Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(R)-2-chloro-6-(2-hydroxy-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propoxy)benzonitrile
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 PubChem ID
CID: 6918446
SID: 12015260
Canonical SMILES
CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1cccc(Cl)c1C#N
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Compound Formula C24H25ClN2O2
Compound Structure
Protein Name
 Protein Info 
Extracellular calcium-sensing receptor
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Ion receptor (family C GPCR)
>
Calcium sensing receptor
>
Calcium sensing receptor
Uniprot ID
P41180
Gene Name
CASR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  3
1
IC50 = 0.058 nM
   TI
   LI
   LO
   TS
2
IC50 = 23 nM
   TI
   LI
   LO
   TS
3
IC50 = 43 nM
   TI
   LI
   LO
   TS
CL000868 PC12
 Cell Line Info 
Rattus norvegicus (Rat)  1
1
IC50 = 26 nM
   TI
   LI
   LO
   TS
CL000425 TT
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 43 nM