Brief Information of the Cell Line and Protein
Cell Line ID: CL000868 , PC12
 Cell Line Info 
Synonyms
PC-12
PC 12
PC12.1
Category Cancer cell line
Organism
Rattus norvegicus (Rat)
Protein ID: PT01916 , Extracellular calcium-sensing receptor
 Protein Info 
Gene Name CASR
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P41180
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000868
 Cell Line Info 
 Protein ID: PT01916
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0454373
 Compound Info 
2'-((1R)-1-{(2R)-3-[2-Methyl-1-(naphthalen-2-yl)propan-2-ylamino]-2-hydroxypropoxy}ethyl)biphenyl-4-carboxylic acid
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C32H35NO4
  1
1
IC50 = 4 nM
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CP0395883
 Compound Info 
2'-((1R)-1-{(2R)-3-[2-methyl-1-(naphthalen-2-yl)propan-2-ylamino]-2-hydroxypropoxy}ethyl)-3-methylbiphenyl-4-carboxylic acid
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C33H37NO4
  1
1
IC50 = 5 nM
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CP0543884
 Compound Info 
(RS)-2'-(1-{(2R)-3-[2-Methyl-1-(naphthalen-2-yl)propan-2-ylamino]-2-hydroxypropoxy}ethyl)biphenyl-4-carboxylic acid
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C32H35NO4
  1
1
IC50 = 11 nM
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CP0085391
 Compound Info 
2'-((1R)-1-{(2R)-3-[1-(4-Chloro-3-fluorophenyl)-2-methylpropan-2-ylamino]-2-hydroxypropoxy}ethyl)-3-methylbiphenyl-4-carboxylic acid hemisulfate
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C29H33ClFNO4
  1
1
IC50 = 12 nM
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CP0150342
 Compound Info 
(R)-1-((R)-cyclopropyl(2-(hydroxymethyl)phenyl)methoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C28H35NO3
  1
1
IC50 = 18 nM
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CP0395882
 Compound Info 
(RS)-3'-(1-{(2R)-3-[2-Methyl-1-(naphthalen-2-yl)propan-2-ylamino]-2-hydroxypropoxy}ethyl)biphenyl-4-carboxylic acid
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C32H35NO4
  1
1
IC50 = 18 nM
 Bioactivity Info 
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CP0106943
 Compound Info 
(R)-1-((R)-cyclopropyl(o-tolyl)methoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C28H35NO2
  1
1
IC50 = 23 nM
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CP0454374
 Compound Info 
2'-((1R)-1-{(2R)-3-[1-(4-Chloro-3-fluorophenyl)-2-methylpropan-2-ylamino]-2-hydroxypropoxy}ethyl)biphenyl-4-carboxylic acid
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C28H31ClFNO4
  1
1
IC50 = 23 nM
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CP0085390
 Compound Info 
3-[2-((1R)-1-{(2R)-2-Hydroxy-3-[2-methyl-1-(naphthalen-2-yl)propan-2-ylamino]propoxy}ethyl)phenyl]propionic acid
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C28H35NO4
  1
1
IC50 = 24 nM
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CP0172829
 Compound Info 
(R)-2-chloro-6-(2-hydroxy-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propoxy)benzonitrile
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C24H25ClN2O2
  1
1
IC50 = 26 nM
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CP0921440
 Compound Info 
(2R)-1-(cyclopropyl(o-tolyl)methoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C28H35NO2
  1
1
IC50 = 37 nM
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CP0513498
 Compound Info 
(2R)-1-(cyclopropyl(2-methoxyphenyl)methoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C28H35NO3
  1
1
IC50 = 41 nM
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CP0400552
 Compound Info 
(2R)-1-(cyclopropyl(phenyl)methoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C27H33NO2
  1
1
IC50 = 70 nM
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CP0536168
 Compound Info 
(2R)-1-(cyclobutyl(phenyl)methoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C28H35NO2
  1
1
IC50 = 74 nM
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CP0491004
 Compound Info 
(R)-1-((S)-cyclopropyl(o-tolyl)methoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C28H35NO2
  1
1
IC50 = 83 nM
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CP0514235
 Compound Info 
(2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(1-phenylpropoxy)propan-2-ol
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C26H33NO2
  1
1
IC50 = 92 nM
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CP0520655
 Compound Info 
(2R)-1-(1-(2-methoxyphenyl)ethoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C26H33NO3
  1
1
IC50 = 120 nM
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CP0506488
 Compound Info 
(2R)-1-(1-(2-chlorophenyl)ethoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C25H30ClNO2
  1
1
IC50 = 140 nM
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CP0520654
 Compound Info 
(2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(1-p-tolylethoxy)propan-2-ol
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C26H33NO2
  1
1
IC50 = 140 nM
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CP0475378
 Compound Info 
(2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(1-phenylbutoxy)propan-2-ol
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C27H35NO2
  1
1
IC50 = 150 nM
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CP0493065
 Compound Info 
2-(1-((R)-2-hydroxy-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propoxy)ethyl)benzonitrile
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C26H30N2O2
  1
1
IC50 = 160 nM
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CP0493057
 Compound Info 
(2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(1-phenylpentyloxy)propan-2-ol
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C28H37NO2
  1
1
IC50 = 170 nM
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CP0509298
 Compound Info 
(2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(1-m-tolylethoxy)propan-2-ol
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C26H33NO2
  1
1
IC50 = 170 nM
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CP0401682
 Compound Info 
(2R)-1-(cyclopentyl(phenyl)methoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C29H37NO2
  1
1
IC50 = 200 nM
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CP0502316
 Compound Info 
(2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(2-methyl-1-phenylpropoxy)propan-2-ol
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C27H35NO2
  1
1
IC50 = 200 nM
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CP0520652
 Compound Info 
(2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(1-o-tolylethoxy)propan-2-ol
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C26H33NO2
  1
1
IC50 = 200 nM
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CP0491002
 Compound Info 
(2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(1-phenylallyloxy)propan-2-ol
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C26H31NO2
  1
1
IC50 = 210 nM
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CP0493056
 Compound Info 
(2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(1-phenylethoxy)propan-2-ol
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C25H31NO2
  1
1
IC50 = 220 nM
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CP0520651
 Compound Info 
(2R)-1-(1-(3-chlorophenyl)ethoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C25H30ClNO2
  1
1
IC50 = 220 nM
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CP0514234
 Compound Info 
(2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(3-phenylbutoxy)propan-2-ol
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C27H35NO2
  1
1
IC50 = 300 nM
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CP0513499
 Compound Info 
(S)-1-((R)-cyclopropyl(o-tolyl)methoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C28H35NO2
  1
1
IC50 = 310 nM
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CP0506487
 Compound Info 
(2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(1-(naphthalen-1-yl)ethoxy)propan-2-ol
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C29H33NO2
  1
1
IC50 = 360 nM
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CP0406728
 Compound Info 
(2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(1-(pyridin-2-yl)ethoxy)propan-2-ol
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C24H30N2O2
  1
1
IC50 = 420 nM
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CP0468572
 Compound Info 
(2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(1-phenylpropan-2-yloxy)propan-2-ol
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C26H33NO2
  1
1
IC50 = 440 nM
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CP0520656
 Compound Info 
(2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(1-(2-nitrophenyl)ethoxy)propan-2-ol
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C25H30N2O4
  1
1
IC50 = 540 nM
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CP0468573
 Compound Info 
(2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(1-(naphthalen-2-yl)ethoxy)propan-2-ol
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C29H33NO2
  1
1
IC50 = 550 nM
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CP0509296
 Compound Info 
(R)-1-(benzyloxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C24H29NO2
  1
1
IC50 = 560 nM
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CP0509297
 Compound Info 
(2R)-1-(2,2-dimethyl-1-phenylpropoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C28H37NO2
  1
1
IC50 = 570 nM
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CP0520650
 Compound Info 
(2R)-1-(cyclohexyl(phenyl)methoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C30H39NO2
  1
1
IC50 = 610 nM
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CP0536169
 Compound Info 
(R)-1-(benzhydryloxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C30H33NO2
  1
1
IC50 = 730 nM
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CP0513500
 Compound Info 
(S)-1-((S)-cyclopropyl(o-tolyl)methoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-ol
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C28H35NO2
  1
1
IC50 = 760 nM
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CP0506486
 Compound Info 
(2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(2-phenylpropoxy)propan-2-ol
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C26H33NO2
  1
1
IC50 = 810 nM
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CP0454371
 Compound Info 
(RS)-3-(Cyclopropyl-{(2R)-2-hydroxy-3-[2-methyl-1-(naphthalen-2-yl)propan-2-ylamino]propoxy}methyl)benzoic acid
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C28H33NO4
  1
1
IC50 = 960 nM
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CP0454372
 Compound Info 
(RS)-4'-(1-{(2R)-3-[2-Methyl-1-(naphthalen-2-yl)propan-2-ylamino]-2-hydroxypropoxy}ethyl)biphenyl-4-carboxylic acid
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C32H35NO4
  1
1
IC50 = 1500 nM
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CP0476568
 Compound Info 
2-[2-((1R)-1-{(2R)-2-Hydroxy-3-[2-methyl-1-(naphthalen-2-yl)propan-2-ylamino]propoxy}ethyl)phenyl]acetic acid
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C27H33NO4
  1
1
IC50 = 2200 nM
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CP0400545
 Compound Info 
(R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(2-phenylpropan-2-yloxy)propan-2-ol
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C26H33NO2
  1
1
IC50 = 2240 nM
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CP0538445
 Compound Info 
(R)-2-hydroxy-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propyl benzoate
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C24H27NO3
  1
1
IC50 > 30000 nM
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CP0101988
 Compound Info 
(RS)-2-(Cyclopropyl-{(2R)-2-hydroxy-3-[2-methyl-1-(naphthalen-2-yl)propan-2-ylamino]propoxy}methyl)benzoic acid
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C28H33NO4
  1
1
IC50 > 3000 nM
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CP0469287
 Compound Info 
(RS)-4-(Cyclopropyl-{(2R)-2-hydroxy-3-[2-methyl-1-(naphthalen-2-yl)propan-2-ylamino]propoxy}methyl)benzoic acid
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C28H33NO4
  1
1
IC50 > 3000 nM
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CP0506019
 Compound Info 
(RS)-2-(1-{(2R)-2-Hydroxy-3-[2-methyl-1-(naphthalen-2-yl)propan-2-ylamino]propoxy}ethyl)benzoic acid
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C26H31NO4
  1
1
IC50 > 3000 nM
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