Brief Information of the Cell Line and Protein
Cell Line ID: CL000196 , MDA-MB-468
 Cell Line Info 
Synonyms
MDA-MB 468
MDA-MB468
MDAMB468
MDA-468
MDA468
MB468
MD Anderson-Metastatic Breast-468
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0419
Protein ID: PT01065 , Serine/threonine-protein kinase mTOR
 Protein Info 
Gene Name MTOR
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P42345
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000196
 Cell Line Info 
 Protein ID: PT01065
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0068244
 Compound Info 
(3R)-3-methyl-4-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrimidin-4-yl]morpholine
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C20H23N5O3S
  2
1
IC50 = 270 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 1400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0127298
 Compound Info 
US9428503, 1
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C26H31N5O3
  1
1
IC50 = 610 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0068243
 Compound Info 
(3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine
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C21H24N4O3S
  2
1
IC50 = 720 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 2400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0076974
 Compound Info 
4-[2-(1H-indol-4-yl)-6-(4-methylsulfonylpiperidin-4-yl)pyrimidin-4-yl]morpholine
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C22H27N5O3S
  1
1
IC50 = 1500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0068245
 Compound Info 
N-methyl-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine
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C21H26N6O3S
  2
1
IC50 = 1500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 4000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0157307
 Compound Info 
4-[2-(1H-indol-4-yl)-6-(2-methylsulfonylpropan-2-yl)pyrimidin-4-yl]morpholine
   Show/Hide
C20H24N4O3S
  1
1
IC50 = 2700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0669285
 Compound Info 
US8552004, 2.03
   Show/Hide
C21H27N7O2S
  2
1
IC50 = 3100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 9800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0102640
 Compound Info 
4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine
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C20H22N4O3S
  1
1
IC50 = 3200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0085622
 Compound Info 
4-[2-(1H-indol-4-yl)-6-(4-methylsulfonyloxan-4-yl)pyrimidin-4-yl]morpholine
   Show/Hide
C22H26N4O4S
  1
1
IC50 = 3300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0808811
 Compound Info 
CERALASERTIB
   Show/Hide
C20H24N6O2S
  2
1
IC50 = 5700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 > 23000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0085620
 Compound Info 
4-[2-(1H-indol-4-yl)-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine
   Show/Hide
C18H20N4O3S
  1
1
IC50 = 5900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS