Brief Information of the Cell Line and Protein
Cell Line ID: CL000278 , RBL-2H3
Synonyms
RBL2H3
RBL 2H3
RBL.2H3
Category Cancer cell line
Organism
Rattus norvegicus (Rat)
Cellosaurus ID
CVCL_0591
Protein ID: PT06374 , Calcium release-activated calcium channel protein 1
Gene Name ORAI1
Organism Rattus norvegicus, Rat
Protein Classification Ion channel
Uniprot ID Q5M848
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000278  Protein ID: PT06374
 
Compound ID Compound Name Compound Formula
CP0635842
N-(2,6-difluorobenzyl)-4-fluoro-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)pyridin-2-amine
   Show/Hide
C17H12F6N4
 1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0639320
5-(2,5-bis(trifluoromethyl)phenoxy)-N-(2,4,6-trifluorobenzyl)pyridin-2-amine
   Show/Hide
C20H11F9N2O
 1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0639359
5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)-2-[2,6-difluorophenyl)methoxy]pyrimidine
   Show/Hide
C19H12F4N2O3
 1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0639458
2-(2,6-difluorobenzyloxy)-5-(1-methyl-3-(trifluoromethyl)pyrazol-5-yl)pyridine
   Show/Hide
C17H12F5N3O
 1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0967650
N-(3-fluoro-2-methylbenzyl)-5-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)pyridin-2-amine
   Show/Hide
C18H16F4N4
 1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0633640
5-(2,5-dimethylthiazol-4-yl)-N-(2-fluorobenzyl)pyridin-2-amine
   Show/Hide
C17H16FN3S
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0633671
N-(2,6-difluorobenzyl)-5-(2-(trifluoromethyl)phenoxy)pyridin-2-amine
   Show/Hide
C19H13F5N2O
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0633672
N-(2-fluorobenzyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)pyrimidin-2-amine
   Show/Hide
C16H13F4N5
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0633673
5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)-2-[2-chloro-6-fluorophenyl)methoxy]pyrimidine
   Show/Hide
C19H12ClF3N2O3
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0633676
5-(6-chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(3-fluorobenzyl)pyridin-2-amine
   Show/Hide
C19H12ClF3N2O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0634218
N-(2,4,6-trifluorobenzyl)-5-(2-(trifluoromethyl)phenoxy)pyridin-2-amine
   Show/Hide
C19H12F6N2O
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0634219
N-(2,6-difluoro-4-methoxybenzyl)-5-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-2-amine
   Show/Hide
C18H15F5N4O
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0634220
5-(2,2-difluoro-6-methylbenzo[d][1,3]dioxol-5-yl)-N-(2,4,6-trifluorobenzyl)pyridin-2-amine
   Show/Hide
C20H13F5N2O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0634221
5-(6-chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(2-chloro-4-fluorobenzyl)pyridin-2-amine
   Show/Hide
C19H11Cl2F3N2O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0634222
5-(6-chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(2-chloro-3-fluorobenzyl)pyridin-2-amine
   Show/Hide
C19H11Cl2F3N2O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0634620
N-(2,6-difluoro-4-methoxybenzyl)-5-(2,2-difluoro-6-methylbenzo[d][1,3]dioxol-5-yl)pyrimidin-2-amine
   Show/Hide
C20H15F4N3O3
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0634621
N-(2,6-difluorobenzyl)-5-(2-(trifluoromethyl)phenoxy)pyrimidin-2-amine
   Show/Hide
C18H12F5N3O
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0634798
6-(1-ethyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-N-(2,4,6-trifluorobenzyl)pyridin-3-amine
   Show/Hide
C18H14F6N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0635620
5-(6-chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(2-chlorobenzyl)pyridin-2-amine
   Show/Hide
C19H12Cl2F2N2O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0635621
5-(2,2-difluoro-6-methylbenzo[d][1,3]dioxol-5-yl)-N-(2,6-difluorobenzyl)pyridin-2-amine
   Show/Hide
C20H14F4N2O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0635622
5-(6-chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(2,6-difluorobenzyl)pyridin-2-amine
   Show/Hide
C19H11ClF4N2O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0635654
5-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-N-(2,6-difluorobenzyl)pyridin-2-amine
   Show/Hide
C17H10F8N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0635715
N-((3,5-difluoropyridin-4-yl)methyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)pyridin-2-amine
   Show/Hide
C16H12F5N5
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0636048
6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-N-(2,4,6-trifluorobenzyl)pyridin-3-amine
   Show/Hide
C17H12F6N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0636119
5-(6-chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(2-methoxybenzyl)pyridin-2-amine
   Show/Hide
C20H15ClF2N2O3
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0636180
N-(4-chloro-2,6-difluorobenzyl)-5-(6-chloro-4-methylpyridin-3-yl)pyrimidin-2-amine
   Show/Hide
C17H12Cl2F2N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0636968
5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-N-(2,3,6-trifluorobenzyl)pyridin-2-amine
   Show/Hide
C17H12F6N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0637163
N-(2-fluoro-6-methylbenzyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)pyridin-2-amine
   Show/Hide
C18H16F4N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0637164
5-(2,2-difluoro-6-methyl-1,3-benzodioxol-5-yl)-N-[(2,6-difluorophenyl)methyl]pyrimidin-2-amine
   Show/Hide
C19H13F4N3O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0637165
5-(2,5-dimethylthiazol-4-yl)-N-(2,4,6-trifluorobenzyl)pyridin-2-amine
   Show/Hide
C17H14F3N3S
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0637938
N-(2-chlorobenzyl)-5-(2,2-difluoro-6-methylbenzo[d][1,3]dioxol-5-yl)pyridin-2-amine
   Show/Hide
C20H15ClF2N2O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0637939
5-(2,5-bis(trifluoromethyl)phenoxy)-N-(2,6-difluorobenzyl)pyridin-2-amine
   Show/Hide
C20H12F8N2O
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0637941
N-(2,6-difluorobenzyl)-5-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-2-amine
   Show/Hide
C17H13F5N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0637942
5-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-N-(2,4,6-trifluorobenzyl)pyridin-2-amine
   Show/Hide
C17H9F9N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0638207
N-(2,6-difluorobenzyl)-5-(7-methyl-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)pyridin-2-amine
   Show/Hide
C21H18F2N2O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0638208
5-(2,2-difluoro-6-methylbenzo[d][1,3]dioxol-5-yl)-N-(2,3,6-trifluorobenzyl)pyridin-2-amine
   Show/Hide
C20H13F5N2O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0638209
5-(2,2-difluoro-6-methylbenzo[d][1,3]dioxol-5-yl)-N-(2-methylbenzyl)pyridin-2-amine
   Show/Hide
C21H18F2N2O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0638247
N-(2,6-difluorobenzyl)-5-(5-fluoro-2-(trifluoromethyl)phenoxy)pyridin-2-amine
   Show/Hide
C19H12F6N2O
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0638249
N-(2,6-difluorobenzyl)-5-(6-methoxy-4-methylpyridin-3-yl)pyrimidin-2-amine
   Show/Hide
C18H16F2N4O
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0638250
N-((3,5-difluoropyridin-4-yl)methyl)-5-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-2-amine
   Show/Hide
C16H12F5N5
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0638438
N2-(2-fluorobenzyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)pyridine-2,6-diamine
   Show/Hide
C17H15F4N5
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0638698
6-(1-ethyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-N-(2-fluorobenzyl)pyridin-3-amine
   Show/Hide
C18H16F4N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639027
N-(2,6-difluorobenzyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)pyrimidin-2-amine
   Show/Hide
C16H12F5N5
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639028
N-(2,6-difluorobenzyl)-5-fluoro-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)pyridin-3-amine
   Show/Hide
C17H12F6N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639029
N-(2-fluorobenzyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)pyridin-2-amine
   Show/Hide
C17H14F4N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639030
5-(7-chloro-2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-6-yl)-N-(4-fluoro-2-methylbenzyl)pyridin-2-amine
   Show/Hide
C20H17ClFN3O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639031
5-(7-chloro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-N-(2,6-difluorobenzyl)pyridin-2-amine
   Show/Hide
C20H15ClF2N2O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639032
5-(2,2-difluoro-6-methylbenzo[d][1,3]dioxol-5-yl)-N-(2,4,6-trifluorobenzyl)pyrazin-2-amine
   Show/Hide
C19H12F5N3O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639033
5-(2,2-difluoro-6-methylbenzo[d][1,3]dioxol-5-yl)-N-(2-fluorobenzyl)pyridin-2-amine
   Show/Hide
C20H15F3N2O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639034
N-(2,6-difluorobenzyl)-5-(6-methyl-2,3-dihydro-1H-inden-5-yl)pyridin-2-amine
   Show/Hide
C22H20F2N2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639149
N-((3,5-difluoropyridin-4-yl)methyl)-5-(5-fluoro-2-(trifluoromethyl)phenoxy)pyridin-2-amine
   Show/Hide
C18H11F6N3O
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639321
N-(2,6-difluorobenzyl)-6-(1-ethyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)pyridin-3-amine
   Show/Hide
C18H15F5N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639322
5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-N-(2,4-difluorobenzyl)pyridin-2-amine
   Show/Hide
C17H13F5N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639323
N-(2,6-difluorobenzyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)pyridin-2-amine
   Show/Hide
C17H13F5N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639324
5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)-2-[(2,6-difluorophenyl)methoxy]pyridine
   Show/Hide
C20H13F4NO3
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639325
5-(7-chloro-2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-6-yl)-N-(2,6-difluorobenzyl)pyridin-2-amine
   Show/Hide
C19H14ClF2N3O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639326
N-(2-chloro-6-fluorobenzyl)-5-(2,2-difluoro-6-methylbenzo[d][1,3]dioxol-5-yl)pyridin-2-amine
   Show/Hide
C20H14ClF3N2O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639354
5-(5-fluoro-2-(trifluoromethyl)phenoxy)-N-(2,4,6-trifluorobenzyl)pyridin-2-amine
   Show/Hide
C19H11F7N2O
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639355
5-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-N-(2,4,6-trifluorobenzyl)pyridin-2-amine
   Show/Hide
C17H12F6N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639356
5-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)-N-(2,4,6-trifluorobenzyl)pyridin-2-amine
   Show/Hide
C17H12F6N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639357
N-(2,6-difluorobenzyl)-5-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)pyridin-2-amine
   Show/Hide
C17H13F5N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639358
5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-N-(2,4,6-trifluorobenzyl)pyridin-2-amine
   Show/Hide
C17H12F6N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0639360
6-(2,2-difluoro-6-methylbenzo[d][1,3]dioxol-5-yl)-N-(2,6-difluorobenzyl)pyridin-3-amine
   Show/Hide
C20H14F4N2O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0850823
N-(3-fluoro-2-methylbenzyl)-5-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-2-amine
   Show/Hide
C18H16F4N4
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0862348
5-(6-chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(2-(trifluoromethyl)benzyl)pyridin-2-amine
   Show/Hide
C20H12ClF5N2O2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0896532
N-(5-fluoro-2-methylbenzyl)-5-(6-methyl-2,3-dihydro-1H-inden-5-yl)pyridin-2-amine
   Show/Hide
C23H23FN2
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0946466
5-(6-chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(5-fluoro-2-methoxybenzyl)pyridin-2-amine
   Show/Hide
C20H14ClF3N2O3
 1
1
IC50 < 600 nM
   TI
   LI
   LO
   TS
CP0634217
5-(2-ethylphenoxy)-N-(2,4,6-trifluorobenzyl)pyridin-2-amine
   Show/Hide
C20H17F3N2O
 1
1
IC50 > 1200 nM
   TI
   LI
   LO
   TS
CP0636779
2-(2,6-difluorobenzyloxy)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)pyrimidine
   Show/Hide
C16H11F5N4O
 1
1
IC50 > 1200 nM
   TI
   LI
   LO
   TS
CP0637940
N-(2,6-difluorobenzyl)-5-(2-ethylphenoxy)pyridin-2-amine
   Show/Hide
C20H18F2N2O
 1
1
IC50 > 1200 nM
   TI
   LI
   LO
   TS
CP0896533
N-((3,5-difluoropyridin-4-yl)methyl)-5-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)pyridin-2-amine
   Show/Hide
C16H12F5N5
 1
1
IC50 > 1200 nM
   TI
   LI
   LO
   TS