F0151
Ferrer Brand of Fluorouracil
Fluoro Uracile ICN
Fluoro-Uracile ICN
Fluoro-uracile
Fluoro-uracilo
Fluoroblastin
Fluoroplex
Fluoroplex (TN)
Fluorouracil
Fluorouracil (JP15/USP/INN)
Fluorouracil GRY
Fluorouracil Mononitrate
Fluorouracil Monopotassium Salt
Fluorouracil Monosodium Salt
Fluorouracil Potassium Salt
Fluorouracil Teva Brand
Fluorouracil [USAN:INN:BAN:JAN]
Fluorouracil-GRY
Fluorouracile
Fluorouracile Dakota
Fluorouracile [DCIT]
Fluorouracilo
Fluorouracilo Ferrer Far
Fluorouracilo [INN-Spanish]
Fluorouracilum
Fluorouracilum [INN-Latin]
Fluoruracil
Fluracedyl
Fluracil
Fluracilum
Fluri
Fluril
Fluro Uracil
Fluroblastin
Flurodex
Ftoruracil
Gry Brand of Fluorouracil
Haemato Brand of Fluorouracil
Haemato fu
Haemato-fu
Hexal Brand of Fluorouracil
ICN Brand of Fluorouracil
IN1335
Inhibits thymilidate synthetase
Kecimeton
Medac Brand of Fluorouracil
Neocorp Brand of Fluorouracil
Neofluor
Onkofluor
Onkoworks Brand of Fluorouracil
Phthoruracil
Phtoruracil
Queroplex
Ribofluor
Ribosepharm Brand of Fluorouracil
Riemser Brand of Fluorouracil
Ro 2-9757
Ro-2-9757
Roche Brand of Fluorouracil
Tetratogen
Teva Brand of Fluorouracil
Timazin
U 8953
U-8953
URF
Ulup
fluorouracil
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| Structure |
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| Formula |
C4H3FN2O2
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| Molecular Weight |
130.078
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| Canonical SMILES |
Fc1c[nH]c(=O)[nH]c1=O
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| InChI |
InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
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| InChIKey |
GHASVSINZRGABV-UHFFFAOYSA-N
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| CAS |
1004-03-1
4921-97-5
51-21-8
79108-01-3
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02997, Isocitrate dehydrogenase [NADP] cytoplasmic
Protein ID: PT01065, Serine/threonine-protein kinase mTOR
Protein ID: PT01883, Thymidylate synthase
Cell Viability or Cytotoxicity Assay
Clinical Information about the Compound
Drug 1 ( Fluorouracil )
| Drug Name | Fluorouracil | ||
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| Company | Hoffmann-La Roche pharmaceutical company | ||
| Indication | |||
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