| Compound ID |
Compound Name |
Compound Formula |
|
CP0535336
|
1-[(2S,3'R)-3'-(2-aminoethyl)-5-(2,5-difluorophenyl)-6'-fluorospiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]ethanone
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|
C20H18F3N3O2S
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0524585
|
1-[(2S,3'R)-3'-(2-aminoethyl)-5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]ethanone
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|
C20H19F2N3O2S
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
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CP0519871
|
1-[(2S,3'R)-3'-(2-aminoethyl)-5-(2,5-difluorophenyl)-6',7'-difluorospiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]ethanone
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|
C20H17F4N3O2S
|
1
|
| 1 |
EC50 = 3 nM
|
|
|
|
CP0389022
|
1-[(2S,3'R)-3'-(2-aminoethyl)-5-(2,5-difluorophenyl)-6',8'-difluorospiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]ethanone
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|
C20H17F4N3O2S
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0481830
|
1-[(2S,3'R)-3'-(2-aminoethyl)-5-(2,5-difluorophenyl)-8'-fluorospiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]ethanone
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|
C20H18F3N3O2S
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0523153
|
1-[3'-(2-aminoethyl)-5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]ethanone
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|
C20H19F2N3O2S
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0560922
|
1-[(2S,3'S)-3'-(2-aminoethyl)-5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]ethanone
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|
C20H19F2N3O2S
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0535337
|
1-[(2S,3'R)-3'-(2-aminoethyl)-6'-chloro-5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]ethanone
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|
C20H18ClF2N3O2S
|
1
|
| 1 |
EC50 = 17 nM
|
|
|
|
CP0462176
|
1-[5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]ethanone
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|
C18H14F2N2O2S
|
1
|
| 1 |
EC50 = 139 nM
|
|
|
|
CP0504751
|
1-[5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydro-1H-quinoline]-3-yl]ethanone
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|
C18H15F2N3OS
|
1
|
| 1 |
EC50 = 179 nM
|
|
|
|
CP0504753
|
1-[(2R,3'R)-3'-(2-aminoethyl)-5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]ethanone
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|
C20H19F2N3O2S
|
1
|
| 1 |
EC50 = 205 nM
|
|
|
|
CP0462185
|
1-[5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,3'-2H-1-benzofuran]-3-yl]ethanone
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|
C17H12F2N2O2S
|
1
|
| 1 |
EC50 = 246 nM
|
|
|
|
CP0462186
|
1-[5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]-4-(dimethylamino)butan-1-one
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|
C22H23F2N3O2S
|
1
|
| 1 |
EC50 = 263 nM
|
|
|
|
CP0451814
|
4-amino-1-[5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]butan-1-one
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|
C20H19F2N3O2S
|
1
|
| 1 |
EC50 = 338 nM
|
|
|
|
CP0481828
|
1-[5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]-4-(methylamino)butan-1-one
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|
C21H21F2N3O2S
|
1
|
| 1 |
EC50 = 367 nM
|
|
|
|
CP0504750
|
1-[5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]propan-1-one
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|
C19H16F2N2O2S
|
1
|
| 1 |
EC50 = 452 nM
|
|
|
|
CP0525126
|
1-[5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]-2-hydroxyethanone
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|
C18H14F2N2O3S
|
1
|
| 1 |
EC50 = 615 nM
|
|
|
|
CP0451867
|
1-[5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]-2-methoxyethanone
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|
C19H16F2N2O3S
|
1
|
| 1 |
EC50 = 665 nM
|
|
|
|
CP0461013
|
1-[5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrothiochromene]-3-yl]ethanone
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|
C18H14F2N2OS2
|
1
|
| 1 |
EC50 = 3313 nM
|
|
|
|
CP0523152
|
3-amino-1-[5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]propan-1-one
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|
C19H17F2N3O2S
|
1
|
| 1 |
EC50 > 500 nM
|
|
|
|
CP0535335
|
1-[5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]-2-methylpropan-1-one
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|
C20H18F2N2O2S
|
1
|
| 1 |
EC50 > 500 nM
|
|
|
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CP0433430
|
1-[5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,5'-3,4-dihydro-2H-1-benzoxepine]-3-yl]ethanone
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|
C19H16F2N2O2S
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
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CP0451868
|
2-amino-1-[5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]ethanone
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|
C18H15F2N3O2S
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
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CP0481829
|
1-[(2R,3'S)-3'-(2-aminoethyl)-5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]ethanone
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|
C20H19F2N3O2S
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
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CP0504752
|
1-[5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]-2,2-dimethylpropan-1-one
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|
C21H20F2N2O2S
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
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CP0535334
|
1-[5-(2,5-difluorophenyl)-1'-methylspiro[1,3,4-thiadiazole-2,4'-2,3-dihydroquinoline]-3-yl]ethanone
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|
C19H17F2N3OS
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
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CP0559286
|
1-[3-acetyl-5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydroquinoline]-1'-yl]ethanone
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|
C20H17F2N3O2S
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
